Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains

Mechanism of the αβ Conformational Change in F 1 -ATPase after ATP Hydrolysis: Free-Energy Simulations

(2015) Yuko Ito et al.   BIOPHYSICAL JOURNAL

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Structure, mechanism and cooperation of bacterial multidrug transporters

(2015) Dijun Du et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Statistical Thermodynamics for Functionally Rotating Mechanism of the Multidrug Efflux Transporter AcrB

(2015) Hirokazu Mishima et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural basis of RND-type multidrug exporters

(2015) Akihito Yamaguchi et al.   Frontiers in Microbiology

Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance

(2014) Jessica MA Blair et al.   Future Microbiology

AcrB, AcrD, and MdtABC Multidrug Efflux Systems Are Involved in Enterobactin Export in Escherichia coli

(2014) Tsukasa Horiyama et al.   PLoS One

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

(2014) Thomas Eicher et al.   eLife

Functional Rotation Induced by Alternating Protonation States in the Multidrug Transporter AcrB: All-Atom Molecular Dynamics Simulations

(2013) Tsutomu Yamane et al.   BIOCHEMISTRY

JLigand: a graphical tool for theCCP4 template-restraint library

(2012) Andrey A. Lebedev et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure and mechanism of the tripartite CusCBA heavy-metal efflux complex

(2012) F. Long et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Three ways in, one way out: Water dynamics in the trans-membrane domains of the inner membrane translocase AcrB

(2011) Nadine Fischer et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella

(2009) Kunihiko Nishino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The AcrB Efflux Pump: Conformational Cycling and Peristalsis Lead to Multidrug Resistance

(2008) Markus Seeger et al.   CURRENT DRUG TARGETS

The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes

(2008) Kunihiko Nishino et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY