Article
Multidisciplinary Sciences
Shi Hao Lee, Yeannie H. Y. Yap, Chew Leng Lim, Amanda Rui En Woo, Valerie C. L. Lin
Summary: This study reveals the crucial role of the activation function AF1 of progesterone receptor (PGR) in mammary development. Gain of function mutant AF1_QQQ shows hyperactivity while loss of function mutant AF1_FFF exhibits hypoactivity on mammary development. AF1_FFF mutation significantly impairs mammary development in response to estrogen and progesterone and during pregnancy, but has no effect on mammary development in nulliparous mice. Furthermore, Rankl is identified as a major target gene of AF1.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Nguyen Xuan Thang, Dong Wook Han, Chanhyeok Park, Hyeonji Lee, Hyeonwoo La, Seonho Yoo, Heeji Lee, Sang Jun Uhm, Hyuk Song, Jeong Tae Do, Kyoung Sik Park, Youngsok Choi, Kwonho Hong
Summary: This study investigated the relationship between INO80 expression and breast cancer sub-classification and progression using weighted gene co-expression network analysis (WCGNA). The findings suggest that INO80 repression is associated with increased risk of breast carcinogenesis and differential responsiveness of estrogen receptors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Gat Rauner, Charlotte Kuperwasser
Summary: Cell fate decisions in the mammary gland are tightly controlled by the microenvironment, specifically by the extracellular matrix, immune microenvironment, and hormones. Pathological changes in the microenvironment can alter cell fates, leading to malignancy. This review highlights how these elements converge to promote DNA damage and affect mammary cell fate.
DEVELOPMENTAL CELL
(2021)
Review
Biochemistry & Molecular Biology
Diana Wu, Lilian U. Thompson, Elena M. Comelli
Summary: Breast cancer, the second most common cancer in women after skin cancer, can be influenced by mammary gland development. miRNAs play a key role in both mammary development and breast cancer, and studying their role in development may provide insights into potential targets for breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Odul Karayazi Atici, Nayantara Govindrajan, Isbel Lopetegui-Gonzalez, Carrie S. Shemanko
Summary: Prolactin plays a crucial role in mammals, influencing mammary gland development, tumor growth, and various hormone-related cancers. It is essential in the pathogenesis of breast cancer and modulation of the bone microenvironment.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Kohei Saeki, Gregory Chang, Noriko Kanaya, Xiwei Wu, Jinhui Wang, Lauren Bernal, Desiree Ha, Susan L. Neuhausen, Shiuan Chen
Summary: The study presents an integrated mammary cell gene expression atlas derived from mouse and human single-cell RNA-sequence data, characterizing key life stages of mammary gland remodeling and inferring cells of origin for various breast cancer subtypes using breast cancer expression data.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
Edmund Charles Jenkins, Mrittika Chattopadhyay, Maria Gomez, Denis Torre, Avi Ma'ayan, Miguel Torres-Martin, Daniela Sia, Doris Germain
Summary: A major limitation in breast cancer research using mouse models is that most mice develop estrogen receptor-alpha (ER alpha)-negative mammary tumors, while in humans, the majority of breast cancers are ER alpha-positive. However, a new study using an inducible mouse model revealed that mammary tumors in young mice are ER alpha-negative, while they are ER alpha-positive in aged mice. The study also identified genes involved in the activation of ER alpha axis and the regulation of UPR stress responses in aged female-derived mammary tumors. These findings suggest that aging alters the oncogenic trajectory towards ER alpha-positive breast cancer subtype.
Article
Pharmacology & Pharmacy
Fatemeh Mahboobifard, Leila Dargahi, Masoumeh Jorjani, Fahimeh Ramezani Tehrani, Mohammad H. Pourgholami
Summary: ER alpha 36, a newly identified isoform of estrogen receptor, is highly expressed in the CNS and plays a role in neuroprotection, as well as maintaining bone density in postmenopausal women. Despite being considered an oncogenic molecule, ER alpha 36 paradoxically may have a protective role in certain tumors according to some studies.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Hongmei Zhu, Qianqian Jia, Yanyan Zhang, Dongming Liu, Diqi Yang, Li Han, Jianguo Chen, Yi Ding
Summary: It is still unclear how ovarian hormones affect goat lactation by regulating cell-cell junctions. This study reveals that ovarian hormones can elevate the expression of cell-cell junction proteins, which may affect intercellular space and molecule transportation between goat mammary epithelial cells. The results suggest that ovarian hormones may play a role in regulating milk production by influencing the expression of cell-cell junction proteins between mammary epithelial cells.
