Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

Effects of Sildenafil Citrate and Heparin Treatments on Placental Cell Morphology in a Murine Model of Pregnancy Loss

(2016) Rayana Leal Luna et al.   CELLS TISSUES ORGANS

Phosphodiesterase-5 inhibition promotes remyelination by MCP-1/CCR-2 and MMP-9 regulation in a cuprizone-induced demyelination model

(2016) Ana Karolina de Santana Nunes et al.   EXPERIMENTAL NEUROLOGY

Sildenafil (Viagra ® ) prevents and restores LPS-induced inflammation in astrocytes

(2016) Ana Karolina de Santana Nunes et al.   NEUROSCIENCE LETTERS

ABCD of the phosphodiesterase family: interaction and differential activity in COPD

(2016) David Halpin   International Journal of Chronic Obstructive Pulmonary Disease

Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model

(2015) Ana Karolina Santana Nunes et al.   BRAIN RESEARCH

Effects of sildenafil citrate and etanercept treatment on TNF-α levels in peripheral blood of women with recurrent miscarriage

(2015) Monika Ohams et al.   Ginekologia Polska

Sildenafil activates antioxidant and antiapoptotic genes and inhibits proinflammatory cytokine genes in a rat model of renal ischemia/reperfusion injury

(2015) Mohamed H. Zahran et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Sildenafil (Viagra ® ) blocks inflammatory injury in LPS-induced mouse abortion: A potential prophylactic treatment against acute pregnancy loss?

(2015) R.L. Luna et al.   PLACENTA

Modulating effects of nonselective and selective phosphodiesterase inhibitors on lymphocyte subsets and humoral immune response in mice

(2014) Marianna Szczypka et al.   Pharmacological Reports

Modulation of Th1/Th2 cytokine production by selective and nonselective phosphodiesterase inhibitors administered to mice

(2014) Marianna Szczypka et al.   Pharmacological Reports

Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions

(2013) Paula Pifarré et al.   EXPERIMENTAL NEUROLOGY

AGEs, contributors to placental bed vascular changes leading to preeclampsia

(2013) L. Guedes-Martins et al.   FREE RADICAL RESEARCH

PDE5 inhibitors: considerations for preference and long-term adherence

(2013) W. B. Smith et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model

(2013) Catarina Raposo et al.   MEDIATORS OF INFLAMMATION

Gender-specific immunological effects of the phosphodiesterase 5 inhibitor sildenafil in healthy mice

(2013) Svetlana Karakhanova et al.   MOLECULAR IMMUNOLOGY

Sildenafil stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells via distinct signaling pathways

(2012) Xiao-ming Liu et al.   BIOCHEMICAL PHARMACOLOGY

Sildenafil Therapy for Interferon-β-1a-Induced Pulmonary Arterial Hypertension: A Case Report

(2012) Sergio Caravita et al.   CARDIOLOGY

Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model

(2012) Ana Karolina de Santana Nunes et al.   CYTOKINE

Immune Cells Have Sex and So Should Journal Articles

(2012) Sabra L. Klein   ENDOCRINOLOGY

Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis

(2011) Paula Pifarre et al.   ACTA NEUROPATHOLOGICA

Sildenafil attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia

(2011) Siqi Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model

(2011) C. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic administration of Sildenafil improves markers of endothelial function in men with Type 2 diabetes

(2010) A. Aversa et al.   DIABETIC MEDICINE

The effects of selective and nonselective phosphodiesterase inhibitors on phagocytic cells in mice

(2010) Marianna Szczypka et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation

(2010) Yoshiro Kobayashi   JOURNAL OF LEUKOCYTE BIOLOGY

Glial cells as sources and targets of natriuretic peptides

(2010) Judith Prado et al.   NEUROCHEMISTRY INTERNATIONAL

Biochemical role of intravaginal sildenafil citrate as a novel antiabortive agent in unexplained recurrent spontaneous miscarriage: first clinical study of four case reports from Egypt

(2009) Mohamed El-Far et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Improvement of pulmonary microcirculation after lung transplantation using phosphodiesterase-5 inhibitor modified preservation solution

(2009) Nikolaus Pizanis et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

A systems biology perspective on sVEGFR1: its biological function, pathogenic role & therapeutic use

(2009) Florence T.H. Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of Chemokines in CNS Health and Pathology: A Focus on the CCL2/CCR2 and CXCL8/CXCR2 Networks

(2009) Bridgette D Semple et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury

(2009) Paula Pifarré et al.   JOURNAL OF NEUROCHEMISTRY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis

(2009) Alper Yildirim et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Sildenafil citrate decreased natural killer cell activity and enhanced chance of successful pregnancy in women with a history of recurrent miscarriage

(2008) Malgorzata Jerzak et al.   FERTILITY AND STERILITY

Oral Phosphodiesterase Type 5 Inhibitors: Nonerectogenic Beneficial Uses

(2008) Taymour Mostafa   Journal of Sexual Medicine