Article
Cardiac & Cardiovascular Systems
Pigi Dikaiou, Lena Bjorck, Martin Adiels, Christina E. Lundberg, Zacharias Mandalenakis, Karin Manhem, Annika Rosengren
Summary: This study found a significant association between body mass index in young women and the risk for early cardiovascular disease and mortality, with overweight and obese women showing a markedly increased risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Mochly-Rosen Daria, Che-Hong Chen, Yung Liaw
Summary: This study found that among Taiwanese adults, the ADH1B rs1229984 TC + CC genotype and alcohol consumption of at least 150 ml/week may increase the risk of developing hemorrhagic stroke. The ALDH2 rs671 genotype was not associated with hemorrhagic or ischemic stroke among alcohol drinkers.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Anping Cai, Zhiqiang Nie, Yanqiu Ou, Jiabin Wang, Yanshuang Chen, Zhisheng Lu, Yanhua Liang, Yingling Zhou, Yingqing Feng
Summary: The burden of cardiovascular risk factors is high in the community populations of Guangdong Province and varies depending on sociodemographic status. Targeted and cost-effective interventions are needed to reduce the burden of cardiovascular risk factors at the population level.
Article
Cardiac & Cardiovascular Systems
Sara Hallum, Saima Basit, Mads Kamper-Jorgensen, Thomas S. G. Sehested, Heather A. Boyd
Summary: Pre-eclampsia increases women's risk of cardiovascular disease, especially within a decade after delivery and for women aged 30-39 years. A history of pre-eclampsia can be used to identify women at increased risk of cardiovascular disease, and targeted interventions should be initiated soon after delivery.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Ziyang Ren, Qian Yi, Leying Hou, Tzu Tsun Luk, Yiwen Qiu, Wei Xia, Yimin Zhu, Peige Song, Kazem Rahimi
Summary: This population-based prospective cohort study found a significant association between lactation and a lower risk of stroke, especially ischemic stroke. This emphasizes the importance of promoting breastfeeding as a targeted prevention strategy for stroke.
Article
Immunology
Zhiqiang Liu, Xiaoli Gao, Lirong Liang, Xuan Zhou, Xiaozhe Han, Ting Yang, Kewu Huang, Yingxiang Lin, Shu Deng, Zuomin Wang, Chen Wang
Summary: The purpose of this study was to assess the prevalence and identify the risk factors of gastroesophageal reflux disease (GERD) in the Chinese adult population. Data from a nationally representative sample of Chinese adults were collected, and the overall prevalence of GERD was found to be 5.6%. Women, smokers, older individuals, those with higher BMI, urban residents, individuals with lower education level or comorbidities were more likely to have GERD. Symptoms of severe periodontitis and lower frequency of tooth brushing were significantly associated with the risk of GERD.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Clinical Neurology
Satoyo Ikehara, Hiroyasu Iso, Yoshihiro Kokubo, Kazumasa Yamagishi, Isao Saito, Hiroshi Yatsuya, Takashi Kimura, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane
Summary: Higher peanut consumption was associated with reduced risk of stroke, particularly ischemic stroke, but not with the risk of ischemic heart disease in Japanese men and women.
Article
Endocrinology & Metabolism
Elif Aribas, Maryam Kavousi, Joop S. E. Laven, M. Arfan Ikram, Jeanine E. Roeters van Lennep
Summary: A clear sex-specific pattern for SHBG levels with age was observed, with men showing a linear increase and women exhibiting a U-shaped pattern. Participants with more cardiovascular risk factors had lower SHBG levels. When stratified by age, older participants had higher SHBG levels. Multivariate models including specific factors explained a significant portion of the variance in SHBG levels. It is important to consider age-related changes in SHBG levels to avoid controversial results in assessing cardiovascular risk associated with SHBG.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Yi-Xin Wang, Lidia Minguez-Alarcon, Audrey J. Gaskins, Liang Wang, Ming Ding, Stacey A. Missmer, Janet W. Rich-Edwards, JoAnn E. Manson, Jorge E. Chavarro
Summary: The aim of this study was to investigate the association between pregnancy loss (PL) and cardiovascular disease (CVD), and to examine the role of subsequent metabolic disorders in mediating this relationship. The results showed that PL was associated with a higher risk of CVD, independent of the development of metabolic disorders.
EUROPEAN HEART JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Zongping Wang, Le Wang, Song Wang, Liping Xie
Summary: The burden of kidney cancer in China has been increasing over the past three decades, with a higher burden among males and older adults. Smoking and high body mass index (BMI) contribute significantly to the burden of kidney cancer.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Qiyu Li, Pengbo Wang, Rui Ma, Xiaofan Guo, Yingxian Sun, Xingang Zhang
Summary: Obesity has become a serious public health problem and brings a heavy burden of cardiovascular disease. Whether individuals with metabolically healthy obesity (MHO) have a lower cardiovascular risk remains controversial. This study aimed to define MHO using a new criterion and assess its predictive value for cardiovascular events and death, while comparing it with the traditional criterion.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yunfeng Xi, Ning Cao, Liwei Niu, Hao Zhu, Han Bao, Liying Qiao, Shuqi Ji, Tao Yan, Xiaoqian Xu, Wenrui Wang, Xingguang Zhang
Summary: This study aimed to investigate the prevalence and treatment of high cardiovascular disease risk in Inner Mongolia. The results showed a high prevalence of hypertension, dyslipidemia, and diabetes among individuals with high CVD risk, but low treatment and control rates.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Fei Tian, Lan Chen, Zhengmin (Min) Qian, Hui Xia, Zilong Zhang, Jingyi Zhang, Chongjian Wang, Michael G. Vaughn, Maya Tabet, Hualiang Lin
Summary: This study examined the age-specific effects of 14 risk factors on CVD and mortality in different age groups. The findings showed that a large fraction of CVD cases and deaths were associated with modifiable risk factors in all age groups, with metabolic factors having the highest population-attributable fractions in each age group. The study suggests that targeted efforts should focus on the most impactful and age-specific modifiable risk factors to prevent and manage CVD and related mortality effectively.
Article
Endocrinology & Metabolism
Meri-Maija Ollila, Riikka K. Arffman, Elisa Korhonen, Laure Morin-Papunen, Stephen Franks, Juhani Junttila, Terhi T. Piltonen
Summary: Polycystic ovary syndrome (PCOS) is associated with various cardiovascular disease (CVD) risk factors, including obesity, type 2 diabetes mellitus, and hypertension. However, it is still unclear whether the presence of multiple CVD risk factors leads to an increased risk of CVD events.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Cell Biology
Howell Leung, Xiaoxue Long, Yueqiong Ni, Lingling Qian, Emmanouil Nychas, Sara Leal Siliceo, Dennis Pohl, Kati Hanhineva, Yan Liu, Aimin Xu, Henrik B. Nielsen, Eugeni Belda, Karine Clement, Rohit Loomba, Huating Li, Weiping Jia, Gianni Panagiotou
Summary: A growing body of evidence suggests that the gut microbiota plays a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study found that machine learning models integrating microbial signatures were able to accurately classify individuals based on their NAFLD status and liver fat accumulation, outperforming other clinical models. These findings raise the possibility of using gut microbiota for early clinical warning of NAFLD development.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Emily C. McKinley, Vera A. Bittner, Todd M. Brown, Ligong Chen, Jason Exter, Michael E. Farkouh, Lei Huang, Elizabeth A. Jackson, Emily B. Levitan, Kate K. Orroth, Stephanie R. Reading, Robert S. Rosenson, Monika M. Safford, Mark Woodward, Paul Muntner, Lisandro D. Colantonio
Summary: A considerable number of recurrent ASCVD events could be averted over 10 years if all adults with ASCVD in the United States achieve and maintain LDL-C<70 mg/dL.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Peripheral Vascular Disease
Katie Harris, Paul Muntner, Mark Woodward, Min Jun, Megumi Oshima, Jessica Gong, Stephen Harrap, Joel Menard, John Chalmers
