Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Qi Zhou, Xiaozhen Lv, Shuzhe Zhou, Qi Liu, Hongjun Tian, Kerang Zhang, Jing Wei, Gang Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Cuixia An, Nan Zhang, Yu Huang, Tianmei Si, Xin Yu, Chuan Shi
Summary: Inflammation and cognition are related to major depressive disorder (MDD). Treatment response in MDD patients is associated with different cognitive defects, especially in speed of processing and executive function. Factors such as smoking, alcohol drinking, baseline cognitive performance, and cytokine levels may influence treatment response.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Mingxia Liu, Wen Ma, Yi He, Zuoli Sun, Jian Yang
Summary: This review summarizes the recent developments of mass spectrometry (MS)-based metabolomics in major depressive disorder (MDD) research, including analytical platforms, strategies, key metabolite changes, and antidepressant treatments. The study provides new insights into the pathophysiology, diagnosis, treatment, and prognosis of MDD.
Article
Clinical Neurology
Tomiki Sumiyoshi, Tatsuya Hoshino, Izumi Mishiro, Lene Hammer-Helmich, Holly Ge, Yoshiya Moriguchi, Keita Fujikawa, Jovelle L. Fernandez
Summary: Early improvement in depressive symptoms predicts better cognitive outcomes in patients with Major Depressive Disorder (MDD). Grouping patients by mood and cognition status in early stages of antidepressant treatments may help improve long-term functional outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Chiara Fabbri, Giuseppe Fanelli, Raffaella Zanardi, Markus Dold, Alexander Kautzky, Dan Rujescu, Daniel Souery, Julien Mendlewicz, Joseph Zohar, Stuart Montgomery, Alessandro Serretti, Siegfried Kasper
Summary: A study found that European patients who were prescribed NaSSAs as first-line antidepressant treatment had characteristics such as older age, male gender, unemployment, additional melancholic and catatonic features, inpatient treatment, lower dosages of antidepressants but higher rates of augmentation with low-potency antipsychotics, and greater reductions of depressive symptoms during their current major depressive episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Daniele Cavaleri, Federico Moretti, Alessandra Bartoccetti, Stefano Mauro, Cristina Crocamo, Giuseppe Carra, Francesco Bartoli
Summary: Based on meta-analyses, this overview suggests that the brain-derived neurotrophic factor (BDNF) may serve as a potential biomarker for major depressive disorder (MDD) and antidepressant response. People with MDD show lower peripheral and central BDNF levels compared to non-depressed individuals, and blood BDNF levels are negatively correlated with symptom severity. Antidepressant treatment can lead to increased blood BDNF levels, proportional to symptom improvement, while non-pharmacological interventions do not affect BDNF concentrations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Zaiquan Dong, Weihong Kuang, Xiaoling Shen, Liantian Tian
Summary: This study found a correlation between plasma IL-6 levels and treatment outcomes of selective serotonin reuptake inhibitors in patients with major depressive disorder (MDD). Patients with lower baseline IL-6 levels were more likely to respond positively to treatment. A negative correlation was also found between baseline IL-6 levels and the reduction rate of HAMD-17 scores after treatment.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Lisha Zhou, Yingying Zhu, Wangyang Chen, Yiping Tang
Summary: miRNAs act as key regulators of synaptic plasticity in the pathogenesis of MDD, and accumulating evidence suggests that peripheral miRNAs may serve as potential biomarkers for MDD diagnosis and antidepressant response. Targeting miRNAs directly could be therapeutically beneficial for MDD, but further research is needed to fully understand their role in MDD pathogenesis and treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Yanran Zhang, Xiaoyun Liu, Zhenghua Hou, Yingying Yin, Chunming Xie, Haisan Zhang, Hongxing Zhang, Youyong Kong, Shuwen Gao, Zhijun Zhang, Yonggui Yuan
Summary: The study found that both MDD patients and NCs have small-world brain networks, but MDD patients have lower clustering coefficient and local efficiency. The characteristic path length is negatively correlated with the antidepressant response in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Francesco Benedetti, Sara Poletti, Benedetta Vai, Mario Gennaro Mazza, Cristina Lorenzi, Silvia Brioschi, Veronica Aggio, Igor Branchi, Cristina Colombo, Roberto Furlan, Raffaella Zanardi
Summary: This study found that certain inflammatory biomarkers, particularly IL-1 beta and TNF-alpha, have predictive value in determining response to antidepressants, with high levels of IL-1 beta predicting non-response and TNF-alpha showing significant negative effects.IL-12 weakly predicted response to antidepressants.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Xiaofeng Lan, Yanling Zhou, Fengchun Wu, Kai Wu, Yanni Zhan, Chengyu Wang, Wei Zheng, Min Yu, Xiurong Deng, Yuping Ning
