Article
Biochemistry & Molecular Biology
Yu-Tsai Lin, Ming-Hsien Tsai, Yan-Ye Su, Wei-Chih Chen, Shun-Chen Huang, Chih-Yen Chien
Summary: This study investigates the expression of Raftlin in cigarette smokers and in chronic rhinosinusitis with nasal polyps (CRSwNP), and finds that increased Raftlin expression in columnar cells might involve nasal epithelial remodeling in smokers with CRSwNP. Additionally, a positive relationship is found between IL-17 and TNF-alpha levels with Raftlin levels.
Article
Biochemistry & Molecular Biology
Leila Saremi, Marziyeh Shafizadeh, Emran Esmaeilzadeh, Mohammad Ebrahim Ghaffari, Mohammad Hosein Mahdavi, Reza Amid, Mahdi Kadkhodazadeh
Summary: Peri-implantitis (PI) is a multifactorial condition caused by the interactions of pathogens and the host immune response. Studies have shown that specific gene polymorphisms of IL-10 819 C/T, IL-10 592 C/A, and IL-1 beta + 3954 C/T may play a significant role in the pathogenesis of PI.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Psychiatry
Rajesh Das, Md. Prova Zaman Emon, Mohammad Shahriar, Zabun Nahar, Sardar Mohammad Ashraful Islam, Mohiuddin Ahmed Bhuiyan, Sheikh Nazrul Islam, Md. Rabiul Islam
Summary: The study found that serum IL-1 beta and TNF-alpha levels are increased in MDD patients and are positively correlated with the severity of depression. Elevated levels of serum IL-1 beta and TNF-alpha could potentially be used as risk assessment indicators for depression.
PSYCHIATRY RESEARCH
(2021)
Article
Oncology
Wenxia Wang, Xiaoshan Liu, Shu Yang, Xiaomin Peng, Yuhan Ma, Xilin Xiong, Yang Li
Summary: This study aimed to identify peripheral parameters associated with the severity of Langerhans cell histiocytosis (LCH) and to look for indicators associated with improvement in LCH patients with risk-organ involvement. The levels of sIL-2R and TNF-a were positively correlated with the extent of disease, while the levels of IgM were negatively correlated with the extent of disease. Additionally, the levels of sIL-2R and CD8+ T-cell count could serve as useful indicators to evaluate the treatment response in RO + MS-LCH patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ana Claudia Lima, Diana Amorim, Ines Laranjeira, Armando Almeida, Rui L. Reis, Helena Ferreira, Filipa Pinto-Ribeiro, Nuno M. Neves
Summary: The immobilization of anti-TNF-α and anti-IL-6 antibodies on polymeric nanoparticles extended and increased therapeutic efficacy while avoiding off-target effects. Biofunctionalized nanoparticles showed greater efficiency in reducing inflammation compared to soluble antibodies, offering a promising therapeutic option for inflammatory conditions with a safe profile and prolonged action.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Rheumatology
Vincenzo Venerito, Pasquale Stefanizzi, Marco Fornaro, Fabio Cacciapaglia, Silvio Tafuri, Simone Perniola, Florenzo Iannone, Giuseppe Lopalco
Summary: This study investigated the humoral response to BNT162b2 vaccination in patients with PsA on TNFi treatment and compared it with healthy controls. The study found that continuing TNFi treatment did not hinder the immunogenicity of the vaccine.
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Maasoumeh Zare Moaiedi, Fatemeh Ahmadpoor, Mojtaba Rashidi, Ahmad Ahmadzadeh, Amir Ahmad Salmasi, Ghorban Mohammadzadeh
Summary: The mRNA expression of resistin and IL-6 in PBMCs of breast cancer patients was significantly increased. Resistin expression correlated with inflammatory markers but not anthropometric indices. IL-6 showed significant diagnostic performance and may serve as a biomarker for early detection of breast cancer.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jesselina Francisco dos Santos Haber, Sandra Maria Barbalho, Jose Augusto Sgarbi, Rafael Santos de Argollo Haber, Roger William de Labio, Lucas Fornari Laurindo, Eduardo Federighi Baisi Chagas, Spencer Luiz Marques Payao
Summary: This study aimed to investigate the expression of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in type 1 diabetes mellitus (T1DM). The study found that cytokine gene expression was higher in T1DM patients, with IL-10 gene expression significantly increased in patients with ketoacidosis and positively correlated with HbA1c levels. IL-10 expression was negatively correlated with the age of diabetes patients and the time of diagnosis. TNF-α expression showed a positive correlation with age. The expression of IL-10 and TNF-α genes significantly increased in T1DM patients.
Article
Oncology
Kang Liu, Yafei Yin, Xinfu Zhou, Kaibo Zhu, Zimian Luo
Summary: The study explored the effect of bortezomib on inflammation and immune lymphocytes in MM patients with herpes zoster infection. Results showed differences in inflammatory markers and immune cell levels between the infection and non-infection groups. High ECOG scores and specific correlations between cytokines and immune cell subsets were identified as risk factors for herpes zoster in MM patients before treatment.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Emilio Marrero, Neha Attal, Ali Nimeri, Rachel M. McGee, Jennifer H. Benbow, Kyle J. Thompson, Laura W. Schrum, Iain H. McKillop
Summary: The interaction between activated hepatic stellate cells (aHSCs) and macrophages play a crucial role in liver fibrosis development. Research shows that aHSC-EXOs contain mRNA that dominantly alters macrophage function and Ectodysplasin-A mRNA is an important component in regulating this process.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Immunology
Hao-Nan Li, Qing-Qing Yang, Wen-Tao Wang, Xue Tian, Fan Feng, Shu-Ting Zhang, Yu-Tong Xia, Jia-Xue Wang, Yuan-Wu Zou, Jun-Yang Wang, Xiao-Yan Zeng
Summary: The red nucleus IL-33 plays a role in the early development of mononeuropathic pain by activating multiple signaling pathways to promote pain effects. The study results suggest that red nucleus IL-33 is involved in the development of mononeuropathic pain by regulating cytokine expression.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Maha Sellami, Nicola Luigi Bragazzi, Baha Aboghaba, Mohamed A. Elrayess
Summary: This review summarizes the effects of acute and chronic exercise on immunoglobulins and cytokines in the elderly. Acute endurance exercise increases salivary SIgA, while acute muscle strengthening exercise raises levels of IL-6, IL-8, and TNF-alpha. Chronic exercise, both short-term and long-term, leads to improvements in immune function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Weronika Pawlik, Jakub Pawlik, Mateusz Kozlowski, Karolina Luczkowska, Sebastian Kwiatkowski, Ewa Kwiatkowska, Boguslaw Machalinski, Aneta Cymbaluk-Ploska
Summary: This study found that serum levels of IL-8 and TNF-alpha were significantly higher in ovarian cancer patients compared to patients with benign ovarian cysts, and they can be used as new useful markers for predicting ovarian cancer. IL-8 and TNF-alpha have a sensitivity and specificity of 70% and 96%, and 85.7% and 79.3% respectively, indicating their utility in predicting the malignant nature of ovarian lesions.