Summary: Using blood pressure and ASCVD risk to guide antihypertensive treatment can reduce the risk of major macrovascular events and death in patients with diabetes, but it has limited predictive ability for major microvascular events.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Clinical Neurology
Sultana Shajahan, Lingli Sun, Katie Harris, Xia Wang, Else Charlotte Sandset, Amy Y. X. Yu, Mark Woodward, Sanne A. E. Peters, Cheryl Carcel
Summary: There are sex differences in the symptom presentation of stroke, with women more commonly experiencing nonfocal symptoms and men more commonly experiencing ataxia and dysarthria. However, the prevalence of focal neurological symptoms is similar for both sexes. Understanding these sex differences and considering the full constellation of presenting symptoms can improve early diagnosis and management in both men and women.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Nursing
Tina G. A. Oostrom, Patricia Cullen, Sanne A. E. Peters
Summary: This study aimed to assess the health impacts of the COVID-19 pandemic on children and adolescents. The results showed that the pandemic had various effects on the health of young people, particularly in terms of mental health conditions, declines in presentations to pediatric emergency departments, and decreases in vaccination rates. Currently, there is limited understanding of protective factors for young people's health and wellbeing, as well as how to mitigate the impacts of the pandemic.
JOURNAL OF CHILD HEALTH CARE
(2023)
Letter
Surgery
Shang Wu, Wenzhen Bu, Deluo Wu, Jianwei Du
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Jian-wei Du, Lei-ming Zhang, Yu-qiu Yan, Ya-ning Zhang, Xue-qin Rong, Song-hua Xiao, Xi-feng Zhang
Summary: Adult degenerative scoliosis (ADS) is a serious disease that causes deformity and severe pain in the lumbar spine. Open surgery is limited in cases of large trauma, and minimally invasive spinal (MIS) surgery has become a rapidly developing alternative method. Percutaneous spinal endoscopic-assisted lumbar interbody fusion (EALIF) and percutaneous pedicle screw fixation are effective treatments for ADS with moderate deformities, providing direct decompression of neural structures and improving pain and deformity.
FRONTIERS IN SURGERY
(2023)
Article
Geriatrics & Gerontology
Huijing He, Li Pan, Dingming Wang, Feng Liu, Jianwei Du, Lize Pa, Xianghua Wang, Ze Cui, Xiaolan Ren, Hailing Wang, Xia Peng, Jingbo Zhao, Guangliang Shan
Summary: This study investigated the relationship between muscle-to-fat ratio and cardiometabolic risk in a representative Chinese population. The results showed that increased muscle-to-fat ratio was associated with lower cardiometabolic risk, particularly in overweight/obese individuals and women.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pek Kei Im, Neil Wright, Ling Yang, Ka Hung Chan, Yiping Chen, Yu Guo, Huaidong Du, Xiaoming Yang, Daniel Avery, Shaojie Wang, Canqing Yu, Jun Lv, Robert Clarke, Junshi Chen, Rory Collins, Robin G. Walters, Richard Peto, Liming Li, Zhengming Chen, Iona Y. Millwood, China Kadoorie Biobank Collab Grp
Summary: Alcohol consumption is associated with 207 diseases in the 12-year China Kadoorie Biobank study, with positive correlations found between alcohol intake and 61 diseases in men, including 33 diseases not considered alcohol-related by WHO.
Article
Endocrinology & Metabolism
Lang Pan, Kexiang Shi, Jun Lv, Yuanjie Pang, Yu Guo, Pei Pei, Huaidong Du, Iona Millwood, Ling Yang, Yiping Chen, Ruqin Gao, Xiaoming Yang, Daniel Avery, Junshi Chen, Canqing Yu, Zhengming Chen, Liming Li
Summary: The aim of this study was to explore the associations between major dietary patterns and lipid profiles, as well as the associations between these profiles and the risks of general and central obesity. The study found that the newly affluent southern pattern was associated with 45 metabolites and with increased risks of obesity. The global lipid profile potentially explained a significant portion of the effects of this dietary pattern on obesity.