Summary: The study found that multiple cytokines were elevated in drug naïve MDD patients. After antidepressant treatment, most cytokines levels normalized. Furthermore, baseline ITAC level may serve as a predictive factor for antidepressant response.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Immunology
Yayun Xu, Jun Liang, Yanhong Sun, Yuanyuan Zhang, Feng Shan, Jinfang Ge, Qingrong Xia
Summary: This study investigates the differences in serum cytokine levels between patients with major depressive disorder (MDD) and healthy controls. It is found that several cytokines can serve as biomarkers for diagnosing MDD and predicting antidepressant response. Additionally, changes in cytokine levels are observed after treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Shui Tian, Qiang Wang, Siqi Zhang, Zhilu Chen, Zhongpeng Dai, Wei Zhang, Zhijian Yao, Qing Lu
Summary: This study used magnetoencephalography (MEG) to explore the neuro-electrophysiological features of major depressive disorder (MDD) at baseline and predicted their early antidepressant response. The results showed that patients with early response (ER) exhibited increased functional couplings across brain regions after treatment, which were significantly correlated with severity of depressive symptoms. The study highlighted the identification ability of large-scale couplings biomarkers in early antidepressant response prediction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Michael C. Flux, David G. Smith, John J. B. Allen, Matthias R. Mehl, Andi Medrano, Tommy K. Begay, Brandon H. Middlemist, Brandon M. Marquart, Steven P. Cole, Christina J. Sauder, Christopher A. Lowry, Charles L. Raison
Summary: This study aimed to explore the acute and longer-term immune effects of whole-body hyperthermia (WBH) in patients with major depressive disorder (MDD), and to investigate whether these effects are associated with the antidepressant properties of WBH. The results showed that WBH produced a rapid and sustained improvement in depressive symptoms, and immediately increased the concentration of interleukin (IL)-6. No significant effects were observed on other cytokines. In the entire sample, the increased IL-6 levels post-treatment were associated with a reduction in depression scores over 6 weeks of follow-up.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Tianyu Wang, Lei Li, Yingying Yue, Xiaoyun Liu, Suzhen Chen, Tian Shen, Zhi Xu, Yonggui Yuan
Summary: This study investigates the influence of P11 gene DNA methylation and life stress on the response to antidepressants in patients with major depressive disorder. The results show that the methylation of the P11 gene is significantly higher in patients with major depressive disorder, and the interaction between P11 DNA methylation and early-life stress may affect the response to short-term antidepressant treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Andre S. L. M. Antunes, Veronica M. Saia-Cereda, Fernanda Crunfli, Daniel Martins-de-Souza
Summary: The 14-3-3 family is involved in various processes in neurological disorders, particularly in relation to dopamine and glutamate theories in schizophrenia. However, a more comprehensive understanding of their role is still needed.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Prabhjot Dhami, Lena C. Quilty, Benjamin Schwartzmann, Rudolf Uher, Timothy A. Allen, Stefan Kloiber, Raymond W. Lam, Glenda MacQueen, Benicio N. Frey, Roumen Milev, Daniel J. Mueller, Stephen C. Strother, Pierre Blier, Claudio N. Soares, Sagar V. Parikh, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Faranak Farzan
Summary: The neurobiological correlates of response inhibition can predict the response of patients with major depressive disorder (MDD) to pharmacological and cognitive behavioral therapy treatment. The integrity of response inhibition may be crucial for the success of treatment for MDD. Electrophysiological correlates of response inhibition may serve as a general prognostic marker for treatment response in MDD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Biographical-Item
Chemistry, Analytical
Daniel Martins-de-Souza
BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Osnat C. Melamed, Sumeet Kalia, Rahim Moineddin, Michelle Greiver, Stefan Kloiber, Benoit H. Mulsant, Peter Selby, Braden G. O'Neill
Summary: This study aims to identify demographic, socioeconomic and medical factors associated with the initiation of antidepressant medication in adult patients with diabetes. The study found that younger age, female gender, insulin treatment, and polypharmacy were associated with higher odds of antidepressant initiation. Patients also had increased visits to primary care after antidepressant initiation.