Review
Oncology
Madison N. Wicker, Kay-Uwe Wagner
Summary: Cellular plasticity, the ability of cells to change their identity, plays a crucial role in mammary gland development and breast cancer progression. This review provides a comprehensive overview of the factors and mechanisms that promote cellular plasticity in the mammary gland. It discusses changes in cell identity during normal development, the role of the gestation cycle, and highlights the importance of the microenvironment and extracellular matrix. The review also explores cellular reprogramming during mammary tumorigenesis, focusing on the origin of basal-like breast cancers and the role of oncogenic signaling networks. Additionally, recent advances in genetically engineered models to study cellular plasticity in vivo are discussed.
Review
Biochemistry & Molecular Biology
Mariam Rusidze, Marine Adlanmerini, Elodie Chantalat, I. Raymond-Letron, Surya Cayre, Jean-Francois Arnal, Marie-Ange Deugnier, Francoise Lenfant
Summary: This review discusses the role of ER alpha in mammary gland development and breast cancer progression, highlighting both the classical nuclear genomic and membrane non-genomic actions of ER alpha in regulating mammary development at different stages. It also provides an overview of the characteristics of luminal cell lineage expressing ER alpha and the impact of ER alpha signaling in transgenic mouse models, emphasizing its pivotal role in mammary gland morphogenesis and function as well as its implication in tumorigenesis. Additionally, the review covers the main features of ER alpha-positive luminal breast cancers and their modeling in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Ramesh Butti, Prachi Kapse, Garima Bhadauriya, Suhail Ahmad, Rohan Chaubal, Pallavi Parab, Rasika Kadam, Soumya S. Mahapatra, Tanuja Shet, Amit Dutt, Sudeep Gupta, Gopal C. Kundu
Summary: By establishing and characterizing patient-derived orthotopic xenografts (PDOXs), researchers successfully identified hormone-resistant breast cancer and demonstrated the reliability and usefulness of these models for biomarker discovery and preclinical drug screening.
Review
Cell Biology
Elena Spina, Pamela Cowin
Summary: Embryonic mammary gland development involves multiple steps, including the formation of mammary placodes and mammary buds, as well as the development of ductal trees. Studies have identified factors and pathways that influence these steps, and there is a deeper understanding of the characteristics of mammary stem cells and progenitor cells.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Swarajit Kumar Biswas, Saswati Banerjee, Ginger Wendolyn Baker, Chieh-Yin Kuo, Indrajit Chowdhury
Summary: The mammary gland, a compound and branched structure, plays a crucial role in mammalian reproduction by producing milk. Its development involves hormonal regulation and different stages of morphogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Priscilla A. Furth, Weisheng Wang, Keunsoo Kang, Brendan L. Rooney, Grace Keegan, Vinona Muralidaran, Xiaojun Zou, Jodi A. Flaws
Summary: Genetically engineered mouse models with overexpression of Esr1 and CYP19A1 revealed divergent disease processes in mammary glands due to distinct molecular pathophysiological intrusions into estrogen signaling during reproductive senescence. Esr1 overexpression led to higher rates of preneoplasia and cancer compared to CYP19A1 overexpression. Tamoxifen and letrozole exposure down-regulated cell proliferation genes and resolved differences between the two models.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Charlene Thiebaut, Henri-Philippe Konan, Marie-Justine Guerquin, Amand Chesnel, Gabriel Livera, Muriel Le Romancer, Helene Dumond
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Gregoire Preud'homme, Kevin Duarte, Kevin Dalleau, Claire Lacomblez, Emmanuel Bresso, Malika Smail-Tabbone, Miguel Couceiro, Marie-Dominique Devignes, Masatake Kobayashi, Olivier Huttin, Joao Pedro Ferreira, Faiez Zannad, Patrick Rossignol, Nicolas Girerd
Summary: The text discusses the selection of the most appropriate unsupervised machine-learning method for heterogeneous data, comparing model-based methods to distance/dissimilarity-based methods. It concludes that model-based methods typically outperform distance-based methods for mixed data.
