Hunger and Satiety Gauge Reward Sensitivity

Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis

(2017) Chia-Shan Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking

(2017) Marta Carus-Cadavieco et al.   NATURE

Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

(2017) Marisela Morales et al.   NATURE REVIEWS NEUROSCIENCE

Melanocortin 4 receptor constitutive activity inhibits L-type voltage-gated calcium channels in neurons

(2017) F. Agosti et al.   NEUROSCIENCE

Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity

(2016) Jong Han Lee et al.   DIABETES

Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome?

(2016) Joseph Polex-Wolf et al.   JOURNAL OF CLINICAL INVESTIGATION

Ventral tegmental area subcircuits process rewarding and aversive experiences

(2016) Sebastiano Bariselli et al.   JOURNAL OF NEUROCHEMISTRY

Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus

(2016) R. S. E. Brown et al.   JOURNAL OF NEUROSCIENCE

Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward

(2016) A. M. Stamatakis et al.   JOURNAL OF NEUROSCIENCE

Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis

(2016) Xiaobing Zhang et al.   NATURE NEUROSCIENCE

Lateral hypothalamic circuits for feeding and reward

(2016) Garret D Stuber et al.   NATURE NEUROSCIENCE

Hunger-Driven Motivational State Competition

(2016) C. Joseph Burnett et al.   NEURON

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward

(2016) Rahul Pandit et al.   NEUROPSYCHOPHARMACOLOGY

Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose ‘Liking’ and Intake but Scopolamine in Caudal Shell Shifts ‘Liking’ Toward ‘Disgust’ and ‘Fear’

(2016) Daniel C Castro et al.   NEUROPSYCHOPHARMACOLOGY

Endogenous Glucagon-like Peptide-1 Receptor Signaling in the Nucleus Tractus Solitarius is Required for Food Intake Control

(2016) Amber L Alhadeff et al.   NEUROPSYCHOPHARMACOLOGY

Optogenetically-induced tonic dopamine release from VTA-nucleus accumbens projections inhibits reward consummatory behaviors

(2016) Maria A. Mikhailova et al.   NEUROSCIENCE

Neurobiologic Advances from the Brain Disease Model of Addiction

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

(2016) Ken-ichiro Nakajima et al.   Nature Communications

Hunger neurons drive feeding through a sustained, positive reinforcement signal

(2016) Yiming Chen et al.   eLife

Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels

(2016) I A Reddy et al.   Translational Psychiatry

Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward

(2016) M Shen et al.   Translational Psychiatry

Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice

(2015) Petra Suchankova et al.   ALCOHOL AND ALCOHOLISM

Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor

(2015) Andras Kern et al.   CELL

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

(2015) Yiming Chen et al.   CELL

Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding

(2015) Marcelo O. Dietrich et al.   CELL

Decoding Neural Circuits that Control Compulsive Sucrose Seeking

(2015) Edward H. Nieh et al.   CELL

Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons

(2015) Maria Fernanda A. Fernandes et al.   Cell Metabolism

Palatability Can Drive Feeding Independent of AgRP Neurons

(2015) Raphaël G.P. Denis et al.   Cell Metabolism

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

Gq/11α and Gsα mediate distinct physiological responses to central melanocortins

(2015) Yong-Qi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

GABAergic Projections from Lateral Hypothalamus to Paraventricular Hypothalamic Nucleus Promote Feeding

(2015) Z. Wu et al.   JOURNAL OF NEUROSCIENCE

Differential Dopamine Release Dynamics in the Nucleus Accumbens Core and Shell Reveal Complementary Signals for Error Prediction and Incentive Motivation

(2015) Michael P. Saddoris et al.   JOURNAL OF NEUROSCIENCE

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

(2015) Hyeong-Kyu Park et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Neurons for hunger and thirst transmit a negative-valence teaching signal

(2015) J. Nicholas Betley et al.   NATURE

Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding

(2015) Eoin C. O’Connor et al.   NEURON

Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence

(2015) Juan L. Gomez et al.   NEUROPHARMACOLOGY

Glucagon-Like Peptide-1 Receptor Activation in the Ventral Tegmental Area Decreases the Reinforcing Efficacy of Cocaine

(2015) Heath D Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

Septal Glucagon-Like Peptide 1 Receptor Expression Determines Suppression of Cocaine-Induced Behavior

(2015) Anne E Harasta et al.   NEUROPSYCHOPHARMACOLOGY

Lateral Hypothalamus GABAergic Neurons Modulate Consummatory Behaviors Regardless of the Caloric Content or Biological Relevance of the Consumed Stimuli

(2015) Montserrat Navarro et al.   NEUROPSYCHOPHARMACOLOGY

The ins and outs of the striatum: Role in drug addiction

(2015) L.M. Yager et al.   NEUROSCIENCE

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

(2015) Marjorie Damian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons

(2015) Daqing Wang et al.   Frontiers in Neuroanatomy

Leptin levels are reduced by intravenous ghrelin administration and correlated with cue-induced alcohol craving

(2015) C L Haass-Koffler et al.   Translational Psychiatry

Central Melanocortins Regulate the Motivation for Sucrose Reward

(2015) Rahul Pandit et al.   PLoS One

Alpha-melanocyte stimulating hormone modulates ethanol self-administration in posterior ventral tegmental area through melanocortin-4 receptors

(2014) Gajanan P. Shelkar et al.   ADDICTION BIOLOGY

Peripherally Circulating Ghrelin Does Not Mediate Alcohol-Induced Reward and Alcohol Intake in Rodents

