On the Role of Additional [4Fe-4S] Clusters with a Free Coordination Site in Radical-SAM Enzymes

Redox Behavior of the S-Adenosylmethionine (SAM)-Binding Fe–S Cluster in Methylthiotransferase RimO, toward Understanding Dual SAM Activity

(2016) Thibaut Molle et al.   BIOCHEMISTRY

Transformations of the FeS Clusters of the Methylthiotransferases MiaB and RimO, Detected by Direct Electrochemistry

(2016) Stephanie J. Maiocco et al.   BIOCHEMISTRY

Maturation of nitrogenase cofactor—the role of a class E radical SAM methyltransferase NifB

(2016) Yilin Hu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Electron Paramagnetic Resonance Characterization of Three Iron–Sulfur Clusters Present in the Nitrogenase Cofactor Maturase NifB from Methanocaldococcus infernus

(2016) Jarett Wilcoxen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystallographic snapshots of sulfur insertion by lipoyl synthase

(2016) Martin I. McLaughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue

(2015) Bradley M. Hover et al.   BIOCHEMISTRY

Mechanistic Studies of the Radical S-Adenosyl-l-methionine Enzyme 4-Demethylwyosine Synthase Reveal the Site of Hydrogen Atom Abstraction

(2015) Anthony P. Young et al.   BIOCHEMISTRY

Auxiliary iron–sulfur cofactors in radical SAM enzymes

(2015) Nicholas D. Lanz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Characterization of a Radical Intermediate in Lipoyl Cofactor Biosynthesis

(2015) Nicholas D. Lanz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis

(2015) Bradley M. Hover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly

(2015) Pedro Dinis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refining the pathway of carbide insertion into the nitrogenase M-cluster

(2015) Jared A. Wiig et al.   Nature Communications

Wybutosine biosynthesis: Structural and mechanistic overview

(2015) Phanélie Perche-Letuvée et al.   RNA Biology

Glycyl radical activating enzymes: Structure, mechanism, and substrate interactions

(2014) Krista A. Shisler et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions

(2014) Jenny E. Harmer et al.   BIOCHEMICAL JOURNAL

The Biosynthesis of Thiol- and Thioether-containing Cofactors and Secondary Metabolites Catalyzed by RadicalS-Adenosylmethionine Enzymes

(2014) Joseph T. Jarrett   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalysis of a New Ribose Carbon-Insertion Reaction by the Molybdenum Cofactor Biosynthetic Enzyme MoaA

(2013) Angad P. Mehta et al.   BIOCHEMISTRY

Molybdopterin Biosynthesis: Trapping an Unusual Purine Ribose Adduct in the MoaA-Catalyzed Reaction

(2013) Angad P. Mehta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Menaquinone Biosynthesis: Formation of Aminofutalosine Requires a Unique Radical SAM Enzyme

(2013) Nilkamal Mahanta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of a Cyclic Nucleotide as a Cryptic Intermediate in Molybdenum Cofactor Biosynthesis

(2013) Bradley M. Hover et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GenK-Catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme

(2013) Hak Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of an Intermediate Methyl Carrier in the Radical S-Adenosylmethionine Methylthiotransferases RimO and MiaB

(2013) Bradley J. Landgraf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases

(2013) Farhad Forouhar et al.   Nature Chemical Biology

4-Demethylwyosine Synthase fromPyrococcus abyssiIs a Radical-S-adenosyl-l-methionine Enzyme with an Additional [4Fe-4S]+2Cluster That Interacts with the Pyruvate Co-substrate

(2012) Phanélie Perche-Letuvée et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A

(2012) Leif Flühe et al.   Nature Chemical Biology

Radical SAM-Dependent Carbon Insertion into the Nitrogenase M-Cluster

(2012) J. A. Wiig et al.   SCIENCE

Pyruvate Is the Source of the Two Carbons That Are Required for Formation of the Imidazoline Ring of 4-Demethylwyosine

(2011) Anthony P. Young et al.   BIOCHEMISTRY

The methylthiolation reaction mediated by the Radical-SAM enzymes

(2011) Mohamed Atta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural Insights into Radical Generation by the Radical SAM Superfamily

(2011) Jessica L. Vey et al.   CHEMICAL REVIEWS

Molybdenum cofactor biosynthesis in plants and humans

(2011) Ralf R. Mendel et al.   COORDINATION CHEMISTRY REVIEWS

Structural Basis for Reductive Radical Formation and Electron Recycling in (R)-2-Hydroxyisocaproyl-CoA Dehydratase

(2011) Stefan H. Knauer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cfr and RlmN Contain a Single [4Fe-4S] Cluster, which Directs Two Distinct Reactivities forS-Adenosylmethionine: Methyl Transfer by SN2 Displacement and Radical Generation

(2011) Tyler L. Grove et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

(2011) T. L. Grove et al.   SCIENCE

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

(2011) A. K. Boal et al.   SCIENCE

Adenosyl Radical: Reagent and Catalyst in Enzyme Reactions

(2010) E. Neil G. Marsh et al.   CHEMBIOCHEM

The history of the discovery of the molybdenum cofactor and novel aspects of its biosynthesis in bacteria

(2010) Silke Leimkühler et al.   COORDINATION CHEMISTRY REVIEWS

Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N6-threonylcarbamoyladenosine in tRNA

(2010) Simon Arragain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural rearrangements of the ribosome at the tRNA proofreading step

(2010) Lasse Jenner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Anaerobic functionalization of unactivated C–H bonds

(2009) Squire J Booker   CURRENT OPINION IN CHEMICAL BIOLOGY

Post-translational Modification of Ribosomal Proteins

(2009) Simon Arragain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ENDOR Spectroscopy Shows That Guanine N1 Binds to [4Fe−4S] Cluster II of theS-Adenosylmethionine-Dependent Enzyme MoaA: Mechanistic Implications

(2009) Nicholas S. Lees et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

tRNA's modifications bring order to gene expression

(2008) Estella M Gustilo et al.   CURRENT OPINION IN MICROBIOLOGY

RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli

(2008) B. P. Anton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA