Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

In vivo comparative study of distinct polymeric architectures bearing a combination of paclitaxel and doxorubicin at a synergistic ratio

(2017) Hemda Baabur-Cohen et al.   JOURNAL OF CONTROLLED RELEASE

Assessing the therapeutic efficacy of VEGFR-1-targeted polymer drug conjugates in mouse tumor models

(2016) Yosi Shamay et al.   JOURNAL OF CONTROLLED RELEASE

Restoring the oncosuppressor activity of microRNA-34a in glioblastoma using a polyglycerol-based polyplex

(2016) Paula Ofek et al.   Nanomedicine-Nanotechnology Biology and Medicine

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

(2016) Y. Shamay et al.   Science Translational Medicine

Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer–drug conjugates

(2015) Yosi Shamay et al.   JOURNAL OF CONTROLLED RELEASE

Smart linkers in polymer–drug conjugates for tumor-targeted delivery

(2015) Minglu Chang et al.   JOURNAL OF DRUG TARGETING

Enhancing Glioblastoma-Specific Penetration by Functionalization of Nanoparticles with an Iron-Mimic Peptide Targeting Transferrin/Transferrin Receptor Complex

(2015) Ting Kang et al.   MOLECULAR PHARMACEUTICS

Dendritic polyglycerol sulfate as a novel platform for paclitaxel delivery: pitfalls of ester linkage

(2015) Ana Sousa-Herves et al.   Nanoscale

Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients

(2015) Sara M. Tolaney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stable and Efficient Paclitaxel Nanoparticles for Targeted Glioblastoma Therapy

(2015) Qingxin Mu et al.   Advanced Healthcare Materials

The Thrombospondin-1 Mimetic ABT-510 Increases the Uptake and Effectiveness of Cisplatin and Paclitaxel in a Mouse Model of Epithelial Ovarian Cancer

(2015) Nicole E. Campbell et al.   NEOPLASIA

Intraoperative visualization of brain tumors with 5-aminolevulinic acid-induced fluorescence

(2014) Georg Widhalm   CLINICAL NEUROPATHOLOGY

Imaging of doxorubicin release from theranostic macromolecular prodrugs via fluorescence resonance energy transfer

(2014) Harald R. Krüger et al.   JOURNAL OF CONTROLLED RELEASE

Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs

(2014) Pengfei Jiang et al.   Journal of Translational Medicine

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis and Biological Evaluation of Radio and Dye Labeled Amino Functionalized Dendritic Polyglycerol Sulfates as Multivalent Anti-Inflammatory Compounds

(2013) Dominic Gröger et al.   BIOCONJUGATE CHEMISTRY

Targeted Delivery of Dendritic Polyglycerol–Doxorubicin Conjugates by scFv-SNAP Fusion Protein Suppresses EGFR+ Cancer Cell Growth

(2013) Ahmad Fawzi Hussain et al.   BIOMACROMOLECULES

Nano-sized polymers and liposomes designed to deliver combination therapy for cancer

(2013) Anat Eldar-Boock et al.   CURRENT OPINION IN BIOTECHNOLOGY

Receptor Mediated Cellular Uptake of Low Molecular Weight Dendritic Polyglycerols

(2013) Marcelo Calderón et al.   Journal of Biomedical Nanotechnology

Brain metastases: pathobiology and emerging targeted therapies

(2012) Matthias Preusser et al.   ACTA NEUROPATHOLOGICA

Thrombospondin-1 Mimetic Peptide ABT-898 Affects Neovascularization and Survival of Human Endometriotic Lesions in a Mouse Model

(2012) Diane S. Nakamura et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of Thrombospondin-1 Expression During Uveal Melanoma Progression and Its Potential Therapeutic Utility

(2012) Shoujian Wang   ARCHIVES OF OPHTHALMOLOGY

Prospective Study of Thrombospondin-1 Mimetic Peptides, ABT-510 and ABT-898, in Dogs with Soft Tissue Sarcoma

(2012) A.I. Sahora et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Prospective Identification of Glioblastoma Cells Generating Dormant Tumors

(2012) Ronit Satchi-Fainaro et al.   PLoS One

Synthesis of Dendritic Polyglycerol Anions and Their Efficiency Toward L-Selectin Inhibition

(2011) Marie Weinhart et al.   BIOMACROMOLECULES

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Therapies using anti-angiogenic peptide mimetics of thrombospondin-1

(2011) Jack Henkin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly(ethylene glycol) shell

(2011) Marcelo Calderón et al.   JOURNAL OF CONTROLLED RELEASE

Administration, distribution, metabolism and elimination of polymer therapeutics

(2011) Ela Markovsky et al.   JOURNAL OF CONTROLLED RELEASE

The Role of Dimension in Multivalent Binding Events: Structure-Activity Relationship of Dendritic Polyglycerol Sulfate Binding to L-Selectin in Correlation with Size and Surface Charge Density

(2011) Marie Weinhart et al.   MACROMOLECULAR BIOSCIENCE

ABT-898 Induces Tumor Regression and Prolongs Survival in a Mouse Model of Epithelial Ovarian Cancer

(2011) N. Campbell et al.   MOLECULAR CANCER THERAPEUTICS

Size-Dependant Cellular Uptake of Dendritic Polyglycerol

(2011) Stephanie Reichert et al.   Small

A Phase 1 Trial of ABT-510 Concurrent With Standard Chemoradiation for Patients With Newly Diagnosed Glioblastoma

(2010) Louis B. Nabors et al.   ARCHIVES OF NEUROLOGY

Structure-biocompatibility relationship of dendritic polyglycerol derivatives

(2010) Jayant Khandare et al.   BIOMATERIALS

Enhanced anti-glioblastoma efficacy by PTX-loaded PEGylated poly(ɛ-caprolactone) nanoparticles: In vitro and in vivo evaluation

(2010) Hongliang Xin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Biopharmaceutical drug targeting to the brain

(2010) William M. Pardridge   JOURNAL OF DRUG TARGETING

Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography

(2010) Sabrina Doblas et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation

(2010) J. Dernedde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selectins promote tumor metastasis

(2010) Heinz Läubli et al.   SEMINARS IN CANCER BIOLOGY

Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype

(2009) N. Almog et al.   CANCER RESEARCH

Phase II Trial of Gliadel plus O6-Benzylguanine in Adults with Recurrent Glioblastoma Multiforme

(2009) J. A. Quinn et al.   CLINICAL CANCER RESEARCH

Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma

(2009) Jennifer A. Quinn et al.   JOURNAL OF CLINICAL ONCOLOGY

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

(2009) Michael Weller et al.   Nature Reviews Neurology

Hydrogel Matrix Entrapping PLGA-Paclitaxel Microspheres: Drug Delivery with Near Zero-Order Release and Implantability Advantages for Malignant Brain Tumour Chemotherapy

(2009) Sudhir Hulikal Ranganath et al.   PHARMACEUTICAL RESEARCH

Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma

(2008) Teri N. Kreisl et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Progression-free survival: An important end point in evaluating therapy for recurrent high-grade gliomas

(2008) Kathleen R. Lamborn et al.   NEURO-ONCOLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE