Review
Chemistry, Multidisciplinary
Mingxuan Kai, Shuyan Wang, Weiwei Gao, Liangfang Zhang
Summary: Recently, there has been significant interest in using metal-organic framework nanoparticles (MOF-NPs) for delivering therapeutic proteins due to their unique hierarchical porous structures. Novel design strategies have led to multifunctional MOF-NPs with improved capabilities for protein delivery in various therapeutic applications. This review summarizes recent advancements in MOF-NP designs for protein delivery, focusing on four design categories: environment-responsive MOF-NPs, cell membrane-coated MOF-NPs, cascade reaction-incorporated MOF-NPs, and composite MOF-NPs. The challenges and opportunities in utilizing MOF-NPs for protein delivery are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biotechnology & Applied Microbiology
Soraya Babaie, Arezou Taghvimi, Joo-Hyun Hong, Hamed Hamishehkar, Seongpil An, Ki Hyun Kim
Summary: Nanotechnology has shown promising applications in pain management, including nanotechnology-based drug delivery, imaging and diagnostic tools, as well as pain measurement. It has provided acceptable results in pain control and has the potential to revolutionize pain management, but further extensive research is needed.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Yu Xia, Guoyi Tang, Yi Chen, Changbing Wang, Min Guo, Tiantian Xu, Mingqi Zhao, Yongjian Zhou
Summary: RNA interference (RNAi) is a promising method for treating malignant tumors, and in this study, RGDfC-SeNPs were successfully synthesized as a tumor-targeted carrier for delivering siSox2 to HepG2 liver cancer cells. The results showed that RGDfC-Se@siSox2 effectively silenced Sox2, inhibited tumor cell proliferation, migration, and invasion, induced apoptosis through reactive oxygen species production and mitochondrial membrane potential disruption, and significantly inhibited tumor growth in mice bearing HepG2 tumors. These findings suggest that RGDfC-SeNPs could be a valuable gene carrier for specific gene-targeted therapy in HCC.
BIOACTIVE MATERIALS
(2021)
Article
Oncology
Ellen S. Smith, Eric Whitty, Byunghee Yoo, Anna Moore, Lorenzo F. Sempere, Zdravka Medarova
Summary: RNA-based drugs, including miRNAs and siRNAs, have shown great potential for personalized treatment of cancer and other diseases. This review provides an overview of the development, challenges, and clinical successes of these RNA drugs, as well as their design, modification, and delivery for different diseases. The article highlights the differences and similarities between miRNA-based and siRNA-based drugs, and discusses their potential in medicine.
Article
Chemistry, Multidisciplinary
Enrico Mastrobattista
Summary: This article introduces the author's research work and future research plans at the Department of Pharmaceutical Sciences at Utrecht University, focusing on the administration and fate control of biotherapeutics. The author's research interests include formulation of biotherapeutics into nanomedicines, intracellular delivery of nucleic acids and protein therapeutics, and targeted delivery of biotherapeutics beyond the liver. Additionally, the author provides an outlook on how current developments in drug delivery and gene therapy may lead to sustainable and cost-effective dosing regimens for biotherapeutics.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Quan Zhou, Jiajia Xiang, Lingqiao Hao, Xiaojie Xu, Zhuxian Zhou, Jianbin Tang, Yuan Ping, Youqing Shen
Summary: Flexible single-strand oligonucleotides can self-assemble with PEG-b-PLL to form nanovesicles for intracellular delivery of siRNA and proteins. The cytotoxic single strand oligonucleotide F20 can form nanovesicles with fast cellular uptake, resulting in significantly higher cell cytotoxicity compared to naked F20.
Review
Chemistry, Multidisciplinary
Cristiana Oliveira, Celso J. O. Ferreira, Miguel Sousa, Juan L. Paris, Ricardo Gaspar, Bruno F. B. Silva, Jose A. Teixeira, Pedro Ferreira-Santos, Claudia M. Botelho
Summary: The impact of nanotechnology on research areas, especially nanomedicine, is significant. Cubosomes, nanocarriers that can incorporate and deliver active molecules, have drawn researchers' attention due to their sustained release and protection capabilities. Various methods and lipids can be used to prepare cubosomes. Extensive characterization is crucial to achieve the desired effect. Cubosomes have exceptional properties, making them suitable for various biomedical applications.
Review
Pharmacology & Pharmacy
Ethan Cisneros, Najia Sherwani, Olivia L. Lanier, Nicholas A. Peppas
Summary: RNA is an important tool for therapeutic purposes, particularly in infectious diseases like HIV/AIDS. Systems must be designed to effectively deliver therapeutics to specific tissues, such as those rich in lymphatic tissue, in order to combat latent infection and achieve a functional cure. Despite many attempts, current therapies for HIV/AIDS have not demonstrated long-term efficacy. RNA interference (RNAi) provides a unique opportunity to suppress viral replication and potentially cure chronic HIV/AIDS. However, the delivery of RNA faces challenges due to its negative charge and susceptibility to degradation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Maryam Sharifiaghdam, Elnaz Shaabani, Zeynab Sharifiaghdam, Herlinde De Keersmaecker, Riet De Rycke, Stefaan De Smedt, Reza Faridi-Majidi, Kevin Braeckmans, Juan C. Fraire
Summary: Nanotechnology has significantly contributed to oncology, especially in drug delivery, with selenium nanoparticles showing promising synergistic effects against cancer cells. Layer-by-layer selenium-based nanocomplexes exhibit enhanced stability and delayed release, leading to effective apoptosis induction and gene silencing in cancer cells. The nanocarrier is a potential off-the-shelf formulation with dual action mechanisms against cancer cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Peter Hauser, Hsiao-Min Chang, Norimoto Yanagawa, Morgan Hamon
Summary: The kidneys are essential organs involved in blood filtration, waste removal, and fluid balance maintenance. Recent research has focused on the interaction between kidneys and nanoparticles, studying the impact of nanoparticle characteristics on renal clearance and approaches for kidney imaging and treatment. Challenges and future directions for nanomedicine in relation to kidney health are also discussed.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Hui Hu, Nan Yang, Jiahui Sun, Fu Zhou, Rui Gu, Yuan Liu, Li Wang, Xuejiao Song, Ruirui Yun, Xiaochen Dong, Guangfeng Wang
Summary: A multifunctional metal-organic framework (MOF) based photothermal therapy with gene therapy platform has been developed, allowing for photothermal/photoacoustic/fluorescence multimodal imaging and specific release of therapeutic cargos as needed, providing an efficient and safe strategy for cancer theranostics.
Article
Chemistry, Multidisciplinary
Esther H. Roh, Thomas H. Epps, Millicent O. Sullivan
Summary: The article introduces a mathematical framework that can predict siRNA-mediated gene silencing with minimal experimental data and guide nanocarrier design. It reveals that siRNA dilution is a key determinant of gene silencing kinetics, and the experimental and predicted results align closely in vitro and in vivo settings.
Review
Chemistry, Multidisciplinary
Shuyan Wang, Dan Wang, Yaou Duan, Zhidong Zhou, Weiwei Gao, Liangfang Zhang
Summary: Cellular nanosponges, as host decoys, have shown great potential for biological neutralization applications. By mimicking susceptible host cells, they can create function-driven and broad-spectrum neutralization solutions against various pathological agents.
ADVANCED MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Amir Barzegar Behrooz, Zahra Talaie, Amir Syahir
Summary: Aggressive glioblastoma (GBM) is a primary brain tumor with no known treatment. However, drug delivery based on nanotechnology holds the potential to address the challenges of treating GBM. Combination therapies have shown better efficacy in GBM treatment, and nanotechnology can enhance the effectiveness of combination treatments.
