Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease

ExoCarta: A Web-Based Compendium of Exosomal Cargo

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Understanding the Role of miR-33 in Brain Lipid Metabolism: Implications for Alzheimer's Disease

(2016) Florence Jaouen et al.   JOURNAL OF NEUROSCIENCE

miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer׳s disease

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Heparanase activates the syndecan-syntenin-ALIX exosome pathway

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Therapeutic Effects of Transplantation of As-MiR-937-Expressing Mesenchymal Stem Cells in Murine Model of Alzheimer's Disease

(2015) Zhen Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA

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Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

(2015) Ismael Santa-Maria et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of peroxisome proliferator-activated receptors (PPAR) α and -γ of rat brain astrocytes in the course of activation by toll-like receptor agonists

(2015) Dmitry V. Chistyakov et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation

(2015) Li-Hua Sun et al.   JOURNAL OF NEUROCHEMISTRY

microRNA-33 Regulates ApoE Lipidation and Amyloid-  Metabolism in the Brain

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Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease

(2015) BIN ZHANG et al.   Molecular Medicine Reports

MicroRNA-29c targets β-site amyloid precursor protein-cleaving enzyme 1 and has a neuroprotective role in vitro and in vivo

(2015) GUOSHUAI YANG et al.   Molecular Medicine Reports

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Transmembrane proteins of the tight junctions at the blood–brain barrier: Structural and functional aspects

(2015) Reiner F. Haseloff et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epigenomics of Alzheimer's disease

(2015) David A. Bennett et al.   Translational Research

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications

(2015) Julieta De Toro et al.   Frontiers in Immunology

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: The need of larger datasets

(2014) Pierre Lau et al.   AGEING RESEARCH REVIEWS

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease

(2014) Federica Agosta et al.   ANNALS OF NEUROLOGY

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

Synaptic and Cognitive Improvements by Inhibition of 2-AG Metabolism Are through Upregulation of MicroRNA-188-3p in a Mouse Model of Alzheimer's Disease

(2014) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer’s disease

(2014) CHEN-GENG LIU et al.   Molecular Medicine Reports

MicroRNAs in Neuronal Communication

(2014) Guilherme Shigueto Vilar Higa et al.   MOLECULAR NEUROBIOLOGY

Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

(2014) L Cheng et al.   MOLECULAR PSYCHIATRY

Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons

(2014) Belinda J. Goldie et al.   NUCLEIC ACIDS RESEARCH

Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release

(2014) Laura Facci et al.   Scientific Reports

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

(2014) Danijela Koppers-Lalic et al.   Cell Reports

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination

(2013) Aya D. Pusic et al.   GLIA

Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

(2013) Aarthi Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination

(2013) Aya D. Pusic et al.   JOURNAL OF NEUROIMMUNOLOGY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Synthetic nucleic acids delivered by exosomes: a potential therapeutic for generelated metabolic brain diseases

(2013) Rutao Liu et al.   METABOLIC BRAIN DISEASE

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies

(2013) Lesley Cheng et al.   Frontiers in Genetics

Exosomes as nano-theranostic delivery platforms for gene therapy

(2012) Aaron Tan et al.   ADVANCED DRUG DELIVERY REVIEWS

Urinary miR-21, miR-29, and miR-93: Novel Biomarkers of Fibrosis

(2012) Gang Wang et al.   AMERICAN JOURNAL OF NEPHROLOGY

The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

(2012) Saumya Pant et al.   BIOCHEMICAL PHARMACOLOGY

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

(2012) N. Ismail et al.   BLOOD

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction

(2012) G Hu et al.   Cell Death & Disease

Emerging Roles of Exosomes in Neuron–Glia Communication

(2012) Carsten Frühbeis et al.   Frontiers in Physiology

Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons

(2011) J. Qi et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation

(2011) Malika Bsibsi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Upregulation of Micro RNA-146a (miRNA-146a), A Marker for Inflammatory Neurodegeneration, in Sporadic Creutzfeldt–Jakob Disease (sCJD) and Gerstmann–Straussler–Scheinker (GSS) Syndrome

(2011) W. J. Lukiw et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

SiRNA delivery with exosome nanoparticles

(2011) Jasper G van den Boorn et al.   NATURE BIOTECHNOLOGY

MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed

(2010) Justin M. Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration

(2010) Sébastien S. Hébert et al.   HUMAN MOLECULAR GENETICS

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-Like Receptor Tolerance as a Mechanism for Neuroprotection

(2010) Keri B. Vartanian et al.   Translational Stroke Research

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY