Article
Biochemistry & Molecular Biology
Christodoula Kourtidou, Konstantinos Tziomalos
Summary: Diabetic kidney disease (DKD) is the main cause of chronic kidney disease, with a multifactorial pathogenesis involving multiple molecular pathways. Recent studies have shown that histone modification plays a crucial role in the development and progression of DKD. Histone modification is believed to induce oxidative stress, inflammation, and fibrosis in the diabetic kidney. This review provides a summary of the current understanding of the association between histone modification and DKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Heng-Cheng Lu, Wen-Ni Dai, Li-Yu He
Summary: Diabetic kidney disease (DKD) is a major complication of diabetes mellitus, affecting a significant percentage of patients with type 1 and type 2 diabetes. Current treatments can alleviate but not prevent the progression of DKD into end-stage renal disease (ESRD). The disease is influenced by both genetic and environmental factors, with emerging research suggesting a role for epigenetic mechanisms such as histone post-translational modifications.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Chemistry, Medicinal
Dan Zhang, Jifa Zhang, Yuxi Wang, Guan Wang, Pan Tang, Yun Liu, Yiwen Zhang, Liang Ouyang
Summary: Parkinson's disease (PD) is a multifactorial disease caused by a complex interplay between genetic and epigenetic factors. Recent studies have revealed the epigenetic mechanisms involved in PD, such as DNA methylation, histone modifications, and microRNA (miRNA) regulation. Epigenetic regulators could be potential therapeutic targets in neurodegenerative disorders. This review summarizes the mechanisms of epigenetic regulation in PD and discusses the use of inhibitors and activators of these regulators, as well as the neuroprotective effects of small molecule epigenetic modulators. Additionally, the contribution of miRNAs to the underlying mechanisms of PD and miRNA-based therapies are also discussed.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Sarah A. Bowden, Euan J. Rodger, Aniruddha Chatterjee, Michael R. Eccles, Cherie Stayner
Summary: ADPKD is a heritable renal disease caused by uncontrolled cyst growth in the kidneys, leading to end-stage kidney disease, with limited therapeutic options available. Due to similarities with neoplasia, research suggests that ADPKD kidneys may have alterations in their epigenetic landscape.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Yuqing Zhang, De Jin, Xiaomin Kang, Rongrong Zhou, Yuting Sun, Fengmei Lian, Xiaolin Tong
Summary: The review discusses the pathological mechanisms of diabetic renal fibrosis and related signaling pathways to provide novel therapeutic intervention insights for clinical research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna Gluba-Sagr, Beata Franczyk, Magdalena Rysz-Gorzynska, Janusz Lawinski, Jacek Rysz
Summary: Chronic kidney disease is a significant health concern, with renal fibrosis being a major mechanism of renal dysfunction. MicroRNAs play important roles in the development of fibrosis and chronic kidney disease. However, the effects and regulation of miRNAs may vary in different tissues and cells.
Review
Biochemistry & Molecular Biology
Irina Bure, Marina Nemtsova, Ekaterina B. Kuznetsova
Summary: In recent years, scientists have increasingly suggested and confirmed that epigenetic regulators are closely linked and form a comprehensive network of regulatory pathways and feedback loops. This is particularly important for a better understanding of the development and progression of various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Wen Zheng, Jia Guo, Zhang-Suo Liu
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes, influenced by genetic and environmental factors. Epigenetic modifications play a crucial role in DKD development and may offer new therapeutic avenues for intervention.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev
Summary: Epigenetic changes associated with histone modifications are important in the emergence and maintenance of various cancer types. Inhibitors of enzymes involved in these modifications are promising for anticancer drug development. This review explores the main features of common histone modifications and their role in malignant neoplasms, discussing strategies for inhibitor development and analyzing the use of multitarget drugs as the most promising strategy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Medicine, General & Internal
Ye Cheng, Yanna Chen, Guodong Wang, Pei Liu, Guiling Xie, Huan Jing, Hongtao Chen, Youlin Fan, Min Wang, Jun Zhou
Summary: This review discusses the relationship between chronic kidney disease (CKD) and diabetic kidney disease (DKD), with a focus on the role of protein methylation. It summarizes the current clinical research status and explores the potential application of protein methyltransferase (PMT) inhibitors in DKD treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Yuqing Zhang, De Jin, Yingying Duan, Yuehong Zhang, Liyun Duan, Fengmei Lian, Xiaolin Tong
Summary: This study provides a comprehensive and visualized view of research on diabetic renal fibrosis (DRF), revealing emerging trends and hotspots. It has important implications for future research.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Shuqin Mei, Lin Li, Xiangjun Zhou, Cheng Xue, Man J. Livingston, Qingqing Wei, Bing Dai, Zhiguo Mao, Changlin Mei, Zheng Dong
Summary: Diabetes enhances kidney fibrosis by enhancing HIF-1 activation, leading to impaired kidney repair. In diabetic mice, unilateral ureteral obstruction induces more renal fibrosis, apoptosis, and interstitial macrophage infiltration. High glucose-conditioned renal tubular cells show higher expression of fibrosis marker protein under hypoxia, which is mediated by increased HIF-1α expression. Knockout of proximal tubule-specific HIF-1α attenuates fibrosis induced by UUO in diabetic mice kidneys.
