Article
Oncology
Shigeyuki Tamari, Toshi Menju, Toshiya Toyazaki, Hideaki Miyamoto, Naohisa Chiba, Misa Noguchi, Hiroyuki Ishikawa, Ryo Miyata, Hidenao Kayawake, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Daisuke Nakajima, Akihiro Ohsumi, Masatsugu Hamaji, Hiroshi Date
Summary: Nrf2 upregulates ABCB1 gene expression and induces vinorelbine resistance along with the nuclear accumulation of p-Fyn.
Article
Oncology
Weikun Qian, Ke Chen, Tao Qin, Ying Xiao, Jie Li, Yangyang Yue, Cancan Zhou, Jiguang Ma, Wanxing Duan, Jianjun Lei, Liang Han, Li Li, Xin Shen, Zheng Wu, Qingyong Ma, Zheng Wang
Summary: In this study, pharmacological inhibition of HSF1 was found to slow pancreatic cancer initiation and suppress pancreatitis-induced formation of pancreatic precancerous lesions. Bioinformatics analysis revealed a close link between HSF1 and the EGFR pathway, with their parallel activation in pancreatic precancerous lesions. Additionally, inhibition of EGFR was shown to suppress pancreatic cancer initiation and HSF1 activation in vivo, indicating a partly HSF1-dependent mechanism of EGFR-mediated pancreatic cancer tumorigenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Mehdi Fattahi, Saeid Shahrabi, Fatemeh Saadatpour, Delsuz Rezaee, Zahra Beyglu, Sana Delavari, Anita Amrolahi, Shirin Ahmadi, Saeid Bagheri-Mohammadi, Effat Noori, Jamal Majidpoor, Shadi Nouri, Seyed Mohsen Aghaei-Zarch, Shahab Falahi, Sajad Najafi, Binh Nguyen
Summary: miR-382, a small non-coding RNA, plays important regulatory roles in various physiological and pathological conditions. It is extensively studied in cancer, where it can act as both an oncogene and a tumor suppressor. Therefore, assessing miR-382 expression may have clinical potential as a prognostic/diagnostic biomarker for cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Emily Pei-Ying Lin, Bo-Tsang Huang, Wei-Yun Lai, Yi-Ting Tseng, Shuenn-Chen Yang, Hao-Cheng Kuo, Pan-Chyr Yang
Summary: This study demonstrates the critical tumor-suppressing role of PINK1 by inhibiting EGFR dimerization, proposing PINK1-CTD as a potential therapeutic agent in EGFR-driven lung cancer.
Review
Biochemistry & Molecular Biology
Pouriya Sameti, Mohammad Amini, Fatemeh Oroojalian, Yalda Baghay Esfandyari, Maryam Tohidast, Seyed Ali Rahmani, Shirin Azarbarzin, Ahad Mokhtarzadeh, Behzad Baradaran
Summary: MicroRNAs (miRNAs), dysregulated in a wide range of human cancers, play critical roles in cancer progression and can be potential targets for cancer detection and treatment. Specifically, miR-425, dysregulated in various human malignancies, participates in the regulation of cellular processes, such as metastasis, invasion, and cell proliferation, by modulating multiple signaling pathways. Therefore, miR-425 has high therapeutic potential.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Cell Biology
Miao Yang, Xiaomei Ling, Jinfang Xiao
Summary: This study suggests that miR-141 is involved in lung ischemia-reperfusion injury by regulating EGFR, beta-catenin, and autophagy. It provides a potential therapeutic target for the treatment of lung ischemia-reperfusion injury.
Review
Oncology
Yaqing Su, Xiaomei Zhang, Shaoqiang Li, Wei Xie, Jianping Guo
Summary: This article comprehensively summarizes the potential causes of copper accumulation in diseases, especially in cancer, and the mechanisms by which copper contributes to tumorigenesis. Copper is involved in tumor development through various mechanisms, including modulation of reactive oxygen species, angiogenesis, immune response, and metabolic homeostasis, as well as direct activation of oncogenic signals by binding to oncoproteins. The article also discusses the emerging applications of copper in cancer diagnosis and highlights promising strategies for cancer therapy targeting the copper-CTR1 axis.
MOLECULAR CANCER RESEARCH
(2022)
Article
Neurosciences
Jiangning Zhao, Huanrong Lin, Kunsong Huang
Summary: Mesenchymal stem cell-derived extracellular vesicles (MSC-EV) can deliver microRNAs (miRNAs) into colorectal cancer (CRC) cells to inhibit malignant phenotype. In this study, it was found that transport of miR-34a-5p by MSC-EV suppressed CRC development by modulating the interaction of c-MYC, DNMT3a, and PTEN. Additionally, restoration of miR-34a-5p or depletion of c-MYC in MSC-EV limited CRC tumor formation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Jing Pan, Donghai Xiong, Qi Zhang, Katie Palen, Robert H. H. Shoemaker, Bryon Johnson, Shizuko Sei, Yian Wang, Ming You
Summary: In this study, immunogenic epitopes for common EGFR mutations in humans were identified and a multi-peptide vaccine (E-mut Vax) targeting these mutations was formulated. The E-mut Vax effectively prevented EGFR mutation-driven lung tumorigenesis in mouse models and enhanced Th1 responses in the tumor microenvironment while decreasing suppressive Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Aaron G. Whitt, Aaron M. Neely, Omar Sadi Sarkar, Shuhan Meng, Sengodagounder Arumugam, Kavitha Yaddanapudi, Chi Li
Summary: Recent research has shown that PON2 is upregulated in various types of tumors, potentially playing a role in modulating lung cancer development by suppressing oxidative stress and apoptosis. However, the specific effects of PON2 on lung cancer cell proliferation and tumor initiation are still unknown.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Longyuan Gong, Jianfeng Shu, Xiaoyu Chen, Hui Pan, Guoan Chen, Yanli Bi, Danrui Cui, Xufan Li, Dian Liu, Linchen Wang, Yue Wang, Pengyuan Liu, Xiufang Xiong, Yongchao Zhao
Summary: DEPTOR acts as a tumor suppressor in lung tumorigenesis, and its reduction may advance the progression of human lung cancer.
Article
Environmental Sciences
Zhiyao Ren, Yunfeng Xu, Xin Wang, Min Ren
Summary: This study identified a KCNQ1OT1/miR-34a/Notch3 axis that promotes breast cancer progression through effects on cell proliferation and metastasis, which is associated with poor patient prognosis. These findings propose a novel treatment approach for breast cancer by targeting this axis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Ying Lin, Yu Wei, Yinghui Wei, Haihui Yu, Weihua Zhang, Chunni Li, Yuan He, Gang Yao, Yanzhuo Zhang
Summary: This study investigated the mechanism of dexmedetomidine in diabetic peripheral neuropathy (DPN) and found that it alleviates oxidative stress and mitochondrial dysfunction associated with DPN by downregulating miR-34a to regulate the SIRT2/S1PR1 axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Yong Zhang, Yuanyuan Mi, Chunhui He
Summary: This study found that 2-MeOE2 inhibited the progression of NSCLC by regulating the circ_0010235/miR-34a-5p/NFAT5 axis, providing a new perspective for 2-MeOE2 treatment in NSCLC.
Article
Cell Biology
Yunshang Chen, Xiaohua Jie, Biyuan Xing, Zilong Wu, Xijie Yang, Xinrui Rao, Yingzhuo Xu, Dong Zhou, Xiaorong Dong, Tao Zhang, Kunyu Yang, Zhenyu Li, Gang Wu
Summary: This study found that the expression of REV1 was significantly upregulated in lung cancer tissues and associated with poor prognosis. Silencing REV1 reduced the growth and proliferation capacity of lung cancer cells. A REV1 inhibitor, JH-RE-06, effectively suppressed lung tumorigenesis.
CELL DEATH & DISEASE
(2022)
Review
Chemistry, Medicinal
Heng Zou, Yanli Li, Xiaomin Liu, Zong Wu, Jingjing Li, Zhongliang Ma
Summary: Plant-derived bioactive compounds can inhibit tumor growth and metastasis by regulating miRNA expression, influencing tumor progression, microenvironment, and drug resistance in various cancers. This review aims to provide a new understanding of the targeting of miRNAs by plant-derived bioactive compounds and shed light on their potential clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Biographical-Item
Cell Biology
Zhongliang Ma, Xianyi Wang, Yanli Li
Article
Medicine, Research & Experimental
Jinbao Zhou, Hongshu Wang, Qiangling Sun, Xiaomin Liu, Zong Wu, Xianyi Wang, Wentao Fang, Zhongliang Ma
Summary: NSCLC is a common form of cancer, and exosomes enriched with miR-224-5p promote tumor growth and metastasis. miR-224-5p affects NSCLC tumor growth by inhibiting AR and mediating EMT.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Binshu Chai, Zhongliang Ma, Xianyi Wang, Linfeng Xu, Yanli Li
Summary: With the development of precision medicine, targeted therapy and immunotherapy have become key approaches for precise cancer treatment. Targeting EGFR is an important treatment method with better selectiveness and fewer side effects. Tumor immunotherapy and the role of ncRNAs in cancer treatment are also significant.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Oncology
Xiaomin Liu, Binshu Chai, Xianyi Wang, Zong Wu, Heng Zou, Yangyang Liu, Saijing Zheng, Guangren Qian, Zhongliang Ma, Jie Lu
Summary: This study revealed that environmentally persistent free radicals (EPFRs) promote cell proliferation and migration, impede cell apoptosis in lung cancer, and can influence the expression of miRNAs (miR-18a and miR-34a). Animal experiments showed different effects of ZnO/MCB and ZnO EPFRs on BALB/c mice, providing evidence for the potential health risks of persistent free radicals in fine particles.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Cell Biology
Hongshu Wang, Xianyi Wang, Xiaomin Liu, Jinbao Zhou, Qianqian Yang, Binshu Chai, Yimin Chai, Zhongliang Ma, Shengdi Lu
Summary: Diabetic foot ulcer (DFU) is a common complication of diabetes mellitus, and abnormal expression of miR-199a-5p may play a crucial role in its development. Inhibiting miR-199a-5p expression can promote wound healing and restore normal cell function.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biotechnology & Applied Microbiology
Xinju Zhang, Xianyi Wang, Binshu Chai, Zong Wu, Xiaomin Liu, Heng Zou, Ziyi Hua, Zhongliang Ma, Weiwei Wang
Summary: The miR-17-92 cluster is upregulated in non-small cell lung cancer (NSCLC), promoting tumor growth and progression. MiR-92a facilitates tumor growth by inhibiting SPRY4 expression and mediating Epithelial-Mesenchymal Transition (EMT). AntagomiR-18a treatment significantly inhibits tumor growth in xenografted mice.
Review
Biochemistry & Molecular Biology
Wei Meng, Yanli Li, Binshu Chai, Xiaomin Liu, Zhongliang Ma
Summary: Lung cancer is the leading cause of cancer death worldwide. miR-199a plays an important role in the genesis and development of lung tumors. This review provides a detailed analysis of the biological functions of miR-199a in lung cancer and discusses its potential roles in diagnosis and treatment. The interplay between miR-199a and other ncRNAs is also explored, along with a review of current diagnosis and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Shuhui Li, Wei Meng, Ziyi Guo, Min Liu, Yanyun He, Yanli Li, Zhongliang Ma
Summary: Cancer, a leading cause of human death, has been found to be closely associated with MicroRNAs. The miR-183 cluster, composed of miR-183, miR-96, and miR-182, is transcribed as a polycistronic miRNA cluster. In most cases, these clusters promote cancer development through different pathways. Exosomes, as extracellular vesicles, play a crucial role in cellular communication and tissue microenvironment regulation. Interestingly, the miR-183 cluster can be detected in exosomes and plays a functional regulatory role in tumor development. This review summarizes the biogenesis and functions of the miR-183 cluster in prevalent cancers, its relationship with other non-coding RNAs, and discusses its potential as a target for cancer therapy.
Review
Multidisciplinary Sciences
Wei Pan, Binshu Chai, Langping Li, Zhijun Lu, Zhongliang Ma
Summary: Cancer is a life-threatening disease and research on understanding and treatment methods are constantly developing. The p53 gene is an important tumor suppressor gene that plays a crucial role in inhibiting tumor formation. miR-34 is considered to be a master regulator of tumor suppression. This review focuses on the latest progress of the p53/miR-34 regulatory network and its application in tumor diagnosis and treatment.
Review
Oncology
Binshu Chai, Jianhua Qiu, Wei Pan, Zhongliang Ma
Summary: Cell pyroptosis, an inflammatory and programmed cell necrosis, is a major cause of organ damage and immunosuppression. It involves the cleavage of the pyroptotic protein Gasdermin family, resulting in membrane pore formation, cell shrinkage, plasma membrane cleavage, chromatin disruption, and release of pro-inflammatory components. Numerous studies have demonstrated the key role of pyroptosis in cancer and inflammatory diseases, highlighting the significance of Gasdermin family and non-coding RNAs in regulating this process.
Article
Biochemistry & Molecular Biology
Xiaomin Liu, Xianyi Wang, Binshu Chai, Zong Wu, Zhitao Gu, Heng Zou, Hui Zhang, Yanli li, Qiangling Sun, Wentao Fang, Zhongliang Ma
Summary: This study found that miR-199a-3p/5p is down-regulated in non-small cell lung cancer (NSCLC), and overexpression of miR-199a-3p/5p can inhibit cell proliferation, migration, and promote apoptosis. Rheb is identified as a common target of miR-199a-3p and miR-199a-5p, participating in the regulation of the mTOR signaling pathway. Additionally, miR-199a significantly inhibits tumor growth and metastasis in NSCLC and enhances the sensitivity of gefitinib in EGFR-T790M mutation. MiR-199a-3p/5p has the potential to serve as an early diagnostic marker or therapeutic target for NSCLC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Yikun Xu, Binshu Chai, Xianyi Wang, Zong Wu, Zhitao Gu, Xiaomin Liu, Yiqi Zhao, Tangbing Chen, Zhongliang Ma, Qiangling Sun
Summary: In this study, low expression of miR-199a-5p in NSCLC sera samples was found, and miR-199a-5p was demonstrated to suppress cell proliferation, migration, and cell cycle arrest in NSCLC cell lines by targeting SLC2A1. This study suggests that miR-199a-5p can inhibit glucose metabolism in NSCLC and provides a novel approach for clinical treatments of NSCLC.
Article
Chemistry, Physical
Tianshu Chen, Qianqian Zhang, Yuchen Song, Albertina N. Isak, Xiaochen Tang, Hao Wang, Zhongliang Ma, Fenyong Sun, Qiuhui Pan, Xiaoli Zhu
Summary: This study introduces a new concept for cancer treatment by spatially confining cells to inhibit cell migration and invasion, reducing side effects by directly addressing the defining trait of cancer on the cellular level.
NANOSCALE HORIZONS
(2021)
Review
Biochemistry & Molecular Biology
Xianyi Wang, Wanqiu Li, Shengdi Lu, Zhongliang Ma
Summary: The roles of noncoding RNAs in the NF-kappa B/GSK-3 beta signaling pathway were summarized, offering new ideas for the treatment of diabetic wound healing.
INTERNATIONAL JOURNAL OF GENOMICS
(2021)