A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys
出版年份 2017 全文链接
标题
A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys
作者
关键词
Myostatin, Hypertrophy, Skeletal muscle, Duchenne muscular dystrophy, Monoclonal antibody, mdx
出版物
Skeletal Muscle
Volume 7, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-11-09
DOI
10.1186/s13395-017-0141-y
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Reduced serum myostatin concentrations associated with genetic muscle disease progression
- (2017) Peter M. Burch et al. JOURNAL OF NEUROLOGY
- Translational Pharmacokinetic/Pharmacodynamic Analysis of MYO-029 Antibody for Muscular Dystrophy
- (2016) P Singh et al. CTS-Clinical and Translational Science
- Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody
- (2016) James R. Apgar et al. mAbs
- Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial
- (2016) Craig Campbell et al. MUSCLE & NERVE
- No longer going to waste
- (2016) Ken Garber NATURE BIOTECHNOLOGY
- Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures
- (2016) Joe N. Kornegay et al. Skeletal Muscle
- Exon skipping therapy for Duchenne muscular dystrophy
- (2015) Ryszard Kole et al. ADVANCED DRUG DELIVERY REVIEWS
- Phase 2a Study of Ataluren-Mediated Dystrophin Production in Patients with Nonsense Mutation Duchenne Muscular Dystrophy
- (2013) Richard S. Finkel et al. PLoS One
- Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy
- (2012) Alberto Malerba et al. Molecular Therapy-Nucleic Acids
- Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy
- (2011) Emidio E. Pistilli et al. AMERICAN JOURNAL OF PATHOLOGY
- Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy
- (2011) Dwi U Kemaladewi et al. BMC Medical Genomics
- Long-Term Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Golden Retriever Muscular Dystrophy
- (2011) Lawrence T. Bish et al. HUMAN GENE THERAPY
- The role of myostatin in muscle wasting: an overview
- (2011) Yulia Elkina et al. Journal of Cachexia Sarcopenia and Muscle
- Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice
- (2010) Kate T. Murphy et al. AMERICAN JOURNAL OF PATHOLOGY
- Hydrodynamic Limb Vein Injection of Adeno-Associated Virus Serotype 8 Vector Carrying Canine Myostatin Propeptide Gene into Normal Dogs Enhances Muscle Growth
- (2009) Chunping Qiao et al. HUMAN GENE THERAPY
- Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management
- (2009) Katharine Bushby et al. LANCET NEUROLOGY
- Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration
- (2009) Kishore M. Lakshman et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy
- (2008) Kathryn R. Wagner et al. ANNALS OF NEUROLOGY
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