Article
Biotechnology & Applied Microbiology
Xinglong Wang, Gongke Li, Ke Li, Yu Shi, Wenzheng Lin, Chun Pan, Dandan Li, Hao Chen, Jianwei Du, Huihui Wang
Summary: Targeted delivery of antitumor drugs using small-sized hollow mesoporous silica nanoparticles with beta-cyclodextrin-benzimidazole supramolecular nanovalve and bone-targeted alendronate sodium has shown high drug loading capacity and efficient release of the drug apatinib. The released drug exhibits potent cytotoxicity in osteosarcoma cells and significantly reduces cell proliferation, migration, and invasion.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Sanne A. E. Peters, Mark Woodward
Summary: Sex and gender are fundamental to health and wellbeing, yet many research studies fail to consider their differences. This article presents a roadmap for conducting sex- and gender-disaggregated health research, including exploring differences, explaining underlying mechanisms, and translating implications to policy and practice. Methodological considerations and practical examples are provided, with a focus on cardiovascular disease. The article stresses the importance of sex and gender research and calls for further disaggregation of identities and intersectionality in future studies.
Editorial Material
Cardiac & Cardiovascular Systems
Sanne A. E. Peters
Article
Cardiac & Cardiovascular Systems
Lena Tschiderer, Sanne A. E. Peters, Yvonne T. van der Schouw, Anniek C. van Westing, Tammy Y. N. Tong, Peter Willeit, Lisa Seekircher, Conchi Moreno-Iribas, Jose Maria Huerta, Marta Crous-Bou, Martin Soderholm, Matthias B. Schulze, Cecilia Johansson, Sara Sjalander, Alicia K. Heath, Alessandra Macciotta, Christina C. Dahm, Daniel B. Ibsen, Valeria Pala, Lene Mellemkjaer, Stephen Burgess, Angela Wood, Rudolf Kaaks, Verena Katzke, Pilar Amiano, Miguel Rodriguez-Barranco, Gunnar Engstrom, Elisabete Weiderpass, Anne Tjonneland, Jytte Halkjaer, Salvatore Panico, John Danesh, Adam Butterworth, N. Charlotte Onland-Moret
Summary: Early menopause is associated with a higher risk of stroke, but the relationships with stroke subtypes are inconsistent. However, genetically proxied age at menopause is not significantly associated with stroke risk, suggesting no causal relationship.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychology, Biological
Qiufen Sun, Yizhen Hu, Canqing Yu, Yu Guo, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Dianjianyi Sun, Yuanjie Pang, Sushila Burgess, Sam Sansome, Feng Ning, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv
Summary: In a study of 451,233 Chinese adults, Sun et al. found that a healthy lifestyle is associated with longer life expectancy free of major non-communicable diseases. The study considered five low-risk lifestyle factors, including never smoking or quitting for non-illness reasons, no excessive alcohol use, physical activity, healthy eating habits, and healthy body fat levels. The results showed that individuals with all five low-risk factors had a significantly longer disease-free life expectancy compared to those with fewer low-risk factors, indicating the importance of promoting healthy lifestyles in the Chinese population.
NATURE HUMAN BEHAVIOUR
(2023)
Review
Peripheral Vascular Disease
Sophie C. de Ruiter, A. Floriaan Schmidt, Diederick E. Grobbee, Hester M. den Ruijter, Sanne A. E. Peters
Summary: Hypertension is a key risk factor for cardiovascular disease, with stronger associations found in women compared to men. However, it is unclear if these differences are due to actual differential effects or confounding factors. The use of Mendelian randomisation (MR) and cis-MR can help uncover causality in sex differences and improve clinical practice.
JOURNAL OF HUMAN HYPERTENSION
(2023)