Article
Immunology
Xin Zhang, Xiaofan Lu, Allen Ka Loon Cheung, Qiuyue Zhang, Zhiying Liu, Zhen Li, Lin Yuan, Rui Wang, Yan Liu, Bin Tang, Huan Xia, Hao Wu, Tong Zhang, Bin Su
Summary: TIGIT expression on NK cells is associated with dysfunction during chronic HIV infection, but its roles in acute HIV-1 infection are unclear. Our study found that TIGIT-expressing NK cells did not increase significantly until chronic infection, and their numbers were positively correlated with HIV-1 viral load in acute infection. Additionally, the expression of CD96 and CD226 on NK cells changed during different infection stages, with opposite associations with viral load and CD4 T-cell counts. Overall, TIGIT(+)NK cells displayed weaker functionalities compared to TIGIT(-)NK cells, indicating their limited ability to combat HIV-1 replication and maintain CD4 T-cell counts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jingnan Liao, Yuan Li, Xiaofeng Li, Xian Su, Jing Peng, Na Xiao, Xiangxiu Fan, Huijun Chen, Guangxiu Lu, Ge Lin, Lamei Cheng, Fei Gong
Summary: The study found that pre-pregnancy blood Treg levels were significantly lower in URPL patients than in controls, and that Treg levels predicted subsequent miscarriages. There were no significant differences among other blood cell types between the two groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Yu Tao, Yan-Hong Li, Di Zhang, Ling Xu, Jia-Jia Chen, Yi-Fei Sang, Hai-Lan Piao, Xue-Ling Jing, Min Yu, Qiang Fu, Sheng-Tao Zhou, Da-Jin Li, Mei-Rong Du
Summary: The CXCR4(+)CD56(bright)dNK subset plays an important immunomodulatory role during early pregnancy, promoting Th2 shift and assisting in the establishment of immune-tolerance. This new dNK cell subset may provide important insights into NK cell mechanisms in early pregnancy, and offer potential prognostic factors for the diagnosis and therapy of recurrent miscarriage.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Nicole Kashani, Eve E. Kelland, Borna Vajdi, Lauren M. Anderson, Wendy Gilmore, Brett T. Lund
Summary: This study revealed that patients treated with alemtuzumab for multiple sclerosis showed an increase in the number and function of regulatory B cells after treatment, which were positively correlated with regulatory T cells. Additionally, an anti-inflammatory bias in monocytes was observed after the second annual course of treatment. These findings highlight the importance of further studies on all regulatory cell types following alemtuzumab treatment to understand the mechanisms of drug action and identify key predictors of durable clinical efficacy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anne Wisgalla, Caren Ramien, Mathias Streitz, Stephan Schlickeiser, Andreea-Roxana Lupu, Anke Diemert, Eva Tolosa, Petra C. Arck, Judith Bellmann-Strobl, Nadja Siebert, Christoph Heesen, Friedemann Paul, Manuel A. Friese, Carmen Infante-Duarte, Stefan M. Gold
Summary: During pregnancy, there are significant shifts in NK cell populations, with an increase in CD56(bright) NK cells and a decrease in CD56(dim) NK cells. These changes occur in both pregnant women with multiple sclerosis and healthy pregnant women, potentially contributing to disease amelioration in multiple sclerosis during pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Kerstin Hellwig, Elisabetta Verdun di Cantogno, Meritxell Sabido
Summary: This systematic review evaluated relapses of multiple sclerosis (MS) during pregnancy and postpartum, showing a complex relationship between disease-modifying therapy (DMT) use and relapse. Some studies suggested that the preconception use of natalizumab or fingolimod may increase the risk of relapses during pregnancy, highlighting the need for effective disease management in these high-risk patients.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Clinical Neurology
Annika Anderson, William Rowles, Shane Poole, Ayushi Balan, Carolyn Bevan, Rachel Brandstadter, Andrea I. Ciplea, Joanna Cooper, Michelle Fabian, Thomas W. Hale, Dina Jacobs, Mihir Kakara, Kristen M. Krysko, Erin E. Longbrake, Jacqueline Marcus, Pavle Repovic, Claire S. Riley, Andrew R. Romeo, Alice Rutatangwa, Timothy West, Kerstin Hellwig, Sara C. LaHue, Riley Bove
