Risk assessment with gut microbiome and metabolite markers in NAFLD development

Gut Microbiome Composition Is Predictive of Incident Type 2 Diabetes in a Population Cohort of 5,572 Finnish Adults

(2022) Matti O. Ruuskanen et al.   DIABETES CARE

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease

(2022) Yeela Talmor-Barkan et al.   NATURE MEDICINE

Microbiome and metabolome features of the cardiometabolic disease spectrum

(2022) Sebastien Fromentin et al.   NATURE MEDICINE

Disease burden and economic impact of diagnosed non‐alcoholic steatohepatitis (nash) in five european countries in 2018: A cost‐of‐illness analysis

(2021) Jörn M. Schattenberg et al.   LIVER INTERNATIONAL

Red Meat Consumption and Risk of Nonalcoholic Fatty Liver Disease in a Population With Low Meat Consumption

(2021) Maryam Hashemian et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

(2021) Jordi Mayneris-Perxachs et al.   Microbiome

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Nonalcoholic fatty liver disease: modulating gut microbiota to improve severity?

(2020) Judith Aron-Wisnewsky et al.   GASTROENTEROLOGY

Prediction of gestational diabetes based on nationwide electronic health records

(2020) Nitzan Shalom Artzi et al.   NATURE MEDICINE

Predictable modulation of cancer treatment outcomes by the gut microbiota

(2020) Yoshitaro Heshiki et al.   Microbiome

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

(2020) Alexander Duscha et al.   CELL

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

A unified catalog of 204,938 reference genomes from the human gut microbiome

(2020) Alexandre Almeida et al.   NATURE BIOTECHNOLOGY

Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes

(2020) Cristina Menni et al.   Gut Microbes

Arachidonic Acid as an Early Indicator of Inflammation during Non-Alcoholic Fatty Liver Disease Development

(2020) Klaudia Sztolsztener et al.   Biomolecules

Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort

(2020) Tracey G Simon et al.   GUT

NAFLD-related mortality: simple hepatic steatosis is not as ‘benign’ as thought

(2020) Herbert Tilg et al.   GUT

Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity

(2020) Emir Tas et al.   Frontiers in Endocrinology

Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis

(2020) Sayuri Takada et al.   LABORATORY INVESTIGATION

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Fatty liver index (FLI) and prediction of new cases of non-alcoholic fatty liver disease: A population-based study of northern Iran

(2019) Nima Motamed et al.   CLINICAL NUTRITION

Microbiome Signatures Associated with Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease

(2019) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

Changing NAFLD Epidemiology in China

(2019) Hye Won Lee et al.   HEPATOLOGY

Western Diet-Induced Metabolic Alterations Affect Circulating Markers of Liver Function before the Development of Steatosis

(2019) Daniela Gabbia et al.   Nutrients

Metabolomic Biomarkers in the Diagnosis of Non-Alcoholic Fatty Liver Disease

(2019) Saeed Chashmniam et al.   Hepatitis Monthly

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

(2019) Yan Liu et al.   Cell Metabolism

Nonalcoholic Fatty Liver Disease: An Update on the Diagnosis

(2019) Jia-Zhen Zhang et al.   GENE EXPRESSION

Low Awareness of Nonalcoholic Fatty Liver Disease in a Population-Based Cohort Sample: the CARDIA Study

(2019) Erin R. Cleveland et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes?

(2018) Peizhu Chen et al.   Cardiovascular Diabetology

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

(2018) Adil Mardinoglu et al.   Cell Metabolism

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

(2018) Judith Aron-Wisnewsky et al.   GUT

Increased Serum Dihomo-γ-linolenic Acid Levels are Associated with Obesity, Body Fat Accumulation, and Insulin Resistance in Japanese Patients with Type 2 Diabetes

(2018) Yuya Tsurutani et al.   INTERNAL MEDICINE

Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers

(2018) Eduardo Vilar-Gomez et al.   JOURNAL OF HEPATOLOGY

Role of imaging-based biomarkers in NAFLD: Recent advances in clinical application and future research directions

(2018) Rohit Loomba   JOURNAL OF HEPATOLOGY

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

Geranylgeranyl diphosphate synthase (GGPPS) regulates NAFLD/fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat-diet conditions

(2018) Jia Liu et al.   JOURNAL OF PATHOLOGY

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Noninvasive biomarkers in NAFLD and NASH — current progress and future promise

(2018) Vincent Wai-Sun Wong et al.   Nature Reviews Gastroenterology & Hepatology

Abdominal Subcutaneous Fat: A Favorable or Nonfunctional Fat Depot for Glucose Metabolism in Chinese Adults?

(2018) Xuhong Hou et al.   Obesity

Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance

(2018) Hannah E. Da Silva et al.   Scientific Reports

Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: the Rotterdam Study

(2018) Louise JM Alferink et al.   GUT

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population

(2018) Ju Young Jung et al.   Hepatology International

Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet

(2018) David A. Muñiz Pedrogo et al.   MAYO CLINIC PROCEEDINGS

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

(2018) Alida Kindt et al.   Nature Communications

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

(2018) Norbert Stefan et al.   Lancet Diabetes & Endocrinology

Explainable machine-learning predictions for the prevention of hypoxaemia during surgery

(2018) Scott M. Lundberg et al.   Nature Biomedical Engineering

Smoking and the Risk of Non-Alcoholic Fatty Liver Disease

(2018) Hyun-Suk Jung et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Microbiota and cancer immunotherapy: in search of microbial signals

(2018) Raad Z Gharaibeh et al.   GUT

A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease

(2018) Rongjiong Zheng et al.   Lipids in Health and Disease

Species-level functional profiling of metagenomes and metatranscriptomes

(2018) Eric A. Franzosa et al.   NATURE METHODS

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study

(2017) L Hodson et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

(2017) Leon A Adams et al.   GUT

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

(2017) Melania Gaggini et al.   HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

ranger: A Fast Implementation of Random Forests for High Dimensional Data in C++ and R

(2017) Marvin N. Wright et al.   Journal of Statistical Software

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

(2017) Yan Zheng et al.   Nature Reviews Endocrinology

Nonalcoholic fatty liver disease: Evolving paradigms

(2017) Amedeo Lonardo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

2016 ESC/EAS Guidelines for the Management of Dyslipidaemias

(2016) Alberico L. Catapano et al.   EUROPEAN HEART JOURNAL

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

(2016) Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Moderate and Vigorous Exercise on Nonalcoholic Fatty Liver Disease

(2016) Hui-Jie Zhang et al.   JAMA Internal Medicine

Altered Fecal Microbiota Correlates with Liver Biochemistry in Nonobese Patients with Non-alcoholic Fatty Liver Disease

(2016) Baohong Wang et al.   Scientific Reports

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Recommendations for Diagnosis, Referral for Liver Biopsy, and Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

(2015) Erin K. Spengler et al.   MAYO CLINIC PROCEEDINGS

MetaPhlAn2 for enhanced metagenomic taxonomic profiling

(2015) Duy Tin Truong et al.   NATURE METHODS

The Economic Costs of Type 2 Diabetes: A Global Systematic Review

(2015) Till Seuring et al.   PHARMACOECONOMICS

Specific gut microbiota features and metabolic markers in postmenopausal women with obesity

(2015) L K Brahe et al.   Nutrition & Diabetes

Building Predictive Models inRUsing thecaretPackage

(2015) Max Kuhn   Journal of Statistical Software

Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus

(2015) Jasmohan S. Bajaj et al.   Scientific Reports

Mapping of the circulating metabolome reveals α-ketoglutarate as a predictor of morbid obesity-associated non-alcoholic fatty liver disease

(2014) E Rodríguez-Gallego et al.   INTERNATIONAL JOURNAL OF OBESITY

Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes

(2014) H Bjørn Nielsen et al.   NATURE BIOTECHNOLOGY

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

(2014) Adil Mardinoglu et al.   Nature Communications

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Differential abundance analysis for microbial marker-gene surveys

(2013) Joseph N Paulson et al.   NATURE METHODS

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China

(2012) Huating Li et al.   JOURNAL OF HEPATOLOGY

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii

(2011) M Million et al.   INTERNATIONAL JOURNAL OF OBESITY

Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

(2010) Huating Li et al.   JOURNAL OF HEPATOLOGY

Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors

(2009) Anna Kotronen et al.   GASTROENTEROLOGY

Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage

(2007) Ranganath Muniyappa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM