Overcoming Linsitinib intrinsic resistance through inhibition of nuclear factor-κ B signaling in esophageal squamous cell carcinoma

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Regulatory Network of MicroRNAs, Host Genes, Target Genes and Transcription Factors in Human Esophageal Squamous Cell Carcinoma

(2015) Tian-Yan Wang et al.   Asian Pacific Journal of Cancer Prevention

Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study

(2015) Martin Fassnacht et al.   LANCET ONCOLOGY

Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells

(2015) Y. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Impact of IGF-1, IGF-1R, and IGFBP-3 promoter methylation on the risk and prognosis of esophageal carcinoma

(2015) Peng Ye et al.   TUMOR BIOLOGY

Can we unlock the potential of IGF-1R inhibition in cancer therapy?

(2014) Helen King et al.   CANCER TREATMENT REVIEWS

Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors

(2014) R. L. Jones et al.   CLINICAL CANCER RESEARCH

A Phase I Study of Continuous Oral Dosing of OSI-906, a Dual Inhibitor of Insulin-Like Growth Factor-1 and Insulin Receptors, in Patients with Advanced Solid Tumors

(2014) I. Puzanov et al.   CLINICAL CANCER RESEARCH

Antitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma

(2014) Tiehong Zhang et al.   Scientific Reports

NF- B Regulates Radioresistance Mediated By  1-Integrin in Three-Dimensional Culture of Breast Cancer Cells

(2013) K. M. Ahmed et al.   CANCER RESEARCH

Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models

(2013) S. A. Flanigan et al.   CLINICAL CANCER RESEARCH

Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumors

(2013) Francesca Cavallo et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma

(2013) Yasushi Adachi et al.   TUMOR BIOLOGY

IGF-1R as an anti-cancer target--trials and tribulations

(2013) Helen X. Chen et al.   Chinese Journal of Cancer

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

(2013) P. Godwin et al.   Frontiers in Oncology

A Novel Small Molecule Inhibitor of FAK and IGF-1R Protein Interactions Decreases Growth of Human Esophageal Carcinoma

(2012) Deniz A. Ucar et al.   Anti-Cancer Agents in Medicinal Chemistry

Targeting the Fas/FasL signaling pathway in cancer therapy

(2012) María Villa-Morales et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Clinical development of insulin-like growth factor receptor—1 (IGF-1R) inhibitors: At the crossroad?

(2012) Andrea Gombos et al.   INVESTIGATIONAL NEW DRUGS

Neoadjuvant versus adjuvant treatment: which one is better for resectable esophageal squamous cell carcinoma?

(2012) Yaping Xu et al.   World Journal of Surgical Oncology

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

(2011) Alberto S. Pappo et al.   JOURNAL OF CLINICAL ONCOLOGY

Dual Targeting of the Insulin-Like Growth Factor and Collateral Pathways in Cancer: Combating Drug Resistance

(2011) Joseph A. Ludwig et al.   Cancers

Anti-apoptosis and cell survival: A review

(2010) Liam Portt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting the Insulin-like Growth Factor Receptor-1R Pathway for Cancer Therapy

(2010) J. Zha et al.   CLINICAL CANCER RESEARCH

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

(2009) A Gualberto et al.   ONCOGENE

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

(2007) Mark J. Mulvihill et al.   BIOORGANIC & MEDICINAL CHEMISTRY