The Implication of PGC-1α on Fatty Acid Transport across Plasma and Mitochondrial Membranes in the Insulin Sensitive Tissues

Challenging of AS160/TBC1D4 Alters Intracellular Lipid milieu in L6 Myotubes Incubated With Palmitate

(2017) Agnieszka Mikłosz et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Defects in skeletal muscle subsarcolemmal mitochondria in a non-obese model of type 2 diabetes mellitus

(2017) Nicola Lai et al.   PLoS One

A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

(2017) Lingling Shu et al.   Nature Communications

The role of lipids in the pathogenesis and treatment of type 2 diabetes and associated co-morbidities

(2016) Derek M. Erion et al.   BMB Reports

PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B

(2016) Annika Mehlem et al.   DIABETES

Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease

(2016) Hitoshi Maruyama et al.   International Journal of Medical Sciences

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α

(2016) Jihyun Kim et al.   PLoS One

Glucocorticoids Alter CRTC-CREB Signaling in Muscle Cells: Impact on PGC-1α Expression and Atrophy Markers

(2016) Jill A. Rahnert et al.   PLoS One

The Mitochondria in Diabetic Heart Failure: From Pathogenesis to Therapeutic Promise

(2015) Joel D. Schilling   ANTIOXIDANTS & REDOX SIGNALING

Modest Decrease in Pgc1α Results in TAG Accumulation but not in Insulin Resistance in L6 Myotubes

(2015) Bartlomiej Lukaszuk et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Role of PGC-1α in the Development of Insulin Resistance in Skeletal Muscle - Revisited

(2015) Bartlomiej Łukaszuk et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation

(2015) R. B. Vega et al.   CIRCULATION RESEARCH

Metabolic roles of PGC-1α and its implications for type 2 diabetes

(2015) A. Besseiche et al.   DIABETES & METABOLISM

The hitchhiker’s guide to PGC-1α isoform structure and biological functions

(2015) Vicente Martínez-Redondo et al.   DIABETOLOGIA

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

(2015) Renáta Váraljai et al.   GENES & DEVELOPMENT

Inhibition of CeramideDe NovoSynthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance

(2015) Krzysztof Kurek et al.   Journal of Diabetes Research

Complex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal Muscle

(2015) Barbara Kupr et al.   Frontiers in Physiology

mRNA PGC-1α levels in blood samples reliably correlates with its myocardial expression: study in patients undergoing cardiac surgery

(2015) Oscar Fabregat-Andres et al.   Anatolian Journal of Cardiology

Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α

(2015) Yukino Hatazawa et al.   PLoS One

Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction

(2014) Kari E. Wong et al.   DIABETES

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor γ co-activator 1α translocation to subsarcolemmal mitochondria in skeletal muscle

(2013) Brennan K. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Protein Level of PGC-1 , a Key Metabolic Regulator, Is Controlled by NADH-NQO1

(2013) Y. Adamovich et al.   MOLECULAR AND CELLULAR BIOLOGY

The lipid peroxidation end-product and oxidant 4-hydroxynonenal induces insulin resistance in rat slow-twitch skeletal muscle

(2013) Mujalin Prasannarong et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Mitochondrial Fatty Acid Oxidation in Obesity

(2012) Dolors Serra et al.   ANTIOXIDANTS & REDOX SIGNALING

PGC-1β regulates mouse carnitine–acylcarnitine translocase through estrogen-related receptor α

(2012) Mar Gacias et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner

(2012) Serge Summermatter et al.   DIABETES

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

(2012) J. Boon et al.   DIABETES

The role of PGC-1 coactivators in aging skeletal muscle and heart

(2012) Lloye M. Dillon et al.   IUBMB LIFE

PGC-1α Induces Mitochondrial and Myokine Transcriptional Programs and Lipid Droplet and Glycogen Accumulation in Cultured Human Skeletal Muscle Cells

(2012) Emma Mormeneo et al.   PLoS One

Development of insulin resistance in mice lacking PGC-1  in adipose tissues

(2012) S. Kleiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute endurance exercise increases plasma membrane fatty acid transport proteins in rat and human skeletal muscle