Summary: This study examined the transfer of anti-CD20 IgG1 monoclonal antibodies (mAb) into breastmilk and evaluated the outcomes for mothers with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) and their infants. The results showed minimal transfer of the antibodies into breastmilk, and postpartum treatment with the antibodies was found to be safe and well-tolerated for both mother and infant.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Sabrina Haben, Andrea Ciplea, Marianne Tokic, Nina Timmesfeld, Sandra Thiel, Ralf Gold, Annette Magdalene Langer-Gould, Kerstin Hellwig
Summary: This study aimed to assess the association between four different postpartum strategies and relapse risk during the first 6 months postpartum. The results showed that early treatment with natalizumab/fingolimod reduced the hazard of postpartum relapse from month 3, but did not diminish the hazard of early postpartum relapse. Therefore, an early postpartum treatment strategy should be determined well before delivery for women with active multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Gabriel Bsteh, Harald Hegen, Katharina Riedl, Patrick Altmann, Franziska Di Pauli, Rainer Ehling, Gudrun Zulehner, Paulus Rommer, Fritz Leutmezer, Florian Deisenhammer, Thomas Berger
Summary: The study aims to generate and validate a risk score for disease reactivation in patients with relapsing multiple sclerosis (RMS) during pregnancy. By analyzing predictors including relapse occurrence, DMT type, DMT washout duration, EDSS at conception, and time until DMT restart postpartum, a predictive score was developed to identify patients at high, intermediate, and low risk of disease reactivation during pregnancy and up to 6 months postpartum.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Federica Murgia, Florianna Giagnoni, Lorena Lorefice, Paola Caria, Tinuccia Dettori, Maurizio N. N. D'Alterio, Stefano Angioni, Aran J. J. Hendren, Pierluigi Caboni, Monica Pibiri, Giovanni Monni, Eleonora Cocco, Luigi Atzori
Summary: Sex hormones are correlated with the clinical activity of multiple sclerosis. Estrogens and progesterone may have a neuroprotective effect in MS, supporting further research on their therapeutic uses.
Review
Immunology
Zhiheng Wu, Yu Zheng, Jin Sheng, Yicheng Han, Yanyan Yang, Hongming Pan, Junlin Yao
Summary: This article comprehensively reviews the origin, distribution, and functions of DN T cells, focusing on their roles in inflammation, immune disorders, and cancer. It also discusses the recent advances in DN T cell-based therapy for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Joao Canto-Gomes, Carolina S. Silva, Rita Rb-Silva, Daniela Boleixa, Ana Martins da Silva, Remi Cheynier, Patricio Costa, Ines Gonzalez-Suarez, Margarida Correia-Neves, Joao J. Cerqueira, Claudia Nobrega
Summary: The aim of this study is to assess the peripheral immune system of newly diagnosed patients with relapsing remitting multiple sclerosis (RRMS) and identify immune features associated with clinical onset.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Longxiang Tao, Shanshan Wang, Guijie Kang, Shanyue Jiang, Wenwei Yin, Lu Zong, Jing Li, Xuefu Wang
Summary: Circulating NKT-like cells in HCC patients exhibit functional impairment, with decreased production of TNF-alpha, IFN-gamma, and cytotoxicity, while the expression of inhibitory receptors PD-1, Tim-3, and CTLA-4 is increased. PD-1 blockade improves the effector function of NKT-like cells in HCC patients and may benefit HCC immunotherapy optimization.
Article
Pathology
Minna Mutka, Kristiina Joensuu, Mine Eray, Paivi Heikkila
Summary: This study compares the quantities of tumor infiltrating lymphocytes (Tils) in primary breast carcinomas and their corresponding recurrences and analyzes the differences in the compositions of tumor Tils in relation to various factors. The results show that fewer Tils are found at recurrences compared to the primaries in certain subgroups. CD4+ cell numbers do not decline from primary to recurrence, unlike other subclasses of lymphocytes. Tumors with a higher grade and proliferation rate tend to have higher percentages of Tils.
DIAGNOSTIC PATHOLOGY
(2023)
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Economics
Laia Alsina, J. Bruno Montoro, Pedro Moral Moral, Olaf Neth, Marta Ortiz Pica, Silvia Sanchez-Ramon, Maria Presa, Itziar Oyaguez, Miguel Angel Casado, Luis Ignacio Gonzalez-Granado
Summary: A cost-minimization model compared the costs of IVIG and SCIG for patients with PID in Spain, revealing that SCIG was associated with lower total costs. The main cost-saving factors for SCIG included differences in annual IG dosage costs and reduced hospital administration costs.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2022)
Letter
Immunology
Kissy Guevara-Hoyer, Eduardo de la Fuente-munoz, Celia Pinedo Sierra, Teresa Robledo, Silvia Sanchez-Ramon
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Manuel Santamaria, Olaf Neth, Jo A. Douglass, Gergely Krivan, Robin Kobbe, Ewa Bernatowska, Sofia Grigoriadou, Claire Bethune, Anita Chandra, Gerd Horneff, Michael Borte, Anja Sonnenschein, Pavlina Kralickova, Silvia Sanchez Ramon, Daman Langguth, Luis Ignacio Gonzalez-Granado, Laia Alsina, Montse Querolt, Rhonda Griffin, Carrie Hames, Elsa Mondou, Jeffrey Price, Ana Sanz, Jiang Lin
Summary: IGSC 20% demonstrated efficacy and good safety and tolerability in patients with primary immunodeficiency.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Correction
Immunology
Manuel Santamaria, Olaf Neth, Jo A. Douglass, Gergely Krivan, Robin Kobbe, Ewa Bernatowska, Sofia Grigoriadou, Claire Bethune, Anita Chandra, Gerd Horneff, Michael Borte, Anja Sonnenschein, Pavlina Kralickova, Silvia Sanchez Ramon, Daman D. Langguth, Luis Ignacio Gonzalez-Granado, Laia Alsina, Montse Querolt, Rhonda Griffin, Carrie Hames, Elsa Mondou, Jeffrey Price, Ana Sanz, Jiang Lin
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Leire Solis, Julia Nordin, Johan Prevot, Nizar Mahlaoui, Silvia Sanchez-Ramon, Adli Ali, Elodie Cassignol, John W. Seymour, Martine Pergent
Summary: This article introduces the development of the Principles of Care for Primary Immunodeficiencies (PIDs) and the PID Life Index. The PID principles set a common goal to ensure appropriate care and good quality of life for PID patients, while the PID Life Index assesses the status and implementation of these principles worldwide.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Immunology
Eduardo de la Fuente-munoz, Ana van den Rym, Blanca Garcia-Solis, Juliana Ochoa Grullon, Kissy Guevara-Hoyer, Miguel Fernandez-Arquero, Lucia Galan Davila, Jorge Matias-Guiu, Silvia Sanchez-Ramon, Rebeca Perez de Diego
Summary: This study describes a patient with tubular aggregate myopathy and Stormorken syndrome (TAM/STRMK) caused by a novel STIM1 mutation. In addition to typical TAM/STRMK manifestations, the patient also exhibited immunological involvement with respiratory infections, chronic cough, and chronic bronchiectasis. Dysregulation of calcium signaling in immune cells may contribute to the immune involvement observed in this patient.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juliana Ochoa-Grullon, Kissy Guevara-Hoyer, Cristina Perez Lopez, Rebeca Perez de Diego, Ascension Pena Cortijo, Marta Polo, Marta Mateo Morales, Eduardo Anguita Mandley, Carlos Jimenez Garcia, Estefania Bolanos, Belen Inigo, Fiorella Medina, Antonia Rodriguez de la Pena, Carmen Izquierdo Delgado, Eduardo de la Fuente Munoz, Elsa Mayol, Miguel Fernandez-Arquero, Ataulfo Gonzalez-Fernandez, Celina Benavente Cuesta, Silvia Sanchez-Ramon
Summary: B-cell chronic lymphoproliferative diseases (B-CLPD) are associated with immune deficiencies, resulting in increased risk of severe infections and earlier cancer progression. This study also suggests that some patients with B-CLPD may have underlying primary immunodeficiencies.
