Enzymatic activation of double-targeted 5′-O-l-valyl-decitabine prodrug by biphenyl hydrolase-like protein and its molecular design basis
出版年份 2017 全文链接
标题
Enzymatic activation of double-targeted 5′-O-l-valyl-decitabine prodrug by biphenyl hydrolase-like protein and its molecular design basis
作者
关键词
Decitabine, Prodrug activation, BPHL, Hepatic portal vein, Molecular docking, Double-targeted strategy
出版物
Drug Delivery and Translational Research
Volume 7, Issue 2, Pages 304-311
出版商
Springer Nature
发表日期
2017-01-10
DOI
10.1007/s13346-016-0356-1
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions
- (2016) Mengchi Sun et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- A novel recombinant AzrC protein proposed by molecular docking and in silico analyses to improve azo dye's binding affinity
- (2015) Fariba Dehghanian et al. GENE
- QSAR prediction of HIV-1 protease inhibitory activities using docking derived molecular descriptors
- (2015) Mohammad H. Fatemi et al. JOURNAL OF THEORETICAL BIOLOGY
- AutoDock4Zn: An Improved AutoDock Force Field for Small-Molecule Docking to Zinc Metalloproteins
- (2014) Diogo Santos-Martins et al. Journal of Chemical Information and Modeling
- A Carrier-Mediated Prodrug Approach To Improve the Oral Absorption of Antileukemic Drug Decitabine
- (2013) Youxi Zhang et al. MOLECULAR PHARMACEUTICS
- Bifunctional Peptidomimetic Prodrugs of Didanosine for Improved Intestinal Permeability and Enhanced Acidic Stability: Synthesis, Transepithelial Transport, Chemical Stability and Pharmacokinetics
- (2011) Zhongtian Yan et al. MOLECULAR PHARMACEUTICS
- Molecular docking and molecular dynamics simulation studies of GPR40 receptor–agonist interactions
- (2010) Shao-Yong Lu et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Specificity of a Prodrug-Activating Enzyme hVACVase: The Leaving Group Effect
- (2010) Jing Sun et al. MOLECULAR PHARMACEUTICS
- Membrane transporters in drug development
- (2010) NATURE REVIEWS DRUG DISCOVERY
- Enhancing the Intestinal Absorption of Molecules Containing the Polar Guanidino Functionality: A Double-Targeted Prodrug Approach
- (2009) Jing Sun et al. JOURNAL OF MEDICINAL CHEMISTRY
- Myelodysplastic Syndromes
- (2009) Ayalew Tefferi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice
- (2009) J. Kuze et al. XENOBIOTICA
- Evolution of decitabine development
- (2008) Elias Jabbour et al. CANCER
- Molecular Basis of Prodrug Activation by Human Valacyclovirase, an α-Amino Acid Ester Hydrolase
- (2008) Longsheng Lai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synthesis, Transport and Pharmacokinetics of 5′-Amino Acid Ester Prodrugs of 1-β-d-Arabinofuranosylcytosine
- (2008) Yongbing Sun et al. MOLECULAR PHARMACEUTICS
- Prodrugs: design and clinical applications
- (2008) Jarkko Rautio et al. NATURE REVIEWS DRUG DISCOVERY
- Receptor-Based Virtual Ligand Screening for the Identification of Novel CDC25 Phosphatase Inhibitors
- (2007) Matthieu Montes et al. Journal of Chemical Information and Modeling
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started