Article
Immunology
Murilo Delgobo, Margarete Heinrichs, Nils Hapke, DiyaaElDin Ashour, Marc Appel, Mugdha Srivastava, Tobias Heckel, Ioakim Spyridopoulos, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: The cardiovascular and immune systems undergo significant changes with aging, and an accumulation of CD4(+) T cells in elderly individuals may contribute to myocardial aging and heart disease progression. By studying young mice with expanded CD4(+) T cell compartments, researchers found that these cells can differentiate and impact the heart, suggesting a link between immunological senescence and age-related cardiac deterioration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Helene Bauby, Christopher C. Ward, Rupert Hugh-White, Chad M. Swanson, Reiner Schulz, Caroline Goujon, Michael H. Malim
Summary: The interaction between HIV-1 and CD4(+) T cells have been studied through transcriptomics analysis, unveiling global changes in gene expression. The viral accessory protein Vpr plays a crucial role in these gene expression changes, highlighting its significance in infection and pathogenesis. This finding sheds new light on the interplay between HIV-1 and its host at the cellular level.
Article
Multidisciplinary Sciences
Paul A. Wilson, Sara Santos Franco, Liu He, Nicholas W. Galwey, Jackie Meakin, Rebecca McIntyre, Simon M. McHugh, Michael A. Nolan, Sarah L. Spain, Thaddeus Carlson, Mercedes Lobera, Justin P. Rubio, Bill Davis, Linda C. McCarthy
Summary: The study revealed that genotype affects transcriptional effects in CD4(+) T cells, but not significantly cell differentiation and frequency. The investigation suggests that the rs4845604 GG genotype may be associated with a differential detoxification response.
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Article
Biotechnology & Applied Microbiology
Stefan Petkov, Francesca Chiodi
Summary: The study analyzed the transcriptome characteristics of blood CD4+ T naive cells from HIV-1 infected patients starting ART at acute infection, revealing a more efficiently controlled inflammation process in early ART patients, but with still affected cell survival profile.
Article
Immunology
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Takanori Kanai
Summary: This study identified the presence of cytotoxic CD4(+)CD8(+) T cells in the human intestine, with a significantly reduced percentage in patients with inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Samuel X. Shi, Yuwen Xiu, Yan Li, Meng Yuan, Kaibin Shi, Qiang Liu, Xiaoying Wang, Wei-Na Jin
Summary: Leukocyte infiltration exacerbates brain injury after intracerebral hemorrhage (ICH), and CD4+ T cells are found to accumulate in the perihematomal regions, playing a role in the development of perihematomal edema (PHE). These T cells disrupt blood-brain barrier integrity and promote PHE progression through interleukin-17 release and engagement of DR5 to trigger endothelial death.
Article
Immunology
Juan Navarro-Barriuso, Maria Jose Mansilla, Bibiana Quirant-Sanchez, Aina Teniente-Serra, Cristina Ramo-Tello, Eva M. Martinez-Caceres
Summary: The use of vitamin D3-generated tolDC (vitD3-tolDC) has shown promising results in inducing antigen-specific hyporesponsiveness in T cells, reducing T(H)1 immune profiles and IFN-γ production. Transcriptomic analysis revealed a significant down-regulation of genes related to cell cycle and pro-inflammatory immune responses, with JUNB gene identified as a potential biomarker in this process. These findings highlight the regulatory properties and therapeutic potential of vitD3-tolDC in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Colwyn A. Headley, Shalini Gautam, Angelica Olmo-Fontanez, Andreu Garcia-Vilanova, Varun Dwivedi, Anwari Akhter, Alyssa Schami, Kevin Chiem, Russell Ault, Hao Zhang, Hong Cai, Alison Whigham, Jennifer Delgado, Amberlee Hicks, Philip S. Tsao, Jonathan Gelfond, Luis Martinez-Sobrido, Yufeng Wang, Jordi B. Torrelles, Joanne Turner
Summary: Mitochondrial dysfunction in CD4(+) T lymphocytes is implicated in the dysregulated signaling and function of these cells in the elderly. This study demonstrates that transferring functional mitochondria into aged CD4(+) T cells improves mitochondrial function and cellular functionality. Furthermore, adoptive transfer of these mito-transferred aged CD4(+) T cells protects immune deficient mice from influenza A and Mycobacterium tuberculosis infections.
Article
Rheumatology
Johannes Fessler, Patrizia Fasching, Andrea Raicht, Sabrina Hammerl, Jennifer Weber, Angelika Lackner, Josef Hermann, Christian Dejaco, Winfried B. Graninger, Wolfgang Schwinger, Martin H. Stradner
Summary: In primary Sjogren's syndrome (pSS), peripheral lymphopenia is associated with decreased proliferation and signs of immune cell aging in naive CD4(+) T cells. Shortened telomeres, reduced telomerase activity, and low levels of T-cell receptor excision circles (TRECs) suggest a history of extensive post-thymic cell division. This senescent phenotype in naive CD4(+) T cells may contribute to the inability to sustain cell numbers and ultimately leads to lymphopenia in pSS.
Review
Biochemistry & Molecular Biology
Magdalena Hagen, Luca Pangrazzi, Lourdes Rocamora-Reverte, Birgit Weinberger
Summary: The expression of CD4 and CD8 co-receptors defines two distinct T cell populations with specialized functions. However, a paradoxical population of CD4(+)CD8(+) double-positive (DP) T cells challenging this paradigm has been found in the peripheral blood. This subset has unique functions and exhibits memory-like features. Strategies to better characterize the role of this minor T cell subset in regulating immune responses are necessary.
Article
Geriatrics & Gerontology
Diana M. Matthe, Oana-Maria Thoma, Tobias Sperka, Markus F. Neurath, Maximilian J. Waldner
Summary: The research found that in telomerase-deficient mice, there was a reduction in CD4+ T cell numbers and an enhancement in proliferation and Th1 polarization, with increased production of IFN gamma-producing cells and reduced CD28 expression. These results suggest that telomerase deficiency replicates several changes in CD4+ T cells seen in aged humans, highlighting its potential role in T cell immunity aging.
Article
Immunology
Qiao Liu, Lisha Wang, Huayu Lin, Zhiming Wang, Jialin Wu, Junyi Guo, Shuqiong Wen, Ling Ran, Zhengliang Yue, Xingxing Su, Qing Wu, Jianfang Tang, Zhirong Li, Li Hu, Lifan Xu, Lilin Ye, Qizhao Huang
Summary: Cytotoxic CD8(+) T cells are the main focus of anti-tumor immunity and immunotherapy research, but transferred tumor-specific CD8(+) T cells have limited effect on suppressing tumor growth. On the other hand, CD4(+) T cells play an important role in curtailing tumor metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Wuerzner, Birgit Weinberger
Summary: The immune system is a tightly regulated network, where regulatory T cells play an important role in maintaining immune homeostasis. Different types of T cells have regulatory functions in modulating immune responses, and the aging process can affect the composition of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Wei Zhang, Siyu Xia, Wei Xiao, Yali Song, Li Tang, Min Cao, Jing Yang, Shuang Wang, Zhijie Li, Chengchao Xu, Jianqiao Liu, Shanchao Zhao, Chuanbin Yang, Jigang Wang
