Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

Immune suppressive mechanisms in the tumor microenvironment

(2016) David H Munn et al.   CURRENT OPINION IN IMMUNOLOGY

CIS is a potent checkpoint in NK cell–mediated tumor immunity

(2016) Rebecca B Delconte et al.   NATURE IMMUNOLOGY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy

(2016) S. J. Blake et al.   Cancer Discovery

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

(2015) Camille Guillerey et al.   JOURNAL OF CLINICAL INVESTIGATION

Cish actively silences TCR signaling in CD8 + T cells to maintain tumor tolerance

(2015) Douglas C. Palmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

NK cells require IL-28R for optimal in vivo activity

(2015) Fernando Souza-Fonseca-Guimaraes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Killer cell control ofBRAFV600Emutant melanoma during targeted therapy

(2015) Lucas Ferrari de Andrade et al.   OncoImmunology

Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis

(2015) Camille Guillerey et al.   OncoImmunology

Natural Killer Cells Are Essential for the Ability of BRAF Inhibitors to Control BRAFV600E-Mutant Metastatic Melanoma

(2014) L. Ferrari de Andrade et al.   CANCER RESEARCH

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

(2014) Christopher J Chan et al.   NATURE IMMUNOLOGY

Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients

(2014) B. Mlecnik et al.   Science Translational Medicine

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

(2014) Priyanka Sathe et al.   Nature Communications

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation

(2013) Xuexian O Yang et al.   NATURE IMMUNOLOGY

The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity

(2013) Shin Foong Ngiow et al.   OncoImmunology

Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

(2010) K. Klages et al.   CANCER RESEARCH

DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors

(2008) Susan Gilfillan et al.   JOURNAL OF EXPERIMENTAL MEDICINE