CANADIAN JOURNAL OF DIABETES
(2023)
Meeting Abstract
Clinical Neurology
Leen Magarbeh, Claudia Hassel, Maximilian Choi, Farhana Islam, Victoria S. Marshe, Clement C. Zai, Roseann S. Gammal, Stefan Kloiber, James L. Kennedy, Sidney H. Kennedy, Chad A. Bousman, Daniel J. Mueller
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pablo Trindade, Juliana Minardi Nascimento, Barbara S. Casas, Tomas Monteverde, Juciano Gasparotto, Camila Tiefensee Ribeiro, Sylvie Devalle, Daniela Sauma, Jose Claudio Fonseca Moreira, Daniel Pens Gelain, Lisiane O. Porciuncula, Veronica Palma, Daniel Martins-de-Souza, Stevens K. Rehen
Summary: This study examined the proteome, inflammatory responses, and secretome effects of astrocytes derived from schizophrenia patients. The findings suggest that these astrocytes exhibit molecular and functional abnormalities, affecting immune function and vascularization. Reduced expression of NF-kappa B p65 subunit was observed, and the secretion of interleukin 8 (IL-8) was particularly elevated. The conditioned medium from these astrocytes could reduce the diameter of newly grown vessels.
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Helena Kyunghee Kim, Suman Banik, Muhammad Ishrat Husain, Victor Tang, Robert Levitan, Zafiris J. J. Daskalakis, Stefan Kloiber
Summary: Structured care pathways (SCPs) show promise in improving outcomes for patients with mood disorders. This systematic review found that SCPs may be equally or more effective than treatment as usual for depressive disorders and bipolar disorder (BD). Further research is needed to confirm their effectiveness and assess factors influencing their feasibility and success.
Review
Pharmacology & Pharmacy
Leen Magarbeh, Claudia Hassel, Maximilian Choi, Farhana Islam, Victoria S. Marshe, Clement C. Zai, Rayyan Zuberi, Roseann S. Gammal, Xiaoyu Men, Maike Scherf-Clavel, Dietmar Enko, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stephen C. Strother, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Stefan Kloiber, James L. Kennedy, Sidney H. Kennedy, Chad A. Bousman, Daniel J. Muller
Summary: In this study, the association between six ABCB1 single-nucleotide polymorphisms (SNPs) and antidepressant treatment outcomes was investigated through a systematic review and meta-analysis. No significant association was found between ABCB1 SNPs and antidepressant treatment outcomes in the CAN-BIND-1 sample. However, a significant association between rs1128503 and treatment response was observed in the meta-analysis. These findings provide limited evidence for the implementation of ABCB1 genotyping to inform antidepressant treatment.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Clinical Neurology
Giuliana S. S. Zuccoli, Juliana M. M. Nascimento, Pedro M. M. Moraes-Vieira, Stevens K. K. Rehen, Daniel Martins-de-Souza
Summary: Schizophrenia is a severe neurodevelopmental psychiatric disorder affecting around 1% of the global population. Proteomic studies on neural stem cells and neurons derived from induced pluripotent stem cells from schizophrenia patients have revealed differentially expressed proteins related to mitochondrial function, cell cycle control, DNA repair, and neuritogenesis. Functional analysis of neural stem cells also showed alterations in mitochondrial oxygen consumption and higher levels of intracellular reactive oxygen species in schizophrenia-derived cells.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Katharina Lechner, Sarah Heel, Manfred Uhr, Tatjana Dose, Florian Holsboer, Susanne Lucae, Ludwig Schaaf, Stephany Fulda, Stefan Kloiber, Johannes M. Hennings
Summary: This study found that the use of mirtazapine, a commonly prescribed antidepressant, is associated with weight gain and dyslipidemia. Despite highly controlled conditions, including diet and physical activity, the administration of mirtazapine negatively affects lipid metabolism in healthy men. This is the first study to demonstrate adverse changes in lipid metabolism under mirtazapine in healthy individuals.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Psychiatry
Marta M. Maslej, Stefan Kloiber, Marzyeh Ghassemi, Joanna Yu, Sean L. Hill