Summary: This study focuses on the reproductive issues of advanced paternal age and analyzes the molecular and cellular changes associated with aging in the testes of mice. The study discovers various aging-related biological processes and identifies an increased subtype of aging-specific macrophages that contribute to a proinflammatory environment during testicular aging.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lindsay M. Reynolds, Kurt Lohman, Gary S. Pittman, R. Graham Barr, Gloria C. Chi, Joel Kaufman, Ma Wan, Douglas A. Bell, Michael J. Blaha, Carlos J. Rodriguez, Yongmei Liu
Article
Multidisciplinary Sciences
Yongmei Liu, Lindsay M. Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, Zhiqing Huang, Carole Grenier, Ma Wan, Hendrik G. Stunnenberg, David Siscovick, Lifang Hou, Bruce M. Psaty, Stephen S. Rich, Jerome I. Rotter, Joel D. Kaufman, Gregory L. Burke, Susan Murphy, David R. Jacobs, Wendy Post, Ina Hoeschele, Douglas A. Bell, David Herrington, John S. Parks, Russell P. Tracy, Charles E. McCall, James H. Stein
NATURE COMMUNICATIONS
(2017)
Review
Nutrition & Dietetics
Floyd H. Chilton, Rahul Dutta, Lindsay M. Reynolds, Susan Sergeant, Rasika A. Mathias, Michael C. Seeds
Article
Environmental Sciences
Ma Wan, Brian D. Bennett, Gary S. Pittman, Michelle R. Campbell, Lindsay M. Reynolds, Devin K. Porter, Christopher L. Growl, Xuting Wang, Dan Su, Neal A. Englert, Isabel J. Thompson, Yongmei Liu, Douglas A. Bell
ENVIRONMENTAL HEALTH PERSPECTIVES
(2018)
Article
Multidisciplinary Sciences
Lindsay M. Reynolds, Timothy D. Howard, Ingo Ruczinski, Kanika Kanchan, Michael C. Seeds, Rasika A. Mathias, Floyd H. Chilton
Article
Substance Abuse
Kaitlyn M. Berry, Lindsay M. Reynolds, Jason M. Collins, Michael B. Siegel, Jessica L. Fetterman, Naomi M. Hamburg, Aruni Bhatnagar, Emelia J. Benjamin, Andrew Stokes
Article
Cardiac & Cardiovascular Systems
Andrew Stokes, Jason M. Collins, Kaitlyn M. Berry, Lindsay M. Reynolds, Jessica L. Fetterman, Carlos J. Rodriguez, Michael B. Siegel, Emelia J. Benjamin
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Multidisciplinary Sciences
Martin Tibuakuu, Daisuke Kamimura, Sina Kianoush, Andrew P. DeFilippis, Mahmoud Al Rifai, Lindsay M. Reynolds, Wendy B. White, Kenneth R. Butler, Thomas H. Mosley, Stephen T. Turner, Iftikhar J. Kullo, Michael E. Hall, Michael J. Blaha
Article
Endocrinology & Metabolism
Jiantao Ma, Jana Nano, Jingzhong Ding, Yinan Zheng, Rachel Hennein, Chunyu Liu, Elizabeth K. Speliotes, Tianxiao Huan, Ci Song, Michael M. Mendelson, Roby Joehanes, Michelle T. Long, Liming Liang, Jennifer A. Smith, Lindsay M. Reynolds, Mohsen Ghanbari, Taulant Muka, Joyce B. J. van Meurs, Louise J. M. Alferink, Oscar H. Franco, Abbas Dehghan, Scott Ratliff, Wei Zhao, Lawrence Bielak, Sharon L. R. Kardia, Patricia A. Peyser, Hongyan Ning, Lisa B. VanWagner, Donald M. Lloyd-Jones, John Jeffrey Carr, Philip Greenland, Alice H. Lichtenstein, Frank B. Hu, Yongmei Liu, Lifang Hou, Sarwa Darwish Murad, Daniel Levy
Review
Cardiac & Cardiovascular Systems
Daniel J. Conklin, Suzaynn Schick, Michael J. Blaha, Alex Carll, Andrew DeFilippis, Peter Ganz, Michael E. Hall, Naomi Hamburg, Tim O'Toole, Lindsay Reynolds, Sanjay Srivastava, Aruni Bhatnagar
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Genetics & Heredity
Sinjini Sikdar, Roby Joehanes, Bonnie R. Joubert, Cheng-Jian Xu, Marta Vives-Usano, Faisal I. Rezwan, Janine F. Felix, James M. Ward, Weihua Guan, Rebecca C. Richmond, Jennifer A. Brody, Leanne K. Kupers, Nour Baiz, Siri E. Haberg, Jennifer A. Smith, Sarah E. Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A. Markunas, Tao Xu, Lindsay M. Reynolds, Allan C. Just, Pooja R. Mandaviya, Akram Ghantous, Brian D. Bennett, Tianyuan Wang, Kelly M. Bakulski, Erik Melen, Shanshan Zhao, Jianping Jin, Zdenko Herceg, Joyce van Meurs, Jack A. Taylor, Andrea A. Baccarelli, Susan K. Murphy, Yongmei Liu, Monica Cheng Munthe-Kaas, Ian J. Deary, Wenche Nystad, Melanie Waldenberger, Isabella Annesi-Maesano, Karen Conneely, Vincent W. V. Jaddoe, Donna Arnett, Harold Snieder, Sharon L. R. Kardia, Caroline L. Relton, Ken K. Ong, Susan Ewart, Hortensia Moreno-Macias, Isabelle Romieu, Nona Sotoodehnia, Myriam Fornage, Alison Motsinger-Reif, Gerard H. Koppelman, Mariona Bustamante, Daniel Levy, Stephanie J. London
Article
Cardiac & Cardiovascular Systems
Jiantao Ma, Casey M. Rebholz, Kim V. E. Braun, Lindsay M. Reynolds, Stella Aslibekyan, Rui Xia, Niranjan G. Biligowda, Tianxiao Huan, Chunyu Liu, Michael M. Mendelson, Roby Joehanes, Emily A. Hu, Mara Z. Vitolins, Alexis C. Wood, Kurt Lohman, Carolina Ochoa-Rosales, Joyce van Meurs, Andre Uitterlinden, Yongmei Liu, Mohamed A. Elhadad, Margit Heier, Melanie Waldenberger, Annette Peters, Elena Colicino, Eric A. Whitsel, Antoine Baldassari, Sina A. Gharib, Nona Sotoodehnia, Jennifer A. Brody, Colleen M. Sitlani, Toshiko Tanaka, W. David Hill, Janie Corley, Ian J. Deary, Yan Zhang, Ben Schoettker, Hermann Brenner, Maura E. Walker, Shumao Ye, Steve Nguyen, Jim Pankow, Ellen W. Demerath, Yinan Zheng, Lifang Hou, Liming Liang, Alice H. Lichtenstein, Frank B. Hu, Myriam Fornage, Trudy Voortman, Daniel Levy
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Lindsay M. Reynolds, Cristian Zamora, Un Jung Lee, Andrew C. Stokes, Emelia J. Benjamin, Aruni Bhatnagar, Thomas J. Payne, Carlos J. Rodriguez
Summary: Many adults with established cardiovascular disease continue to use tobacco products despite the known harmful effects, and only a small percentage have quit smoking over a four-year period.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biology
Chaojie Yang, Brian Hallmark, Jin Choul Chai, Timothy D. O'Connor, Lindsay M. Reynolds, Alexis C. Wood, Michael Seeds, Yii-Der Ida Chen, Lyn M. Steffen, Michael Y. Tsai, Robert C. Kaplan, Martha L. Daviglus, Lawrence J. Mandarino, Amanda M. Fretts, Rozenn N. Lemaitre, Dawn K. Coletta, Sarah A. Blomquist, Laurel M. Johnstone, Chandra Tontsch, Qibin Qi, Ingo Ruczinski, Stephen S. Rich, Rasika A. Mathias, Floyd H. Chilton, Ani Manichaikul
Summary: This study reveals a strong negative association between Amerind genetic ancestry and LC-PUFA levels, particularly low levels of n-3 LC-PUFAs. The single nucleotide polymorphism rs174537 on the FADS gene plays a significant role in influencing LC-PUFA levels, especially for n-3 LC-PUFAs at low levels.
COMMUNICATIONS BIOLOGY
(2021)