Article
Chemistry, Analytical
Lin Liu, Xiaotong Li, Hua Zhang, Hongda Chen, Murad M. A. Abualrejal, Daqian Song, Zhenxin Wang
Summary: A six-in-one peptide functionalized upconversion@polydopamine nanoparticle-based ratiometric fluorescence sensing platform has been developed for real-time monitoring of anticancer efficacy through detection of caspase-3 activity. The platform shows high sensitivity and real-time feedback capability, allowing successful evaluation of tumor response to various treatment modalities.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Shiyu He, Hui Xiang, Gan Zhao, Mengting Zhang, Jian Lin, Lina Yang, Honglin Liu
Summary: Developing reliable probes for accurate monitoring peroxynitrite (ONOO-) in living systems is crucial for understanding its functions in diseases and improving therapies. In this study, a novel nano-assembly structure (D-AuGP) was developed using gold nanoclusters (Au NCs) and induced fluorescence resonance energy transfer (FRET). The probe showed a quantitative ratiometric fluorescence response toward ONOO- with good stability and biocompatibility. It was successfully used for biological imaging and monitoring ONOO- levels in living cells and zebrafish.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Spectroscopy
Zi-Bo Ma, Yan Zhang, Xing-Hui Ren, Xi-Wen He, Wen-You Li, Yu-Kui Zhang
Summary: The study successfully achieved dual-reverse-signal ratiometric fluorescence detection of malachite green using synergistic effect of fluorescence resonance energy transfer (FRET) and inner filter effect (IFE), demonstrating low detection limit, rapid response, and satisfactory recoveries in real water samples, making it a promising method for MG detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Guangming Li, Hang Gao, Ningning Wang, Zhaohui Li, Huangxian Ju
Summary: This study proposed a simple and sensitive method for ratiometric fluorescent detection of nucleic acids by controlling the pH-dependent adsorption of dye-labeled DNA on polymer dots. The method showed promising application in bioanalysis with excellent performance and good extendability.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Yutong Li, Xinhui Gu, Jiayin Zhao, Fengna Xi
Summary: In this study, a novel ratiometric fluorescence sensing platform based on carbon dots (CDs) as both luminophores and nanozymes was constructed for the sensitive detection of hydrogen peroxide (H2O2). The CDs with peroxidase-mimicking activity were prepared using a hydrothermal method, and exhibited bright blue fluorescence. The catalytic oxidation of o-phenylenediamine (OPD) by CDs in the presence of H2O2 resulted in the generation of 2,3-diaminophenolazine (DAP), leading to fluorescence resonance energy transfer (FRET) and a ratiometric fluorescence system. The CD nanozymes showed good affinity for both OPD and H2O2 substrates, and a low limit of detection (LOD) of 0.42 μM was achieved for H2O2.
Article
Chemistry, Analytical
Hua-Rui Nan, Yun-Hai Liu, Wen-Juan Gong, Hong-Bo Peng, You-Qun Wang, Zhi-Bin Zhang, Xiao-Hong Cao
Summary: A ratiometric fluorescence system was developed for the detection of trace UO22+ in water using the inner filter effect between AuNPs and AuNCs. The fluorescent sensor exhibited a color change from red to blue when UO22+ was added, with a detection limit of 8.4 nM. It showed good performance for UO22+ determination in real-world water samples.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
A. Muthurasu, V. Ganesh
Summary: Nitrogen-doped carbon dots prepared with Rhodamine B as a donor molecule showed emission color tuning from blue to red, utilized for ratiometric sensing of mercury ion. The photoluminescence properties of N-CDs were effectively quenched by Hg2+ ions, leading to the development of a cheap and selective sensing matrix for the detection of toxic metal ions such as mercury (Hg2+).