Review
Endocrinology & Metabolism
Zhe Liu, Jiahui Liu, Wanning Wang, Xingna An, Ling Luo, Dehai Yu, Weixia Sun
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes and a leading cause of mortality. It is characterized by proteinuria and decreased renal function. Currently available treatments and biomarkers only offer limited efficacy in slowing disease progression, hence the need for novel therapeutic methods, targets, and biomarkers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Dan-Dan Liu, Chao-Yang Zhang, Jing-Ting Zhang, Li-Min Gu, Guo-Tong Xu, Jing-Fa Zhang
Summary: Epigenetics focuses on gene regulation mechanisms beyond the DNA sequence, such as DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs. Recent studies have shown that despite tight control of glucose levels, epigenetic modifications play a role in the development and progression of diabetic retinopathy. However, the underlying mechanisms of these modifications are still not well understood.
NEURAL REGENERATION RESEARCH
(2023)
Review
Medicine, Research & Experimental
Zhuo Li, Jia Li, Xiao Miao, Wenpeng Cui, Lining Miao, Lu Cai
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in obesity-related renal injury, exerting renal protection by modulating lipid metabolism, autophagy, oxidative stress, and other pathways. Further investigation is needed to explore the mechanisms of AMPK in renal diseases.
Article
Medicine, Research & Experimental
Lihua Liu, Aosong Duan, Qiaoyan Guo, Guangdong Sun, Wenpeng Cui, Xuehong Lu, Hongyu Yu, Ping Luo
Summary: The study found that the levels of miR-33a-5p in the serum, urine, and kidney tissues of IgA nephropathy (IgAN) patients were significantly lower compared to healthy individuals. Furthermore, the levels of miR-33a-5p decreased with the severity of renal injury and the progression of renal failure in IgAN patients. This suggests that miR-33a-5p detected in the serum and urine could serve as a non-invasive biomarker to reflect the progression of renal injury and renal failure in IgAN patients.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Hematology
Qiaoyan Guo, Yangyang Chen, Liming Yang, Xueyan Zhu, Xiaoxuan Zhang, Qiao Zhao, Xiaohua Zhuang, Yanfeng Wu, Ping Luo, Wenpeng Cui
Summary: The occurrence of early-onset peritonitis (EOP) is significantly associated with lower rates of PDAP-related death and poorer clinical outcomes in patients with diabetes undergoing PD.
BLOOD PURIFICATION
(2022)
Article
Biochemistry & Molecular Biology
Feng Xu, Man Wu, Xuehong Lu, Hong Zhang, Lin Shi, Yue Xi, Huifen Zhou, Junhong Wang, Lining Miao, Da-Wei Gong, Wenpeng Cui
Summary: The study found that ELA treatment can reduce tissue damage, ROS production, and apoptosis caused by renal ischemia/reperfusion injury. ELA can also inhibit cell apoptosis and restore cell proliferation induced by IRI.
Article
Hematology
Lingfei Meng, Liming Yang, Xueyan Zhu, Zhanshan Sun, Xiaoxuan Zhang, Xinyang Li, Siyu Cheng, Shizheng Guo, Xiaohua Zhuang, Hongbin Zou, Ping Luo, Wenpeng Cui
Summary: Older age, hypoproteinemia, hyperglycemia, higher eGFR, and severe heart failure were independent predicting factors for early death in patients who underwent urgent-start peritoneal dialysis (USPD).