Review
Polymer Science
Azeez Yusuf, Awatif Rashed Z. Almotairy, Hanan Henidi, Ohoud Y. Alshehri, Mohammed S. Aldughaim
Summary: Nanotechnology has experienced rapid development in the past four decades and has revolutionized various aspects of everyday life. It has had significant impacts on fields like medicine and food industry, leading to improvements in shelf life of food, drug delivery, and development of specific therapeutics.
Article
Engineering, Biomedical
Manse Kim, Abhishek Sahu, Youngmin Hwang, Gi Beom Kim, Gi Hoon Nam, In-San Kim, Ick Chan Kwon, Giyoong Tae
Article
Clinical Neurology
Jiwon Kim, Hee Jeong Jang, Dawid Schellingerhout, Su-Kyoung Lee, Ha Kim, Young Dae Kim, Kyung-Yul Lee, Hye-Yeon Choi, Han-Jin Cho, Seong-Soo Jang, Sangmin Jeon, Ick Chan Kwon, Kwangmeyung Kim, Wi-Sun Ryu, Matthias Nahrendorf, Seungbum Choi, Dong-Eog Kim
Summary: The study found that short-term cessation of dabigatran therapy can lead to a rebound prothrombotic state, increasing thrombus volume. This effect can be prevented by single-dose aspirin pretreatment, and cessation of dabigatran increases platelet aggregability for 2 days after drug cessation, which can be significantly attenuated by single-dose aspirin pretreatment.
ANNALS OF NEUROLOGY
(2021)
Article
Biochemical Research Methods
Seungho Lim, Woojun Kim, Sukyung Song, Man Kyu Shim, Hong Yeol Yoon, Byung-Soo Kim, Ick Chan Kwon, Kwangmeyung Kim
Summary: The development of BCN-AuNPs allows for enhanced cellular uptake of nanoparticles through bioorthogonal click chemistry on metabolically engineered stem cells.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Woojun Kim, Hong Yeol Yoon, Seungho Lim, Patrick S. Stayton, In-San Kim, Kwangmeyung Kim, Ick Chan Kwon
Summary: The non-invasive tracking of T-cells using bioorthogonal click chemistry can predict and induce therapeutic responses in cell therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Gyeong Taek Lim, Dong Gil You, Hwa Seung Han, Hansang Lee, Sol Shin, Byeong Hoon Oh, E. K. Pramod Kumar, Wooram Um, Chan Ho Kim, Seungsu Han, Sangho Lee, Seungho Lim, Hong Yeol Yoon, Kwangmeyung Kim, Ick Chan Kwon, Dong-Gyu Jo, Yong Woo Cho, Jae Hyung Park
Summary: This study successfully prepared surface-edited EVs using bioorthogonal copper-free click chemistry and metabolic glycoengineering, which effectively accumulated in target tissues in animal models, primarily due to prolonged circulation in the bloodstream and active targeting mechanism.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Chemistry, Multidisciplinary
Gijung Kwak, Hyosuk Kim, Jooho Park, Eun Hye Kim, Hochung Jang, Geonhee Han, Sun Young Wang, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim
Summary: MI-Anti-miRNAs, a carrier-free delivery system, piggyback onto albumin in vivo and effectively target and silence disease-associated miRNAs, showing superior antitumor activity in both solid and metastatic tumors.
