Eosinophils: The unsung heroes in cancer?

Eosinophilic count as a biomarker for prognosis of melanoma patients and its importance in the response to immunotherapy

(2017) Alvaro Moreira et al.   Immunotherapy

Phase II Trial of Atezolizumab As First-Line or Subsequent Therapy for Patients With Programmed Death-Ligand 1–Selected Advanced Non–Small-Cell Lung Cancer (BIRCH)

(2017) Solange Peters et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulatory Eosinophils Suppress T Cells Partly through Galectin-10

(2017) Christine Lingblom et al.   JOURNAL OF IMMUNOLOGY

Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus

(2017) Amali E. Samarasinghe et al.   JOURNAL OF IMMUNOLOGY

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

(2017) Alexandra Taracanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo

(2017) S. M. O'Flaherty et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

(2017) Cristian Tomasetti et al.   SCIENCE

The cancer epigenome: Concepts, challenges, and therapeutic opportunities

(2017) Mark A. Dawson   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Cancer Inflammation and Cytokines

(2017) Maria Rosaria Galdiero et al.   Cold Spring Harbor Perspectives in Biology

Reslizumab and Eosinophilic Asthma: One Step Closer to Precision Medicine?

(2017) Gilda Varricchi et al.   Frontiers in Immunology

Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils

(2017) Stefania Loffredo et al.   Frontiers in Immunology

The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface Ligands

(2017) Silvia Pesce et al.   Frontiers in Immunology

Are Mast Cells MASTers in Cancer?

(2017) Gilda Varricchi et al.   Frontiers in Immunology

The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases

(2017) Brad Griesenauer et al.   Frontiers in Immunology

IL-33 restricts tumor growth and inhibits pulmonary metastasis in melanoma-bearing mice through eosinophils

(2017) Valeria Lucarini et al.   OncoImmunology

IL-33 mediates reactive eosinophilopoiesis in response to airborne allergen exposure

(2016) E. L. Anderson et al.   ALLERGY

Paradoxical Role of HMGB1 in Pancreatic Cancer: Tumor Suppressor or Tumor Promoter?

(2016) MARÍA JOSÉ GARCÍA CEBRIÁN et al.   ANTICANCER RESEARCH

Cellular analysis of the histamine H4 receptor in human myeloid cells

(2016) Ricardo Capelo et al.   BIOCHEMICAL PHARMACOLOGY

Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients

(2016) Lucia De Monte et al.   CANCER RESEARCH

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab

(2016) Benjamin Weide et al.   CLINICAL CANCER RESEARCH

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

(2016) A. Martens et al.   CLINICAL CANCER RESEARCH

Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation

(2016) Shigeharu Ueki et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Eosinophils in Cancer: Favourable or Unfavourable?

(2016) Samy Sakkal et al.   CURRENT MEDICINAL CHEMISTRY

Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders

(2016) Gilda Varricchi et al.   Current Opinion in Allergy and Clinical Immunology

Mast cells and basophils in inflammatory and tumor angiogenesis and lymphangiogenesis

(2016) Gianni Marone et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Controversial role of mast cells in skin cancers

(2016) Gilda Varricchi et al.   EXPERIMENTAL DERMATOLOGY

Effective antigen presentation to helper T cells by human eosinophils

(2016) Ruhaifah K. Farhan et al.   IMMUNOLOGY

Eosinophil extracellular trap cell death–derived DNA traps: Their presence in secretions and functional attributes

(2016) Shigeharu Ueki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung-resident eosinophils represent a distinct regulatory eosinophil subset

(2016) Claire Mesnil et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis

(2016) Laura K. Johnston et al.   JOURNAL OF IMMUNOLOGY

SiglecF + Gr1 hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice

(2016) Caroline M. Percopo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women’s Health Study

(2016) Anna E Prizment et al.   MODERN PATHOLOGY

Interleukin 33 is a guardian of barriers and a local alarmin

(2016) Nikolas T Martin et al.   NATURE IMMUNOLOGY

Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing

(2016) Roy Drissen et al.   NATURE IMMUNOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Player and Coordinator: The Versatile Roles of Eosinophils in the Immune System

(2016) Hai Long et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Eosinophils in Helminth Infection: Defenders and Dupes

(2016) Lu Huang et al.   TRENDS IN PARASITOLOGY

Antimicrobial Activity of Mast Cells: Role and Relevance of Extracellular DNA Traps

(2016) Helene Möllerherm et al.   Frontiers in Immunology

Predictive immune markers in advanced melanoma patients treated with ipilimumab

(2016) Viktor Umansky et al.   OncoImmunology

The immune network in thyroid cancer

(2016) Maria Rosaria Galdiero et al.   OncoImmunology

Mast cell phenotype, TNFα expression and degranulation status in non-small cell lung cancer

(2016) A. Shikotra et al.   Scientific Reports

Phenotypic plasticity and targeting of Siglec-FhighCD11cloweosinophils to the airway in a murine model of asthma

(2015) H. Abdala Valencia et al.   ALLERGY

The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell

(2015) Feng Xie et al.   CANCER LETTERS

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

(2015) J. Cedervall et al.   CANCER RESEARCH

A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells

(2015) Michael Hölzel et al.   CANCER RESEARCH

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

The early history of the eosinophil

(2015) A. B. Kay   CLINICAL AND EXPERIMENTAL ALLERGY

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab

(2015) C. Gebhardt et al.   CLINICAL CANCER RESEARCH

The βc receptor family – Structural insights and their functional implications

(2015) Sophie E. Broughton et al.   CYTOKINE

IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells

(2015) Masaaki Hashiguchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

(2015) Hideaki Morita et al.   IMMUNITY

The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

(2015) Yusuke Endo et al.   IMMUNITY

Novel Therapies for Eosinophilic Disorders

(2015) Bruce S. Bochner   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

(2015) Solène Gatault et al.   JOURNAL OF IMMUNOLOGY

Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma

(2015) Soo Young Kim et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Angiogenesis and lymphangiogenesis in inflammatory skin disorders

(2015) Gilda Varricchi et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

(2015) Hanna Siiskonen et al.   MELANOMA RESEARCH

Eosinophils in mucosal immune responses

(2015) J Travers et al.   Mucosal Immunology

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production

(2015) Y Jung et al.   Mucosal Immunology

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells

(2015) Rafael Carretero et al.   NATURE IMMUNOLOGY

Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8–Akt–Slug pathway

(2015) C Visciano et al.   ONCOGENE

Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy

(2015) Ismael Riquelme et al.   Oncotarget

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses

(2015) Barbara Platzer et al.   Cell Reports

ATP drives eosinophil effector responses through P2 purinergic receptors

(2015) Takehito Kobayashi et al.   ALLERGOLOGY INTERNATIONAL

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Changing roles of eosinophils in health and disease

(2014) Glenn T. Furuta et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

Peritumoral eosinophils predict recurrence in colorectal cancer

(2014) Lars Harbaum et al.   MODERN PATHOLOGY

Eosinophils and Cancer

(2014) B. P. Davis et al.   Cancer Immunology Research

Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival

(2013) J. Delyon et al.   ANNALS OF ONCOLOGY

Epidemiological associations of allergy, IgE and cancer

(2013) Debra H. Josephs et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

(2013) Laurence Zitvogel et al.   IMMUNITY

Novel allergic asthma model demonstrates ST2-dependent dendritic cell targeting by cypress pollen

(2013) Lucia Gabriele et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-33 Markedly Activates Murine Eosinophils by an NF- B-Dependent Mechanism Differentially Dependent upon an IL-4-Driven Autoinflammatory Loop

(2013) C. Bouffi et al.   JOURNAL OF IMMUNOLOGY

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Detection of VEGF-Axxxb Isoforms in Human Tissues

(2013) David O. Bates et al.   PLoS One

SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis

(2013) Raul Aguirre-Gamboa et al.   PLoS One

Mast cells play a protumorigenic role in primary cutaneous lymphoma

(2012) A. Rabenhorst et al.   BLOOD

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Involvement of eosinophils in the anti-tumor response

(2012) Solène Gatault et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor associated macrophages and neutrophils in tumor progression

(2012) Maria R. Galdiero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting Epigenetic Readers in Cancer

