Article
Cell Biology
Wenqian Zhang, Jun Hong, Hanwen Zhang, Wencheng Zheng, Ying Yang
Summary: The study found that astrocyte-derived exosomes can protect against traumatic brain injury-induced oxidative stress and neuronal apoptosis by activating the Nrf2 signaling pathway.
Review
Biochemistry & Molecular Biology
Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodia
Summary: Neurodegeneration is a progressive phenomenon associated with aging, where activated microglia and neuroinflammation play crucial roles. Mitochondrial dysfunction and excessive neuroinflammatory responses are important factors contributing to age-dependent neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yan Tang, Ya Hou, Yong Zeng, Yao Hu, Yi Zhang, Xiaobo Wang, Xianli Meng
Summary: Salidroside alleviates hypoxic injury in PC12 cells by inhibiting oxidative stress, anti-apoptosis, and enhancing mitochondrial energy synthesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Teresa Puig-Pijuan, Leticia R. Q. Souza, Carolina da S. G. Pedrosa, Luiza M. Higa, Fabio Luis Monteiro, Amilcar Tanuri, Rafael H. F. Valverde, Marcelo Einicker-Lamas, Stevens Kastrup Rehen
Summary: The imbalance of copper homeostasis plays a role in the pathology of Zika virus in astrocytes, which may also contribute to developmental abnormalities in the central nervous system. Evaluating micronutrient levels and using copper chelators could be promising strategies for managing congenital Zika virus syndrome.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ilenia Martinelli, Mathieu Cinato, Sokhna Keita, Dimitri Marsal, Valentin Antoszewski, Junwu Tao, Oksana Kunduzova
Summary: The study found that short-term exposure to EMF did not have a significant effect on the myocardial antioxidant defense system and apoptotic cell death in cardiac cells and tissues.
Article
Biochemistry & Molecular Biology
Yosuke Tabei, Hiroko Abe, Shingo Suzuki, Nobuaki Takeda, Jun-ichiro Arai, Yoshihiro Nakajima
Summary: This study demonstrated that Sedanolide enhances cellular resistance to oxidative damage through the activation of the KEAP1-NRF2 pathway and upregulation of antioxidant enzymes. Additionally, Sedanolide attenuates cytosolic and mitochondrial ROS generation induced by H2O2, thereby exerting cytoprotective effects against H2O2-induced cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ning Li, Meiyu Chang, Qiang Zhou, Lin Zhang, Yongheng Wang, Yi Guan, Haibin Li, Yingzheng Zhao, Chunjie Ding, Shan Hong, Sanqiao Yao
Summary: Metformin can attenuate silica-induced pulmonary fibrosis by regulating oxidative stress and the mitochondrial apoptotic pathway. Daily administration of 100 mg/kg Metformin for 21 consecutive days effectively alleviates pulmonary fibrosis through activation of AMPK signaling and relief of oxidative stress and mitochondrial apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yurong Fu, Yongcheng Jin, Yue Tian, Hao Yu, Ruqi Wang, Huiyu Qi, Bo Feng, Jing Zhang
Summary: The synergistic effect of ZEA and LPS aggravates cytotoxicity by increasing the accumulation of ROS and MDA, decreasing MMP and SOD levels, and reducing GSH levels. Additionally, ZEA and LPS promote cell apoptosis by activating ER stress and suppressing anti-apoptotic proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Rosa Vona, Nadia Maria Sposi, Lorenza Mattia, Lucrezia Gambardella, Elisabetta Straface, Donatella Pietraforte
Summary: Sickle cell disease is a hereditary disorder of hemoglobin characterized by abnormal sickle hemoglobin production, leading to oxidative stress and organ damage. Antioxidant agents have been shown to reduce disease consequences and delay organ complications. Understanding oxidative stress may lead to targeted antioxidant therapies to prevent organ complications in sickle cell patients.
Article
Environmental Sciences
Xiaorui Wang, Hongyue Wu, Kunlun Yang, Peng Gu, Yu Zheng, Manman Li, Yonggui Wu, Hengfeng Miao
Summary: This study assessed the hepatotoxicity of sludge leachate on zebrafish and described the underlying mechanism. The results showed that the leachate induced oxidative stress and caused liver damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yong Kwon Han, Ji Su Kim, GiBong Jang, Kwon Moo Park
Summary: Cisplatin induces lung cell damage, ciliary fragmentation, and increased oxidative stress, but these effects can be prevented by the mitochondria-specific antioxidant Mito-TEMPO.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Yongshui Wang, Yao Guo, Haohao Liu, Xingde Du, Linjia Shi, Wenjun Wang, Shenshen Zhang
Summary: This study discussed the protective effect of hawthorn fruit extract on liver damage caused by microcystins, and found that it can alleviate oxidative stress and apoptosis, thus reducing hepatotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Kusaczuk, Rafal Kretowski, Monika Naumowicz, Anna Stypulkowska, Marzanna Cechowska-Pasko
Summary: The study investigated the interaction of dietary flavonoid quercetin with human glioblastoma cell lines. The results showed that quercetin induced apoptosis and cell death through activation of the intrinsic pathway of apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Jiabin Shi, Yaling Wang, Wenlin Xu, Guodong Cai, Hui Zou, Yan Yuan, Jianhong Gu, Zongping Liu, Jianchun Bian
Summary: This study investigates the molecular mechanism of liver damage induced by BEA, revealing that Nrf2 nuclear translocation plays a crucial role in BEA-induced oxidative stress and hepatotoxicity. Furthermore, the study shows a correlation between Nrf2 activation and autophagy.