SCIENTIFIC REPORTS
(2021)
Article
Medical Informatics
Emmanuel Bresso, Pierre Monnin, Cedric Bousquet, Francois-Elie Calvier, Ndeye-Coumba Ndiaye, Nadine Petitpain, Malika Smail-Tabbone, Adrien Coulet
Summary: In this study, a method using knowledge graphs to identify biomolecular features for distinguishing drug causality for ADRs was proposed. By training classifiers and extracting features, drugs causative for drug-induced liver injuries and severe cutaneous adverse reactions were successfully distinguished. The most discriminative features extracted could potentially provide insights into the mechanisms behind ADRs.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Article
Cardiac & Cardiovascular Systems
Masatake Kobayashi, Olivier Huttin, Martin Magnusson, Joao Pedro Ferreira, Erwan Bozec, Anne-Cecile Huby, Gregoire Preud'homme, Kevin Duarte, Zohra Lamiral, Kevin Dalleau, Emmanuel Bresso, Malika Smail-Tabbone, Marie-Dominique Devignes, Peter M. Nilsson, Margret Leosdottir, Jean-Marc Boivin, Faiez Zannad, Patrick Rossignol, Nicolas Girerd
Summary: This study identified three echocardiographic phenotypes in community-based cohorts, including mostly normal, diastolic changes, and diastolic changes with structural remodeling. These phenotypes were associated with vascular function and circulating biomarkers. In a separate cohort, they were also found to be associated with cardiovascular mortality or heart failure hospitalization.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Tripti Rastogi, Nicolas Girerd, Zohra Lamiral, Emmanuel Bresso, Erwan Bozec, Jean-Marc Boivin, Patrick Rossignol, Faiez Zannad, Joao Pedro Ferreira
Summary: This study aimed to investigate the impact of smoking on the cardiovascular system and circulating proteins. The results showed that current smoking is associated with signs of early onset of cardiovascular ageing and protein biomarkers that regulate inflammation, endothelial function, metabolism, oncological processes, and apoptosis.
Article
Cell Biology
Charlene Thiebaut, Virginie Vlaeminck-Guillem, Olivier Tredan, Coralie Poulard, Muriel Le Romancer
Summary: Steroid receptors play a crucial role in regulating cellular responses to steroids through both genomic and non-genomic signaling pathways. Research on non-genomic signaling in breast and prostate cancers has shown its clinical importance and potential for developing therapeutic strategies. Understanding the non-genomic pathways of ER, PR, AR, and GR may offer new perspectives for cancer treatment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cell Biology
Alex Hirtz, Nolwenn Lebourdais, Fabien Rech, Yann Bailly, Athenais Vaginay, Malika Smail-Tabbone, Helene Dubois-Pot-Schneider, Helene Dumond
Summary: Glioblastoma is the most common and aggressive brain tumor in adults, affecting men more than women. Research suggests that the hormone estrogen plays a protective role in GBM female patient survival, and that the GPER agonist G-1 can inhibit cell proliferation independent of GPER, while enhancing the efficacy of standard chemotherapy.
Review
Biology
Charlene Thiebaut, Louisane Eve, Coralie Poulard, Muriel Le Romancer
Summary: PRMT1, the major protein arginine methyltransferase in mammals, plays essential roles in various biological processes such as transcriptional regulation, signal transduction, and DNA repair. It catalyzes monomethylation and asymmetric dimethylation of arginine side chains in proteins, with a wide range of substrates identified including histone and non-histone proteins. The enzyme is also involved in embryonic development, DNA damage repair, and the progression of various cancers.