Article
Cardiac & Cardiovascular Systems
Agnieszka Jablonska, Branislav Zagrapan, Christoph Neumayer, Wolf Eilenberg, Andreas Scheuba, Christine Brostjan, Svitlana Demyanets, Markus Klinger, Josif Nanobachvili, Ihor Huk
Summary: The study found that mutations in IL-6 -174G/C genotype were associated with an increased risk of AAA occurrence, while heterozygous carriers of TNF-α -308G/A genotype also showed an increased risk of AAA incidence. The wild-type genotypes of IL-6 -174G/C and TNF-α -308G/A appeared more frequently in healthy subjects, and were associated with a decreased risk of AAA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Ping Wang, Xinwei Hao, Xiaohan Li, Yizhi Yan, Wenxiu Tian, Lin Xiao, Zhenming Wang, Junhong Dong
Summary: Curcumin inhibits tumor proliferation and invasion induced by psychological stress, possibly by suppressing NE-induced signaling pathways and related protein expression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Chemistry, Physical
Zhiyue Zhao, Yinghong Li, Jilei Wu, Zhenyu Shi, Peiqing Zhao, Hui Su, Qinghai Wang, Lili Jin
Summary: The study successfully prepared composite nanofibers using CM-CD to improve curdlan solubility, incorporating a drug for cardiovascular diseases. The resulting NOFs demonstrated improved mechanical properties, disintegration behavior, dissolution performance, and higher bioavailability compared to commercial tablets, suggesting potential for buccal mucosa drug delivery.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Oncology
Yunwei Lou, Miaomiao Song, Meijuan Han, Jiateng Zhong, Xueqin Tian, Yahan Ren, Yaru Song, Liangwei Duan, Peiqing Zhao, Xiangfeng Song, Wen Zhang, Youhai H. Chen, Hui Wang
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Environmental Sciences
Liping Zhang, Xiuru Bi, Zuo Wang, Ali Serol Erturk, Gokhan Elmaci, Haiyu Zhao, Peiqing Zhao, Xu Meng
Summary: In this study, a manganese oxide nanomaterial with abundant acid sites was synthesized, and the catalytic performance for the degradation of phthalate esters was tested. The catalyst showed high efficiency in degrading and mineralizing the organic pollutants, and it could be reused for multiple cycles. Moreover, the catalyzed advanced oxidation processes significantly reduced the developmental toxicity of the wastewater on zebrafish.
Article
Engineering, Environmental
Xiaopei Wang, Xiuru Bi, Nan Yao, Gokhan Elmaci, Ali Serol Erturk, Qianru Lv, Peiqing Zhao, Xu Meng
Summary: In this study, a Cu-Nd-OMS-2 catalyst was synthesized and demonstrated to efficiently degrade water-soluble parabens by converting the radical mechanism into a non-radical pathway. The results showed that singlet oxygen and mediated electron transfer played important roles in the removal of pollutants.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Weifeng Wang, Xiuru Bi, Tian Chai, Peiqing Zhao, Jun-Li Yang, Xu Meng
Summary: In this study, manganese oxide octahedral molecular sieve-modified zirconia nanocomposites were fabricated and their adsorption performance towards rutin was investigated. The results showed that manganese oxide modification significantly improved the textural properties of the nanocomposites. Moreover, the optimal adsorbent exhibited high adsorption rate and desorption rate, and could be reused for multiple times.
Article
Cell Biology
Minghao Yang, Yuzhu Zhang, Guangping Liu, Ziqian Zhao, Jigang Li, Le Yang, Kui Liu, Wei Hu, Yunwei Lou, Jie Jiang, Qing Liu, Peiqing Zhao
Summary: This study found that TIPE1 expression is decreased in osteosarcoma tissues and is negatively related to tumor stage and size. TIPE1 inhibits osteosarcoma carcinogenesis and metastasis by inhibiting PRMT1-mediated STAT3 arginine methylation. These findings provide a potential molecular target for the treatment of osteosarcoma.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Analytical
Yamei Li, Zhaosong Li, Haibo Tan, Yueyuan Li, Feng Tang, Ping Wang, Yueyun Li, Hui Liu, Peiqing Zhao, Qing Liu
Summary: Developing heterojunctions with high visible light absorption capability, fast e(-)/h(+) separation and sufficient chemical stability is crucial for developing efficient photoelectrochemical (PEC) biosensing systems. In this work, we developed an intercalated ZnCdS/NiS/ZnCdS dual heterojunction based on the hydrophilicity of bimetallic sulfides ZnCdS solid solution to construct a PEC immunosensor for PD-L1 detection. The constructed dual heterojunction sensing platform exhibits high sensitivity and selectivity in detecting PD-L1, showing a good linear range and low detection limit.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Chemical
