Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative

Effect of Antioxidant Flavonoids (Quercetin and Taxifolin) on In vitro Maturation of Porcine Oocytes

(2016) Jung-Taek Kang et al.   ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES

Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells

(2016) Akbar Minaei et al.   MOLECULAR BIOLOGY REPORTS

CYP1B1 inhibition attenuates doxorubicin-induced cardiotoxicity through a mid-chain HETEs-dependent mechanism

(2016) Zaid H. Maayah et al.   PHARMACOLOGICAL RESEARCH

The role of mid-chain hydroxyeicosatetraenoic acids in the pathogenesis of hypertension and cardiac hypertrophy

(2015) Zaid H. Maayah et al.   ARCHIVES OF TOXICOLOGY

Cardiovascular Disease: A Target for the Pharmacological Effects of Quercetin

(2015) Juan Gormaz et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway

(2015) Yuanzhou He et al.   EXPERIMENTAL CELL RESEARCH

Human fetal ventricular cardiomyocyte, RL-14 cell line, is a promising model to study drug metabolizing enzymes and their associated arachidonic acid metabolites

(2015) Zaid H. Maayah et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: Structural features and biological implications

(2014) Daniel Agudelo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Heme Oxygenase-1 Induction Improves Cardiac Function following Myocardial Ischemia by Reducing Oxidative Stress

(2014) Yossi Issan et al.   PLoS One

Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study

(2014) Laura C. Kobashigawa et al.   PLoS One

Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation

(2013) Zaid H. Maayah et al.   ARCHIVES OF TOXICOLOGY

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: Selectivity, kinetic characterization, and molecular modeling

(2013) Sheng-Nan Lo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rapid dimerization of quercetin through an oxidative mechanism in the presence of serum albumin decreases its ability to induce cytotoxicity in MDA-MB-231 cells

(2012) Anh Pham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influence of fatty acid patterns on the intestinal absorption pathway of quercetin in thoracic lymph duct-cannulated rats

(2012) Kaeko Murota et al.   BRITISH JOURNAL OF NUTRITION

Quercetin Potentiates Doxorubicin Mediated Antitumor Effects against Liver Cancer through p53/Bcl-xl

(2012) Guanyu Wang et al.   PLoS One

The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin

(2012) Ji-Eon Kim et al.   XENOBIOTICA

Effects of quercetin on the bioavailability of doxorubicin in rats: Role of CYP3A4 and P-gp inhibition by quercetin

(2011) Jun-Shik Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer

(2010) Shuang Cai et al.   JOURNAL OF CONTROLLED RELEASE

Doxorubicin pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

Lymphatic Absorption of Quercetin and Rutin in Rat and Their Pharmacokinetics in Systemic Plasma

(2009) I-Lin Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vitro solubility, stability and permeability of novel quercetin–amino acid conjugates

(2008) Mi Kyoung Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

(2008) Y. Tang et al.   BLOOD

Modulation of Cytochrome P450 Gene Expression and Arachidonic Acid Metabolism during Isoproterenol-Induced Cardiac Hypertrophy in Rats

(2008) B. N. M. Zordoky et al.   DRUG METABOLISM AND DISPOSITION