Article
Biochemistry & Molecular Biology
Vessela Atanasova, Emmanuel Bresso, Bernard Maigret, Natalia Florencio Martins, Florence Richard-Forget
Summary: Cereal crops are commonly affected by toxigenic Fusarium species, and there is an urgent need to develop new, environmentally-friendly plant protection solutions. Through virtual screening, two compounds were identified as potential inhibitors of fungal toxin production. Biological tests confirmed their inhibitory effects on fungal growth.
Article
Multidisciplinary Sciences
Nicolas Girerd, John Cleland, Stefan D. Anker, William Byra, Carolyn S. P. Lam, David Lapolice, Mandeep R. Mehra, Dirk J. van Veldhuisen, Emmanuel Bresso, Zohra Lamiral, Barry Greenberg, Faiez Zannad
Summary: This study evaluated the associations between clinical events and proteomic biomarkers in patients with HF and CAD. The results showed that biomarkers associated with inflammation and remodeling mechanisms were strong predictors of various cardiovascular events.
SCIENTIFIC REPORTS
(2022)
Article
Computer Science, Interdisciplinary Applications
Emmanuel Bresso, Joao-Pedro Ferreira, Nicolas Girerd, Masatake Kobayashi, Gregoire Preud'homme, Patrick Rossignol, Fayez Zannad, Marie-Dominique Devignes, Malika Smail-Tabbone
Summary: Machine learning is an essential part of biomedical studies, but its integration into effective Learning Health Systems is still in progress. In this study, a model of an Inductive Clinical Database (ICDB) was proposed to host patient data and learned models. Experiments conducted on patient data in a heart failure project demonstrated the effectiveness of the ICDB approach in identifying biomarker combinations that are predictive of heart fibrosis phenotype and generating hypotheses about underlying mechanisms. This proof of concept paves the way for the development of a next-generation Knowledge Discovery Environment (KDE).
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Article
Oncology
Alex Hirtz, Nolwenn Lebourdais, Magalie Thomassin, Fabien Rech, Helene Dumond, Helene Dubois-Pot-Schneider
Summary: This study demonstrates a link between the expression of steroid biosynthesis enzymes or hormone receptors and patient survival in low-grade and anaplastic gliomas, which is dependent on gender and molecular subtype. The study also identifies genes associated with these steroid signaling factors and their functions, providing insights into the mechanisms underlying gender-dependent differences. These findings have important implications for refining the classification and personalized management of glioma patients.
Article
Biochemistry & Molecular Biology
Alex Hirtz, Yann Bailly, Fabien Rech, Julien Pierson, Helene Dumond, Helene Dubois-Pot-Schneider
Summary: Glioblastoma is a common primary brain tumor with poor treatment outcomes. High expression of GPER1 is associated with better survival, suggesting the protective role of estrogen signaling. The G-1 agonist demonstrates anti-tumor effects on GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Tomona Fujikawa, Masatake Kobayashi, Sandra Wagner, Kevin Duarte, Pauline Scherdel, Barbara Heude, Vincent Dupont, Erwan Bozec, Emmanuel Bresso, Faiez Zannad, Patrick Rossignol, Nicolas Girerd
Summary: The association between childhood adiposity and increased carotid intima-media thickness (cIMT) in adults has been confirmed, which may be related to the association between childhood adiposity and inflammation in adults. However, longitudinal data on the biological pathways associated with childhood adiposity are still lacking.
JOURNAL OF HYPERTENSION
(2023)
Article
Statistics & Probability
B. Bastien, T. Boukhobza, H. Dumond, A. Gegout-Petit, A. Muller-Gueudin, C. Thiebaut
Summary: This article proposes a new methodology for selecting and ranking covariates associated with a variable of interest in a context of high-dimensional data under dependence but few observations. The methodology includes clustering, decorrelation, selection, and ranking, and has been validated through simulation studies. Using this method, the researchers successfully selected transcriptomic covariates that explained the survival outcome of chemotherapy in patients with advanced non-small-cell lung cancer, and defined patient profiles for a new metastatic biomarker and associated gene network in breast tumor samples to personalize treatments.
JOURNAL OF APPLIED STATISTICS
(2022)