Methodological issues associated with clinical trials in epilepsy

Which outcomes should we measure in adult epilepsy trials? The views of people with epilepsy and informal carers

(2016) A.J. Noble et al.   EPILEPSY & BEHAVIOR

Conversion to eslicarbazepine acetate monotherapy

(2016) Michael R. Sperling et al.   NEUROLOGY

Preventing epileptogenesis: A realistic goal?

(2016) Gaetano Terrone et al.   PHARMACOLOGICAL RESEARCH

Challenges in the clinical development of new antiepileptic drugs

(2016) Valentina Franco et al.   PHARMACOLOGICAL RESEARCH

Confusing placebo effect with natural history in epilepsy: A big data approach

(2015) Daniel M. Goldenholz et al.   ANNALS OF NEUROLOGY

Brivaracetam in Unverricht-Lundborg disease (EPM1): Results from two randomized, double-blind, placebo-controlled studies

(2015) Reetta Kälviäinen et al.   EPILEPSIA

Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: A randomized historical-control phase III study based in North America

(2015) Michael R. Sperling et al.   EPILEPSIA

The promise of futility trials in neurological diseases

(2015) Marcus W. Koch et al.   Nature Reviews Neurology

Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy

(2015) Jacqueline A. French et al.   NEUROLOGY

Novel Methods and Technologies for 21st-Century Clinical Trials

(2015) E. Ray Dorsey et al.   JAMA Neurology

Antiepileptogenesis in humans

(2014) Eugen Trinka et al.   CURRENT OPINION IN NEUROLOGY

Conversion to lacosamide monotherapy in the treatment of focal epilepsy: Results from a historical-controlled, multicenter, double-blind study

(2014) Robert T. Wechsler et al.   EPILEPSIA

Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial

(2014) J. French et al.   NEUROLOGY

Progressive myoclonic epilepsies: Definitive and still undetermined causes

(2014) S. Franceschetti et al.   NEUROLOGY

Anti-epileptogenic Clinical Trial Designs in Epilepsy: Issues and Options

(2014) Dieter Schmidt et al.   Neurotherapeutics

Past and Present Definitions of Epileptogenesis and Its Biomarkers

(2014) Asla Pitkänen et al.   Neurotherapeutics

Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study

(2013) Mark J Cook et al.   LANCET NEUROLOGY

Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: Results of randomized global phase III study 305

(2012) Jacqueline A. French et al.   EPILEPSIA

Seizure diaries for clinical research and practice: Limitations and future prospects

(2012) Robert S. Fisher et al.   EPILEPSY & BEHAVIOR

Levetiracetam extended release conversion to monotherapy for the treatment of patients with partial-onset seizures: A double-blind, randomised, multicentre, historical control study

(2012) Steve Chung et al.   EPILEPSY RESEARCH

Clinical trials for therapeutic assessment of antiepileptic drugs in the 21st century: obstacles and solutions

(2012) Daniel Friedman et al.   LANCET NEUROLOGY

Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial

(2012) Michel Baulac et al.   LANCET NEUROLOGY

Patterns of treatment response in newly diagnosed epilepsy

(2012) M. J. Brodie et al.   NEUROLOGY

Trial Design: How Do We Figure Out if an AED Works

(2012) Jacqueline A. French   Epilepsy Currents

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

Lamotrigine XR Conversion to Monotherapy: First Study Using a Historical Control Group

(2011) Jacqueline A. French et al.   Neurotherapeutics

Epilepsy surgery, antiepileptic drug trials, and the role of evidence

(2010) Jozsef Janszky et al.   EPILEPSIA

Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial

(2010) Steve Chung et al.   EPILEPSIA

Historical control monotherapy design in the treatment of epilepsy

(2010) Jacqueline A. French et al.   EPILEPSIA

Does lacosamide aggravate Lennox–Gastaut syndrome? Report on three consecutive cases

(2010) Antonella Cuzzola et al.   EPILEPSY & BEHAVIOR

Lennox–Gastaut syndrome in adulthood: Clinical and EEG features

(2010) Edoardo Ferlazzo et al.   EPILEPSY RESEARCH

Placebo responses in randomized trials of antiepileptic drugs

(2009) A.B. Guekht et al.   EPILEPSY & BEHAVIOR

Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study

(2009) Jakob Christensen et al.   LANCET

Designing Clinical Trials to Assess Antiepileptic Drugs as Monotherapy

(2008) Emilio Perucca   CNS DRUGS

Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology

(2008) Alexis Arzimanoglou et al.   LANCET NEUROLOGY

Randomized, controlled, dose-ranging trial of carisbamate for partial-onset seizures

(2008) E. Faught et al.   NEUROLOGY