Article
Medicine, Research & Experimental
Shibo Zhang, Bingfan Xie, Lijie Wang, Hua Yang, Haopei Zhang, Yuming Chen, Feng Wang, Changqing Liu, Huanhuan He
Summary: The research revealed that M2 macrophages regulate the vascular barrier through the VCAM1/RAC1/ROS/p-PYK2/p-VE-cad cascade, providing specific therapeutic targets for the treatment of malignant ascites.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Clinical Neurology
Aurelie Leboyan, Florence Esselin, Anne-Laure Bascou, Claire Duflos, Ioana Ion, Mahmoud Charif, Giovanni Castelnovo, Clarisse Carra-Dalliere, Xavier Ayrignac, Philippe Kerschen, Mohamed Chbicheb, Ludovic Nguyen, Alexandre T. J. Maria, Philippe Guilpain, Mathilde Carriere, Nicolas Menjot de Champfleur, Thierry Vincent, Alexandre Jentzer, Pierre Labauge, Jerome J. Devaux, Guillaume Taieb
Summary: Various immune diseases can involve both the central nervous system and peripheral nervous system. The type of immune disease can be determined based on clinical, electrophysiological, and radiological features.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hao Wang, Dongyue Zhang, Xiaoxi Cui, Yibo Dai, Chenchen Wang, Wenli Feng, Xiaoqian Lv, Yifei Li, Lina Wang, Yongxin Ru, Yingchi Zhang, Qian Ren, Guoguang Zheng
Summary: This study investigates the intrinsic effects of interferon regulatory factor 7 (IRF7) in acute myeloid leukemia (AML) and identifies a potential strategy to control central nervous system myeloid leukemia. The absence of IRF7 accelerates disease progression and AML cell invasion in the brain, while overexpression of IRF7 reduces cell proliferation and leukemia stem cell levels. Furthermore, blocking the VCAM1-VLA-4 axis delays disease progression and attenuates intracerebral invasion of AML cells.
Article
Biochemistry & Molecular Biology
Kazufumi Ohmura, Takamasa Kinoshita, Hiroyuki Tomita, Hideshi Okada, Masayoshi Shimizu, Kosuke Mori, Toshiaki Taniguchi, Akio Suzuki, Toru Iwama, Akira Hara
Summary: The study found that Vincristine-induced peripheral neuropathy can be improved by protecting the endothelial glycocalyx. The results suggest that nafamostat may be a potential new drug for the treatment of VIPN.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Clinical Neurology
Nathalie Deschamps, Stephane Mathis, Mathilde Duchesne, Karima Ghorab, Gael Gallouedec, Laurence Richard, Jean-Marc Boulesteix, Philippe Corcia, Laurent Magy, Jean-Michel Vallat
Summary: CIDP is an immune-mediated disease that may be associated with various hemopathies. This study analyzed 21 patients with both CIDP and hemopathies, all of whom fulfilled the diagnostic criteria for CIDP and had compatible nerve biopsy results. It is important to consider CIDP in cases of peripheral neuropathy and malignant hemopathy, as CIDP is accessible to appropriate therapies with potential positive clinical responses. Collaboration between neurologists, hematologists, and oncologists is crucial for the management of such patients.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Abhishek Shastri, Ahmad Al Aiyan, Uday Kishore, Maria Elena Farrugia
Summary: Dysfunction of the immune system can lead to peripheral nervous system damage. The immune mechanisms involve inflammation and proliferation of Schwann cells and result in demyelination and axonal degeneration. Animal models have contributed to understanding the pathophysiology of inflammatory polyradiculoneuropathies. Detection of specific antibodies aids in diagnosis. Paraneoplastic neuropathies are immune-mediated reactions to tumor cells. This review discusses the immunological and pathophysiological mechanisms, as well as the electrophysiological characteristics, laboratory features, and treatment options of dysimmune neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Bashdar Mahmud Hussen, Fwad Nicknafs, Hazha Jamal Hidayat, Arezou Sayad, Soudeh Ghafouri-Fard, Mohammad Taheri
Summary: Long non-coding RNAs have been found to be significantly downregulated in individuals with acute and chronic inflammatory demyelinating polyneuropathy, regardless of gender. While there were significant correlations among certain lncRNAs in healthy subjects, these correlations were not observed in cases with AIDP and CIDP. Combining multiple lncRNAs could be a sensitive and specific diagnostic panel for acquired immune-mediated polyneuropathies, with high diagnostic power values for differentiation between cases and controls.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Ruihua Sun, Junkui Shang, Xi Yan, Jingran Zhao, Wan Wang, Wenjing Wang, Wei Li, Chenhao Gao, Fengyu Wang, Haohan Zhang, Yanliang Wang, Huixia Cao, Jiewen Zhang
Summary: Chronic cerebral hypoperfusion (CCH) is associated with neuronal loss and blood-brain barrier (BBB) impairment in vascular dementia (VaD). This study aimed to explore the relationship and molecular mechanisms between BBB dysfunction and neuronal loss. Using a rat model, the authors observed the pathological changes of cortical neurons and BBB following CCH. Transcriptome analysis of cortical microvessels revealed that vascular inflammation-related processes mainly occurred in the chronic phase, and the adhesion molecule VCAM1 played an important role.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Marta Ruiz, Marco Puthenparampil, Marta Campagnolo, Francesca Castellani, Alessandro Salvalaggio, Susanna Ruggero, Elisabetta Toffanin, Mario Cacciavillani, Paolo Gallo, Diego Franciotta, Chiara Briani
Summary: CIDP, GBS, and anti-MAG antibody neuropathies had significantly increased CSF protein and blood-spinal nerve root barrier damage compared with NINP. Intrathecal humoral immune response was rare in CIDP patients, while systemic oligoclonal activation was more frequent, but not significantly different from the control groups.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Sonja Koerner, Markus Maximilian Koch, Lars Hendrik Mueschen, Tabea Seeliger, Olivia Schreiber-Katz, Stefan Gingele, Martin Stangel, Reinhard Dengler, Susanne Petri, Thomas Skripuletz, Alma Osmanovic
Summary: This study assessed cranial nerve involvement in immune-mediated neuropathy patients undergoing immunoglobulin treatment by measuring blink reflex R1 latency prolongation. It identified prolonged R1 latencies in 23 out of 104 patients, who had more severe functional impairments and limited clinical presentation. The study highlights the potential of blink reflex studies to detect subclinical cranial nerve involvement and calls for further research on the clinical utility of measuring R1 latency.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Veterinary Sciences
Ninja Kolb, Kaspar Matiasek, Jana van Renen, Andrea Fischer, Yury Zablotski, Franziska Wielaender, Jasmin Nessler, Andrea Tipold, Rodolfo Cappello, Thomas Flegel, Shenja Loderstedt, Josephine Dietzel, Kirsten Gnirs, Kai Rentmeister, Stephan Rupp, Thilo von Klopmann, Frank Steffen, Konrad Jurina, Omar V. Del Vecchio, Martin Deutschland, Florian Koenig, Gualtiero Gandini, Tom Harcourt-Brown, Marion Kornberg, Ezio Bianchi, Teresa Gagliardo, Marika Menchetti, Henning Schenk, Joana Tabanez, Marco Rosati
Summary: The study investigates the prognostic biopsy findings in cats with inflammatory polyradiculoneuropathy, aiming to identify histologic features that are correlated with outcome. Hierarchical k-means clustering was performed to classify tissue samples into different categories, and the impact of histological parameters on outcome was evaluated. The study provides valuable insights into the prognosis of feline IMPN.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Clinical Neurology
Chiara Briani, Dario Cocito, Marta Campagnolo, Pietro Emiliano Doneddu, Eduardo Nobile-Orazio
Summary: Chronic immune-mediated neuropathies, including CIDP, neuropathies associated with monoclonal gammopathy, and MMN, can be treated with immune therapies that vary in effectiveness, such as steroids, plasma exchange, and IVIg or SCIg immunoglobulins. New biological agents like rituximab have shown promise in treating neuropathy associated with IgM monoclonal gammopathy and are being tested for CIDP.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Fabian Preisner, Kalliopi Pitarokoili, Benjamin Lueling, Jeremias Motte, Anna Lena Fisse, Thomas Grueter, Tim Godel, Daniel Schwarz, Sabine Heiland, Ralf Gold, Martin Bendszus, Moritz Kronlage
Summary: This study evaluated the effectiveness of MRN for the longitudinal assessment of patients with CIDP. The results showed that changes in nerve cross-sectional area and fractional anisotropy can reflect the clinical and electrophysiological course of CIDP patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Immunology
Mohammad Taheri, Somayeh Sangseifid, Pariya Shahani, Mohammad Mahdi Eftekharian, Shahram Arsang-Jang, Soudeh Ghafouri-Fard
Summary: This study found that the expression levels of SOCS1 and SOCS2 were significantly lower in male CIDP patients compared with controls, with a sex-specific pattern also observed for SOCS3 down-regulation. The diagnostic powers of SOCS1, SOCS2, SOCS3, and SOCS5 genes in the mentioned disorder were 0.61, 0.73, 0.68, and 0.58 respectively. None of the gene expressions were correlated with the age of enrolled cases. The study provides evidence for the involvement of SOCS genes in the pathophysiology of acquired immune-mediated polyneuropathies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Junji Ikeda, Yasuhiro Shimojima, Akira Yamada, Yoshiki Sekijima
Summary: This study found that in patients with immune-mediated HP, the volume of contrast-enhanced dura mater was higher, particularly in the convexity, cranial fossa, and tentorium cerebelli regions; patients with cranial nerve VIII neuropathy had significantly higher volume of contrast-enhanced dura mater in the cranial fossa; the volume of contrast-enhanced dura mater in the tentorium cerebelli was positively correlated with CSF protein levels.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Genetics & Heredity
Jean-Michel Vallat, Cyril Goizet, Laurent Magy, Stephane Mathis
JOURNAL OF MEDICAL GENETICS
(2016)
Article
Clinical Neurology
Mathilde Duchesne, Laurent Magy, Laurence Richard, Pierre Ingrand, Jean-Philippe Neau, Stephane Mathis, Jean-Michel Vallat
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2016)
Letter
Clinical Neurology
Stephane Mathis, Cyril Goizet, Meriem Tazir, Laurent Magy, Jean-Michel Vallat
ANNALS OF NEUROLOGY
(2016)
Review
Clinical Neurology
Flavien Bessaguet, Laurent Magy, Alexis Desmouliere, Claire Demiot
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2016)
Review
Clinical Neurology
Jean-Michel Vallat, Laurent Magy, Jonathan Ciron, Philippe Corcia, Gwendal Le Masson, Stephane Mathis
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2016)
Review
Immunology
Stephane Mathis, Jean-Michel Vallat, Laurent Magy
Article
Clinical Neurology
Paul O'Connor, Giancarlo Comi, Mark S. Freedman, Aaron E. Miller, Ludwig Kappos, Jean-Pierre Bouchard, Christine Lebrun-Frenay, Jan Mares, Myriam Benamor, Karthinathan Thangavelu, Jinjun Liang, Philippe Truffinet, Victoria J. Lawson, Jerry S. Wolinsky
Article
Clinical Neurology
Laetitia Barbin, Chloe Rousseau, Natacha Jousset, Romain Casey, Marc Debouverie, Sandra Vukusic, Jerome De Seze, David Brassat, Sandrine Wiertlewski, Bruno Brochet, Jean Pelletier, Patrick Vermersch, Gilles Edan, Christine Lebrun-Frenay, Pierre Clavelou, Eric Thouvenot, Jean-Philippe Camdessanche, Ayman Tourbah, Bruno Stankoff, Abdullatif Al Khedr, Philippe Cabre, Caroline Papeix, Eric Berger, Olivier Heinzlef, Thomas Debroucker, Thibault Moreau, Olivier Gout, Bertrand Bourre, Alain Creange, Pierre Labauge, Laurent Magy, Gilles Defer, Yohann Foucher, David A. Laplaud
Article
Clinical Neurology
Maxime Jouaud, Pierre-Marie Gonnaud, Laurence Richard, Philippe Latour, Elisabeth Ollagnon-Roman, Franck Sturtz, Stephane Mathis, Laurent Magy, Jean-Michel Vallat
NEUROMUSCULAR DISORDERS
(2016)
Correction
Genetics & Heredity
Shahram Attarian, Jean-Michel Vallat, Laurent Magy, Benoit Funalot, Pierre-Marie Gonnaud, Arnaud Lacour, Yann Pereon, Odile Dubourg, Jean Pouget, Joelle Micallef, Jerome Franques, Marie-Noelle Lefebvre, Karima Ghorab, Mahmoud Al-Moussawi, Vincent Tiffreau, Marguerite Preudhomme, Armelle Magot, Laurene Leclair-Visonneau, Tanya Stojkovic, Laura Bossi, Philippe Lehert, Walter Gilbert, Viviane Bertrand, Jonas Mandel, Aude Milet, Rodolphe Hajj, Lamia Boudiaf, Catherine Scart-Gres, Serguei Nabirotchkin, Mickael Guedj, Ilya Chumakov, Daniel Cohen
ORPHANET JOURNAL OF RARE DISEASES
(2016)
Article
Multidisciplinary Sciences
Celine Dogan, Marie De Antonio, Dalil Hamroun, Hugo Varet, Marianne Fabbro, Felix Rougier, Khadija Amarof, Marie-Christine Arne Bes, Anne-Laure Bedat-Millet, Anthony Behin, Remi Bellance, Francoise Bouhour, Celia Boutte, Francois Boyer, Emmanuelle Campana-Salort, Francoise Chapon, Pascal Cintas, Claude Desnuelle, Romain Deschamps, Valerie Drouin-Garraud, Xavier Ferrer, Helene Gervais-Bernard, Karima Ghorab, Pascal Laforet, Armelle Magot, Laurent Magy, Dominique Menard, Marie-Christine Minot, Aleksandra Nadaj-Pakleza, Sybille Pellieux, Yann Pereon, Marguerite Preudhomme, Jean Pouget, Sabrina Sacconi, Guilhem Sole, Tanya Stojkovich, Vincent Tiffreau, Andoni Urtizberea, Christophe Vial, Fabien Zagnoli, Gilbert Caranhac, Claude Bourlier, Gerard Riviere, Alain Geille, Romain K. Gherardi, Bruno Eymard, Jack Puymirat, Sandrine Katsahian, Guillaume Bassez
Article
Clinical Neurology
J-M Vallat, C. Goizet, M. Tazir, P. Couratier, L. Magy, S. Mathis
REVUE NEUROLOGIQUE
(2016)
Review
Clinical Neurology
Flavien Bessaguet, Laurent Magy, Alexis Desmouliere, Claire Demiot
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2016)
Review
Clinical Neurology
Jean-Michel Vallat, Laurent Magy, Jonathan Ciron, Philippe Corcia, Gwendal Le Masson, Stephane Mathis
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2016)
Article
Biochemistry & Molecular Biology
Laurent Magy, Pauline Chazelas, Laurence Richard, Nathalie Deschamps, Simon Frachet, Jean-Michel Vallat, Corinne Magdelaine, Frederic Favreau, Flavien Bessaguet, Anne-Sophie Lia, Mathilde Duchesne
Summary: CANVAS is a rare disorder characterized by late-onset ataxia and autosomal recessive inheritance. This study investigated eight patients with sensory neuropathy and/or an unexplained cough who showed symptoms of CANVAS, emphasizing the importance of early diagnosis. The findings reveal that chronic cough and neuropathic pain can be significant impairments in these patients, suggesting the need for early recognition to avoid unnecessary immunotherapy.
