Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma

Concomitant Use of Panobinostat and Reirradiation in Progressive DIPG

(2017) Zhihong J. Wang et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

(2017) Faizaan Mohammad et al.   NATURE MEDICINE

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

(2017) Andrea Piunti et al.   NATURE MEDICINE

Robot-Assisted Stereotactic Biopsy of Diffuse Intrinsic Pontine Glioma: A Single-Center Experience

(2017) Andrea Carai et al.   World Neurosurgery

Role of adaptive radiation therapy for pediatric patients with diffuse pontine glioma

(2017) Chris Beltran et al.   Journal of Applied Clinical Medical Physics

Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models

(2017) Tammy Hennika et al.   PLoS One

Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma

(2016) Amy Bredlau et al.   Current Neuropharmacology

Investigational new drugs for brain cancer

(2016) Verena Staedtke et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3

(2016) M. Wiese et al.   KLINISCHE PADIATRIE

The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors

(2016) Jiao Chen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations

(2015) David A. Solomon et al.   BRAIN PATHOLOGY

Surgical approaches for brainstem tumors in pediatric patients

(2015) Sergio Cavalheiro et al.   CHILDS NERVOUS SYSTEM

Biopsy in a series of 130 pediatric diffuse intrinsic Pontine gliomas

(2015) Stephanie Puget et al.   CHILDS NERVOUS SYSTEM

Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition

(2015) Isabella C. Taylor et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Panobinostat active against diffuse intrinsic pontine glioma

(2015) Sanjeet Bagcchi   LANCET ONCOLOGY

Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

(2015) Y. Chornenkyy et al.   MOLECULAR CANCER THERAPEUTICS

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

(2015) Catherine S Grasso et al.   NATURE MEDICINE

Prospects of immune checkpoint modulators in the treatment of glioblastoma

(2015) Matthias Preusser et al.   Nature Reviews Neurology

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent

(2015) Kyle G. Halvorson et al.   PLoS One

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

(2015) Michael Christoph Haffner et al.   Oncotarget

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft

(2015) Alexandra Borodovsky et al.   Oncotarget

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

(2015) Sevin Turcan et al.   Oncotarget

Subventricular spread of diffuse intrinsic pontine glioma

(2014) Viola Caretti et al.   ACTA NEUROPATHOLOGICA

Diffuse intrinsic pontine glioma: a reassessment

(2014) Nathan J. Robison et al.   JOURNAL OF NEURO-ONCOLOGY

Strategy for “Detoxification” of a Cancer-Derived Histone Mutant Based on Mapping Its Interaction with the Methyltransferase PRC2

(2014) Zachary Z. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

(2014) Pawel Buczkowicz et al.   NATURE GENETICS

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

(2014) Kathryn R Taylor et al.   NATURE GENETICS

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

(2014) Liwei Zhang et al.   NATURE GENETICS

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

(2014) Adam M Fontebasso et al.   NATURE GENETICS

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

(2014) Yujie Tang et al.   NATURE MEDICINE

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

(2014) Rintaro Hashizume et al.   NATURE MEDICINE

Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma

(2014) U. Bartels et al.   NEURO-ONCOLOGY

Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma

(2014) Nathalène Truffaux et al.   NEURO-ONCOLOGY

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized trial on radiotherapy for paediatric diffuse intrinsic pontine glioma (DIPG)

(2014) Daniel E. Roos et al.   RADIOTHERAPY AND ONCOLOGY

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

(2014) H.-M. Herz et al.   SCIENCE

Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes

(2013) Amanda M. Saratsis et al.   ACTA NEUROPATHOLOGICA

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

(2013) Sebastian Bender et al.   CANCER CELL

Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

(2013) B. S. Paugh et al.   CANCER RESEARCH

Poisoning the “histone code” in pediatric gliomagenesis

(2013) Peter W. Lewis et al.   CELL CYCLE

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

(2013) P. Bandopadhayay et al.   CLINICAL CANCER RESEARCH

Histone variants in pluripotency and disease

(2013) P. J. Skene et al.   DEVELOPMENT

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

(2013)   NATURE GENETICS

Phase I trial of capecitabine rapidly disintegrating tablets and concomitant radiation therapy in children with newly diagnosed brainstem gliomas and high-grade gliomas

(2013) Lindsay B. Kilburn et al.   NEURO-ONCOLOGY

In Vitro Drug Response and Efflux Transporters Associated with Drug Resistance in Pediatric High Grade Glioma and Diffuse Intrinsic Pontine Glioma

(2013) Susanna J. E. Veringa et al.   PLoS One

PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma

(2013) Kelly L. Barton et al.   PLoS One

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN

(2013) Lynn Bjerke et al.   Cancer Discovery

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

(2013) Alexandre Puissant et al.   Cancer Discovery

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts

(2012) G. J. Kitange et al.   CLINICAL CANCER RESEARCH

Motexafin-Gadolinium and Involved Field Radiation Therapy for Intrinsic Pontine Glioma of Childhood: A Children's Oncology Group Phase 2 Study

