Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants—Genotype to Cellular Phenotype
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants—Genotype to Cellular Phenotype
Authors
Keywords
-
Journal
Frontiers in Physiology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-03-14
DOI
10.3389/fphys.2017.00151
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention
- (2016) Yanhang Zhang et al. ANNALS OF BIOMEDICAL ENGINEERING
- A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy
- (2016) Jennifer Davis et al. CELL
- Genetic basis of dilated cardiomyopathy
- (2016) Alexandra Pérez-Serra et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Influence of V54M mutation in giant muscle protein titin: a computational screening and molecular dynamics approach
- (2016) D. Thirumal Kumar et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation
- (2016) A.C. Zeigler et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation
- (2016) Wenjun Zheng et al. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
- Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study
- (2016) Sukriti Dewan et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy
- (2016) Uros Kuzmanov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling
- (2016) Lorenzo R. Sewanan et al. Frontiers in Physiology
- Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization
- (2016) Mohun Ramratnam et al. PLoS One
- Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain
- (2015) William Lehman et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Contributions of Ca 2+ -Independent Thin Filament Activation to Cardiac Muscle Function
- (2015) Yasser Aboelkassem et al. BIOPHYSICAL JOURNAL
- Effects of HCM cTnI Mutation R145G on Troponin Structure and Modulation by PKA Phosphorylation Elucidated by Molecular Dynamics Simulations
- (2015) Steffen Lindert et al. BIOPHYSICAL JOURNAL
- Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs
- (2015) Monica X. Li et al. GENE
- Quantifying inter-species differences in contractile function through biophysical modelling
- (2015) Kristin Tøndel et al. JOURNAL OF PHYSIOLOGY-LONDON
- Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases
- (2014) James A. Spudich BIOPHYSICAL JOURNAL
- Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies
- (2014) Athanasia Kalyva et al. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
- Molecular Dynamics Simulations of the Cardiac Troponin Complex Performed with FRET Distances as Restraints
- (2014) Jayant James Jayasundar et al. PLoS One
- Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin
- (2014) Audrey N. Chang et al. Frontiers in Physiology
- Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca2+ sensitivity
- (2013) Massimiliano Memo et al. CARDIOVASCULAR RESEARCH
- Genetic mutations and mechanisms in dilated cardiomyopathy
- (2013) Elizabeth M. McNally et al. JOURNAL OF CLINICAL INVESTIGATION
- The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy
- (2012) Xiaochuan (Edward) Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Long-Timescale Molecular Dynamics Simulations Elucidate the Dynamics and Kinetics of Exposure of the Hydrophobic Patch in Troponin C
- (2012) Steffen Lindert et al. BIOPHYSICAL JOURNAL
- Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor
- (2012) Jeffrey R. Moore et al. CIRCULATION RESEARCH
- It’s Never Too Early to Look
- (2012) Jil C. Tardiff Circulation-Cardiovascular Genetics
- Subtle Abnormalities in Contractile Function Are an Early Manifestation of Sarcomere Mutations in Dilated Cardiomyopathy
- (2012) Neal K. Lakdawala et al. Circulation-Cardiovascular Genetics
- Correlation of Molecular and Functional Effects of Mutations in Cardiac Troponin T Linked to Familial Hypertrophic Cardiomyopathy
- (2012) Edward P. Manning et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Network Reconstruction and Systems Analysis of Cardiac Myocyte Hypertrophy Signaling
- (2012) Karen A. Ryall et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Dynamics Studies on Troponin (Tnl-TnT-TnC) Complexes: Insight into the Regulation of Muscle Contraction
- (2012) Jayson F. Varughese et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Molecular Dynamics and Docking Studies on Cardiac Troponin C
- (2012) Jayson F. Varughese et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Genetic Testing for Dilated Cardiomyopathy in Clinical Practice
- (2012) Neal K. Lakdawala et al. JOURNAL OF CARDIAC FAILURE
- Dynamics and Calcium Association to the N-Terminal Regulatory Domain of Human Cardiac Troponin C: A Multiscale Computational Study
- (2012) Steffen Lindert et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Truncations of Titin Causing Dilated Cardiomyopathy
- (2012) Daniel S. Herman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator
- (2012) Seiryo Sugiura et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
- (2012) N. Sun et al. Science Translational Medicine
- Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study
- (2012) Peter Michael Kekenes-Huskey et al. PLoS Computational Biology
- Tropomyosin Flexural Rigidity and Single Ca2+ Regulatory Unit Dynamics: Implications for Cooperative Regulation of Cardiac Muscle Contraction and Cardiomyocyte Hypertrophy
- (2012) Campion K. P. Loong et al. Frontiers in Physiology
- A Model of Calcium Activation of the Cardiac Thin Filament
- (2011) Edward P. Manning et al. BIOCHEMISTRY
- Approximation for Cooperative Interactions of a Spatially-Detailed Cardiac Sarcomere Model
- (2011) Takumi Washio et al. Cellular and Molecular Bioengineering
- Whole-Heart Modeling
- (2011) Natalia A. Trayanova CIRCULATION RESEARCH
- Functional Characterization ofTNNC1Rare Variants Identified in Dilated Cardiomyopathy
- (2011) Jose Renato Pinto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype
- (2011) S. G. Campbell et al. Journal of the Royal Society Interface
- A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload
- (2011) Roy C.P. Kerckhoffs et al. MECHANICS RESEARCH COMMUNICATIONS
- A Metabolite-Sensitive, Thermodynamically Constrained Model of Cardiac Cross-Bridge Cycling: Implications for Force Development during Ischemia
- (2010) Kenneth Tran et al. BIOPHYSICAL JOURNAL
- Coupling of Adjacent Tropomyosins Enhances Cross-Bridge-Mediated Cooperative Activation in a Markov Model of the Cardiac Thin Filament
- (2010) Stuart G. Campbell et al. BIOPHYSICAL JOURNAL
- Distribution of Electromechanical Delay in the Heart: Insights from a Three-Dimensional Electromechanical Model
- (2010) V. Gurev et al. BIOPHYSICAL JOURNAL
- Peripartum Cardiomyopathy as a Part of Familial Dilated Cardiomyopathy
- (2010) Karin Y. van Spaendonck-Zwarts et al. CIRCULATION
- Coding Sequence Rare Variants Identified in MYBPC3 , MYH6 , TPM1 , TNNC1 , and TNNI3 From 312 Patients With Familial or Idiopathic Dilated Cardiomyopathy
- (2010) Ray E. Hershberger et al. Circulation-Cardiovascular Genetics
- Ventricular Dilation and Electrical Dyssynchrony Synergistically Increase Regional Mechanical Nonuniformity But Not Mechanical Dyssynchrony
- (2010) Roy C.P. Kerckhoffs et al. Circulation-Heart Failure
- Late Onset Sporadic Dilated Cardiomyopathy Caused by a Cardiac Troponin T Mutation
- (2010) Ana Morales et al. CTS-Clinical and Translational Science
- A Dilated Cardiomyopathy Troponin C Mutation Lowers Contractile Force by Reducing Strong Myosin-Actin Binding
- (2010) David Dweck et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Myofilament length dependent activation
- (2010) Pieter P. de Tombe et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coil
- (2010) Xiaochuan (Edward) Li et al. JOURNAL OF STRUCTURAL BIOLOGY
- Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation
- (2010) Neal K. Lakdawala et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis
- (2010) Serdar Göktepe et al. JOURNAL OF THEORETICAL BIOLOGY
- Analysis of the sarcomere protein gene mutation on cardiomyopathy – Mutations in the cardiac troponin I gene
- (2010) Chikako Murakami et al. Legal Medicine
- Three-Wall Segment (TriSeg) Model Describing Mechanics and Hemodynamics of Ventricular Interaction
- (2009) Joost Lumens et al. ANNALS OF BIOMEDICAL ENGINEERING
- Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy
- (2009) Sebastian Carballo et al. CIRCULATION RESEARCH
- Clinical and Functional Characterization of TNNT2 Mutations Identified in Patients With Dilated Cardiomyopathy
- (2009) Ray E. Hershberger et al. Circulation-Cardiovascular Genetics
- The Shape and Flexibility of Tropomyosin Coiled Coils: Implications for Actin Filament Assembly and Regulation
- (2009) Xiaochuan (Edward) Li et al. JOURNAL OF MOLECULAR BIOLOGY
- The Dilated Cardiomyopathy G159D Mutation in Cardiac Troponin C Weakens the Anchoring Interaction with Troponin I†
- (2008) Olga K. Baryshnikova et al. BIOCHEMISTRY
- A Novel Mutant Cardiac Troponin C Disrupts Molecular Motions Critical for Calcium Binding Affinity and Cardiomyocyte Contractility
- (2008) Chee Chew Lim et al. BIOPHYSICAL JOURNAL
- Approximate Model of Cooperative Activation and Crossbridge Cycling in Cardiac Muscle Using Ordinary Differential Equations
- (2008) John Jeremy Rice et al. BIOPHYSICAL JOURNAL
- Challenging Current Paradigms Related to Cardiomyopathies
- (2008) David Dweck et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C
- (2008) Andrew P. Landstrom et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The Role of Cardiac Troponin T Quantity and Function in Cardiac Development and Dilated Cardiomyopathy
- (2008) Ferhaan Ahmad et al. PLoS One
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now