Article
Multidisciplinary Sciences
Alejandro Pizzoni, Xuefeng Zhang, Nyla Naim, Daniel L. Altschuler
Summary: cAMP, traditionally thought to originate solely from the plasma membrane, can also be generated from internalized GsPCRs. In this study, the endogenously expressed TSHR was found to trigger internalization-dependent sAC activation, leading to PKA activation and cell proliferation. Inhibition of nuclear sAC impaired nuclear cAMP accumulation, PKA activation, and cell proliferation, while increased expression of nuclear sAC enhanced cell proliferation. These findings suggest a novel three-wave model in which the third wave of cAMP, generated by nuclear sAC, is sufficient and rate-limiting for thyroid cell proliferation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Xin Gao, Chenguang Wang, Suhaib Abdelrahman, Nermin Kady, Carlos Murga-Zamalloa, Peter Gann, Maria Sverdlov, Ashley Wolfe, Avery Polk, Noah Brown, Nathanael G. Bailey, Kedar Inamdar, Sandro Casavilca-Zambrano, Jaime Montes, Carlos Barrionuevo, Luis Taxa, John Reneau, Christian W. Siebel, Ivan Maillard, Ryan A. Wilcox
Summary: Notch signaling pathway plays a crucial role in the pathogenesis of peripheral T-cell lymphoma, and Notch1 activation is associated with proliferation. Blockade of Notch1/Notch2 and DLL1/DLL4 can inhibit the proliferation of malignant T cells and tumor progression.
Article
Hematology
Derek B. Oien, Samanta Sharma, Maureen M. Hattersley, Michelle DuPont, Steven W. Criscione, Laura Prickett, Anne U. Goeppert, Lisa Drew, Yi Yao, Jingwen Zhang, Ho Man Chan
Summary: The combination of AZD5153 and acalabrutinib enhances the efficacy of treatment for ABC-DLBCL by regulating PAX5 and BCR mechanisms, inhibiting cell growth and metastasis.
Article
Biochemistry & Molecular Biology
Xuehua Li, Jacob Kordsmeier, Intawat Nookaew, Ha-Neui Kim, Jinhu Xiong
Summary: In this study, the researchers found that the mechanically sensitive ion channel Piezo1 plays a critical role in mitochondrial adaptation to mechanical stimulation. They also discovered that cAMP signaling contributes to the increase in mitochondrial oxidative phosphorylation (OXPHOS) induced by activation of Piezo1.
Article
Biology
Peng Yang, Yaohui Chen, Zhiqi Huang, Huidan Xia, Ling Cheng, Hao Wu, Yueling Zhang, Fan Wang
Summary: By using single-cell RNA-seq, this study identified three major cell types in the white shrimp hemolymph and discovered a novel macrophage-like subset. The findings suggest that this subset plays a critical role in immune responses to infectious diseases in shrimp.
Article
Medicine, Research & Experimental
Andrea N. Mazzarello, Eva Gentner-Goebel, Marcus Duehren-von Minden, Tatyana N. Tarasenko, Antonella Nicolo, Gerardo Ferrer, Stefano Vergani, Yun Liu, Davide Bagnara, Kanti R. Rai, Jan A. Burger, Peter J. McGuire, Palash C. Maity, Hassan Jumaa, Nicholas Chiorazzi
Summary: This study found that IgM plays a critical and selective role in BCR signaling and B cell fate decisions in chronic lymphocytic leukemia (CLL), which may open up new avenues for CLL therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Navchaa Gombodorj, Yoko Azuma, Takehiko Yokobori, Bilguun Erkhem-Ochir, Takayuki Kosaka, Yoichi Ohtaki, Seshiru Nakazawa, Akira Mogi, Toshiki Yajima, Hiroyuki Kuwano, Hiroshi Saeki, Ken Shirabe
Summary: This study found that RAB11A regulates the FGFR signaling pathway and is a strong predictor of poor prognosis in lung squamous cell carcinoma (LSCC) patients. Additionally, overexpression of RAB11A promotes cell proliferation and invasion, while suppresses RAB11A has the opposite effect.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Karren Dai Yang, Anastasiya Belyaeva, Saradha Venkatachalapathy, Karthik Damodaran, Abigail Katcoff, Adityanarayanan Radhakrishnan, G. Shivashankar, Caroline Uhler
Summary: The authors use autoencoders to learn a probabilistic coupling and map different data modalities to a shared latent space, presenting an approach for integrating vastly different modalities. The integration of imaging and transcriptomics is still an open challenge, but this method provides a framework for diverse applications in biomedical discovery.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Huayuan Tang, Yali Li, Shijia Wang, Jing Ji, Xiangbin Zhu, Yutong Bao, Can Huang, Ye Luo, Lei Huang, Yan Gao, Chaoliang Wei, Jie Liu, Xi Fang, Lu Sun, Kunfu Ouyang
Summary: Emerging evidence suggests that metabolic regulation plays a critical role in B cell activation and function, and Ca2+ signaling and calcineurin may regulate B cell metabolism by activating metabolic reprogramming. Both IP3R-mediated Ca2+ signaling and calcineurin contribute to the regulation of oxidative phosphorylation and glycolysis in stimulated B cells, affecting glucose uptake, glycolytic enzyme expression, and mitochondrial remodeling, which in turn influence cell cycle entry and survival. These findings have important implications for understanding the pathogenesis of immune-related disorders associated with genetic defects in IP3R.