(2011) Nicolette S. Bradley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Clenbuterol, a β2-adrenergic agonist, reciprocally alters PGC-1 alpha and RIP140 and reduces fatty acid and pyruvate oxidation in rat skeletal muscle

(2011) Daisuke Hoshino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity

(2011) Serge Summermatter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

(2011) F. Amati et al.   DIABETES

Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1α overexpressing mice

(2011) Joris Hoeks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increased FAT/CD36 Cycling and Lipid Accumulation in Myotubes Derived from Obese Type 2 Diabetic Patients

(2011) Celine Aguer et al.   PLoS One

Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α

(2011) Rosario Pardo et al.   PLoS One

The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells

(2010) David Álvarez-Guardia et al.   CARDIOVASCULAR RESEARCH

Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation

(2010) Pascal P. H. Hommelberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart Is Augmented by the Nuclear Receptor PPARα

(2010) Natasha H. Banke et al.   CIRCULATION RESEARCH

PGC-1 Coactivators in Cardiac Development and Disease

(2010) Glenn C. Rowe et al.   CIRCULATION RESEARCH

Peroxisome Proliferator-Activated Receptor δ Is an Essential Transcriptional Regulator for Mitochondrial Protection and Biogenesis in Adult Heart

(2010) Peiyong Wang et al.   CIRCULATION RESEARCH

Peroxisome Proliferator-Activated Receptor-  Coactivator-1  Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals

(2010) L. A. Consitt et al.   DIABETES

Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats

(2010) C. R. Benton et al.   DIABETOLOGIA

Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes

(2010) Bryan C. Bergman et al.   JOURNAL OF APPLIED PHYSIOLOGY

Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Promotes Skeletal Muscle Lipid Refuelingin Vivoby Activatingde NovoLipogenesis and the Pentose Phosphate Pathway

(2010) Serge Summermatter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid (FFA) Transport in Cardiomyocytes Revealed by Imaging Unbound FFA Is Mediated by an FFA Pump Modulated by the CD36 Protein

(2010) Andrew N. Carley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid transport across the cell membrane: Regulation by fatty acid transporters

(2010) Robert W. Schwenk et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Subsarcolemmal and intermyofibrillar mitochondria proteome differences disclose functional specializations in skeletal muscle

(2010) Rita Ferreira et al.   PROTEOMICS

In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation

(2009) Graham P. Holloway et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gene expression of PPARγ and PGC-1α in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training

(2009) Karen Ruschke et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-γ coactivator-1α and -1β in cultured myotubes

(2009) Daniel O. Espinoza et al.   FASEB JOURNAL

Differential effects of chronic, in vivo, PPAR's stimulation on the myocardial subcellular redistribution of FAT/CD36 and FABPpm

(2009) Agnieszka Kalinowska et al.   FEBS LETTERS

Greater Transport Efficiencies of the Membrane Fatty Acid Transporters FAT/CD36 and FATP4 Compared with FABPpm and FATP1 and Differential Effects on Fatty Acid Esterification and Oxidation in Rat Skeletal Muscle

(2009) James G. Nickerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation Attenuates the Function of PGC-1α

(2009) Miia M. Rytinki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle

(2008) I. Nieto-Vazquez et al.   DIABETES

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

(2008) S. Kajimura et al.   GENES & DEVELOPMENT

Rapid exercise-induced changes in PGC-1α mRNA and protein in human skeletal muscle

(2008) Anila S. Mathai et al.   JOURNAL OF APPLIED PHYSIOLOGY

Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake

(2008) Jennifer A. Calvo et al.   JOURNAL OF APPLIED PHYSIOLOGY

Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells

(2008) Teresa Coll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1α Integrates Insulin Signaling, Mitochondrial Regulation, and Bioenergetic Function in Skeletal Muscle

(2008) Ines Pagel-Langenickel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High circulating levels of RBP4 and mRNA levels of aP2, PGC-1α and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects

(2008) A. Hammarstedt et al.   JOURNAL OF INTERNAL MEDICINE

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY

Paradoxical effects of increased expression of PGC-1  on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

(2008) C. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac PPARαProtein Expression is Constant as Alternate Nuclear Receptors and PGC-1 Coordinately Increase During the Postnatal Metabolic Transition

(2008) Norman E. Buroker et al.   PPAR Research