Enzymatic activation of double-targeted 5′-O-l-valyl-decitabine prodrug by biphenyl hydrolase-like protein and its molecular design basis

Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions

(2016) Mengchi Sun et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A novel recombinant AzrC protein proposed by molecular docking and in silico analyses to improve azo dye's binding affinity

(2015) Fariba Dehghanian et al.   GENE

QSAR prediction of HIV-1 protease inhibitory activities using docking derived molecular descriptors

(2015) Mohammad H. Fatemi et al.   JOURNAL OF THEORETICAL BIOLOGY

AutoDock4Zn: An Improved AutoDock Force Field for Small-Molecule Docking to Zinc Metalloproteins

(2014) Diogo Santos-Martins et al.   Journal of Chemical Information and Modeling

A Carrier-Mediated Prodrug Approach To Improve the Oral Absorption of Antileukemic Drug Decitabine

(2013) Youxi Zhang et al.   MOLECULAR PHARMACEUTICS

Bifunctional Peptidomimetic Prodrugs of Didanosine for Improved Intestinal Permeability and Enhanced Acidic Stability: Synthesis, Transepithelial Transport, Chemical Stability and Pharmacokinetics

(2011) Zhongtian Yan et al.   MOLECULAR PHARMACEUTICS

Molecular docking and molecular dynamics simulation studies of GPR40 receptor–agonist interactions

(2010) Shao-Yong Lu et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Specificity of a Prodrug-Activating Enzyme hVACVase: The Leaving Group Effect

(2010) Jing Sun et al.   MOLECULAR PHARMACEUTICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Enhancing the Intestinal Absorption of Molecules Containing the Polar Guanidino Functionality: A Double-Targeted Prodrug Approach

(2009) Jing Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Myelodysplastic Syndromes

(2009) Ayalew Tefferi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice

(2009) J. Kuze et al.   XENOBIOTICA

Evolution of decitabine development

(2008) Elias Jabbour et al.   CANCER

Molecular Basis of Prodrug Activation by Human Valacyclovirase, an α-Amino Acid Ester Hydrolase

(2008) Longsheng Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, Transport and Pharmacokinetics of 5′-Amino Acid Ester Prodrugs of 1-β-d-Arabinofuranosylcytosine

(2008) Yongbing Sun et al.   MOLECULAR PHARMACEUTICS

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Receptor-Based Virtual Ligand Screening for the Identification of Novel CDC25 Phosphatase Inhibitors

(2007) Matthieu Montes et al.   Journal of Chemical Information and Modeling