A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Reduced serum myostatin concentrations associated with genetic muscle disease progression

(2017) Peter M. Burch et al.   JOURNAL OF NEUROLOGY

Translational Pharmacokinetic/Pharmacodynamic Analysis of MYO-029 Antibody for Muscular Dystrophy

(2016) P Singh et al.   CTS-Clinical and Translational Science

Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody

(2016) James R. Apgar et al.   mAbs

Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial

(2016) Craig Campbell et al.   MUSCLE & NERVE

No longer going to waste

(2016) Ken Garber   NATURE BIOTECHNOLOGY

Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures

(2016) Joe N. Kornegay et al.   Skeletal Muscle

Exon skipping therapy for Duchenne muscular dystrophy

(2015) Ryszard Kole et al.   ADVANCED DRUG DELIVERY REVIEWS

Phase 2a Study of Ataluren-Mediated Dystrophin Production in Patients with Nonsense Mutation Duchenne Muscular Dystrophy

(2013) Richard S. Finkel et al.   PLoS One

Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy

(2012) Alberto Malerba et al.   Molecular Therapy-Nucleic Acids

Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy

(2011) Emidio E. Pistilli et al.   AMERICAN JOURNAL OF PATHOLOGY

Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy

(2011) Dwi U Kemaladewi et al.   BMC Medical Genomics

Long-Term Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Golden Retriever Muscular Dystrophy

(2011) Lawrence T. Bish et al.   HUMAN GENE THERAPY

The role of myostatin in muscle wasting: an overview

(2011) Yulia Elkina et al.   Journal of Cachexia Sarcopenia and Muscle

Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice

(2010) Kate T. Murphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Hydrodynamic Limb Vein Injection of Adeno-Associated Virus Serotype 8 Vector Carrying Canine Myostatin Propeptide Gene into Normal Dogs Enhances Muscle Growth

(2009) Chunping Qiao et al.   HUMAN GENE THERAPY

Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management

(2009) Katharine Bushby et al.   LANCET NEUROLOGY

Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration

(2009) Kishore M. Lakshman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

(2008) Kathryn R. Wagner et al.   ANNALS OF NEUROLOGY