ANALYTICAL METHODS
(2021)
Article
Chemistry, Multidisciplinary
Yuanjin Zhan, Shuangting Yang, Lifen Chen, Yanbo Zeng, Lei Li, Zhenyu Lin, Longhua Guo, Wei Xu
Summary: A ratiometric fluorescence sensor based on FRET strategy was developed for detecting ALP activity and its inhibitor Na3VO4. The sensor showed high FRET efficiency, ratiometric change in fluorescence intensity, and dual-emission self-correction ability, enabling quantitative detection and visual analysis of ALP activity. This biosensor provides a promising alternative for evaluating ALP-related diseases and can also be utilized for assessing Cu2+, PPi, and Na3VO4 levels, as well as screening ALP inhibitors.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Analytical
Kunshan Huang, Song Xie, Weijun Wang, Zai-Sheng Wu, Juhong Wu, Lizhi Jiang, Juanjuan Chen, Jinyu Li
Summary: In this study, a new prodrug was developed for real-time monitoring of SN-38 release and reducing activation in normal cells. The prodrug showed significantly enhanced fluorescence and activity upon selective and rapid activation by hydrogen sulfide (H2S). Moreover, the prodrug exhibited remarkable toxicity towards H2S-overexpressed cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Electrical & Electronic
Wenjia Li, Chang Liu, Dong Liu, Shuda Liu, Tianyan You
Summary: The study developed a ratiometric fluorescence assay using nanozyme and fluorescence resonance energy transfer to efficiently detect mercury ion, which was validated for its reliability in Yangtze river water samples.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Biochemical Research Methods
Neha Irfan, Neha Soleja, Mohd Mohsin
Summary: Inadequate folic acid intake is associated with various diseases, but traditional methods of determining folic acid levels are unreliable and time-consuming. We have developed SenFol, a highly specific and quick-responding nanosensor, which shows potential for dynamic detection of intracellular folic acid content in different cells.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Lingang Yang, Shumin Shen, Jie Zhu, Yuqing Zhang, Yuting Lin, Jiamin Wang, Feifei Tao, Lingzhi Wang, Jinlong Zhang
Summary: The creation of yolk-shell nanoparticles (YS NPs) with a movable core and periodic mesoporous organosilica (PMO) shell has been simplified using a self-template strategy. A ratiometric Cu2+ fluorescence sensor is created by incorporating a silver nanocore into the YS NP (Ag-PMO-YS), driven by the like dissolves like principle. Due to the coordination of Cu2+ and its ligands and their impact on the emission of fluorescein derivatives, this sensor system demonstrates extraordinary detection sensitivity to Cu2+ (10-7 M), strengthened by the movable Ag nanocore's metal-enhanced fluorescence (MEF) effect.
ACS APPLIED NANO MATERIALS
(2023)
Review
Chemistry, Inorganic & Nuclear
Zoufeng Xu, Zhigang Wang, Zhiqin Deng, Guangyu Zhu
Summary: Platinum-based anticancer drugs have been widely used in clinical practice for over 40 years, with a focus on developing platinum(IV) prodrugs based on traditional platinum(II) anticancer drugs. Recent progress in the field includes synthesizing platinum(IV) prodrugs with new oxidizing reagents, understanding the hydrolysis and stability of platinum(IV) complexes, and exploring reduction processes to achieve controllable intracellular reduction of platinum(IV) prodrugs. This review aims to enhance researchers' understanding of platinum(IV) anticancer prodrugs and inspire new strategies, ideas, and applications in metal-based drugs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Analytical
Mengting Guan, Haibo He, Ruxing Li, Xiaojing Si, Xitian Peng, Xiaoxia Yan, Zhaosheng Yang, Enhsuan Nien, Yunyi Lei, Liqiang Luo
Summary: In this work, a La3+ assisted GSH-Au NCs/CDs nanoplatform was fabricated for sensitive detection of FEN. The fluorescence response of GSH-Au NCs was significantly enhanced by La3+ and further enhanced by the coordination between La3+ and FEN. The ratiometric fluorescence of GSH-Au NCs and CDs showed a good linear relationship with FEN concentration and exhibited good sensitivity at a low detection limit. The nanoplatform demonstrated desirable selectivity and applicability for monitoring trace level of FEN in fruit and vegetable samples. The non-enzymatic strategy using AIEE of GSH-Au NCs has a great potential for facile screening of organophosphate pesticides in agro-products.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Jialing Zhou, Ruoxi Zhao, Yaqian Du, Shikai Liu, Wenting Li, Shili Gai, Fei He, Lili Feng, Piaoping Yang
Summary: This study introduces a novel Si-CdTe quantum dots probe for sensitive detection of H2O2 and glucose. It has low toxicity, high specificity, and good stability, as well as an excellent lysosomal colocalization effect.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Wei Liang Teo, Weigiang Zhou, Cheng Qian, Yanli Zhao
Summary: This review provides an up-to-date summary of the progress towards industrialization of metal-organic frameworks (MOFs), discussing the latest developments in scalable production and processing methods, as well as evaluating their industrial utilization potentials.
