Review
Cardiac & Cardiovascular Systems
Nasim Kiaie, Armita Mahdavi Gorabi, Zeljko Reiner, Tannaz Jamialahmadi, Massimiliano Ruscica, Amirhossein Sahebkar
Summary: Statins not only lower serum LDL-cholesterol, but also have important effects on the renin-angiotensin system pathway, offering new therapeutic possibilities beyond cholesterol lowering.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Chuanming Xu, Chunju Liu, Jianhua Xiong, Jun Yu
Summary: Cardiovascular diseases are major public health problems globally and the activation of the (Pro)renin receptor (PRR) plays a significant role in cardiovascular homeostasis. PRR activation is associated with myocardial ischemia/reperfusion injury, cardiac hypertrophy, heart failure, vascular smooth muscle cell proliferation, endothelial cell dysfunction, and the progression of vascular diseases. Targeting PRR may have benefits for patients with cardiovascular diseases.
Review
Medicine, General & Internal
Adrian Martyniak, Przemyslaw J. Tomasik
Summary: Cardiovascular disease is the leading cause of death worldwide and hypertension is a serious medical issue in both adults and children. The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in regulating blood pressure and electrolyte balance. Recent studies reveal that the RAAS system acts not only through endocrine pathways but also through paracrine, autocrine, and intracrine pathways. The alternative pathways of RAAS, which include components like Ang 1-7 and Mas receptors, have been found to have antihypertensive and cardioprotective effects. Proteolytic enzymes such as angiotensin convertase enzyme type 1 and 2 are also important in the functioning of the RAAS system and serve as therapeutic targets for hypertension. Furthermore, tissue-specific enzymes contribute to the local renin-angiotensin system. The ACE2/ang 1-7/MasR axis shows promising potential for new treatments in hypertension.
Review
Cardiac & Cardiovascular Systems
Boyang Wang, Haipeng Jie, Shuangxi Wang, Bo Dong, Yunzeng Zou
Summary: (Pro)renin receptor (PRR) is a component of the renin-angiotensin system (RAS) and is involved in the pathogenesis of cardiovascular diseases. This review focuses on the effects of PRR and its soluble form on various cardiovascular conditions, including hypertension, myocardial ischemia reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Sarah M. Nwia, Ana Paula O. Leite, Xiao Chun Li, Jia Long Zhuo
Summary: Cardiovascular disease demonstrates significant biological sex differences, allowing for tailored approaches to prevention and treatment. Hypertension, a major risk factor for various diseases, affects a significant percentage of the American population. Women have lower rates of hypertension during reproductive years, but this protection diminishes after menopause. Treatment-resistant hypertension remains a challenge, suggesting unknown mechanisms in blood pressure regulation. Understanding the genetic and hormonal differences in hypertension can lead to sex-specific treatments and improved outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Wei Xu, Yan-min Yang, Jun Zhu, Shuang Wu, Juan Wang, Han Zhang, Xing-hui Shao
Summary: This study found that ACEI/ARB therapy was significantly associated with a reduced risk of all-cause death, cardiovascular death, and MAEs in ED patients with AF and hypertension.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Urology & Nephrology
Edouard L. Fu, Marie Evans, Catherine M. Clase, Laurie A. Tomlinson, Merel van Diepen, Friedo W. Dekker, Juan J. Carrero
Summary: The study found that stopping RAS inhibitor therapy in patients with advanced CKD was associated with higher risks of mortality and major adverse cardiovascular events, but lower risk of initiating kidney replacement therapy (KRT).
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jordan B. King, Ransmond O. Berchie, Catherine G. Derington, Zachary A. Marcum, Daniel O. Scharfstein, Tom H. Greene, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Adam P. Bress, Jordana B. Cohen
Summary: This study compared the effects of new users of ARBs versus ACEIs on cardiovascular disease events and death. The results showed similar rates of cardiovascular disease events between the two groups, with lower death rates associated with ARBs. There were subgroup differences in the effects of ARBs versus ACEIs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Multidisciplinary Sciences
Sajini D. Hettiarachchi, Young M. Kwon, Yadollah Omidi, Robert C. Speth
Summary: The renin-angiotensin system (RAS) plays a role in several disorders and drugs that target this system are limited in their efficacy. Nanoparticle-mediated drug delivery systems offer a potential solution to overcome these limitations.
Review
Biochemistry & Molecular Biology
Raul Loera-Valencia, Francesca Eroli, Sara Garcia-Ptacek, Silvia Maioli
Summary: The article explores the role of the brain renin-angiotensin system in cognition and Alzheimer's disease pathogenesis, as well as its relationship with risk factors such as hypercholesterolemia. Current RAS inhibition therapy's efficacy in improving cognition in AD patients is uncertain, with only one therapy under consideration in clinical trials. Additionally, research on novel drugs may offer potential for highly specific treatments targeting the brain RAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Shamil Haroon, Anuradhaa Subramanian, Jennifer Cooper, Astha Anand, Krishna Gokhale, Nathan Byne, Samir Dhalla, Dionisio Acosta-Mena, Thomas Taverner, Kelvin Okoth, Jingya Wang, Joht Singh Chandan, Christopher Sainsbury, Dawit Tefra Zemedikun, G. Neil Thomas, Dhruv Parekh, Tom Marshall, Elizabeth Sapey, Nicola J. Adderley, Krishnarajah Nirantharakumar
Summary: This study investigated the association between prescription of ACE inhibitors or ARBs and the incidence of COVID-19 and all-cause mortality. The results showed that there was no significant difference in COVID-19 incidence between users of ACE inhibitors and CCBs, while users of ARBs had a slightly higher incidence rate. However, there were no significant associations between prescription of either ACE inhibitors or ARBs and all-cause mortality.
BMC INFECTIOUS DISEASES
(2021)
Article
Oncology
Marcin Zeman, Wladyslaw Skalba, Agata Malgorzata Wilk, Alexander Jorge Cortez, Adam Maciejewski, Agnieszka Czarniecka
Summary: The use of ARBs instead of ACEIs may improve the outcome of the combined therapy for rectal cancer patients with associated hypertension.
Article
Oncology
Tianshu Ren, Hui Jia, Qiong Wu, Yan Zhang, Qun Ma, Dong Yao, Xudong Gao, Danni Xie, Zihua Xu, Qingchun Zhao, Yingshi Zhang
Summary: This study suggests that renin-angiotensin system inhibitors (RASIs) combined with bevacizumab (Bev) have a synergistic effect in the treatment of colorectal cancer. The combination treatment improves overall survival (OS) and progression-free survival (PFS) in patients. RASIs may also be an optimal choice for the treatment of Bev-induced hypertension.
FRONTIERS IN ONCOLOGY
(2022)
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Transplantation
Carmine Zoccali, Alberto Ortiz, Inga Arune Blumbyte, Sarina Rudolf, Annette G. Beck-Sickinger, Jolanta Malyszko, Goce Spasovski, Sol Carriazo, Davide Viggiano, Justina Kurganaite, Vaiva Sarkeviciene, Daiva Rastenyte, Andreja Figurek, Merita Rroji, Christopher Mayer, Mustapha Arici, Gianvito Martino, Gioacchino Tedeschi, Annette Bruchfeld, Belinda Spoto, Ivan Rychlik, Andrzej Wiecek, Mark Okusa, Giuseppe Remuzzi, Francesca Mallamaci
Summary: NPY, a 36-amino-acid peptide, regulates various biological functions and plays a key role in chronic kidney disease progression, cardiovascular events, and cognitive decline. Interfering with the NPY system has potential for treating diverse diseases, although challenges in drug delivery, cost, and complexity of diseases remain.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Takashi Suzuki, Masahiko Morita, Toshio Hayashi, Ayako Kamimura
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2017)
Article
Geriatrics & Gerontology
Hitoshi Komiya, Hiroyuki Umegaki, Atsushi Asai, Shigeru Kanda, Keiko Maeda, Takuya Shimojima, Hideki Nomura, Masafumi Kuzuya
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2018)
Article
Biochemistry & Molecular Biology
Xiao-Jian Sun, Soohyun Park Kim, Dongming Zhang, Helen Sun, Qi Cao, Xin Lu, Zhekang Ying, Liwu Li, Robert R. Henry, Theodore P. Ciaraldi, Simeon I. Taylor, Michael J. Quon
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Huei L. H. Ng, Dino Premilovac, Stephen Rattigan, Stephen M. Richards, Ranganath Muniyappa, Michael J. Quon, Michelle A. Keske
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2017)
Review
Cardiac & Cardiovascular Systems
Kyoung Im Cho, Ichiro Sakuma, Il Suk Sohn, Toshio Hayashi, Kazunori Shimada, Kwang Kon Koh
CIRCULATION JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Li Zhou, Xiang Liu, Zhen-Qing Wang, Yan Li, Mao-Mao Shi, Zhe Xu, Zhi-Jun Ou, Hua-Ming Li, Tian-Pu Cheng, Yu-Peng Jian, Wen Zhang, Chen Liu, Xi Zhang, Michael J. Quon, Chun-Xiang Zhang, Ying-Qi Xu, Zhi-Ping Wang, Jing-Song Ou
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Tomoe Tsuboi, Morihiko Maeda, Toshio Hayashi
Article
Nutrition & Dietetics
Jeannie Tay, Amy M. Goss, W. Timothy Garvey, Mark E. Lockhart, Nikki C. Bush, Michael J. Quon, Gordon Fisher, Barbara A. Gower
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Article
Endocrinology & Metabolism
Ranganath Muniyappa, Hui Chen, Monica Montagnani, Arthur Sherman, Michael J. Quon
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Physiology
Joon Ha, Ranganath Muniyappa, Arthur S. Sherman, Michael J. Quon
Summary: The Bergman-Cobelli Minimal Model used to estimate S-I during an IVGTT may lead to underestimated results, especially when evaluating differences between Blacks and Whites.
FRONTIERS IN PHYSIOLOGY
(2021)
Meeting Abstract
Geriatrics & Gerontology
T. Hayashi
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2019)
Meeting Abstract
Geriatrics & Gerontology
T. Hayashi, M. Maeda
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2019)
Letter
Endocrinology & Metabolism
Xiaoquan Rao, Jeffrey A. Deiuliis, Georgeta Mihai, Juliet Varghese, Chang Xia, Matthew B. Frieman, Carole Sztalryd, Xiao Jian Sun, Michael J. Quon, Simeon I. Taylor, Sanjay Rajagopalan, Jixin Zhong
Article
Immunology
Kikumi D. Ono-Moore, Ling Zhao, Shurong Huang, Jeonga Kim, Jennifer M. Rutkowsky, Ryan G. Snodgrass, Dina A. Schneider, Michael J. Quon, James L. Graham, Peter J. Havel, Daniel H. Hwang
IMMUNITY INFLAMMATION AND DISEASE
(2017)
Meeting Abstract
Endocrinology & Metabolism
Toshio Hayashi, Koutaro Yokote, Koichiro Ina, Mitsuhiko Noda