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Hematology
Qiaoyan Guo, Yangyang Chen, Ren Wu, Liming Yang, Xueyan Zhu, Qiao Zhao, Xiaohua Zhuang, Yanfeng Wu, Ping Luo, Wenpeng Cui
Summary: Early-onset peritonitis in elderly PD patients is significantly associated with poorer clinical outcomes, including multiple episodes of PD-associated peritonitis (PDAP), technique failure, and all-cause death.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Review
Pharmacology & Pharmacy
Wen Li, Jing Sun, Xiaoxi Zhou, Yue Lu, Wenpeng Cui, Lining Miao
Summary: Pyroptosis is a lytic programmed cell death that plays a crucial role in diabetic complications. Research has identified various signaling pathways associated with pyroptosis, and explored the potential value of pyroptosis inhibitors in the treatment of diabetic nephropathy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Dan Gao, Yan Lou, Yingchun Cui, Shengmao Liu, Wenpeng Cui, Guangdong Sun
Summary: According to the current evidence, preoperative serum calcium, preoperative ALP, and preoperative iPTH were significant predictors of hypocalcemia in patients with SHPT after PTX. More attention should be given to patients with these risk factors for the prevention of postoperative hypocalcemia.
Article
Urology & Nephrology
Xi Wen, Liming Yang, Zhanshan Sun, Xiaoxuan Zhang, Xueyan Zhu, Wenhua Zhou, Xiaoqing Hu, Shichen Liu, Ping Luo, Wenpeng Cui
Summary: The study aimed to investigate the safety of initiating peritoneal dialysis (PD) within 24 hours. The results showed that initiating PD within 24 hours of catheter insertion was not associated with increased mechanical complications, infectious complications, or technique failures.
Article
Hematology
Feng Xu, Yue Yang, Man Wu, Wenhua Zhou, Dongxue Wang, Wenpeng Cui
Summary: Chinese patients with diabetes and end-stage renal disease have similar survival rates whether they undergo hemodialysis or peritoneal dialysis. The choice of dialysis modality should be individualized based on patients' physical condition and local practices.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Endocrinology & Metabolism
Si-Yu Cheng, Li-Ming Yang, Zhan-Shan Sun, Xiao-Xuan Zhang, Xue-Yan Zhu, Ling-Fei Meng, Shi-Zheng Guo, Xiao-Hua Zhuang, Ping Luo, Wen-Peng Cui
Summary: This retrospective cohort study aimed to identify risk factors for mortality during high-risk periods in patients with diabetes undergoing urgent-start peritoneal dialysis (USPD). The results showed that cardiovascular disease was the leading cause of mortality within 6 months and after 6 months. Patients with more obvious baseline heart failure symptoms had a higher risk of mortality both within the first 6 months and after. Independent risk factors for mortality within the first 6 months were advanced age, lower baseline serum creatinine level, higher baseline serum phosphorus level, and baseline NYHA class III-IV. Independent risk factors for mortality after 6 months were advanced age and baseline NYHA class III-IV.
WORLD JOURNAL OF DIABETES
(2022)
Article
Hematology
Siyu Cheng, Liming Yang, Zhanshan Sun, Xiaoxuan Zhang, Xueyan Zhu, Lingfei Meng, Shizheng Guo, Xiaohua Zhuang, Ping Luo, Wenpeng Cui
Summary: This study suggests that initiating peritoneal dialysis within 24 hours after catheter insertion is feasible in elderly patients with ESRD, and the break-in period does not increase the risk of complications.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Pharmacology & Pharmacy
Shunyun Xie, Feng Xu, Yue Lu, Yixian Zhang, Xinyang Li, Mengyuan Yu, Wenpeng Cui
Summary: Peritoneal fibrosis is a common complication in patients receiving peritoneal dialysis, and effective treatment is currently unavailable. ELA and APLN have potential therapeutic effects on PD-related fibrosis. ELA-32 can interfere with the EMT of HPMCs by inhibiting the activation of the TGF-beta 1/SMAD2/3, ERK1/2, and AKT pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Pei-Ting Luo, Wei Li, Xin-Yang Li, Yu Zhang, Bing Du, Wen-Peng Cui
Summary: This study conducted a systematic review and meta-analysis to determine the impact of peritoneal dialysis (PD) modality, specifically automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD), on all-cause mortality and PD failure. The findings indicate that APD significantly reduces the risk of all-cause mortality compared to CAPD. However, APD and CAPD have similar effectiveness in terms of PD survival. These results support the increased utilization of APD globally, particularly in developing nations where reimbursement for care has been a barrier.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Hematology
Shichen Liu, Liming Yang, Xueyan Zhu, Xiaoxuan Zhang, Lingfei Meng, Xinyang Li, Jing Zhao, Xiaohua Zhuang, Wenpeng Cui
Summary: This study found that the duration of peritoneal dialysis, previous episodes of peritonitis, high dialysate white cell count, Pseudomonas aeruginosa, and polymicrobial infections were all associated with catheter removal. The prevalence of polymicrobial peritonitis and fungal peritonitis has increased.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)