Article
Immunology
Pekka Hurme, Miisa Komulainen, Marleena Tulkki, Annamari Leino, Beate Ruckert, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Cezmi A. Akdis, Tuomas Jartti
Summary: The cytokine profiles of Rhinovirus (RV) and respiratory syncytial virus (RSV)-induced first wheezing episode differ, with higher cytokine expression and longer hospitalization time in the RSV group. In the RV group, increased expression of I-309 (CCL1) and TARC is associated with fewer relapses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Juliana Cristina Santiago Bastos, Paulo Vitor Marques Simas, Leonardo Cardia Caserta, Alfonso Eduardo Alvarez Bragunde, Fernando Augusto de Lima Marson, Matheus Cavalheiro Martini, Marina Aiello Padilla, Jose Dirceu Ribeiro, Marcia Merces Aparecida Bianchi dos Santos, Clarice Weis Arns
Summary: RSV and rhinoviruses are the most commonly detected viruses in severe bronchiolitis cases in infants. However, a significant portion of cases do not show RSV presence, indicating the presence of other viral agents like rhinoviruses.
JORNAL DE PEDIATRIA
(2022)
Article
Immunology
Chun Yi Lee, Chia Hsin Sung, Meng Che Wu, Yu Chuan Chang, Jih Chin Chang, Yu Ping Fang, Nancy M. Wang, Teh Ying Chou, Yu Jiun Chan
Summary: This study investigated the clinical characteristics and cytokines/chemokines profiles among respiratory syncytial virus (RSV), rhinovirus (RV), and their dual infection in Taiwanese children with viral bronchiolitis. The findings revealed that RV bronchiolitis had comparable severity to RSV but was more common in older children with a history of recurrent wheezing and blood eosinophilia. Different viral infections elicited characteristic clinical presentations and immune profiles in bronchiolitis. The study also highlighted the role of the IL-33/IL-31 axis in the immunopathogenesis of bronchiolitis.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Review
Allergy
Heidi Makrinioti, Kohei Hasegawa, John Lakoumentas, Paraskevi Xepapadaki, Maria Tsolia, Jose A. Castro-Rodriguez, Wojciech Feleszko, Tuomas Jartti, Sebastian L. Johnston, Andrew Bush, Vasiliki Papaevangelou, Carlos A. Camargo, Nikolaos G. Papadopoulos
Summary: This study compares the associations of RSV-induced bronchiolitis and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma through a meta-analysis. The results show that the RV-bronchiolitis group is more likely to develop recurrent wheeze and asthma. This study is clinically significant for understanding the relationship between viruses and asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo
Summary: This study aimed to investigate the association between severe bronchiolitis profiles identified by clustering and childhood asthma. The results showed that children with a history of wheezing and/or eczema and rhinovirus infection had a higher risk of developing childhood asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Pediatrics
Julie Magnier, Valerie Julian, Aurelien Mulliez, Alexandra Usclade, Emmanuelle Rochette, Bertrand Evrard, Flore Amat, Carole Egron
Summary: The study revealed that male infants with a family history of allergies may be at higher risk for asthma at school age following their first episode of acute bronchiolitis. Additionally, rhinovirus infection and specific gene may have significant associations with asthma at age seven.
