Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Article
Nutrition & Dietetics
Lin Yan, Sneha Sundaram, Bret M. Rust, Daniel G. Palmer, LuAnn K. Johnson, Huawei Zeng
Summary: The study hypothesized that consumption of a high-fat diet alters metabolic rhythms in pubertal mice. The results showed that the high-fat diet affected the expression of certain genes related to metabolism in the liver of mice, with the greatest changes occurring during the dark phase. These alterations in metabolic rhythms may disrupt metabolic homeostasis during puberty and contribute to the development of metabolic disorders.
FRONTIERS IN NUTRITION
(2023)
Article
Biology
Dongyang Li, Reina Ikaga, Haruko Ogawa, Tomomi Yamazaki
Summary: Sucrose consumption and high-fat diet can lead to obesity and nonalcoholic fatty liver disease, which disrupt circadian rhythms. Research shows that a high-sucrose diet can increase the expression of certain genes related to circadian rhythms in the liver, potentially affecting the normal functioning of the biological clock.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Microbiology
Katya Frazier, Amal Kambal, Elizabeth A. Zale, Joseph F. Pierre, Nathaniel Hubert, Sawako Miyoshi, Jun Miyoshi, Daina L. Ringus, Dylan Harris, Karen Yang, Katherine Carroll, Jake B. Hermanson, John S. Chlystek, Katherine A. Overmyer, Candace M. Cham, Mark W. Musch, Joshua J. Coon, Eugene B. Chang, Vanessa A. Leone
Summary: The diurnal oscillations of gut microbiota play an important role in maintaining the host’s circadian rhythms and metabolism, ensuring optimal energy balance. This study reveals that the interaction between diet, microbes, and host factors, particularly the C-type lectin antimicrobial peptide Reg3 gamma, is complex and bidirectional. The high-fat diet disrupts the microbial oscillators, leading to dysregulated host Reg3 gamma expression, which subsequently affects the abundance and oscillation of key gut microbes. These findings highlight the coordination of biological rhythms between the host and microbial components, primarily influenced by diet.
CELL HOST & MICROBE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Christine Merlin
Summary: The molecular mechanism behind organisms' ability to anticipate variations in environmental conditions caused by tides in the intertidal zone has been unknown. A recent study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms.
Article
Cell Biology
Stine M. Praestholm, Catarina M. Correia, Victor E. Goitea, Majken S. Siersbaek, Mathilde Jorgensen, Jesper F. Havelund, Thomas A. Pedersen, Nils J. Faergeman, Lars Grontved
Summary: The transition from a fasted to a fed state leads to extensive transcriptional remodeling in hepatocytes, with a subset of hepatic feeding-induced genes requiring glucocorticoid receptor (GR) for full expression. This includes the important gene Gck, which is involved in hepatic glucose metabolism. GR cooperatively regulates hepatic Gck expression with insulin in a direct manner, affecting postprandial glucose uptake and storage in the liver.
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Yuan Cui, Yan Yin, Shilan Li, Yisha Xie, ZhengLi Wu, Hao Yang, Qingfan Qian, Xinli Li
Summary: The study reveals that apple polyphenol extract (APE) can improve circadian rhythm disturbances caused by high-fat diet, and restore the circadian rhythms of lipid metabolism. These findings suggest that the circadian clock may be a novel target for APE in regulating metabolic homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Oncology
Maria Crespo, Magdalena Leiva, Guadalupe Sabio
Summary: The circadian regulation of liver metabolism plays a crucial role in maintaining homeostasis and preventing metabolic disorders, such as non-alcoholic fatty liver disease and impaired glucose metabolism, that can increase the risk of liver cancer. Understanding the molecular mechanisms controlling the liver clock and its impact on metabolic and oncogenic pathways could lead to new targets for the prevention and management of hepatocellular carcinoma.
Article
Food Science & Technology
Atsushi Haraguchi, Tomohiro Yamazaki, Conn Ryan, Kaede Ito, Shuhei Sato, Konomi Tamura, Masataka Sekiguchi, Siyuan Cao, Shigenobu Shibata
Summary: This study investigated the effects of caffeine intake timing on anti-obesity effect and found that caffeine intake at the beginning of the active period can suppress weight gain induced by a high-fat diet.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Endocrinology & Metabolism
Xuemin Peng, Yong Chen
Summary: The relationship between circadian rhythms and thermogenic fat and its potential in treating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Francesca Battaglin, Priscilla Chan, Yuanzhong Pan, Shivani Soni, Meng Qu, Erin R. Spiller, Sofi Castanon, Evanthia T. Roussos Torres, Shannon M. Mumenthaler, Steve A. Kay, Heinz-Josef Lenz
Summary: Disruption of the circadian clock pathway is associated with cancer risk, development, and progression. Dysregulation of core circadian clock genes is common in human tumors, with varied effects and mechanisms depending on cancer types. Pharmacological modulation of clock components shows promise as a novel anti-cancer therapeutic approach.
Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Article
Biochemistry & Molecular Biology
Weiyun Zhang, Chi-Tang Ho, Muwen Lu
Summary: This study found that piperine improves lipid metabolism disorders in HepG2 cells by regulating the Bmal1 and Clock genes, reducing circadian desynchrony, ROS overproduction, and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sarah Koop, Henrik Oster
Summary: This article explains how the circadian clock regulates sleep-wake cycles, food intake, and mating and bonding behaviors through endocrine networks.
Article
Biochemistry & Molecular Biology
Cathleen Geissler, Christin Krause, Anne-Marie Neumann, Jan H. Britsemmer, Natalie Taege, Martina Grohs, Meike Kaehler, Ingolf Cascorbi, Alfor G. Lewis, Randy J. Seeley, Henrik Oster, Henriette Kirchner
Summary: This study examined the dynamic regulation of DNA methylation in metabolic diseases and found that Fgf21 DNA methylation decreased before the onset of increased Fgf21 expression and metabolic changes. Intervention strategies like surgery or medication could not reverse Fgf21 DNA methylation or expression despite improvements in weight and glucose tolerance.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Neurosciences
Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
Summary: The use of animal models is crucial for understanding the mechanisms of Parkinson's disease. This review examines the extent to which different mouse models accurately reflect the sleep and circadian abnormalities observed in Parkinson's disease.
MOLECULAR NEURODEGENERATION
(2022)
Article
Neurosciences
Alexander Dueck, Olaf Reis, Henrike Wagner, Katja Wunsch, Frank Haessler, Michael Koelch, Mariana Astiz, Johannes Thome, Christoph Berger, Henrik Oster
Summary: This study compared circadian rhythms at the behavioral, endocrine, and molecular levels between children with ADHD and age- and BMI-matched controls. Significant differences were found in sleep onset and duration, cortisol secretion profiles, and expression of clock genes in the ADHD group. The analysis of circadian molecular rhythms may provide a new approach for diagnosing ADHD in children and adults.
Review
Physiology
Leonardo Vinicius Monteiro de Assis, Muenevver Demir, Henrik Oster
Summary: This review focuses on the role of circadian rhythms in the liver and their impact on the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The disruption of circadian rhythms and its potential consequences are discussed, as well as the potential use of the clock system in prevention and treatment of NAFLD/NASH. Attention to circadian timing may provide new avenues for optimizing therapies and targeting these prevalent disorders.
Review
Physiology
Iwona Olejniczak, Kimberly Begemann, Ines Wilhelm, Henrik Oster
Summary: Circadian clocks play a crucial role in regulating physiology and behavior, particularly in the central reward system. They impact neurotransmitter signaling, neuroendocrine circuits, and sensitivity to external stimuli. Disruption of circadian rhythms can affect reward signaling, leading to the development of behavioral and substance use disorders. This review summarizes current knowledge on the interaction between circadian clocks and reward, highlighting the effects of chronodisruption on reward signaling in animal models. The translation of these findings to human reward (dys-) function and the clinical implications are discussed, along with the challenges and approaches in incorporating circadian medicine concepts into the therapy of substance use disorders.
Review
Physiology
Rodrigo Chamorro, Celine Jouffe, Henrik Oster, N. Henriette Uhlenhaut, Sebastian M. Meyhoefer
Summary: This review article discusses the circadian clock's role in regulating physiological and behavioral functions, especially in relation to food intake and metabolic regulation. It emphasizes the importance of meal timing in controlling appetite and metabolic responses. The article provides a fundamental research axis for maintaining a healthy eating behavior by exploring the mechanisms of food intake regulation and focusing on the crucial role of the circadian clock.
Correction
Biology
Anthony H. Tsang, Christiane E. Koch, Jana-Thabea Kiehn, Cosima X. Schmidt, Henrik Oster
Article
Endocrinology & Metabolism
Kimberly Begemann, Isabel Heyde, Pia Witt, Julica Inderhees, Brinja Leinweber, Christiane E. Koch, Olaf Joehren, Rebecca Oelkrug, Arkadiusz Liskiewicz, Timo D. Mueller, Henrik Oster
Summary: Snacking during the rest phase leads to weight gain and disruption of metabolic circadian rhythms, while snacking during the active phase does not have the same effect.
MOLECULAR METABOLISM
(2023)
Review
Physiology
Hong-Viet V. Ngo, Henrik Oster, Christina Andreou, Jonas Obleser
Summary: Circadian rhythms are inherent in all organisms and have an impact on various aspects of physiology and behavior in response to the 24-hour day-night cycle. The review focuses on the potential role of circadian disruption in auditory hallucinations, a cardinal symptom of psychosis. The dysbalance in excitation and inhibition within cortical networks, leading to disinhibition of dopaminergic signaling, is highlighted as a central physiological mechanism. Two avenues for experimentally intervening on circadian influences to alleviate hallucinations in psychotic disorders are proposed.
Review
Physiology
Dieter Kunz, Henrik Oster, Oliver Rawashdeh, Wolf-Julian Neumann, Thomas Muente, Daniela Berg
Summary: The prevalence of neurodegenerative diseases, particularly Parkinson's disease, in the global north is increasing at an alarming rate, with some even calling it a pandemic. While lifestyle factors are known to contribute, the role of circadian rhythms in these diseases has not been extensively explored. Sleep and circadian rhythm disruption have been found to play a key role in neurodegeneration, particularly during the early stages of the disease. This review summarizes the current knowledge on sleep and circadian rhythm disruptions in neurodegenerative diseases, with a focus on molecular aspects and therapeutic potentials, providing valuable insights into the pathogenesis and potential treatment interventions.
Review
Neurosciences
Marianne Lehmann, Katharina Haury, Henrik Oster, Mariana Astiz
Summary: Glucocorticoids (GCs) play a crucial role in the development of the circadian system during the perinatal period and continue to regulate various functions such as energy metabolism and behavior in adulthood. This article explores the bidirectional interaction between GCs and the circadian clock at the molecular and systemic levels, with a focus on the influence of GC rhythm on the master clock in the suprachiasmatic nuclei (SCN) of the hypothalamus during development and in the adult system.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biology
Iwona Olejniczak, Violetta Pilorz, Henrik Oster
Summary: This review summarizes the development and maturation of circadian clocks in humans and experimental rodents, including their changes during embryonic development, after birth, and during puberty, adolescence, and aging. The focus is on the circadian regulation of reproductive systems as major organizers of life stages and lifespan. The differences between sexes are also discussed, and potential areas for future research are outlined. Finally, potential options for medical applications of lifespan chronobiology are discussed.
Editorial Material
Nutrition & Dietetics
Henrik Oster, Ines Chaves
Meeting Abstract
Clinical Neurology
H. Oster
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)