Review
Biochemistry & Molecular Biology
Hee Sook Hwang, Hyosuk Kim, Geonhee Han, Jong Won Lee, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim
Summary: Extracellular vesicles play an important role in inflammatory diseases, and can be engineered to target specific cells, making them promising nanoparticles for personalized therapeutic carriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Min Ju Kim, Hyosuk Kim, Xueliang Gao, Ju Hee Ryu, Yoosoo Yang, Ick Chan Kwon, Thomas M. Roberts, Sun Hwa Kim
Summary: A multi-targeting siRNA delivery system was proposed for PI3K-targeted anticancer therapy, effectively inhibiting the PI3K signaling pathway in PTEN-deficient cancer cells, leading to delays in cell proliferation and migration.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Correction
Chemistry, Multidisciplinary
Min Ju Kim, Hyosuk Kim, Xueliang Gao, Ju Hee Ryu, Yoosoo Yang, Ick Chan Kwon, Thomas M. Roberts, Sun Hwa Kim
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Eun Hye Kim, Jongwon Lee, Gijung Kwak, Hochung Jang, Hyosuk Kim, Haeun Cho, Yeongji Jang, Jiwoong Choi, Sung Gil Chi, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim
Summary: This study developed a dual-targeting drug delivery system (Pep-21) that can inhibit miR-21 activity in both cancer cells and tumor-associated macrophages (TAMs). The study found that Pep-21 treatment reduced tumor cell migration, reprogrammed immunosuppressive TAMs into immunostimulatory macrophages, and restrained tumor progression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Hyosuk Kim, Byeong-Wook Song, Soon-Jung Park, Seong Woo Choi, Hanbyeol Moon, Ki-Chul Hwang, Sun-Woong Kang, Sung-Hwan Moon, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim
Summary: This study proposes an extracellular vesicle (EV)-guided, nonviral, direct lineage conversion strategy to enhance the transdifferentiation of fibroblasts to induced cardiomyocyte-like cells (iCMs). The resulting iCMs show typical cardiac features and have gene expression profiles similar to cardiomyocytes. This method achieves a high conversion efficiency (>60%) and establishes a more accessible platform for generating specialized somatic cells through direct lineage conversion.
Article
Engineering, Biomedical
Hyosuk Kim, Hyun-Ju Park, Hyo Won Chang, Ji Hyun Back, Su Jin Lee, Yae Eun Park, Eun Hye Kim, Yeonsun Hong, Gijung Kwak, Ick Chan Kwon, Ji Eun Lee, Yoon Se Lee, Sang Yoon Kim, Yoosoo Yang, Sun Hwa Kim
Summary: The highly immunosuppressive tumor microenvironment with protumoral immune cells accelerates malignant transformation and treatment resistance. Tumor-associated macrophages (TAMs), as the predominant immune cells in tumors, play a crucial role in regulating the immunosuppressive tumor microenvironment. This study explores an exosome-guided direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages, potentially enhancing antitumor immunity.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jangwook Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee
Summary: A new anticancer strategy exploiting abnormal cancer cell metabolism is reported. An antiglycolytic amphiphilic polymer is synthesized and regulates glucose metabolism to inhibit tumor growth. This strategy highlights the necessity for safe and effective cancer treatment without conventional drugs.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Ashita Nair, Kaila Javius-Jones, Jason Bugno, Michael J. Poellmann, Narsimha Mamidi, In-San Kim, Ick Chan Kwon, Heejoo Hong, Seungpyo Hong
Summary: Nanoscale drug delivery systems combining natural exosomes and synthetic dendrimers have been developed to improve the selectivity and reduce the toxicity of cancer treatment. These hybrid nanoparticles exhibit advantageous biological properties and have shown enhanced delivery and downregulation of gene and protein targets in cancer cells.
CHEMISTRY OF MATERIALS
(2023)
Article
Materials Science, Biomaterials
Sanghyo Park, Hyungkyu Park, Chaewon Park, Wan Su Yun, Soonjae Hwang, Hong Yeol Yoon, Ick Chan Kwon, Kwangmeyung Kim, Jaehong Key
Summary: A simple method was developed to enhance the delivery efficiency of doxorubicin in a lung metastasis model by manipulating the size, shape, loading content, and biodegradability of the drug delivery system. The system exhibited high drug release and delivered doxorubicin to lung cancer cells with minimal off-target effects, showing comparable anticancer efficacy to the free drug.
BIOMATERIALS SCIENCE
(2022)