Article
Immunology
Ryohei Shibata, Zhaozhong Zhu, Tadao Ooka, Robert J. Freishtat, Jonathan M. Mansbach, Marcos Perez-Losada, Ignacio Ramos-Tapia, Stephen Teach, Carlos A. Camargo, Kohei Hasegawa
Summary: Using tIgE and virus data, we identified phenotypes of infant bronchiolitis and studied their association with asthma development and biological characteristics. We found 4 phenotypes, and infants with the tIgE(high)virus(RSV-low/RV) phenotype had a significantly higher risk for developing asthma. These phenotypes also exhibited different biological characteristics, such as depleted type I interferon and enriched antigen presentation pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Flavio De Maio, Danilo Buonsenso, Delia Mercedes Bianco, Martina Giaimo, Bruno Fosso, Francesca Romana Monzo, Michela Sali, Brunella Posteraro, Piero Valentini, Maurizio Sanguinetti
Summary: The study investigated fecal microbiota composition in infants with RSV and non-RSV bronchiolitis, finding significant differences in clinical characteristics between the two groups, but no direct association between microbiota composition and severity of bronchiolitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Respiratory System
Yoshihiko Raita, Marcos Perez-Losada, Robert J. Freishtat, Andrea Hahn, Eduardo Castro-Nallar, Ignacio Ramos-Tapia, Nathaniel Stearrett, Yury A. Bochkov, James E. Gern, Jonathan M. Mansbach, Zhaozhong Zhu, Carlos A. Camargo, Kohei Hasegawa
Summary: Through transcriptome and clustering analysis, we identified biologically distinct metatranscriptome profiles with differential risks of asthma in infant bronchiolitis.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Sara Roggiani, Daniele Zama, Federica D'Amico, Alessandro Rocca, Marco Fabbrini, Camilla Totaro, Luca Pierantoni, Patrizia Brigidi, Silvia Turroni, Marcello Lanari
Summary: This study simultaneously reconstructed the dynamics of the gut, oral, and nasopharyngeal microbiota in infants with RSV bronchiolitis. The study found that all ecosystems underwent rearrangements over time, but with distinct configurations depending on the clinical course of bronchiolitis. Infants hospitalized for longer showed early and persistent signatures of unhealthy microbiota in all ecosystems.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Respiratory System
Maria Luz Garcia-Garcia, Beatriz Sastre, Maria Arroyas, Maite Beato, Patricia Alonso, Jose Manuel Rodrigo-Munoz, Victoria Del Pozo, Inmaculada Casas, Cristina Calvo
Summary: This study investigated the association between nasal detection of periostin and thymic stromal lymphopoietin (TSLP) during severe bronchiolitis and the development of asthma at 4 years of age. The results showed that nasal TSLP detection was associated with current asthma, prescription of asthma maintenance treatment, and respiratory admissions, while nasal periostin detection was associated with a lower risk of asthma at 4 years and reduced respiratory admissions.
RESPIRATORY RESEARCH
(2023)
Article
Pediatrics
Jefferson Antonio Buendia, Erika Fernanda Lindarte, Fernando P. Polack
Summary: This study evaluated the interaction between TLR4 gene polymorphisms and Ascaris infection with severe bronchiolitis. The results showed that TLR4 Asp299Gly was associated with a low risk of severe bronchiolitis in infants with RSV acute infection and positive anti-Ascaris IgE, while it was associated with an increased risk in infants RSV negative with negative anti-Ascaris IgE.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Andres Pizzorno, Blandine Padey, Victoria Duliere, William Mouton, Justine Oliva, Emilie Laurent, Cedrine Milesi, Bruno Lina, Aurelien Traversier, Thomas Julien, Sophie Trouillet-Assant, Manuel Rosa-Calatrava, Olivier Terrier
Summary: This study investigates the interactions between SARS-CoV-2 and other respiratory viruses, revealing that virus type and sequence of infections play a crucial role in determining virus-virus interactions, with the primary infection having a determinant role in the immune response to the secondary infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Malgorzata Kobialka, Teresa Jackowska, August Wrotek
Summary: RSV hospitalizations are associated with risk factors such as age (up to 3 months), prematurity, and presence of apnea. Protective factors include older age and presence of fever.
Article
Virology
Styliani Pappa, Katerina Haidopoulou, Charalampos Zarras, Eleni Theodorakou, Eleni Papadimitriou, Elias Iosifidis, Ioanna Gkeka, Konstantina Stoikou, Eleni Vagdatli, Lemonia Skoura, Anna Papa
Summary: An unexpected surge of RSV infections among children was observed in Greece, with RSV-A being the predominant subtype. This may be attributed to the lack of immunity among children and mothers due to the COVID-19 pandemic. Awareness and molecular epidemiology are crucial for diagnosing and monitoring RSV infections.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Emergency Medicine
Rebecca E. Cash, Anjali J. Kaimal, Mark A. Clapp, Margaret E. Samuels-Kalow, Carlos A. Jr Jr Camargo
Summary: During the COVID-19 pandemic, there was a short-term increase in the rate of out-of-hospital deliveries, although they remained rare. Geographic variation in the rate was also observed.
PREHOSPITAL EMERGENCY CARE
(2023)
Article
Health Care Sciences & Services
Tehnaz P. Boyle, Julianne N. Dugas, James Liu, Stephanie N. Stapleton, Ron Medzon, Barbara M. Walsh, Pamela Corey, Leonard Shubitowski, John R. Horne, Richard O'Connell, Graham Williams, Kerrie P. Nelson, Vinay M. Nadkarni, Carlos A. Camargo, James A. Feldman
Summary: This study adapted a simulation model and checklist tool to assess prehospital team performance and evaluated interrater reliability. The modified checklist showed very good agreement in assessing the composite performance of prehospital teams and can be used to test the effects of patient safety interventions.
SIMULATION IN HEALTHCARE-JOURNAL OF THE SOCIETY FOR SIMULATION IN HEALTHCARE
(2023)
Article
Health Care Sciences & Services
Rain E. Freeman, Cordelia Zhong, Piroz Bahar, Krislyn M. Boggs, Mohammed K. Faridi, Ashley F. Sullivan, Kori S. Zachrison, Carlos A. Camargo Jr
Summary: Although many emergency departments receive telepsychiatry services, national research on the usage of telepsychiatry in emergency departments is limited. This study investigated the usage of telepsychiatry in a sample of emergency departments in 2019 and found that telepsychiatry was the primary form of emergency psychiatric care for most emergency departments.
TELEMEDICINE AND E-HEALTH
(2023)
Article
Pediatrics
Traci A. Bekelman, Emily A. Knapp, Yanan Dong, Dana Dabelea, Tracy M. Bastain, Carrie Breton, Kecia N. Carroll, Carlos A. Camargo, Ann M. Davis, Anne L. Dunlop, Amy J. Elliott, Assiamira Ferrara, Rebecca C. Fry, Jody M. Ganiban, Diane Gilbert-Diamond, Frank D. Gilliland, Monique M. Hedderson, Alison E. Hipwell, Christine W. Hockett, Kathi C. Huddleston, Margaret R. Karagas, Nichole Kelly, Jin-Shei Lai, Barry M. Lester, Maristella Lucchini, Melissa M. Melough, Nicole L. Mihalopoulos, T. Michael O'Shea, Andrew G. Rundle, Joseph B. Stanford, Sara VanBronkhorst, Rosalind J. Wright, Qi Zhao, Katherine A. Sauder
Summary: Societal changes during the COVID-19 pandemic may affect children's health behaviors. Parents experiencing financial strain may need additional support to promote healthy behaviors. Changing work schedules to care for children can lead to shorter screen time and longer sleep duration.
Article
Health Care Sciences & Services
Krislyn M. Boggs, Dorsey Glew, Kashfia N. Rahman, Jingya Gao, Tehnaz P. Boyle, Margaret E. Samuels-Kalow, Ashley F. Sullivan, Kori S. Zachrison, Carlos A. Camargo
Summary: This study aimed to understand the usage of pediatric telehealth in emergency departments (EDs) in the United States before the COVID-19 pandemic. The survey results showed that among the EDs receiving pediatric telehealth, there was a lack of pediatric emergency medicine physicians and pediatricians available, and most EDs used pediatric telehealth services infrequently.
TELEMEDICINE AND E-HEALTH
(2023)
Article
Emergency Medicine
Moon O. Lee, Jessica Wall, Olga Saynina, Carlos A. Camargo, N. Ewen Wang
Summary: This study aimed to identify hospital characteristics and patient demographics and conditions associated with pediatric emergency department transfers in California. The results showed that general hospitals without pediatric intensive care units and certain clinical classifications were associated with higher likelihood of transfer.
