Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios

(2020) Lingli Zhang et al.   Translational Psychiatry

Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder

(2020) Alessandra Pecorelli et al.   FASEB JOURNAL

Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double‐blind, placebo‐controlled clinical trial

(2020) Sara Momtazmanesh et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

(2020) Hua Liu et al.   Scientific Reports

Developmental regression and mitochondrial function in children with autism

(2020) Kanwaljit Singh et al.   Annals of Clinical and Translational Neurology

An Observational Study With the Janssen Autism Knowledge Engine (JAKE®) in Individuals With Autism Spectrum Disorder

(2019) Seth L. Ness et al.   Frontiers in Neuroscience

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

(2019) Jonathan K. M. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration

(2019) Jed W. Fahey et al.   Nutrients

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

(2019) Yoko Yagishita et al.   MOLECULES

Differential regulation of Nrf2 is linked to elevated inflammation and nitrative stress in monocytes of children with autism

(2019) Ahmed Nadeem et al.   PSYCHONEUROENDOCRINOLOGY

Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi

(2018) Shawn Tahata et al.   Cancer Prevention Research

Cytokine profile in autistic patients

(2018) Mohammad Mahdi Eftekharian et al.   CYTOKINE

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli

(2018) Stephen Bent et al.   Molecular Autism

OxInflammation: From Subclinical Condition to Pathological Biomarker

(2018) Giuseppe Valacchi et al.   Frontiers in Physiology

Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder

(2018) Shannon Rose et al.   Molecular Diagnosis & Therapy

Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism

(2017) Karen J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

(2017) Albena T. Dinkova-Kostova et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children

(2017) Jiang Xie et al.   Oncotarget

Adjust for Multiple Comparisons? It’s Not That Simple

(2016) Andrew D. Althouse   ANNALS OF THORACIC SURGERY

Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD)

(2016) Hua Liu et al.   CNS & Neurological Disorders-Drug Targets

Genetic heterogeneity in autism: From single gene to a pathway perspective

(2016) Joon Yong An et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

(2016) Robert A. Wise et al.   PLoS One

Characterizing autism spectrum disorders by key biochemical pathways

(2015) Megha Subramanian et al.   Frontiers in Neuroscience

Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase

(2015) Jed W. Fahey et al.   PLoS One

Sulforaphane treatment of autism spectrum disorder (ASD)

(2014) K. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

(2014) Daniel A. Rossignol et al.   Frontiers in Physiology

Baseline Factors Predicting Placebo Response to Treatment in Children and Adolescents With Autism Spectrum Disorders

(2013) Bryan H. King et al.   JAMA Pediatrics

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

(2012) S Rose et al.   Translational Psychiatry

Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China

(2011) P. A. Egner et al.   Cancer Prevention Research

Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression

(2011) Claude A. Piantadosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome

(2010) Paul Ashwood et al.   BRAIN BEHAVIOR AND IMMUNITY

Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27

(2010) Nanqin Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology

(2008) Nazzareno Ballatori et al.   MOLECULAR ASPECTS OF MEDICINE