Article
Engineering, Biomedical
Jason Tan, Yanli Zhao, James L. Hedrick, Yi Yan Yang
Summary: Hydrophobic side chains in polymers play a significant role in antimicrobial activity and selectivity, with more hydrophobic polymers showing faster bacteria elimination but reduced selectivity at higher percentage content. Highly hydrophobic co-polymers with hexyl-functionalized cyclic carbonate kill bacteria via membrane-disruptive mechanism, with micelle formation leading to lower extent of membrane disruption. This study provides insights into the design of new antimicrobial polymers based on the effects of hydrophobic side chains.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Beibei Lu, Yiyang Bo, Mingjie Yi, Zhenyuan Wang, Jichuan Zhang, Zhenye Zhu, Yanli Zhao, Jiaheng Zhang
Summary: The study successfully synthesized an L-(-)-carnitine-based ionic liquid and developed IL/O ME to improve drug solubility and protein permeability.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Zhonghao Wang, Yan Zheng, Yan Su, Liang Gao, Yinyin Zhu, Jie Xia, Yongfeng Zhang, Chang Wang, Xian Zheng, Yanli Zhao, Chaolong Yang, Youbing Li
Summary: By doping organic chromophore molecules into polymer matrix, dynamic stimulus-responsive long-lived RTP systems with various emission colors are achieved. The phosphorescence intensity, lifetime, afterglow brightness, and quantum yield of one representative film increase dramatically after UV light irradiation.
SCIENCE CHINA-MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Anivind Kaur Bindra, Sivaramapanicker Sreejith, Rajendra Prasad, Mahadeo Gorain, Rijil Thomas, Deblin Jana, Mui Hoon Nai, Dongdong Wang, Abhimanyu Tharayil, Gopal C. Kundu, Rohit Srivastava, Sabu Thomas, Chwee Teck Lim, Yanli Zhao
Summary: Designing organic-inorganic hybrids by anchoring plasmonic materials on self-assembled organic substrates is challenging but useful. The in situ anchoring of plasmonic nanoparticles on a designed spherical assembly via bonding formation is presented. This approach paves the way for developing intelligent multifunctional nanosystems capable of cancer detection and imaging.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Qiuhong Zhang, Meijuan He, Xiaodong Zhang, Hongwei Yu, Jiawei Liu, Yi Guo, Junmin Zhang, Xiangzhong Ren, Han Wang, Yanli Zhao
Summary: This study reports the development of a tumor microenvironment-activable ROS-generating system using a protein-based nanomedicine that undergoes multistage self-assembly. The system offers effective self-protection for normal tissues and achieves tumor-specific therapy, providing a powerful strategy for nanomedicine design and precise cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chang Wang, Yongfeng Zhang, Zhonghao Wang, Yan Zheng, Xian Zheng, Liang Gao, Qian Zhou, Jinqiu Hao, Bingxue Pi, Qiankun Li, Chaolong Yang, Youbing Li, Kaiti Wang, Yanli Zhao
Summary: This study successfully designed and synthesized two polymer acceptors that exhibit long-lived room temperature phosphorescence (RTP) when doped into a poly(methyl methacrylate) matrix. The long-lived RTP performance is highly dependent on the grafting rate of the polymers, with higher grafting rates leading to better green long-lived RTP effects.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Shuming Dong, Yushan Dong, Bin Liu, Jing Liu, Shikai Liu, Zhiyu Zhao, Wenting Li, Boshi Tian, Ruoxi Zhao, Fei He, Shili Gai, Ying Xie, Piaoping Yang, Yanli Zhao
Summary: The authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities to disrupt the H2O2 homeostasis, achieve intensive NCDT, and induce tumor apoptosis and death. The nanozyme catalyzes the conversion of superoxide anion into H2O2 in the tumor region and inhibits the off-target decomposition of H2O2. The elevated H2O2 is then converted into toxic hydroxyl radicals, leading to tumor cell death.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yue Zhao, Shanliang Song, Xiangzhong Ren, Junmin Zhang, Quan Lin, Yanli Zhao
Summary: Tissue engineering offers a promising approach for treating organ or tissue loss, with supramolecular adhesive hydrogels showing great potential due to their unique properties. This review comprehensively summarizes the design principles and applications of adhesive hydrogels, highlighting their efficacy in various tissue repair processes.