Article
Biochemistry & Molecular Biology
Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon, Fu-Shi Quan
Summary: This study revealed that HDACi suppresses the expression of GPX8, sensitizing HCC cells to ER stress and oxidative stress, leading to apoptosis.
Article
Food Science & Technology
Kais Rtibi, Slimen Selmi, Khouloud Saidani, Dhekra Grami, Mohamed Amri, Hichem Sebai, Lamjed Marzouki
JOURNAL OF FOOD SCIENCE
(2018)
Article
Cardiac & Cardiovascular Systems
Hayfa Medfai, Alia Khalil, Alexandre Rousseau, Vincent Nuyens, Martina Paumann-Page, Benjamin Sevcnikar, Paul G. Furtmueller, Christian Obinger, Nicole Moguilevsky, Olivier Peulen, Michael Herfs, Vincent Castronovo, Mohamed Amri, Pierre Van Antwerpen, Luc Vanhamme, Karim Zouaoui Boudjeltia
CARDIOVASCULAR RESEARCH
(2019)
Article
Neurosciences
Olfa Rebai, Mohamed Amri
NEUROTOXICITY RESEARCH
(2018)
Article
Reproductive Biology
Rym Belhareth, Soraya Mezouar, Amira Ben Amara, Celine Chartier, Eya Ben Azzouz, Eric Chabriere, Mohamed Amri, Jean-Louis Mege
REPRODUCTIVE TOXICOLOGY
(2018)
Article
Clinical Neurology
Sami Aboudhiaf, Georges Alves, Sandrine Parrott, Mohamed Amri, Megane M. Simonnet, Yael Grosjean, Gerard Maniere, Laurent Seugnet
Article
Clinical Neurology
Sami Aboudhiaf, Georges Alves, Sandrine Parrott, Mohamed Amri, Megane M. Simonnet, Yael Grosjean, Gerard Maniere, Laurent Seugnet
Review
Pharmacology & Pharmacy
Olfa Masmoudi-Kouki, Yosra Hamdi, Ikram Ghouili, Seyma Bahdoudi, Hadhemi Kaddour, Jerome Leprince, Helene Castel, Hubert Vaudry, Mohamed Amri, David Vaudry, Marie-Christine Tonon
CURRENT PHARMACEUTICAL DESIGN
(2018)
Article
Biochemistry & Molecular Biology
Hadhemi Kaddour, Yosra Hamdi, Fatma Amri, Seyma Bahdoudi, Ibtissem Bouannee, Jerome Leprince, Sami Zekri, Hubert Vaudry, Marie-Christine Tonon, David Vaudry, Mohamed Amri, Sana Mezghani, Olfa Masmoudi-Kouki
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Sarah Ben Youssef, Guillaume Brisson, Helene Doucet-Beaupre, Anne-Marie Castonguay, Charles Gora, Mohamed Amri, Martin Levesque
Summary: The study demonstrated the neuroprotective effect of GSSE on midbrain dopaminergic neurons in both in vitro and in vivo models of Parkinson's disease. GSSE effectively protected dopamine neurons from 6-OHDA toxicity by reducing apoptosis, ROS levels, and inflammation, ultimately improving neuronal loss and motor function in a PD model.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Samia Bouzghaya, Mohamed Amri, Fabrice Homble
JOURNAL OF MEDICINAL FOOD
(2020)
Article
Sport Sciences
Ghazi Racil, Mohamed C. Jlid, Mohamed S. Bouzid, Rime Sioud, Riadh Khalifa, Mohamed Amri, Sabri Gaied, Jeremy Coquart
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2020)
Article
Food Science & Technology
Mohamed Nizar Zourgui, Mbarka Hfaiedh, Dalel Brahmi, Wissal Affi, Neji Gharsallah, Lazhar Zourgui, Mohamed Amri
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2020)
Article
Biochemistry & Molecular Biology
Wafaa Laabbar, Abdellatif Abbaoui, Abdeljalil Elgot, Meherzia Mokni, Mohamed Amri, Olfa Masmoudi-Kouki, Halima Gamrani
Summary: Aluminum is a potent neurotoxic metal that induces oxidative stress and neuronal cell death, while curcumin acts as a multi-functional drug with antioxidant activity that can protect against aluminum toxicity in astrocytes. The protective effect of curcumin is initiated by stimulating the endogenous antioxidant system.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Pharmacology & Pharmacy
Heyfa Hadriche-Jarraya, Ferid Limam, Ezzedine Aouani, Mohamed Amri, Meherzia Mokni
Summary: Garlic, also known as Allium sativum (As), has been shown to modulate vascular activity by increasing blood vessel permeability and inducing vasodilation. The active component responsible for these effects appears to be a low molecular weight peptide, different from DAS and DADS.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Seyma Bahdoudi, Ikram Ghouili, Mansour Hmiden, Jean-Luc do Rego, Benjamin Lefranc, Jerome Leprince, Julien Chuquet, Jean-Claude do Rego, Ann-Britt Marcher, Susanne Mandrup, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri, Olfa Masmoudi-Kouki, David Vaudry
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)