Nan Yao, Haiyu Zhao, Xiang Liu, Ali Serol Erturk, Gokhan Elmaci, Peiqing Zhao, Xu Meng
Summary: This study introduced the use of acidified rod-like manganese dioxide as an effective activator and adsorbent for the removal of polyvinyl alcohol. The results showed that the H-OMS-2 could efficiently adsorb and degrade PVA, and it had good recyclability. The presence of acid sites and highly structured mesoporous pore size on H-OMS-2 promoted the degradation of PVA.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Engineering, Chemical
Xiaopei Wang, Yiqian Jiang, Peiqing Zhao, Xu Meng
Summary: A novel 3D hierarchical cryptomelane-type manganese oxide nanocomposite (APM-OMS-2) was prepared using ammonium phosphomolybdate (APM) as an additive for the first time. The APM dosage influenced the morphology, crystal phase, textural properties and redox ability. APM-OMS-2 exhibited a unique nanoprism morphology coated by APM and consisted of a hierarchical framework. The catalytic ability of APM-OMS-2 was examined for the degradation of phenolics using peroxymonosulfate (PMS). The optimized catalytic system showed high degradation and mineralization rates for 4-chlorophenol.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Yamei Li, Shujun Wang, Yan Zhao, Yueyuan Li, Ping Wang, Hongqiang Xie, Peiqing Zhao, Yueyun Li, Qing Liu, Qin Wei
Summary: In this study, a double-photoelectrode PEC sensing platform was fabricated by integrating a p-type metal-organic framework (MIL-68-(In)-NH2) photocatalyst as a photocathode and CdSe/MgIn2S4 type-II heterojunction as a photoanode using an antenna-like strategy. The platform exhibited 2.5 times stronger photocurrent response compared to traditional heterojunction single electrode. Based on this strategy, a PEC biosensor for the detection of PD-L1 was constructed, which showed sensitive and precise detection capability with a detection range of 1 x10(-5) to 1 x 10(3) ng/mL.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Wei Hu, Wenxiang Zheng, Jianxin Du, Zhaobing Tian, Yixin Zhao, Peiqing Zhao, Junsheng Li
Summary: Drug resistance is a major challenge in breast cancer treatment, and drug-induced autophagy and cancer stem cells play important roles in this process. However, the inhibitory role of TIPE2 in paclitaxel resistance in breast cancer cells has not been fully understood. This study demonstrated that TIPE2 can sensitize breast cancer cells to paclitaxel by suppressing drug-induced autophagy and cancer stem cell properties, suggesting that TIPE2 may be a potential target for breast cancer chemotherapy.
Article
Genetics & Heredity
Yongting Lan, Qing Jia, Min Feng, Peiqing Zhao, Min Zhu
Summary: This study aimed to develop a novel prognostic signature for pancreatic cancer (PC) patients by analyzing NK cell-related genes (NKGs). A total of 32 prognostic NKGs were identified and used to generate three distinct clusters. PC patients were divided into high and low risk groups based on the risk signature, which showed differences in prognosis, clinicopathological features, immune infiltration, immunotherapy response, and drug sensitivity. A decision tree and nomogram model were successfully constructed for prognostic prediction.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, Research & Experimental
Ziying Jiang, Xinyu Wang, Haoqiang Zhang, Jian Yin, Peiqing Zhao, Qingqing Yin, Zhenfu Wang
Summary: The ketogenic diet, a low-carbohydrate, high-fat regime, can protect against neurodegenerative diseases like Parkinson's disease by regulating the gut microbiota and reducing inflammation.
Article
Materials Science, Multidisciplinary
Na Yang, Lan Yang, Xiang Zhu, Peiqing Zhao, Honglai Liu, Chungu Xia, Sheng Dai, Chengcheng Tian
Summary: Highly crystalline covalent triazine frameworks (CTFs) were synthesized for the first time using a solvent-and catalyst-free approach. The CTFs were then transformed into isolated single-atom catalysts (SACs) through a new condensation reaction. These SACs exhibited efficient performance in electrochemical carbon dioxide reduction.
ACS MATERIALS LETTERS
(2022)