Update on Dendritic Cell-Induced Immunological and Clinical Tolerance

Human Bronchial Epithelial Cells Induce CD141/CD123/DC-SIGN/FLT3 Monocytes That Promote Allogeneic Th17 Differentiation

(2017) Amiq Gazdhar et al.   Frontiers in Immunology

Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes

(2016) A. Nicole Desch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

(2016) G. Bakdash et al.   CANCER RESEARCH

Antigen-Encoding Bone Marrow Terminates Islet-Directed Memory CD8+T-Cell Responses to Alleviate Islet Transplant Rejection

(2016) Miranda A. Coleman et al.   DIABETES

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c + or CD141 + DCs

(2016) Gaëlle Breton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cells and Monocytes with Distinct Inflammatory Responses Reside in Lung Mucosa of Healthy Humans

(2016) Faezzah Baharom et al.   JOURNAL OF IMMUNOLOGY

Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer

(2016) Michal Radomski et al.   Journal for ImmunoTherapy of Cancer

Targeting Memory T Cells in Type 1 Diabetes

(2015) Mario R. Ehlers et al.   Current Diabetes Reports

The TGF-β superfamily in dendritic cell biology

(2015) Pascal Seeger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Additive effects of rapamycin and aspirin on dendritic cell allostimulatory capacity

(2015) Marc-Estienne Roehrich et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow

(2015) Jaeyop Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Flow cytometric detection of circulating dendritic cells in healthy subjects

(2015) B Rovati et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Efficacy and safety of subcutaneous interferon-β-1a in patients with a first demyelinating event and early multiple sclerosis

(2014) Mark S Freedman   EXPERT OPINION ON BIOLOGICAL THERAPY

Potential and limitations of regulatory T-cell therapy in solid organ transplantation

(2014) Lerisa Govender et al.   Expert Review of Clinical Immunology

Tolerogenic signaling by pulmonary CD1c+ dendritic cells induces regulatory T cells in patients with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand

(2014) Maria Tsoumakidou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human CD141+Dendritic Cells Induce CD4+T Cells To Produce Type 2 Cytokines

(2014) Chun I. Yu et al.   JOURNAL OF IMMUNOLOGY

1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice

(2014) G. B. Ferreira et al.   JOURNAL OF IMMUNOLOGY

Human Dendritic Cell Functional Specialization in Steady-State and Inflammation

(2014) Arjan Boltjes et al.   Frontiers in Immunology

Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates

(2013) M. B. Ezzelarab et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Therapeutic Potential of Tolerogenic Dendritic Cells in IBD: From Animal Models to Clinical Application

(2013) Raquel Cabezón et al.   Clinical & Developmental Immunology

Protection of Islet Grafts Through Transforming Growth Factor-β–Induced Tolerogenic Dendritic Cells

(2013) David C. Thomas et al.   DIABETES

Plasmacytoid, conventional, and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation

(2013) Thien-Phong Vu Manh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Human dendritic cell subsets

(2013) Matthew Collin et al.   IMMUNOLOGY

Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ–resident dendritic cells

(2013) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The  7 0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells

(2013) R. Olivar et al.   JOURNAL OF IMMUNOLOGY

Tolerogenic Donor-Derived Dendritic Cells Risk Sensitization In Vivo owing to Processing and Presentation by Recipient APCs

(2013) L. A. Smyth et al.   JOURNAL OF IMMUNOLOGY

Lung Dendritic Cells in Respiratory Viral Infection and Asthma: From Protection to Immunopathology

(2012) Bart N. Lambrecht et al.   Annual Review of Immunology

Viral and Non-Viral Methods to Genetically Modify Dendritic Cells

(2012) Jean-Marc Humbert et al.   CURRENT GENE THERAPY

Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients

(2012) Dàlia Raϊch-Regué et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Absence of Galectin-1 accelerates CD8+ T cell-mediated graft rejection

(2012) Aurélie Moreau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

(2012) C. Scotta et al.   HAEMATOLOGICA

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

Characterization of resident and migratory dendritic cells in human lymph nodes

(2012) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident CD141 (BDCA3)+dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

(2012) Chung-Ching Chu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

α-MSH-Stimulated Tolerogenic Dendritic Cells Induce Functional Regulatory T Cells and Ameliorate Ongoing Skin Inflammation

(2012) Matteo Auriemma et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Relative Resistance of Human CD4+ Memory T Cells to Suppression by CD4+CD25+ Regulatory T Cells

(2011) B. Afzali et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ex vivo-expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin grafts

(2011) T. Yamano et al.   BLOOD

Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn's disease and ulcerative colitis

(2011) D. C. Baumgart et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction — A comparative study of human clinical-applicable DC

(2011) Martine A. Boks et al.   CLINICAL IMMUNOLOGY

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

(2011) John J. Worthington et al.   GASTROENTEROLOGY

Bronchial Epithelial Cell-Derived Prostaglandin E2 Dampens the Reactivity of Dendritic Cells

(2011) L. M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

IL-2 Controls the Stability of Foxp3 Expression in TGF- -Induced Foxp3+ T Cells In Vivo

(2011) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

Estriol Generates Tolerogenic Dendritic Cells In Vivo That Protect against Autoimmunity

(2011) T. L. Papenfuss et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 and -3 gene silencing in immature and mature dendritic cells enhances T cell activation and interferon-γ production

(2011) Anne Mobergslien et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Comparative study of clinical grade human tolerogenic dendritic cells

(2011) M Naranjo-Gómez et al.   Journal of Translational Medicine

Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy

(2011) Susanna Celli et al.   NATURE MEDICINE

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Host Alloreactive Memory T Cells Influence Tolerance to Kidney Allografts in Nonhuman Primates

(2011) O. Nadazdin et al.   Science Translational Medicine

Role of CD4+CD25high+FOXP3+Regulatory T Cells in Psoriasis

(2010) Woo-Jin Yun et al.   Annals of Dermatology

Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis

(2010) R. A. Harry et al.   ANNALS OF THE RHEUMATIC DISEASES

Apoptotic cell-based therapies against transplant rejection: role of recipient’s dendritic cells

(2010) Adrian E. Morelli et al.   APOPTOSIS

Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation

(2010) S. J. Divito et al.   BLOOD

Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development

(2010) E. Martin-Gayo et al.   BLOOD

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

Interleukin-2 receptor downstream events in regulatory T cells: Implications for the choice of immunosuppressive drug therapy

(2010) Robert Zeiser et al.   CELL CYCLE

The immunotherapeutic potential of dendritic cells in type 1 diabetes

(2010) G. Mukherjee et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Negative vaccination by tolerogenic dendritic cells in organ transplantation

(2010) Marcelo Hill et al.   Current Opinion in Organ Transplantation

Tolerogenic plasmacytoid DC

(2010) Benjamin M. Matta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

(2010) G. Matteoli et al.   GUT

Defining dendritic cells by conditional and constitutive cell ablation

(2010) Liat Bar-On et al.   IMMUNOLOGICAL REVIEWS

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

(2010) Melissa Swiecki et al.   IMMUNOLOGICAL REVIEWS

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse CD8α+DCs and human BDCA3+DCs are major producers of IFN-λ in response to poly IC

(2010) Henning Lauterbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting MHC Class I Monomers to Dendritic Cells Inhibits the Indirect Pathway of Allorecognition and the Production of IgG Alloantibodies Leading to Long-Term Allograft Survival

(2010) Yakup Tanriver et al.   JOURNAL OF IMMUNOLOGY

Tolerogenic Dendritic Cells Generated with Different Immunosuppressive Cytokines Induce Antigen-Specific Anergy and Regulatory Properties in Memory CD4 + T Cells

(2010) Honorio Torres-Aguilar et al.   JOURNAL OF IMMUNOLOGY

Editorial: Heme oxygenase-1 and dendritic cells: what else?

(2010) Philippe Blancou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsiveness

(2010) Daniel Hawiger et al.   NATURE IMMUNOLOGY

Ustekinumab: Lessons Learned from Targeting Interleukin-12/23p40 in Immune-Mediated Diseases

(2009) Michael Elliott et al.   Annals of the New York Academy of Sciences

Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells

(2009) D. J. Chung et al.   BLOOD

Immunosuppressive Drugs and Tregs: A Critical Evaluation!

(2009) S. A. De Serres et al.   Clinical Journal of the American Society of Nephrology

Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice

(2009) Dae-Seog Lim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates

(2009) A. Moreau et al.   FASEB JOURNAL

Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells

(2009) I D Iliev et al.   GUT

Generating tolerogenic dendritic cells with neuropeptides

(2009) Mario Delgado   HUMAN IMMUNOLOGY

CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4+CD25+Foxp3+ regulatory T cell population

(2009) Hyeok-Jae Ko et al.   JOURNAL OF AUTOIMMUNITY

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

(2009) Wei Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4+CD25+ Foxp3+ T Regulatory Cells

(2009) M. Brenk et al.   JOURNAL OF IMMUNOLOGY

IFN- , as Secreted during an Alloresponse, Induces Differentiation of Monocytes into Tolerogenic Dendritic Cells, Resulting in FoxP3+ Regulatory T Cell Promotion

(2009) A. Eljaafari et al.   JOURNAL OF IMMUNOLOGY

Targeting Antigen to Diverse APCs Inactivates Memory CD8+ T Cells without Eliciting Tissue-Destructive Effector Function

(2009) T. J. Kenna et al.   JOURNAL OF IMMUNOLOGY

An Anti-Inflammatory Role for Plasmacytoid Dendritic Cells in Allergic Airway Inflammation

(2009) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Mammalian Target of Rapamycin Inhibition and Alloantigen-Specific Regulatory T Cells Synergize To Promote Long-Term Graft Survival in Immunocompetent Recipients

(2009) G. Raimondi et al.   JOURNAL OF IMMUNOLOGY

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

(2009) Juan M Ilarregui et al.   NATURE IMMUNOLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lung Myeloid Dendritic Cells Coordinately Induce TH1 and TH17 Responses in Human Emphysema

(2009) M. Shan et al.   Science Translational Medicine

Comparative analysis of dendritic cells and anti-CD3/CD28 expanded regulatory T cells for application in transplantation

(2009) Menghua Zeng et al.   TRANSPLANT IMMUNOLOGY

High PD-L1/CD86 Ratio on Plasmacytoid Dendritic Cells Correlates With Elevated T-Regulatory Cells in Liver Transplant Tolerance

(2009) Daisuke Tokita et al.   TRANSPLANTATION

Regulation of Rat and Human T-Cell Immune Response by Pharmacologically Modified Dendritic Cells

(2009) Henrieta Fazekasova et al.   TRANSPLANTATION

Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells

(2008) E. Hauben et al.   BLOOD

Distinctive localization of antigen-presenting cells in human lymph nodes

(2008) C. E. Angel et al.   BLOOD

Successful granulocyte-colony stimulating factor treatment of Crohn's disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propria plasmacytoid dendritic cells

(2008) P. J. Mannon et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin-Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes

(2008) G. Besin et al.   DIABETES

Tolerance-Inducing Immunosuppressive Strategies in Clinical Transplantation

(2008) Dela Golshayan et al.   DRUGS

α-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effectsin Vitroandin Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases

(2008) Thomas Brzoska et al.   ENDOCRINE REVIEWS

Dexamethasone/1α-25-dihydroxyvitamin D3-treated dendritic cells suppress colitis in the SCID T-cell transfer model

(2008) Anders Elm Pedersen et al.   IMMUNOLOGY

Induction of human CD4+ regulatory T cells by mycophenolic acid-treated dendritic cells

(2008) Christine Lagaraine et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD3-specific antibody–induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells

(2008) Sylvain Perruche et al.   NATURE MEDICINE

Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond

(2008) Nick Giannoukakis et al.   PEDIATRIC DIABETES

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimization of calcineurin inhibitors to improve long-term outcomes in kidney transplantation

(2008) Dela Golshayan et al.   TRANSPLANT IMMUNOLOGY

Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion

(2007) Elaine K. Horibe et al.   TRANSPLANT IMMUNOLOGY