Article
Cell Biology
Tong Gao, Peng Yang, Dongliang Fu, Mengru Liu, Xinyi Deng, Mingjing Shao, Jiangquan Liao, Hong Jiang, Xianlun Li
Summary: Allicin has a protective effect on myocardial ischemia-reperfusion injury, which may be associated with inhibiting Ca2+ overload-induced apoptosis and the PI3K-mediated GRK2/PLC-gamma/IP3R signaling pathway.
Article
Oncology
Joseph B. Hiatt, Holly Sandborg, Sarah M. Garrison, Henry U. Arnold, Sheng-You Liao, Justin P. Norton, Travis J. Friesen, Feinan Wu, Kate D. Sutherland, Hugh Y. Rienhoff Jr, Renato Martins, A. McGarry Houghton, Shivani Srivastava, David MacPherson
Summary: This study found that the combination of LSD1 inhibitor and PD-1 inhibitor can enhance the treatment response in SCLC, leading to increased CD8 T cell infiltration, tumor growth inhibition, and increased MHC-I expression, thus increasing the killing activity of tumor-specific T cells.
CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Bingbing Wu, Yu Li, Nanfang Nie, Xilin Shen, Wei Jiang, Yanshan Liu, Lin Gong, Chengrui An, Kun Zhao, Xudong Yao, Chunhui Yuan, Jinghui Hu, Wei Zhao, Jianhua Qian, XiaoHui Zou
Summary: Our study characterized the cells of human uterus using single cell RNA-sequencing, revealing the cell heterogeneity and population architecture of uterine tissues during the menstrual cycle. We identified a subpopulation of SFRP4(+) stromal cells that play a role in the regeneration of endometrial epithelial cells and injury repair.
Review
Cell Biology
Bari Aamna, Aritra Kumar Dan, Raghaba Sahu, Santosh Kumar Behera, Sagarika Parida
Summary: beta-Arrestins are intracellular proteins with various functions, playing roles in GPCR desensitization, receptor endocytosis, and ubiquitylation. They also act as adaptor proteins, controlling the recruitment, activation, and scaffolding of signaling complexes, and participate in cellular processes such as proliferation, migration, apoptosis, and transcription. Additionally, their involvement in cancer onset and progression has been recognized.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Luana S. Lenz, Juliano L. Faccioni, Paula A. Bracco, Jephesson A. F. Santos, Luiza C. Pereira, Julieti H. Buss, Mauricio T. Tamborindeguy, Daphne Torgo, Thayana Monteiro, Giovana B. Mantovani, Carolina N. Santo, Julia C. Marcolin, Eloisa Dalsin, Alvaro Vigo, Sidia M. Callegari-Jacques, Andrew O. Silva, Giovana R. Onzi, Karine R. Begnini, Guido Lenz
Summary: The fitness of cancer cells in colony formation is dynamic, influenced by factors such as ERK activity, cell-cycle duration, and DNA repair capacity. Colonies exhibit dynamic resistance to drugs, indicating an adaptability to drug presence.