(2014) Elisabet Jerlhag et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Intravenous Ghrelin Administration Increases Alcohol Craving in Alcohol-Dependent Heavy Drinkers: A Preliminary Investigation

(2014) Lorenzo Leggio et al.   BIOLOGICAL PSYCHIATRY

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Role of Glutamatergic Projections from Ventral Tegmental Area to Lateral Habenula in Aversive Conditioning

(2014) D. H. Root et al.   JOURNAL OF NEUROSCIENCE

Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry

(2014) Zhenyu Sheng et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Glucose Rapidly Induces Different Forms of Excitatory Synaptic Plasticity in Hypothalamic POMC Neurons

(2014) Jun Hu et al.   PLoS One

Decreased consumption of rewarding sucrose solutions after injection of melanocortins into the ventral tegmental area of rats

(2014) Haw-Han Yen et al.   PSYCHOPHARMACOLOGY

Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

(2014) Ana I Domingos et al.   eLife

The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors

(2013) Elizabeth G. Mietlicki-Baase et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The expression of MC4Rs in D1R neurons regulates food intake and locomotor sensitization to cocaine

(2013) H. Cui et al.   GENES BRAIN AND BEHAVIOR

Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

(2013) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

A Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward

(2013) Alice M. Stamatakis et al.   NEURON

Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice

(2013) P. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

(2013) Marie Schaeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction

(2013) Ashley M. Blouin et al.   Nature Communications

Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells

(2012) Ichiro Sakata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

Promiscuous Dimerization of the Growth Hormone Secretagogue Receptor (GHS-R1a) Attenuates Ghrelin-mediated Signaling

(2012) Harriët Schellekens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

(2012) Byung Kook Lim et al.   NATURE

Ancient deuterostome origins of vertebrate brain signalling centres

(2012) Ariel M. Pani et al.   NATURE

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

(2012) Jeremiah Y. Cohen et al.   NATURE

AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors

(2012) Marcelo O Dietrich et al.   NATURE NEUROSCIENCE

MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation?

(2012) Anne Rediger et al.   NEUROENDOCRINOLOGY

Identification of Distant Agouti-Like Sequences and Re-Evaluation of the Evolutionary History of the Agouti-Related Peptide (AgRP)

(2012) Åke Västermark et al.   PLoS One

Involvement of the opioid system in the orexigenic and hedonic effects of melanin-concentrating hormone

(2011) Carlos Andres Lopez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats

(2011) Adrie W. Bruijnzeel et al.   BEHAVIOURAL BRAIN RESEARCH

Cocaine Cues Drive Opposing Context-Dependent Shifts in Reward Processing and Emotional State

(2011) Robert A. Wheeler et al.   BIOLOGICAL PSYCHIATRY

Phasic Nucleus Accumbens Dopamine Encodes Risk-Based Decision-Making Behavior

(2011) Jonathan A. Sugam et al.   BIOLOGICAL PSYCHIATRY

Molecular Annotation of Integrative Feeding Neural Circuits

(2011) Cristian A. Pérez et al.   Cell Metabolism

GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

(2011) Amber L. Alhadeff et al.   ENDOCRINOLOGY

Structure, function and regulation of the melanocortin receptors

(2011) Yingkui Yang   EUROPEAN JOURNAL OF PHARMACOLOGY

Sapap3 Deletion Anomalously Activates Short-Term Endocannabinoid-Mediated Synaptic Plasticity

(2011) M. Chen et al.   JOURNAL OF NEUROSCIENCE

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Leptin regulates the reward value of nutrient

(2011) Ana I Domingos et al.   NATURE NEUROSCIENCE

Projection-Specific Modulation of Dopamine Neuron Synapses by Aversive and Rewarding Stimuli

(2011) Stephan Lammel et al.   NEURON

Food restriction increases acquisition, persistence and drug prime-induced expression of a cocaine-conditioned place preference in rats

(2011) Danielle Zheng et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Clarifying Exercise Addiction: Differential Diagnosis, Co-occurring Disorders, and Phases of Addiction

(2011) Marilyn Freimuth et al.   International Journal of Environmental Research and Public Health

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Ventral Tegmental Area Leptin Receptor Neurons Specifically Project to and Regulate Cocaine- and Amphetamine-Regulated Transcript Neurons of the Extended Central Amygdala

(2010) R. L. Leshan et al.   JOURNAL OF NEUROSCIENCE

Regulation of Nucleus Accumbens Activity by the Hypothalamic Neuropeptide Melanin-Concentrating Hormone

(2010) R. M. Sears et al.   JOURNAL OF NEUROSCIENCE

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

(2009) Grace W.C. Cheung et al.   Cell Metabolism

The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system

(2009) Rodrigo A. España et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Proopiomelanocortin Expression in both GABA and Glutamate Neurons

(2009) S. T. Hentges et al.   JOURNAL OF NEUROSCIENCE

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Direct effects of nutrients, acetylcholine, CCK, and insulin on ghrelin release from the isolated stomachs of rats

(2009) Yogendra B. Shrestha et al.   PEPTIDES

The melanin-concentrating hormone system modulates cocaine reward

(2009) S. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of central ghrelin signaling for alcohol reward

(2009) E. Jerlhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat.

(2008) Jon F. Davis et al.   BEHAVIORAL NEUROSCIENCE

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood–brain barrier

(2008) William A. Banks et al.   PEPTIDES

Brain segmentation and trigeminal projections in the lamprey; with reference to vertebrate brain evolution

(2007) Yasunori Murakami et al.   BRAIN RESEARCH BULLETIN