Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications

Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells

(2016) Maria Antonietta Ajmone-Cat et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurodevelopmental origins of bipolar disorder: iPSC models

(2016) K. Sue O'Shea et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The effect of lithium on hematopoietic, mesenchymal and neural stem cells

(2016) Ewa Ferensztajn-Rochowiak et al.   Pharmacological Reports

Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers

(2016) Ather Muneer   Psychiatry Investigation

Staging Models in Bipolar Disorder: A Systematic Review of the Literature

(2016) Ather Muneer   Clinical Psychopharmacology and Neuroscience

Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism

(2015) Andrea de Bartolomeis et al.   CNS DRUGS

Cellular models to study bipolar disorder: A systematic review

(2015) Biju Viswanath et al.   JOURNAL OF AFFECTIVE DISORDERS

Circadian Rhythmicity of Active GSK3 Isoforms Modulates Molecular Clock Gene Rhythms in the Suprachiasmatic Nucleus

(2015) Rachel C. Besing et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders

(2015) Guido Furlotti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lithium increases platelet serine-9 phosphorylated GSK-3β levels in drug-free bipolar disorder during depressive episodes

(2015) Rafael T. de Sousa et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

(2015) J M Madison et al.   MOLECULAR PSYCHIATRY

Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease

(2015) Mojtaba Golpich et al.   PHARMACOLOGICAL RESEARCH

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

FXR1P is a GSK3β substrate regulating mood and emotion processing

(2015) Thomas Del’Guidice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Region-specific dysregulation of glycogen synthase kinase-3β and β-catenin in the postmortem brains of subjects with bipolar disorder and schizophrenia

(2014) Ghanshyam N Pandey et al.   BIPOLAR DISORDERS

Signaling Pathways Involved in Antidepressant-Induced Cell Proliferation and Synaptic Plasticity

(2014) Fuencisla Pilar-Cuellar et al.   CURRENT PHARMACEUTICAL DESIGN

mTOR regulates brain morphogenesis by mediating GSK3 signaling

(2014) M. Ka et al.   DEVELOPMENT

Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin

(2014) O Durak et al.   MOLECULAR PSYCHIATRY

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin

(2014) S M Ochs et al.   MOLECULAR PSYCHIATRY

Wnt signaling in neuropsychiatric disorders: Ties with adult hippocampal neurogenesis and behavior

(2014) Syed Mohammed Qasim Hussaini et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Wnt and lithium: a common destiny in the therapy of nervous system pathologies?

(2013) Delphine Meffre et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia

(2013) Adam R. Cole   FEBS Journal

The mood stabilizer valproate activates humanFGF1gene promoter through inhibiting HDAC and GSK-3 activities

(2013) Chien-Yu Kao et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2

(2013) S J Winham et al.   MOLECULAR PSYCHIATRY

Genetic and clinical factors predict lithium’s effects on PER2 gene expression rhythms in cells from bipolar disorder patients

(2013) M J McCarthy et al.   Translational Psychiatry

Altered Wnt signalling in the teenage suicide brain: focus on glycogen synthase kinase-3β and β-catenin

(2012) Xinguo Ren et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase 3

(2012) J.R. Paul et al.   NEUROSCIENCE

Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders

(2012) Hans O. Kalkman   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Akt/PKB Controls the Activity-Dependent Bulk Endocytosis of Synaptic Vesicles

(2012) Karen J. Smillie et al.   TRAFFIC

GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder

(2012) Alexander J. Valvezan et al.   Frontiers in Molecular Neuroscience

Migración neuronal, apoptosis y trastorno bipolar

(2012) Ezequiel Uribe et al.   Revista de Psiquiatria y Salud Mental

Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice

(2011) Alan P. Kozikowski et al.   ChemMedChem

Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania

(2011) Mikhail Kalinichev et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

(2011) W. Timothy O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

A genome-wide association study of attempted suicide

(2011) V L Willour et al.   MOLECULAR PSYCHIATRY

Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice

(2011) Olivia F. O’Leary et al.   NEUROPHARMACOLOGY

HDAC6 Regulates LPS-Tolerance in Astrocytes

(2011) Eléonore Beurel   PLoS One

Glycogen Synthase Kinase-3 in the Etiology and Treatment of Mood Disorders

(2011) Richard Scott Jope   Frontiers in Molecular Neuroscience

Regulation of glycogen synthase kinase-3 during bipolar mania treatment

(2010) Xiaohong Li et al.   BIPOLAR DISORDERS

A haplotype of glycogen synthase kinase 3β is associated with early onset of unipolar major depression

(2010) E. Saus et al.   GENES BRAIN AND BEHAVIOR

Deficiency in the Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3 Increases Sensitivity to Mood Disturbances

(2010) Abigail Polter et al.   NEUROPSYCHOPHARMACOLOGY

The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis

(2009) Rodrigo Machado-Vieira et al.   BIPOLAR DISORDERS

Evidence for Selective microRNAs and Their Effectors as Common Long-Term Targets for the Actions of Mood Stabilizers

(2008) Rulun Zhou et al.   NEUROPSYCHOPHARMACOLOGY