Summary: Advancements in AI have led to the development of clinical support tools in psychiatry, but it is important to understand how psychiatrists will respond to AI-based information, especially if it is incorrect. An experiment was conducted to examine psychiatrists' perceptions of AI-based tools for treating major depressive disorder (MDD). The findings suggest that psychiatrists prefer human-derived clinical support tools.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Farhana Islam, Leen Magarbeh, Samar S. M. Elsheikh, Stefan Kloiber, Caroline W. Espinola, Venkat Bhat, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Rudolf Uher, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Daniel J. Mueller
Summary: Treatment-emergent sexual dysfunction is a common issue in individuals with major depressive disorder on antidepressants. This study found that polymorphisms in genes encoding drug-metabolizing enzymes and the transmembrane efflux pump were associated with changes in sexual function and satisfaction. Specifically, CYP2C19 metabolizer phenotypes were linked to changes in sexual arousal, and higher concentrations of the escitalopram metabolite, S-desmethylcitalopram, were associated with a decline in sexual function and satisfaction in females.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Biology
Natalia S. Brunetti, Gustavo G. Davanzo, Diogo de Moraes, Allan J. R. Ferrari, Gabriela F. Souza, Stefanie Primon Muraro, Thiago L. Knittel, Vinicius O. Boldrini, Lauar B. Monteiro, Joo Victor Virgilio-da-Silva, Gerson S. Profeta, Natalia S. Wassano, Luana Nunes Santos, Victor C. Carregari, Artur H. S. Dias, Flavio P. Veras, Lucas A. Tavares, Julia Forato, Icaro M. S. Castro, Licia C. Silva-Costa, Andre C. Palma, Eli Mansour, Raisa G. Ulaf, Ana F. Bernardes, Thyago A. Nunes, Luciana C. Ribeiro, Marcus V. Agrela, Maria Luiza Moretti, Lucas I. Buscaratti, Fernanda Crunfli, Raissa G. Ludwig, Jaqueline A. Gerhardt, Natalia Munhoz-Alves, Ana Maria Marques, Renata Sesti-Costa, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Pierina Lorencini Parise, Matheus Cavalheiro Martini, Karina Bispos-dos-Santos, Camila L. Simeoni, Fabiana Granja, Virginia C. Silvestrini, Eduardo B. de Oliveira, Vitor M. Faca, Murilo Carvalho, Bianca G. Castelucci, Alexandre B. Pereira, Lais D. Coimbra, Marieli M. G. Dias, Patricia B. Rodrigues, Arilson Bernardo S. P. Gomes, Fabricio B. Pereira, Leonilda M. B. Santos, Louis-Marie Bloyet, Spencer Stumpf, Marjorie C. Pontelli, Sean Whelan, Andrei C. Sposito, Robson F. Carvalho, Andre S. Vieira, Marco A. R. Vinolo, Andre Damasio, Licio Velloso, Ana Carolina M. Figueira, Luis L. P. da Silva, Thiago Mattar Cunha, Helder I. Nakaya, Henrique Marques-Souza, Rafael E. Marques, Daniel Martins-de-Souza, Munir S. Skaf, Jose Luiz Proenca-Modena, Pedro M. M. Moraes-Vieira, Marcelo A. Mori, Alessandro S. Farias
Summary: Research has found that SARS-CoV-2 mainly infects T helper cells (CD4+), but not T cells (CD8+). The infected T helper cells express higher levels of IL-10, which may contribute to viral persistence and increased disease severity, leading to poor immune response in COVID-19 patients.
Review
Neurosciences
Andre S. L. M. Antunes, Daniel Martins-de-Souza
Summary: Neuroscience is a challenging research field due to the complexity of the mammalian nervous system. Recent technological advances in single-cell RNA sequencing have greatly improved our understanding of neurodevelopment and neurological disorders.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Article
Psychiatry
Helena K. Kim, Vanessa F. Gonsalves, Muhammad I. Husain, Daniel J. Mueller, Benoit H. Mulsant, Gwyneth Zai, Stefan Kloiber
Summary: The study investigates the association between the endocannabinoid system (ECS) and multiple mental disorders using a cross-disorder genome-wide association study (GWAS) meta-analysis. The findings suggest that the ECS may be a shared pathway in mental disorders. Nine single nucleotide polymorphisms (SNPs) were identified as significantly associated with a change in risk of having a mental disorder, with the DAGLA gene showing the strongest association.
PSYCHIATRY RESEARCH
(2023)