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Critical Care Medicine
Nicolle J. Domnik, Matthew D. James, Robin E. Scheeren, Grace A. Ayoo, Sarah M. Taylor, Amanda T. Di Luch, Kathryn M. Milne, Sandra G. Vincent, Devin B. Phillips, Amany F. Elbehairy, Sophie J. Crinion, Helen S. Driver, J. Alberto Neder, Denis E. O'Donnell
Summary: Evening dosing of dual, long-acting bronchodilation can improve detailed nocturnal respiratory mechanics and inspiratory neural drive, providing sustained overnight improvements in dynamic respiratory mechanics and inspiratory neural drive compared with placebo.
Article
Critical Care Medicine
Cheng-Yu Wu, Anis Cilic, Oleg Pak, Ruth Charlotte Dartsch, Jochen Wilhelm, Magdalena Wujak, Kevin Lo, Monika Brosien, Ruoyu Zhang, Ibrahim Alkoudmani, Biruta Witte, Frauke Pedersen, Henrik Watz, Robert Voswinckel, Andreas G. Unther, Hossein A. Ghofrani, Ralf P. Brandes, Ralph T. Schermuly, Friedrich Grimminger, Werner Seeger, Natascha Sommer, Norbert Weissmann, Stefan Hadzic
Summary: CEACAM6 gene expression determines the susceptibility of some smokers to nitrosative/oxidative stress, thereby promoting the development and progression of COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Oncology
Avik Dutta, Dipmoy Nath, Yue Yang, Bao T. Le, Golam Mohi
Summary: The CDK4/6 inhibitor palbociclib, alone or in combination with ruxolitinib, shows significant efficacy in reducing leukocytosis, splenomegaly, and bone marrow fibrosis in murine models of myelofibrosis, especially in inhibiting Jak2V617F mutant hematopoietic progenitors. This drug combination could have therapeutic potential for the treatment of myelofibrosis and warrants further clinical investigation.
Article
Physiology
Anthony Tam, Pascal Leclair, Ling Vicky Li, Chen X. Yang, Xuan Li, Dominik Witzigmann, Jayesh A. Kulkarni, Tillie-Louise Hackett, Delbert R. Dorscheid, Gurpreet K. Singhera, James C. Hogg, Pieter R. Cullis, Don D. Sin, Chinten James Lim
Summary: FAM13A gene plays a crucial role in COPD, interacting with TGF-beta 1 signaling and affecting the expression of airway epithelial cells. Overexpression of FAM13A can partially protect airway tissues, potentially serving as a therapeutic approach to reduce the extent of airway remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Physiology
Min Cao, Robert A. Calmelat, Peter Kierstead, Nicolo Carraro, William W. Stringer, Janos Porszasz, Richard Casaburi, Harry B. Rossiter
Summary: Exercise intolerance in COPD is associated with dyspnea and reduced inspiratory capacity. Combination bronchodilator therapy did not improve neuromuscular performance or increase exercise tolerance in COPD patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Noriho Sakamoto, Daisuke Okuno, Takatomo Tokito, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Yoshimasa Tanaka, Hiroshi Mukae
Summary: Idiopathic pulmonary fibrosis is a chronic lung disease characterized by a decline in lung function and poor prognosis. Type I collagen, a major component of the extracellular matrix, is a potential target for fibrosis treatment. HSP47, a collagen-binding protein, is increased in pulmonary fibrosis and has implications in the development of therapeutic strategies.
Article
Physiology
Yoshitaka Oku
Summary: Dysphagia is a common comorbidity of COPD, and it can be detected early as a manifestation of breathing-swallowing discoordination. Low-pressure CPAP and IFC-TESS have shown potential in counteracting swallowing disorders and reducing exacerbations in COPD patients. Further studies are needed to evaluate the impact of these interventions on COPD exacerbations.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu
Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jiaming Xue, Joelle S. Suarez, Michael Minaai, Shuangjing Li, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Summary: HMGB1 has been reassessed as a damage-associated molecular pattern protein with crucial roles in the extracellular matrix; Different isoforms of HMGB1 present distinctive physiological functions in diseases; Targeting HMGB1 as a therapeutic strategy involves antagonists interfering with its activity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Wei Ruan, Xiaoyi Yuan, Holger K. Eltzschig
Summary: The circadian clock plays a crucial role in integrating external environmental changes and internal physiology, providing temporal precision and robust adaptation to the environment. Disruption of circadian rhythms can lead to adverse health consequences, but there is still an underappreciation of how to take advantage of biological timing for health benefits. Promising progress in research and clinical applications should drive efforts towards a new era of circadian medicine.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Review
Immunology
Pan Shen, Xuan Deng, Zhe Chen, Xin Ba, Kai Qin, Ying Huang, Yao Huang, Tingting Li, Jiahui Yan, Shenghao Tu
Summary: SIRT1, as a member of the class III family of nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylases, plays a crucial role in the progression of various diseases, including autoimmune diseases. Modulating the functions of SIRT1 may serve as a potential therapeutic strategy for these diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hai Zhao, Shuangshuang Song, Junwei Ma, Zhiyong Yan, Hongwei Xie, Ying Feng, Shusheng Che
Summary: CD47 is a protein that is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. It modulates cellular phagocytosis, determines the lifespan of erythrocytes, regulates immune cell activation, and manipulates synaptic pruning during neuronal development. Recently, CD47 has been identified as a novel target for cancer immunotherapy. This review discusses the diverse functions of CD47, its role in immune system homeostasis, and its potential therapeutic roles against cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Borja Ruiz-Fernandez de Cordoba, Rafael Martinez-Monge, Fernando Lecanda
Summary: ENPP1 is frequently overexpressed in local relapses and tumor metastases, promoting an immunosuppressive tumor micro-environment and impairing immune response. Blocking ENPP1 could enhance immune remodeling and activate the STING pathway. Combination therapy with ENPP1 inhibitors and other modalities shows potential in improving antitumor-immune responses and clinical outcomes. This review summarizes the current state of the art and provides new perspectives for novel treatment strategies.
CLINICAL CANCER RESEARCH
(2023)
Article
Critical Care Medicine
Srinadh Annangi, Angel O. Coz-Yataco
Summary: Bronchodilation testing is crucial for accurately diagnosing COPD and distinguishing it from ACO. Omitting this procedure in spirometry testing can lead to misclassification of ACO and overdiagnosis of COPD.
Review
Cell Biology
Olga M. Rusiecka, Malaury Tournier, Filippo Molica, Brenda R. Kwak
Summary: Exaggerated inflammatory response is associated with various disorders, and ATP and Panx1 channels play important roles in regulating the inflammatory response. Inhibiting Panx1 channels can alleviate inflammation and improve inflammatory diseases in multiple organs. However, most current drugs lack specificity and stability, and new drugs targeting Panx1 channels need to be developed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Allergy
Sinthia Bosnic-Anticevich, Christina Callan, Henry Chrystyn, Federico Lavorini, Vasilis Nikolaou, Vicky Kritikos, P. N. Richard Dekhuijzen, Nicolas Roche, Leif Bjermer, Cynthia Rand, Nicholas Zwar, David B. Price
Meeting Abstract
Oncology
Melanie Schellekens, Desiree Van den Hurk, Judith Prins, A. Donders, Johan Molema, Richard Dekhuijzen, Miep Van der Drift, Anne Speckens
JOURNAL OF THORACIC ONCOLOGY
(2017)
Article
Oncology
M. P. J. Schellekens, D. G. M. van den Hurk, J. B. Prins, A. R. T. Donders, J. Molema, R. Dekhuijzen, M. A. van der Drift, A. E. M. Speckens
Review
Cardiac & Cardiovascular Systems
James Mahon, Anita Fitzgerald, Julie Glanville, Richard Dekhuijzen, Josefine Glatte, Sascha Glanemann, Saku Torvinen
RESPIRATORY MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
A. Lewis, S. Torvinen, P. N. R. Dekhuijzen, H. Chrystyn, A. Melani, Y. Zoellner, K. Kolbe, A. T. Watson, M. Blackney, A. Plich
RESPIRATORY MEDICINE
(2017)
Article
Allergy
Dirkje S. Postma, Richard Dekhuijzen, Thys van der Molen, Richard J. Martin, Wim van Aalderen, Nicolas Roche, Theresa W. Guilbert, Elliot Israel, Daniela van Eickels, Javaria Mona Khalid, Ron M. C. Herings, Jetty A. Overbeek, Cristiana Miglio, Victoria Thomas, Catherine Hutton, Elizabeth V. Hillyer, David B. Price
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2017)
Article
Respiratory System
R. G. Duenk, C. Verhagen, E. M. Bronkhorst, P. J. W. B. van Mierlo, M. E. A. C. Broeders, S. M. Collard, P. N. R. Dekhuijzen, K. C. P. Vissers, Y. Heijdra, Y. Engels
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2017)
Article
Respiratory System
R. G. Dunek, C. Verhagen, E. M. Bronkhorst, R. S. Djamin, G. J. Bosman, E. Lammers, P. N. R. Dekhuijzen, K. C. P. Vissers, Y. Engels, Y. Heijdra
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2017)
Article
Respiratory System
R. G. Duenk, C. Verhagen, P. N. R. Dekhuijzen, K. C. P. Vissers, Y. Engels, Y. Heijdra
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2017)
Article
Primary Health Care
Persijn J. Honkoop, Hilary Pinnock, Regien M. M. Kievits-Smeets, Peter J. Sterk, P. N. Richard Dekhuijzen, Johannes C. C. M. in't Veen
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2017)
Review
Allergy
Richard Dekhuijzen, Federico Lavorini, Omar S. Usmani, Job F. M. van Boven
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2018)
Review
Respiratory System
Omar Sharif Usmani, Federico Lavorini, Jonathan Marshall, William Christopher Nigel Dunlop, Louise Heron, Emily Farrington, Richard Dekhuijzen
RESPIRATORY RESEARCH
(2018)
Article
Respiratory System
S. Zewari, P. Vos, F. van den Elshout, R. Dekhuijzen, Y. Heijdra
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2017)
Letter
Respiratory System
R. G. Duenk, C. Verhagen, E. M. Bronkhorst, R. S. Djamin, G. J. Bosman, E. Lammers, P. N. R. Dekhuijzen, K. C. P. Vissers, Y. Engels, Y. Heijdra
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2017)
