AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity

Astrocytic control of synaptic function

(2017) Thomas Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice

(2017) Yan Bergeron et al.   Frontiers in Molecular Neuroscience

Membrane-tethered AKT kinase regulates basal synaptic transmission and early phase LTP expression by modulation of post-synaptic AMPA receptor level

(2016) Y. Pen et al.   HIPPOCAMPUS

Neural plasticity and behavior - sixty years of conceptual advances

(2016) J. David Sweatt   JOURNAL OF NEUROCHEMISTRY

Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia

(2016) Mizuki Hino et al.   JOURNAL OF PSYCHIATRIC RESEARCH

A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type

(2016) YUNCHENG ZHANG et al.   Oncology Letters

RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer’s disease

(2015) Helen Wong et al.   ACTA NEUROPATHOLOGICA

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Reduced protein synthesis in schizophrenia patient-derived olfactory cells

(2015) J A English et al.   Translational Psychiatry

Phenotypes ofAKT3deletion: A case report and literature review

(2014) Dayu Gai et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor

(2014) T. Nakai et al.   JOURNAL OF NEUROSCIENCE

Antipsychotics Activate mTORC1-Dependent Translation to Enhance Neuronal Morphological Complexity

(2014) H. Bowling et al.   Science Signaling

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication

(2013) Nishantha Kumarasinghe et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

Reduced Juvenile Long-Term Depression in Tuberous Sclerosis Complex Is Mitigated in Adults by Compensatory Recruitment of mGluR5 and Erk Signaling

(2013) Wyatt B. Potter et al.   PLOS BIOLOGY

Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients

(2013) A Hatzimanolis et al.   Translational Psychiatry

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

(2013) Josien Levenga et al.   Acta Neuropathologica Communications

Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation

(2012) Charles A. Hoeffer et al.   JOURNAL OF NEUROPHYSIOLOGY

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Marked Reduction of AKT1 Expression and Deregulation of AKT1-Associated Pathways in Peripheral Blood Mononuclear Cells of Schizophrenia Patients

(2012) Nico J. M. van Beveren et al.   PLoS One

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Regulation of Ribosomal Protein S6 Phosphorylation by Casein Kinase 1 and Protein Phosphatase 1

(2011) John A. Hutchinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Akt-Specific Inhibitor MK2206 Selectively Inhibits Thyroid Cancer Cells Harboring Mutations That Can Activate the PI3K/Akt Pathway

(2011) Ruixin Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Loss of Akt1 in Mice Increases Energy Expenditure and Protects against Diet-Induced Obesity

(2011) M. Wan et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity

(2011) T. O. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

(2009) Karla F. Leavens et al.   Cell Metabolism

Inhibitor hijacking of Akt activation

(2009) Tatsuya Okuzumi et al.   Nature Chemical Biology

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity

(2008) M. D. Antion et al.   LEARNING & MEMORY

mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice

(2008) M. D. Antion et al.   MOLECULAR AND CELLULAR BIOLOGY

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

(2008) Charles A. Hoeffer et al.   NEURON