Article
Immunology
Alejandra Comins-Boo, Lorena Valdeolivas, Fernando Perez-Pla, Ignacio Cristobal, Nabil Subhi-Issa, Angeles Dominguez-Soto, Lydia Pilar-Suarez, Pilar Gasca-Escorial, Marta Calvo-Urrutia, Miguel Fernandez-Arquero, Miguel Angel Herraiz, Angel Corbi, Silvia Sanchez-Ramon
Summary: This study aimed to evaluate the role of monocyte subsets and cytokines in RPL and RIF women. The study found that CX3CR1+ and CCR5+ intermediate monocytes were significantly higher in RPL and RIF, and there was a significant positive correlation between CX3CR1+ intermediate monocytes and IL-17A. The combination of specific monocyte subsets and cytokines could aid in identifying RPL and RIF women with a pro-inflammatory profile.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Oncology
Javier David Benitez Fuentes, Kauzar Mohamed Mohamed, Alicia de Luna Aguilar, Carlos Jimenez Garcia, Kissy Guevara-Hoyer, Miguel Fernandez-Arquero, M. Antonia Rodriguez de la Pena, Laura Garciia Bravo, Alejandro Francisco Jimenez Ortega, Paloma Flores Navarro, Jorge Bartolome Arcilla, Barbara Alonso Arenilla, Elvira Baos Munoz, Alberto Delgado-Iribarren Garcia-Campero, Maria Montealegre Sanz, Silvia Sanchez-Ramon, Pedro Perez Segura
Summary: This study investigated the long-term cellular and humoral responses to the SARS-CoV-2 mRNA vaccine in cancer patients and found the possibility of T cell exhaustion. The results suggest that an additional booster dose might be beneficial for patients with a decrease in specific IFN-γ response after vaccination.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Letter
Dermatology
Rosa Sacedon, M. Carmen de Arriba, Lucia Martinez-Santamaria, Rocio Maseda, Sara Herraiz-Gil, Eva Jimenez, Isabel Rosales, Lucia Quintana, Nuria Illera, Marta Garcia, Nora Butta, Ihosvany Fernandez-Bello, Su M. Lwin, Miguel Fernandez-Arquero, Carlos Leon, John A. Mcgrath, M. Angeles Vicente, Marcela del Rio, Raul de Lucas, Silvia Sanchez-Ramon, Maria Jose Escamez
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kauzar Mohamed Mohamed, Maria Paula Alvarez-Hernandez, Carlos Jimenez Garcia, Kissy Guevara-Hoyer, Dalifer Freites, Cristina Martinez Prada, Ines Perez-Sancristobal, Benjamin Fernandez Gutierrez, Gloria Mato Chain, Maria Rodero, Antonia Rodriguez de la Pena, Teresa Mulero, Cecilia Bravo, Esther Toledano, Esther Culebras Lopez, Beatriz Mediero Valeros, Pedro Perez Segura, Silvia Sanchez-Ramon, Gloria Candelas Rodriguez
Summary: This study evaluated the immune response in patients with immune-mediated rheumatic diseases (IMRDs) who received the third dose of anti-SARS-CoV-2 vaccine. The majority of patients developed cellular and humoral responses, but the specific response magnitude varied depending on the immunosuppressive therapy administered.
Meeting Abstract
Rheumatology
Ines Perez Sancristobal, Maria Paula Alvarez Hernandez, Silvia Sanchez-Ramon, Cristina Martinez, Eduardo de la Fuente, Concepcion Morado, Dalifer Freites Nunez, Benjamin Fernandez Gutierrez, Gloria Candelas
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
R. Gil Laborda, E. Carrillo de Albornoz, J. Vidal, V. Verdu, A. De la Fuente, M. Farinas, A. Garcia Segovia, D. Pintado Vera, J. L. Vicario, F. Ros Berruezo, F. M. Canadas, M. Ordenes, M. Fernandez-Arquero, S. Sanchez-Ramon
HUMAN REPRODUCTION
(2022)
Article
Immunology
Laura Garcia-Bravo, Myriam Calle-Rubio, Miguel Fernandez-Arquero, Kauzar Mohamed Mohamed, Teresa Guerra-Galan, Maria Guzman-Fulgencio, Antonia Rodriguez de la Pena, Cristina Canizares, Barbara Lopez, Cristina Vadillo, Jorge Matias-Guiu, Asuncion Nieto Barbero, Jose Luis Alvarez-Sala Walther, Silvia Sanchez-Ramon, Juliana Ochoa-Grullon
Summary: This study retrospectively investigated the global incidence of autoantibodies associated with myositis (non Jo1-RNA synthetases: antiPL7, anti-PL12, anti-EJ, anti-OJ and RNA-sensor: anti-MDA5) in a cohort of 444 patients with suspected inflammatory myopathy from 2015 to 2021. The results showed an increased incidence of anti-synthetase antibodies during the COVID-19 pandemic and SARS-CoV-2 vaccination, with differential profiles of antibody specificities observed between 2020 and 2021.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2022)