Article
Cell Biology
Yujie Liu, Ao Leng, Lin Li, Bo Yang, Shihui Shen, Hui Chen, Enhao Zhu, Qiyue Xu, Xiaoyu Ma, Peilin Shi, Yun Liu, Tielong Liu, Lei Li, Kun Li, Dan Zhang, Jianru Xiao
Summary: The study identifies TRPM8 as a potential therapeutic target in osteosarcoma and demonstrates the antitumoral effects of the TRPM8 antagonist, AMTB. AMTB suppresses osteosarcoma cell proliferation and metastasis, induces cellular apoptosis, and increases sensitivity to cisplatin. The mechanism involves the repression of the TGF beta signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Desiree Massberg, Annika Simon, Dieter Haeussinger, Verena Keitel, Guenter Gisselmann, Heike Conrad, Hanns Hatt
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2015)
Article
Neurosciences
Sara Letzner, Annika Simon, Onur Guentuerkuen
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Oncology
Desiree Massberg, Nikolina Jovancevic, Anne Offermann, Annika Simon, Aria Baniahmad, Sven Perner, Thanakorn Pungsrinont, Katarina Luko, Stathis Philippou, Burkhard Ubrig, Markus Heiland, Lea Weber, Janine Altmueller, Christian Becker, Guenter Gisselmann, Lian Gelis, Hanns Hatt
Article
Cell Biology
Michaela Matthey, Richard Roberts, Alexander Seidinger, Annika Simon, Ralf Schroeder, Markus Kuschak, Suvi Annala, Gabriele M. Koenig, Christa E. Mueller, Ian P. Hall, Evi Kostenis, Bernd K. Fleischmann, Daniela Wenzel
SCIENCE TRANSLATIONAL MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Vanessa Neumann, Ralf Knies, Alexander Seidinger, Annika Simon, Kristina Lorenz, Michaela Matthey, Johannes Breuer, Daniela Wenzel
Article
Dermatology
Sebastian Wojcik, Daniel Weidinger, Sonja Staender, Thomas Luger, Hanns Hatt, Nikolina Jovancevic
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Physiology
Daniel Weidinger, Nikolina Jovancevic, Denise Zwanziger, Sarah Theurer, Judith Hoenes, Dagmar Fuehrer, Hanns Hatt
Summary: This study found that olfactory receptors (ORs) expressed in healthy and malignant thyroid tissues have an impact on physiological processes such as migration, proliferation, and invasion.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniel Weidinger, Kaschin Jamal Jameel, Desiree Alisch, Julian Jacobsen, Paul Buerger, Matthias Ruhe, Faisal Yusuf, Simon Rohde, Klemens Stoertkuhl, Peter Kaufmann, Juliane Kronsbein, Marcus Peters, Hanns Hatt, Nikolaos Giannakis, Juergen Knobloch
Summary: This study identified the expression of olfactory receptors (ORs) in human primary alveolar macrophages and investigated their role in pathophysiological processes, suggesting their potential as therapeutic targets. Stimulation of these ORs led to a reduction in phagocytic capacity and release of proinflammatory cytokines, indicating their potential use in treating steroid-resistant lung diseases with non-type 2 inflammation.
MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Annika Simon, Thomas von Einem, Alexander Seidinger, Michaela Matthey, Laura Bindila, Daniela Wenzel
Summary: Chronic obstructive airway diseases are a global burden that is expected to increase. The authors demonstrate the role of anandamide (AEA), an endocannabinoid, in inducing airway relaxation. They identify the source of AEA-induced relaxation and highlight its potential as a therapeutic target for airway relaxation.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jonghui Kim, Karla Hegener, Claudia Hagedorn, Kaschin Jamal Jameel, Daniel Weidinger, Inga Marte Charlott Seuthe, Sabine Eichhorn, Florian Kreppel, Juergen Knobloch, Jonas Jae-Hyun Park
Summary: Epithelial cells from cryopreserved tissue showed comparable outgrowth, proliferation, and functionality to that of fresh tissue. This study established a method for long-term cryopreservation of polyp tissue, enabling the isolation and cell culture of primary epithelial cells at a later time. The availability of epithelial cells could be greatly improved by including this method in a biobank.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
