Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

(2017) Sarang Tartey et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88

(2016) Fenli Shao et al.   BIOCHEMICAL PHARMACOLOGY

Modulation of Toll-like receptor signaling in innate immunity by natural products

(2016) Luxi Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod-induced psoriasis-like skin inflammation in mice

(2016) Shi-Wei Huang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Toll-like receptors: potential targets for lupus treatment

(2015) Yan-wei Wu et al.   ACTA PHARMACOLOGICA SINICA

Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation

(2015) Ming-Han Li et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension

(2015) R Hernanz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation

(2015) Yanwei Wu et al.   Cellular & Molecular Immunology

Adalimumab: A Review in Chronic Plaque Psoriasis

(2015) Celeste B. Burness et al.   DRUGS

Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7–9

(2015) Chao-Yang Lai et al.   JOURNAL OF IMMUNOLOGY

Update on psoriasis immunopathogenesis and targeted immunotherapy

(2015) Satveer K. Mahil et al.   Seminars in Immunopathology

Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice

(2015) Thomas Nordstrøm Kjær et al.   PLoS One

Treatment of Psoriasis: Focus on Clinic-based Management with Infliximab

(2014) Esther de Eusebio et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

Linking the activity of bortezomib in multiple myeloma and autoimmune diseases

(2014) Zdeněk Škrott et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Bortezomib in multiple myeloma: systematic review and clinical considerations

(2014) T.C. Kouroukis et al.   Current Oncology

The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome

(2014) Tsung-Teng Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats

(2014) Mitsuhiro Kondo et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Trafficking of endosomal Toll-like receptors

(2014) Bettina L. Lee et al.   TRENDS IN CELL BIOLOGY

TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7

(2014) Chao-Yang Lai et al.   VACCINE

Pattern recognition receptors in innate immunity, host defense, and immunopathology

(2013) Rahul Suresh et al.   ADVANCES IN PHYSIOLOGY EDUCATION

The psychophysiological stress response in psoriasis and rheumatoid arthritis

(2013) S.J.M. de Brouwer et al.   BRITISH JOURNAL OF DERMATOLOGY

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Resveratrol has inhibitory effects on the hypoxia-induced inflammation and angiogenesis in human adipose tissue in vitro

(2013) Karina B. Cullberg et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mustard seed (Sinapis Alba Linn) attenuates imiquimod-induced psoriasiform inflammation of BALB/c mice

(2013) Runping Yang et al.   JOURNAL OF DERMATOLOGY

Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys

(2013) Aikaterini Thanou et al.   Nature Reviews Rheumatology

Effect of weather and environmental factors on the clinical course of psoriasis: Table 1

(2013) Nicola Balato et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases

(2013) Jing Li et al.   PHARMACOLOGY & THERAPEUTICS

Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of the mushroom Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB/c allograft tumor model

(2013) Fon-Chang Liu et al.   PHYTOMEDICINE

Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6 Production in Mice

(2013) Jun Sun et al.   PLoS One

Suppression of Molecular Inflammatory Pathways by Toll-Like Receptor 7, 8, and 9 Antagonists in a Model of IL-23-Induced Skin Inflammation

(2013) Mayte Suárez-Fariñas et al.   PLoS One

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

(2013) Masahiro Onji et al.   Nature Communications

UNC93B1 mediates differential trafficking of endosomal TLRs

(2013) Bettina L Lee et al.   eLife

Nucleic acids and endosomal pattern recognition: how to tell friend from foe?

(2013) Eva Brencicova et al.   Frontiers in Cellular and Infection Microbiology

Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease

(2012) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37

(2012) G. Chamilos et al.   BLOOD

Proteasome Inhibitors: A New Perspective for Treating Autoimmune Diseases

(2012) Alessandra Fierabracci   CURRENT DRUG TARGETS

Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice

(2012) A. M. Avalos et al.   JOURNAL OF IMMUNOLOGY

SM934 Treated Lupus-Prone NZB×NZW F1 Mice by Enhancing Macrophage Interleukin-10 Production and Suppressing Pathogenic T Cell Development

(2012) Li-Fei Hou et al.   PLoS One

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Long-Term Safety of Adalimumab Treatment in Moderate to Severe Psoriasis

(2011) Craig Leonardi et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Oral administration of artemisinin analog SM934 ameliorates lupus syndromes in MRL/lpr mice by inhibiting Th1 and Th17 cell responses

(2011) Li-Fei Hou et al.   ARTHRITIS AND RHEUMATISM

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

(2011) H. Travis Ichikawa et al.   ARTHRITIS AND RHEUMATISM

DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature

(2011) Yue Li et al.   EMBO JOURNAL

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands

(2011) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Antioxidant activities of extracts and metabolites isolated from the fungusAntrodia cinnamomea

(2011) Ming-Der Wu et al.   NATURAL PRODUCT RESEARCH

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Mustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesis

(2011) Haifeng Yuan et al.   REDOX REPORT

Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis

(2010) M. Hirai et al.   BLOOD

Imiquimod 5% cream induced psoriasis: a case report, summary of the literature and mechanism

(2010) U. Patel et al.   BRITISH JOURNAL OF DERMATOLOGY

Localisation and trafficking of Toll-like receptors: an important mode of regulation

(2010) Anne F McGettrick et al.   CURRENT OPINION IN IMMUNOLOGY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants

(2010) J Ølholm et al.   INTERNATIONAL JOURNAL OF OBESITY

Dendritic cells: Bridging innate and adaptive immunity in atopic dermatitis

(2010) Natalija Novak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

(2010) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Is ustekinumab superior to etanercept for psoriasis?

(2010) Annegret Kuhn et al.   Nature Reviews Rheumatology

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients

(2010) Federica Capolunghi et al.   RHEUMATOLOGY

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

(2009) Fernando E. Sepulveda et al.   IMMUNITY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

A Novel, Highly Selective, Tight Binding I B Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor- B Pathway in Arthritis-Relevant Cells and Animal Models

(2009) G. Mbalaviele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Azithromycin and Clarithromycin Inhibit Lipopolysaccharide-Induced Murine Pulmonary Neutrophilia Mainly through Effects on Macrophage-Derived Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-1 

(2009) M. Bosnar et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition

(2009) Jin Liu et al.   MOLECULAR IMMUNOLOGY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

(2009) James F Curtin et al.   PLOS MEDICINE

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Antimicrobial peptides and self-DNA in autoimmune skin inflammation

(2008) Michel Gilliet et al.   CURRENT OPINION IN IMMUNOLOGY

Ustekinumab for chronic plaque psoriasis

(2008) Brenda L Bartlett et al.   LANCET

Curcumin suppresses constitutive activation of nuclear factor-κB and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines

(2008) Azhar R. Hussain et al.   MOLECULAR CANCER THERAPEUTICS

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

Ustekinumab poised to enter the psoriasis market

(2008) Charlie Schmidt   NATURE BIOTECHNOLOGY

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY

Toll-like receptors — taking an evolutionary approach

(2008) François Leulier et al.   NATURE REVIEWS GENETICS