Review
Engineering, Biomedical
Zhaoyu Ma, Mohamed F. Foda, Yanli Zhao, Heyou Han
Summary: Rapid development of nanotechnology provides promising strategies in biomedicine, especially in tumor therapy. Improve cellular internalization from extracellular to intracellular via active targeting and enhance the intracellular retention of therapeutics by subcellular localization are crucial for the development of advanced anticancer nanosystems for strengthening the tumor therapy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Fei Yang, Ran Li, Wei Wei, Xingwei Ding, Zhenzhen Xu, Ping Wang, Guo Wang, Yanqing Xu, Hongbing Fu, Yanli Zhao
Summary: In this study, a water-soluble PDI cyclophane Gemini Box (GBox-1(4+)) was developed, which effectively eliminated the self-aggregation of PDIs and could be used for lysosome-targetable live-cell imaging. Furthermore, GBox-1(4+) stabilized the highly concentrated aqueous solution of PDI radical anion, leading to excellent near-infrared photothermal effect for efficient and selective antibacterial applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Nanoscience & Nanotechnology
Xiaodong Zhang, Xiaokai Chen, Yanli Zhao
Summary: Traditional enzymes have limitations in terms of cost, denaturation, and yield, while nanozymes, as a new type of artificial enzyme combining nanomaterials and enzymes, show promising potential in various applications due to their high catalytic activity and versatility.
NANO-MICRO LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Dong Wang, Shuo Shi, Yanyun Mao, Leqi Lei, Shaohai Fu, Jinlian Hu
Summary: A novel dual-network design strategy is proposed to prepare a high-performance cellulosic composite bioplastic metafilm with exceptional mechanical toughness, flame retardance, and solvent resistance. The metafilm exhibits a higher maximum usage temperature, lower thermal expansion coefficient, good biocompatibility, and natural biodegradation, making it a competitive substitute for plastics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Zhaohui Zong, Aiyou Hao, Pengyao Xing, Yanli Zhao
Summary: This work presents a molecular folding strategy to construct giant POSS molecules with inherent chirality. The folding of amino acid arms facilitated the chirality transfer from amino acids to ferrocene and POSS. The chiral orientation and chiroptical properties of POSS were found to depend on the substituents of alpha-amino acids. Through the kinetic nanoprecipitation protocol, chirality transfer from the molecular scale to the micrometer scale was achieved. This work opens up a new way to obtain discrete chiral molecular nanoparticles for potential chiroptical applications.
Article
Materials Science, Multidisciplinary
Hongzhong Chen, Tao Sun, Weiwei Zeng, Xiaowei Zeng, Lin Mei, Chen Jiang, Yanli Zhao
Summary: A hypoxia-activated prodrug has been developed in this study for combination therapy with photodynamic therapy (PDT), making the best use of the hypoxic tumor microenvironment. The combination of a hypoxia-responsive camptothecin (CPT)-based prodrug and a near-infrared (NIR) BODIPY photosensitizer allows for effectively combined PDT and chemotherapy, providing a promising approach for cancer treatment.
ACS MATERIALS LETTERS
(2022)