c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease

Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background

(2016) Sook In Chung et al.   BMC GASTROENTEROLOGY

New molecular interactions of c-Myc in cholangiocarcinoma may open new therapeutic opportunities

(2016) Carmen Berasain et al.   HEPATOLOGY

Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans‡

(2016) Heping Yang et al.   HEPATOLOGY

Enhanced expression of c-myc in hepatocytes promotes initiation and progression of alcoholic liver disease

(2016) Yulia A. Nevzorova et al.   JOURNAL OF HEPATOLOGY

A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

(2016) Daniel Dauch et al.   NATURE MEDICINE

Alcohol and hepatocellular carcinoma: A review and a point of view

(2016) Gianni Testino et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma

(2015) Hongli Yan et al.   HEPATOLOGY

Hepatitis B virus X protein enhances Myc stability by inhibiting SCFSkp2 ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis

(2015) S Lee et al.   ONCOGENE

Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer

(2015) Junyan Tao et al.   Oncotarget

MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism

(2014) H. Akita et al.   CANCER RESEARCH

Inactivation of MYC reverses tumorigenesis

(2014) Y. Li et al.   JOURNAL OF INTERNAL MEDICINE

Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis

(2013) Yulia A. Nevzorova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of Myc in hepatocellular proliferation and hepatocarcinogenesis

(2013) Aijuan Qu et al.   JOURNAL OF HEPATOLOGY

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

c-Myc and Cancer Metabolism

(2012) D. M. Miller et al.   CLINICAL CANCER RESEARCH

Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events

(2012) M R Higgs et al.   ONCOGENE

The 8q24 Gene Desert: An Oasis of Non-Coding Transcriptional Activity

(2012) Konrad Huppi et al.   Frontiers in Genetics

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Tumor microenvironment: becoming sick of Myc

(2011) Jonathan R. Whitfield et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Myc, Max, and Mnt: Molecular Mechanisms of Enhancement of Cholangiocarcinogenesis by Cholestasis

(2011) Ikuo Nakamura et al.   GASTROENTEROLOGY

A Mouse Model of Cholestasis-Associated Cholangiocarcinoma and Transcription Factors Involved in Progression

(2011) Heping Yang et al.   GASTROENTEROLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Myc Target miRs and Liver Cancer: Small Molecules to Get Myc Sick

(2011) Marie–Annick Buendia et al.   GASTROENTEROLOGY

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

(2011) S. Rahman et al.   MOLECULAR AND CELLULAR BIOLOGY

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

(2010) Jonghwan Kim et al.   CELL

Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma

(2010) Julia Freimuth et al.   Molecular Cancer

Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer

(2010) S. Cairo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alcohol and gastrointestinal oncology

(2010) Gianni Testino   World Journal of Gastrointestinal Oncology

Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis

(2009) P. Kaposi-Novak et al.   CANCER RESEARCH

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Alcoholic liver disease

(2009) Robert S. O'Shea et al.   HEPATOLOGY

Experimental mouse models for hepatocellular carcinoma research

(2009) Femke Heindryckx et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

microRNAs: small molecules with big roles -C. elegans to human cancer

(2008) Masaomi Kato et al.   BIOLOGY OF THE CELL

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

(2008) Stefano Cairo et al.   CANCER CELL

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

(2008) Jianxia Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance

(2008) C. M. Shachaf et al.   CANCER RESEARCH

c-Myc: Linking Transformation and Genomic Instability

(2008) Edward Prochownik   CURRENT MOLECULAR MEDICINE

c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo

(2008) C. He et al.   DEVELOPMENT

E2F1 Inhibits c-Myc-Driven Apoptosis via PIK3CA/Akt/mTOR and COX-2 in a Mouse Model of Human Liver Cancer

(2008) Sara Ladu et al.   GASTROENTEROLOGY

Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes

(2008) Heping Yang et al.   HEPATOLOGY

Max-independent functions of Myc in Drosophila melanogaster

(2008) Dominik Steiger et al.   NATURE GENETICS

miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression

(2008) M T Pickering et al.   ONCOGENE

Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis

(2008) Shelly Beer et al.   PLoS One