PEDIATRIC EMERGENCY CARE
(2023)
Article
Emergency Medicine
Rebecca E. Cash, Scott A. Goldberg, Jonathan R. Powell, Gregory A. Peters, Ashish R. Panchal, Carlos A. A. Camargo Jr
Summary: This study examined the geographic distribution and density of EMS personnel in the U.S. It found that EMS personnel density is higher in rural areas compared to urban areas. There were significant associations between EMS density and life expectancy and all-cause mortality, but these associations became non-significant after adjusting for population characteristics and other health resources.
PREHOSPITAL EMERGENCY CARE
(2023)
Letter
Emergency Medicine
Cameron J. Gettel, D. Mark Courtney, Christopher L. Bennett, Samuel M. Keim, Carlos A. Camargo Jr, Arjun K. Venkatesh
ANNALS OF EMERGENCY MEDICINE
(2023)
Article
Emergency Medicine
Krislyn M. Boggs, Janice A. Espinola, Ashley F. Sullivan, Joyce Li, Marc Auerbach, Kohei Hasegawa, Margaret E. Samuels-Kalow, Carlos A. Camargo
Summary: According to a 2019 survey, only 22% of US emergency departments (EDs) have pediatric emergency care coordinators (PECCs). The data shows that EDs in the Northeast and with higher visit volumes are more likely to have PECCs.
PEDIATRIC EMERGENCY CARE
(2023)
Letter
Pediatrics
Elie J. Mitri, Sabrina Ferhani, Jingya Gao, Vanessa Cardenas, Janice A. Espinola, Geneva Mehta, Kohei Hasegawa, Carlos A. Camargo
PEDIATRIC RESEARCH
(2023)
Article
Emergency Medicine
Gregory A. Peters, Rebecca E. Cash, Scott A. Goldberg, Lily M. Kolb, Alexander J. Ordoobadi, Carlos A. Camargo
Summary: This study aimed to evaluate the quality of prehospital management of bronchospasm by emergency medical services (EMS) in the US. The findings revealed important gaps in the prehospital care of suspected bronchospasm, particularly in the administration of medication in basic life support and advanced life support units, as well as the treatment of pediatric patients.
PREHOSPITAL EMERGENCY CARE
(2023)
Article
Immunology
Ryohei Shibata, Zhaozhong Zhu, Tadao Ooka, Robert J. Freishtat, Jonathan M. Mansbach, Marcos Perez-Losada, Ignacio Ramos-Tapia, Stephen Teach, Carlos A. Camargo, Kohei Hasegawa
Summary: Using tIgE and virus data, we identified phenotypes of infant bronchiolitis and studied their association with asthma development and biological characteristics. We found 4 phenotypes, and infants with the tIgE(high)virus(RSV-low/RV) phenotype had a significantly higher risk for developing asthma. These phenotypes also exhibited different biological characteristics, such as depleted type I interferon and enriched antigen presentation pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Geneva D. Mehta, Joumane El Zein, Isis Felippe Baroni, Myrha Qadir, Carol Mita, Rebecca E. Cash, Carlos A. Camargo Jr
Summary: This study investigated whether epinephrine use for food-induced and other cause anaphylaxis in United States and Canadian emergency departments has changed over time. The results showed that there has been an increase in epinephrine treatment for food-induced anaphylaxis, but no clear change for anaphylaxis of any cause. Approximately 45% of emergency department patients with anaphylaxis received epinephrine in the last 10 years. A limitation of the study is the heterogeneity in anaphylaxis definitions.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Isis F. Baroni, Geneva D. Mehta, Ashley F. Sullivan, Carlos A. Camargo Jr, Orianne Dumas
Summary: The study found no association between exposure to household cleaning products in infancy and the development of recurrent wheeze or asthma in children.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2023)
Letter
Pediatrics
Anna Chen Arroyo, Lacey B. Robinson, Kaitlyn James, Sijia Li, Mohammad Kamal Faridi, Camille E. Powe, Carlos A. Camargo Jr
PEDIATRIC PULMONOLOGY
(2023)