(2012) Mark A. Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Galectin-10, a Potential Biomarker of Eosinophilic Airway Inflammation

(2012) Justin C. Chua et al.   PLoS One

Tumor metabolism as modulator of immune response and tumor progression

(2012) Eva Gottfried et al.   SEMINARS IN CANCER BIOLOGY

Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort

(2011) B. Schlehofer et al.   ALLERGY

Plasticity in mast cell responses during bacterial infections

(2011) Cheryl Y Chan et al.   CURRENT OPINION IN MICROBIOLOGY

Effect of eosinophil cationic protein (ECP) on Hodgkin lymphoma cell lines

(2011) Ingrid Glimelius et al.   EXPERIMENTAL HEMATOLOGY

Skin Mast Cells Protect Mice against Vaccinia Virus by Triggering Mast Cell Receptor S1PR2 and Releasing Antimicrobial Peptides

(2011) Z. Wang et al.   JOURNAL OF IMMUNOLOGY

Eosinophils Regulate Dendritic Cells and Th2 Pulmonary Immune Responses following Allergen Provocation

(2011) E. A. Jacobsen et al.   JOURNAL OF IMMUNOLOGY

Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

(2011) M. Ikutani et al.   JOURNAL OF IMMUNOLOGY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Ultrastructural Descriptions of Heterotypic Aggregation between Eosinophils and Tumor Cells in Human Gastric Carcinomas

(2011) Rosario Alberto Caruso et al.   ULTRASTRUCTURAL PATHOLOGY

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation

(2010) T. Müller et al.   ALLERGY

The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells

(2010) S. Drube et al.   BLOOD

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Eosinophils in health and disease: the LIAR hypothesis

(2010) J. J. Lee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Production of Vascular Endothelial Growth Factors from Human Lung Macrophages Induced by Group IIA and Group X Secreted Phospholipases A2

(2010) F. Granata et al.   JOURNAL OF IMMUNOLOGY

Human Eosinophils Exert TNF-  and Granzyme A-Mediated Tumoricidal Activity toward Colon Carcinoma Cells

(2010) F. Legrand et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognostic significance of mast cell count following curative resection for pancreatic ductal adenocarcinoma

(2010) Shou-Wang Cai et al.   SURGERY

Osteopontin is expressed and functional in human eosinophils

(2009) I. Puxeddu et al.   ALLERGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Atopic Disease and Risk of Non-Hodgkin Lymphoma: An InterLymph Pooled Analysis

(2009) C. M. Vajdic et al.   CANCER RESEARCH

Mast cell phenotypes and microvessels in non–small cell lung cancer and its prognostic significance

(2009) María José Carlini et al.   HUMAN PATHOLOGY

Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects

(2009) Aikaterini Detoraki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antitumor IgE Adjuvanticity: Key Role of Fc RI

(2009) E. A. Nigro et al.   JOURNAL OF IMMUNOLOGY

Eosinophils Oxidize Damage-Associated Molecular Pattern Molecules Derived from Stressed Cells

(2009) R. Lotfi et al.   JOURNAL OF IMMUNOLOGY

Gene-Expression Signatures in Breast Cancer

(2009) Christos Sotiriou et al.   NEW ENGLAND JOURNAL OF MEDICINE

AllergoOncology: the role of IgE-mediated allergy in cancer

(2008) E. Jensen-Jarolim et al.   ALLERGY

SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment

(2008) B. Huang et al.   BLOOD

Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33

(2008) T. Pecaric-Petkovic et al.   BLOOD

VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy

(2008) A H R Varey et al.   BRITISH JOURNAL OF CANCER

Eosinophils: Biological Properties and Role in Health and Disease

(2008) SIMON P. HOGAN et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

(2008) Paola Allavena et al.   IMMUNOLOGICAL REVIEWS

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils

(2008) W. Brett Cherry et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The anticancer immune response: indispensable for therapeutic success?

(2008) Laurence Zitvogel et al.   JOURNAL OF CLINICAL INVESTIGATION

Melanoma and Lymphoma Rejection Associated With Eosinophil Infiltration Upon Intratumoral Injection of Dendritic and NK/LAK Cells

(2008) Annalisa Capobianco et al.   JOURNAL OF IMMUNOTHERAPY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE