Review
Immunology
Xiang Wang, Zuozhou Xie, Jinhong Zhao, Zhenghua Zhu, Chen Yang, Yi Liu
Summary: Respiratory infections pose significant challenges, especially with the increasing antibiotic resistance. Phage therapy has emerged as a promising non-antibiotic approach, showing effectiveness against bacterial pathogens including drug resistant strains. Advances in delivery methods, such as targeted electrospray and nebulization techniques, have improved outcomes in the treatment of pulmonary infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoshinori Sato, Tsuneyuki Ubagai, Shigeru Tansho-Nagakawa, Yusuke Yoshino, Yasuo Ono
Summary: The study investigated the antimicrobial effects of colistin (CST) and tigecycline (TGC) alone or in combination on biofilm-dispersed and biofilm-embedded multidrug-resistant Acinetobacter baumannii (MDRAB) strains. The results showed that the combination of CST and TGC enhanced their bactericidal effects, while low concentrations of TGC attenuated the effects. Additionally, CST was able to disrupt biofilms, unlike TGC.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Vasundhra Bhandari, Akash Suresh
Summary: This article discusses the emergence of resistance in bacterial species over time and the various protective mechanisms employed by bacterial cells. Additionally, it highlights the importance of new approaches and practices for tackling antimicrobial resistance and identifying new treatment options.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Microbiology
Greater Kayode Oyejobi, Xiaoxu Zhang, Dongyan Xiong, Faith Ogolla, Heng Xue, Hongping Wei
Summary: Phage treatment shows potential for bacterial infections, but bacterial resistance to phage is a challenge. Research on phage resistance and coevolutionary dynamics between phage and bacteria is crucial for successful phage therapy.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Seyedeh Zahra Bahojb Mahdavi, Fatemeh Oroojalian, Shirin Eyvazi, Maryam Hejazi, Behzad Baradaran, Nasser Pouladi, Mohammad Reza Tohidkia, Ahad Mokhtarzadeh, Serge Muyldermans
Summary: Antibodies, as therapeutic and diagnostic molecules, play a crucial role in disease treatment, especially in cancer therapy. Alternative approaches, such as display selection technologies, have been developed to overcome the limitations of traditional hybridoma technology. These methods, including phage display, bacterial display, and yeast display, enable the screening and generation of high affinity antibodies with low immunogenicity risk. Understanding the basics of each method is important for antibody design suitable for different diseases, including cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Public, Environmental & Occupational Health
Ahlam Alsaadi, Mohammed Imam, Abdulrahman A. Alghamdi, Majed F. Alghoribi
Summary: The escalating threat of antibiotic-resistant pathogens worldwide necessitates international action and multisectoral cooperation. Bacteriophages represent a promising tool for combatting this global threat. While extensive research has been conducted on phages and their applications in Europe and the United States, phage research in the Middle East is relatively limited.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Review
Virology
Nicole Marie Hitchcock, Danielle Devequi Gomes Nunes, Job Shiach, Katharine Valeria Saraiva Hodel, Josiane Dantas Viana Barbosa, Leticia Alencar Pereira Rodrigues, Brahm Seymour Coler, Milena Botelho Pereira Soares, Roberto Badaro
Summary: With the global spread of antimicrobial resistance, there is a growing demand for new and innovative antimicrobials. Bacteriophages have potential clinical applications in lysing bacteria but were hindered by the introduction of antibiotics. However, recently phage therapy has re-emerged as a promising strategy to combat antimicrobial resistance.
Article
Medicine, General & Internal
Fernando L. Gordillo Altamirano, Xenia Kostoulias, Dinesh Subedi, Denis Korneev, Anton Y. Peleg, Jeremy J. Barr
Summary: This study demonstrates that the combination of phage and ceftazidime has a significant bactericidal effect against Acinetobacter baumannii AB900 in vivo. The combination treatment group showed a lower bacterial burden compared to the other treatment groups, suggesting that the combination therapy may be an effective strategy for treating multidrug-resistant Acinetobacter baumannii infections.
Review
Infectious Diseases
Celia Ferriol-Gonzalez, Pilar Domingo-Calap
Summary: The irrational use of antibiotics has led to a high emergence of multi-drug resistant bacteria, particularly in the animal feed industry and companion animal infections. Phages have been proposed as an alternative for antibiotics, showing potential applications in treating infections in livestock and companion animals.
Review
Microbiology
Nannan Wu, Tongyu Zhu
Summary: Nosocomial infections are a significant healthcare burden globally, exacerbated by antimicrobial resistance. Utilizing bacteriophages from an expanding library offers a promising alternative for tackling AMR bacteria and provides a database for monitoring and treatment of hospital-acquired infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Lavanya Khullar, Kusum Harjai, Sanjay Chhibber
Summary: The rampant consumption of antibiotics in the 21st century has led to an increase in antimicrobial resistance among bacterial pathogens, particularly Staphylococcus aureus. As a result, phage therapy has been highlighted as an effective strategy to combat this pathogen, especially in immunosuppressed individuals.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Ngozi Joannes Anyaegbunam, Chijioke Chinedu Anekpo, Zikora Kizito Glory Anyaegbunam, Yandev Doowuese, Chinwe Blessing Chinaka, Oluchi Joannes Odo, Hyelnaya Cletus Sharndama, Onyekachi Philomena Okeke, Ifeanyi Elibe Mba
Summary: Phage therapy, which was abandoned when antibiotics emerged, has garnered renewed attention as an alternative therapeutic approach due to the rapid emergence of drug-resistant bacteria and the unavailability of new drugs. Phages and phage-derived proteins have shown potential as antimicrobial agents, with promising therapeutic efficacy observed in animal models and clinical trials. However, challenges and limitations remain to be addressed for the full clinical application of phage therapy.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Immunology
Anisha M. Thanki, Steven Hooton, Natasha Whenham, Michael G. Salter, Mike R. Bedford, Helen V. Masey O'Neill, Martha R. J. Clokie
Summary: This study showed that adding a phage cocktail to chicken feed effectively reduced Salmonella colonization in chickens, with the optimal dose of phage being 10(5) PFU/day. By the end of the study, no Salmonella was detected in the group that received phage at this dose. Phage treatment also improved the growth performance of challenged birds.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Virology
Danielle L. Peters, Carly M. Davis, Greg Harris, Hongyan Zhou, Philip N. Rather, Sabahudin Hrapovic, Edmond Lam, Jonathan J. Dennis, Wangxue Chen
Summary: The world is currently facing a global health crisis due to the rapid increase in antimicrobial-resistant bacterial infections. Acinetobacter baumannii, a Gram-negative bacterium with many intrinsic antibiotic resistance mechanisms and the ability to quickly acquire new resistance determinants, is one of the most concerning pathogens. Phage therapy, especially the myoviruses DLP1 and DLP2, shows potential as a treatment option against A. baumannii infections. These phages have a limited host range and exhibit different burst sizes, latency periods, and virulence indices.
Article
Fisheries
Liting Wu, Yuan Tian, Maoda Pang, Zhenquan Yang, Hongduo Bao, Yan Zhou, Lichang Sun, Ran Wang, Hui Zhang
Summary: The study investigated the phenotypic characterization and antimicrobial susceptibility patterns of 54 V. harveyi strains collected from Larimichthys crocea in China. The isolates displayed resistance to a variety of antibiotics and carried multiple virulence genes. Additionally, a novel V. harveyi-specific phage with broad host range was discovered and showed high efficacy in preventing and controlling V. harveyi infection in a zebrafish model.
Article
Food Science & Technology
Xianglian Liu, Pu Guo, Aimei Liu, Qinghua Wu, Xijuan Xue, Menghong Dai, Haihong Hao, Wei Qu, Shuyu Xie, Xu Wang, Zonghui Yuan
FOOD AND CHEMICAL TOXICOLOGY
(2017)
Article
Pharmacology & Pharmacy
J. Nan, H. Hao, S. Xie, Y. Pan, C. Xi, F. Mao, Z. Liu, L. Huang, Z. Yuan
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2017)
Article
Chemistry, Analytical
Ting Chen, Guyue Cheng, Saeed Ahmed, Yulian Wang, Xu Wang, Haihong Hao, Zonghui Yuan
Article
Pharmacology & Pharmacy
Xianglian Liu, Deyu Huang, Pu Guo, Qinghua Wu, Menghong Dai, Guyue Cheng, Haihong Hao, Shuyu Xie, Zonghui Yuan, Xu Wang
Article
Multidisciplinary Sciences
Hafiz I. Hussain, Zahid Iqbal, Mohamed N. Seleem, Deyu Huang, Adeel Sattar, Haihong Hao, Zonghui Yuan
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Guyue Cheng, Yamei Xu, Xudong Zhu, Shuyu Xie, Liye Wang, Lingli Huang, Haihong Hao, Zhenli Liu, Yuanhu Pan, Dongmei Chen, Yulian Wang, Zonghui Yuan
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Haihong Hao, Xia Fang, Jing Han, Steven L. Foley, Yulian Wang, Guyue Cheng, Xu Wang, Lingli Huang, Menghong Dai, Zhenli Liu, Zonghui Yuan
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Microbiology
Kun Mi, Da Sun, Mei Li, Haihong Hao, Kaixiang Zhou, Zhenli Liu, Zonghui Yuan, Lingli Huang
Summary: This study established the clinical breakpoint of cefquinome against Haemophilus parasuis and monitored resistance change based on pharmacodynamic and pharmacokinetic parameters. The findings help distinguish wild type H. parasuis and reduce the risk of treatment failure.
Article
Infectious Diseases
Muhammad Kashif Maan, Zhifei Weng, Menghong Dai, Zhenli Liu, Haihong Hao, Guyue Cheng, Yulian Wang, Xu Wang, Lingli Huang
Summary: Cyadox shows strong antibacterial activity and has the potential to be used as a single drug for the treatment of bacterial infectious diseases. The in vitro antibacterial activities of cyadox were tested, and its efficacy against facultative anaerobes was determined under anaerobic conditions.
Article
Biochemistry & Molecular Biology
Yufeng Gu, Lulu Huang, Cuirong Wu, Junhong Huang, Haihong Hao, Zonghui Yuan, Guyue Cheng
Summary: This study systematically investigated the mechanism of resistance evolution in Salmonella to fluoroquinolones under sub-MICs, revealing the critical roles of outer membrane porin genes and efflux pump genes in resistance development. The research also identified hub genes and key biological processes associated with FQs resistance, providing valuable insights for further studies in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Infectious Diseases
Lulu Huang, Cuirong Wu, Haijiao Gao, Chao Xu, Menghong Dai, Lingli Huang, Haihong Hao, Xu Wang, Guyue Cheng
Summary: This review comprehensively discusses the role and potential applications of multidrug efflux pumps in bacterial resistance to antimicrobial agents. These pumps not only decrease the intracellular concentration of drugs but also promote multidrug resistance, biofilm formation, quorum sensing, and other biological functions in bacteria. The potential applications of efflux pump-related genes/proteins for the detection of antibiotic residues and antimicrobial resistance are also analyzed. Additionally, the review discusses efflux pump inhibitors, especially those of plant origin.
Article
Pharmacology & Pharmacy
Anxiong Huang, Xiao Huang, Zhihao Zhang, Zonghui Yuan, Lingli Huang, Yulian Wang, Yanfei Tao, Dongmei Chen, Zhenli Liu, Haihong Hao
Summary: This study recommends an optimal dosing regimen for the treatment of G. parasuis infection through pharmacokinetics-pharmacodynamics modeling, providing novel therapeutic options to decrease the disease burden caused by G. parasuis.
Article
Biochemistry & Molecular Biology
Jingchao Guo, Yaqi Sun, Yongxia Zhao, Lingli Huang, Dapeng Peng, Haihong Hao, Yanfei Tao, Dongmei Chen, Guyue Cheng, Xu Wang, Yuanhu Pan
Summary: The metabolism, distribution, and elimination of SMZ were investigated in pigs, chickens, and rats. The residue marker and target tissue of SMZ in food animals were determined, providing a reliable basis for food safety.
