Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 41, Issue 9, Pages 2472-2476Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201141715
Keywords
Adhesion-GPCRs; EGF-TM7 family; Macrophages
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Funding
- National Science Council, Taiwan [NSC-98-2320-B-182-028]
- MRC [G0500623] Funding Source: UKRI
- Medical Research Council [G0500623] Funding Source: researchfish
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The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.
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