(2012) Kristin A. Bradley et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas

(2012) Gordon Li et al.   JOURNAL OF NEURO-ONCOLOGY

B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma

(2012) Zhiping Zhou et al.   JOURNAL OF NEURO-ONCOLOGY

WEE1 Kinase Inhibition Enhances the Radiation Response of Diffuse Intrinsic Pontine Gliomas

(2012) V. Caretti et al.   MOLECULAR CANCER THERAPEUTICS

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

(2012) Paul A. Northcott et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

(2012) Ian Maze et al.   NEUROPSYCHOPHARMACOLOGY

Pediatric brainstem gangliogliomas show overexpression of neuropeptide prepronociceptin (PNOC) by microarray and immunohistochemistry

(2012) Michael H. Chan et al.   PEDIATRIC BLOOD & CANCER

Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas

(2012) Stephanie Puget et al.   PLoS One

Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma

(2012) Brent A. Orr et al.   PLoS One

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

(2011) Till Milde et al.   ACTA NEUROPATHOLOGICA

Palliative Reirradiation for Progressive Diffuse Intrinsic Pontine Glioma

(2011) Hiral P. Fontanilla et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Nanoparticle-based Drug Delivery Systems for Solid Brain Tumors

(2011) Bin Feng et al.   Current Nanoscience

The molecular classification of medulloblastoma

(2011) Sarah E.S. Leary et al.   CURRENT OPINION IN PEDIATRICS

Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG

(2011) Ute Bartels et al.   JOURNAL OF NEURO-ONCOLOGY

Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anderson Cancer Center experience

(2011) Johannes E. Wolff et al.   JOURNAL OF NEURO-ONCOLOGY

A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study

(2011) Katherine E. Warren et al.   JOURNAL OF NEURO-ONCOLOGY

A Comparative Study of Neural and Mesenchymal Stem Cell-Based Carriers for Oncolytic Adenovirus in a Model of Malignant Glioma

(2011) Atique U. Ahmed et al.   MOLECULAR PHARMACEUTICS

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas

(2011) D. A. Haas-Kogan et al.   NEURO-ONCOLOGY

A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: A report from the Pediatric Brain Tumor Consortium

(2011) I. F. Pollack et al.   NEURO-ONCOLOGY

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma

(2010) Alberto Broniscer et al.   CANCER

Overview of Cellular Immunotherapy for Patients with Glioblastoma

(2010) Elodie Vauleon et al.   Clinical & Developmental Immunology

Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor α and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets

(2010) Maryam Zarghooni et al.   JOURNAL OF CLINICAL ONCOLOGY

Lack of Efficacy of Bevacizumab Plus Irinotecan in Children With Recurrent Malignant Glioma and Diffuse Brainstem Glioma: A Pediatric Brain Tumor Consortium Study

(2010) Sridharan Gururangan et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease

(2010) Barbara S. Paugh et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Therapeutic efficacy and safety of TRAIL-producing human adipose tissue-derived mesenchymal stem cells against experimental brainstem glioma

(2010) S. A. Choi et al.   NEURO-ONCOLOGY

Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas

(2010) Jennifer Barrow et al.   NEURO-ONCOLOGY

Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

(2010) B. Geoerger et al.   NEURO-ONCOLOGY

Characterization and outcomes of infratentorial malignant glioma: A population-based study using the Surveillance Epidemiology and End-Results database

(2010) Justin Rineer et al.   RADIOTHERAPY AND ONCOLOGY

Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells

(2009) Ji S. Park et al.   BIOMATERIALS

Bevacizumab as Therapy for Radiation Necrosis in Four Children With Pontine Gliomas

(2009) Arthur K. Liu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The Epidermal Growth Factor Variant III Peptide Vaccine for Treatment of Malignant Gliomas

(2009) Gordon Li et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles

(2009) Fan Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the IDH1 codon 132 mutation in brain tumors

(2008) Jörg Balss et al.   ACTA NEUROPATHOLOGICA

Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma

(2008) L. Ellis et al.   CLINICAL CANCER RESEARCH

Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo

(2008) M A Tyler et al.   GENE THERAPY

Natural history and management of brainstem gliomas in adults

(2008) A. Salmaggi et al.   JOURNAL OF NEUROLOGY

In vivo tracking of superparamagnetic iron oxide nanoparticle–labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging

(2008) Xing Wu et al.   JOURNAL OF NEUROSURGERY

Diffusion tensor imaging of brainstem tumors: axonal degeneration of motor and sensory tracts

(2008) Kathleen J. Helton et al.   Journal of Neurosurgery-Pediatrics

Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: A Children's Oncology Group phase I study

(2008) Kristin A. Bradley et al.   NEURO-ONCOLOGY

Concurrent radiotherapy with temozolomide followed by adjuvant temozolomide and cis-retinoic acid in children with diffuse intrinsic pontine glioma

(2008) Nongnuch Sirachainan et al.   NEURO-ONCOLOGY

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE