Co-delivery of the NKT agonist α-galactosylceramide and tumor antigens to cross-priming dendritic cells breaks tolerance to self-antigens and promotes antitumor responses

Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8 + T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells

(2016) Jordana G. Coelho-dos-Reis et al.   CLINICAL IMMUNOLOGY

Vaccine adjuvants as potential cancer immunotherapeutics

(2016) Burcu Temizoz et al.   INTERNATIONAL IMMUNOLOGY

Efficient Regeneration of Human Vα24+Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo

(2016) Daisuke Yamada et al.   STEM CELLS

PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity

(2016) A. L. Silva et al.   Human Vaccines & Immunotherapeutics

Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells

(2016) Shuichi Kitayama et al.   Stem Cell Reports

Co-operation of  -galactosylceramide-loaded tumour cells and TLR9 agonists induce potent anti-tumour responses in a murine colon cancer model

(2015) T. Dong et al.   BIOCHEMICAL JOURNAL

Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8 + T-cell responses and prevent tumour progression

(2015) Silke Neumann et al.   VACCINE

Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses

(2015) Yusuf Dölen et al.   OncoImmunology

Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas

(2014) Gianfranco Picco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-10–producing NKT10 cells are a distinct regulatory invariant NKT cell subset

(2014) Duygu Sag et al.   JOURNAL OF CLINICAL INVESTIGATION

Human XCR1+Dendritic Cells Derived In Vitro from CD34+Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells

(2014) Sreekumar Balan et al.   JOURNAL OF IMMUNOLOGY

Targeted Delivery of α-Galactosylceramide to CD8α+Dendritic Cells Optimizes Type I NKT Cell–Based Antitumor Responses

(2014) Elodie Macho-Fernandez et al.   JOURNAL OF IMMUNOLOGY

Induction of Antigen-Specific Immunity with a Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205

(2014) M. V. Dhodapkar et al.   Science Translational Medicine

Harnessing Human Cross-Presenting CLEC9A+XCR1+ Dendritic Cells for Immunotherapy

(2014) Kirsteen M. Tullett et al.   Frontiers in Immunology

Cytotoxic and Proinflammatory CD8 + T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice

(2013) Tin Kyaw et al.   CIRCULATION

Dendritic cell-based nanovaccines for cancer immunotherapy

(2013) Leonie E Paulis et al.   CURRENT OPINION IN IMMUNOLOGY

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Immune system targeting by biodegradable nanoparticles for cancer vaccines

(2013) Joana M. Silva et al.   JOURNAL OF CONTROLLED RELEASE

Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN Secretion

(2013) J. Tel et al.   JOURNAL OF IMMUNOLOGY

The Ratios of CD8+ T Cells to CD4+CD25+ FOXP3+ and FOXP3- T Cells Correlate with Poor Clinical Outcome in Human Serous Ovarian Cancer

(2013) Claudia C. Preston et al.   PLoS One

Exploiting invariant NKT cells to promote T-cell responses to cancer vaccines

(2013) Martin K. Hunn et al.   OncoImmunology

Skin-Test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell-Based Vaccination in Metastatic Melanoma

(2012) E. H. J. G. Aarntzen et al.   CANCER RESEARCH

From crucial to negligible: Functional CD8+T-cell responses and their dependence on CD4+T-cell help

(2012) Melanie Wiesel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Consequences of direct and indirect activation of dendritic cells on antigen presentation: Functional implications and clinical considerations

(2012) Javier Vega-Ramos et al.   MOLECULAR IMMUNOLOGY

NKT-cell-based immunotherapies in clinical trials

(2011) Mark A. Exley et al.   CLINICAL IMMUNOLOGY

Harnessing natural killer T (NKT) cells in human myeloma: Progress and challenges

(2011) Madhav V. Dhodapkar et al.   CLINICAL IMMUNOLOGY

Novel Highly Sensitive IL-10- -Lactamase Reporter Mouse Reveals Cells of the Innate Immune System as a Substantial Source of IL-10 In Vivo

(2011) H. Bouabe et al.   JOURNAL OF IMMUNOLOGY

Multimodal Imaging of Nanovaccine Carriers Targeted to Human Dendritic Cells

(2011) Luis J. Cruz et al.   MOLECULAR PHARMACEUTICS

Clinical experience with α-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection

(2010) Famke L. Schneiders et al.   CLINICAL IMMUNOLOGY

Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy

(2010) Kazuki Yamasaki et al.   CLINICAL IMMUNOLOGY

Therapeutic cancer vaccines: are we there yet?

(2010) Christopher A. Klebanoff et al.   IMMUNOLOGICAL REVIEWS

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

(2010) Luis J. Cruz et al.   JOURNAL OF CONTROLLED RELEASE

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell–licensed DCs

(2010) Verena Semmling et al.   NATURE IMMUNOLOGY

PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells

(2009) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

A Phase I-II Study of  -Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer

(2009) S. Motohashi et al.   JOURNAL OF IMMUNOLOGY

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

(2008) David Sancho et al.   JOURNAL OF CLINICAL INVESTIGATION

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE