Metabolic Engineering for Advanced Biofuels Production and Recent Advances Toward Commercialization

High-throughput enzyme screening platform for the IPP-bypass mevalonate pathway for isopentenol production

(2017) Aram Kang et al.   METABOLIC ENGINEERING

Improving monoterpene geraniol production through geranyl diphosphate synthesis regulation in Saccharomyces cerevisiae

(2016) Jianzhi Zhao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biological lignocellulose solubilization: comparative evaluation of biocatalysts and enhancement via cotreatment

(2016) Julie M. D. Paye et al.   Biotechnology for Biofuels

Engineering Escherichia coli to produce branched-chain fatty acids in high percentages

(2016) Gayle J. Bentley et al.   METABOLIC ENGINEERING

Isopentenyl diphosphate (IPP)-bypass mevalonate pathways for isopentenol production

(2016) Aram Kang et al.   METABOLIC ENGINEERING

Heterologous biosynthesis and manipulation of alkanes in Escherichia coli

(2016) Ying-Xiu Cao et al.   METABOLIC ENGINEERING

High production of fatty alcohols in Escherichia coli with fatty acid starvation

(2016) Yilan Liu et al.   Microbial Cell Factories

Rewriting yeast central carbon metabolism for industrial isoprenoid production

(2016) Adam L. Meadows et al.   NATURE

Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis

(2016) Yi Xiao et al.   Nature Chemical Biology

EngineeringYarrowia lipolyticaas a platform for synthesis of drop-in transportation fuels and oleochemicals

(2016) Peng Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of β-caryophyllene, a novel terpene-based high-density biofuel precursor, using engineered Escherichia coli

(2016) Jianming Yang et al.   RENEWABLE ENERGY

Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories

(2016) Yongjin J. Zhou et al.   Nature Communications

Comprehensive in Vitro Analysis of Acyltransferase Domain Exchanges in Modular Polyketide Synthases and Its Application for Short-Chain Ketone Production

(2016) Satoshi Yuzawa et al.   ACS Synthetic Biology

Bacterial Production of Pinene by a Laboratory-Evolved Pinene-Synthase

(2016) Miki Tashiro et al.   ACS Synthetic Biology

Disrupted short chain specific β-oxidation and improved synthase expression increase synthesis of short chain fatty acids in Saccharomyces cerevisiae

(2015) Christopher Leber et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property

(2015) Hui Tao et al.   Biotechnology for Biofuels

Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel

(2015) Wei Suong Teo et al.   Biotechnology for Biofuels

Metabolic engineering of Saccharomyces cerevisiae for linalool production

(2015) Pegah Amiri et al.   BIOTECHNOLOGY LETTERS

Microbial Synthesis of Myrcene by Metabolically Engineered Escherichia coli

(2015) Eun-Mi Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biosynthesis of odd-chain fatty alcohols in Escherichia coli

(2015) Ying-Xiu Cao et al.   METABOLIC ENGINEERING

Development of an orthogonal fatty acid biosynthesis system in E. coli for oleochemical production

(2015) Robert W. Haushalter et al.   METABOLIC ENGINEERING

Principal component analysis of proteomics (PCAP) as a tool to direct metabolic engineering

(2015) Jorge Alonso-Gutierrez et al.   METABOLIC ENGINEERING

Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica

(2015) Kangjian Qiao et al.   METABOLIC ENGINEERING

Metabolic engineering strategies for microbial synthesis of oleochemicals

(2015) Brian F. Pfleger et al.   METABOLIC ENGINEERING

Natural products as biofuels and bio-based chemicals: fatty acids and isoprenoids

(2015) Harry R. Beller et al.   NATURAL PRODUCT REPORTS

Challenges and opportunities in improving the production of bio-ethanol

(2015) Jan Baeyens et al.   PROGRESS IN ENERGY AND COMBUSTION SCIENCE

ABE fermentation products recovery methods—A review

(2015) Anna Kujawska et al.   RENEWABLE & SUSTAINABLE ENERGY REVIEWS

Oleaginous yeasts for biodiesel: Current and future trends in biology and production

(2014) Irnayuli R. Sitepu et al.   BIOTECHNOLOGY ADVANCES

Enhancing fatty acid ethyl ester production inSaccharomyces cerevisiaethrough metabolic engineering and medium optimization

(2014) R. Adam Thompson et al.   BIOTECHNOLOGY AND BIOENGINEERING

Correlation analysis of targeted proteins and metabolites to assess and engineer microbial isopentenol production

(2014) Kevin W. George et al.   BIOTECHNOLOGY AND BIOENGINEERING

Overproduction of fatty acids in engineeredSaccharomyces cerevisiae

(2014) Xiaowei Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction inEscherichia coli

(2014) Fayin Zhu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of Escherichia coli for production of fatty acid short-chain esters through combination of the fatty acid and 2-keto acid pathways

(2014) Daoyi Guo et al.   METABOLIC ENGINEERING

Utilizing an endogenous pathway for 1-butanol production in Saccharomyces cerevisiae

(2014) Tong Si et al.   METABOLIC ENGINEERING

Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains

(2014) Jiazhang Lian et al.   METABOLIC ENGINEERING

Production of anteiso-branched fatty acids in Escherichia coli ; next generation biofuels with improved cold-flow properties

(2014) Robert W. Haushalter et al.   METABOLIC ENGINEERING

Substantial improvements in methyl ketone production in E. coli and insights on the pathway from in vitro studies

(2014) Ee-Been Goh et al.   METABOLIC ENGINEERING

Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase

(2014) Zhe Rui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving fatty acids production by engineering dynamic pathway regulation and metabolic control

(2014) P. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retro-biosynthetic screening of a modular pathway design achieves selective route for microbial synthesis of 4-methyl-pentanol

(2014) Micah J. Sheppard et al.   Nature Communications

An engineered pathway for the biosynthesis of renewable propane

(2014) Pauli Kallio et al.   Nature Communications

Microbial Synthesis of Pinene

(2014) Stephen Sarria et al.   ACS Synthetic Biology

Engineering ofSaccharomyces cerevisiaefor the synthesis of short chain fatty acids

(2013) Christopher Leber et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of Escherichia coli for high-specificity production of isoprenol and prenol as next generation of biofuels

(2013) Yanning Zheng et al.   Biotechnology for Biofuels

Synthetic Biology and Metabolic Engineering Approaches To Produce Biofuels

(2013) Christine A. Rabinovitch-Deere et al.   CHEMICAL REVIEWS

Chemistry and combustion of fit-for-purpose biofuels

(2013) David A Rothamer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineering Escherichia coli for selective geraniol production with minimized endogenous dehydrogenation

(2013) Jia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism

(2013) Anastasia Krivoruchko et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production

(2013) Jorge Alonso-Gutierrez et al.   METABOLIC ENGINEERING

Production of medium chain length fatty alcohols from glucose in Escherichia coli

(2013) J. Tyler Youngquist et al.   METABOLIC ENGINEERING

Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli

(2013) Ran Liu et al.   METABOLIC ENGINEERING

Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals

(2013) Weerawat Runguphan et al.   METABOLIC ENGINEERING

Increased isobutanol production in Saccharomyces cerevisiae by eliminating competing pathways and resolving cofactor imbalance

(2013) Fumio Matsuda et al.   Microbial Cell Factories

Microbial production of short-chain alkanes

(2013) Yong Jun Choi et al.   NATURE

Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols

(2013) José L Avalos et al.   NATURE BIOTECHNOLOGY

Tailored fatty acid synthesis via dynamic control of fatty acid elongation

(2013) J. P. Torella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular optimization of multi-gene pathways for fatty acids production in E. coli

(2013) Peng Xu et al.   Nature Communications

Engineering Monoterpene Production in Yeast Using a Synthetic Dominant Negative Geranyl Diphosphate Synthase

(2013) Codruta Ignea et al.   ACS Synthetic Biology

A Synthetic Recursive “+1” Pathway for Carbon Chain Elongation

(2012) Ryan J. Marcheschi et al.   ACS Chemical Biology

Synthetic Pathway for Production of Five-Carbon Alcohols from Isopentenyl Diphosphate

(2012) Howard H. Chou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cytosolic re-localization and optimization of valine synthesis and catabolism enables inseased isobutanol production with the yeast Saccharomyces cerevisiae

(2012) Dawid Brat et al.   Biotechnology for Biofuels

Genetic engineering to enhance the Ehrlich pathway and alter carbon flux for increased isobutanol production from glucose by Saccharomyces cerevisiae

(2012) Takashi Kondo et al.   JOURNAL OF BIOTECHNOLOGY

Enhancing fatty acid production by the expression of the regulatory transcription factor FadR

(2012) Fuzhong Zhang et al.   METABOLIC ENGINEERING

Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production

(2012) Mitchell Tai et al.   METABOLIC ENGINEERING

Production of extracellular fatty acid using engineered Escherichia coli

(2012) Hui Liu et al.   Microbial Cell Factories

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

(2012) Fuzhong Zhang et al.   NATURE BIOTECHNOLOGY

Controlled biosynthesis of odd-chain fuels and chemicals via engineered modular metabolic pathways

(2012) H.-C. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Driving Forces Enable High-Titer Anaerobic 1-Butanol Synthesis in Escherichia coli

(2011) Claire R. Shen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineering of Bacterial Methyl Ketone Synthesis for Biofuels

(2011) Ee-Been Goh et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Terminal Olefin (1-Alkene) Biosynthesis by a Novel P450 Fatty Acid Decarboxylase fromJeotgalicoccusSpecies

(2011) Mathew A. Rude et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Modular Synthase-Encoding Gene Involved in α-Olefin Biosynthesis in Synechococcus sp. Strain PCC 7002

(2011) Daniel Mendez-Perez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

High-flux isobutanol production using engineered Escherichia coli: a bioreactor study with in situ product removal

(2011) Antonino Baez et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Increased isobutanol production in Saccharomyces cerevisiae by overexpression of genes in valine metabolism

(2011) Xiao Chen et al.   Biotechnology for Biofuels

Metabolic engineering of Escherichia coli for α-farnesene production

(2011) Chonglong Wang et al.   METABOLIC ENGINEERING

Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli

(2011) Sabine Bastian et al.   METABOLIC ENGINEERING

Policy: Fuelling politics

(2011) Martin Robbins   NATURE

Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals

(2011) Clementina Dellomonaco et al.   NATURE

Relative potential of biosynthetic pathways for biofuels and bio-based products

(2011) Deepak Dugar et al.   NATURE BIOTECHNOLOGY

Conversion of proteins into biofuels by engineering nitrogen flux

(2011) Yi-Xin Huo et al.   NATURE BIOTECHNOLOGY

Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways

(2011) Brooks B Bond-Watts et al.   Nature Chemical Biology

Identification and microbial production of a terpene-based advanced biofuel

(2011) Pamela P. Peralta-Yahya et al.   Nature Communications

Enhanced Production of a Plant Monoterpene by Overexpression of the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Catalytic Domain in Saccharomyces cerevisiae

(2010) J. Rico et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Advanced biofuel production in microbes

(2010) Pamela P. Peralta-Yahya et al.   Biotechnology Journal

The role of butanol in the development of sustainable fuel technologies

(2010) Benjamin G. Harvey et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Microbial Biosynthesis of Alkanes

(2010) A. Schirmer et al.   SCIENCE

Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes

(2009) Shota Atsumi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Production of first and second generation biofuels: A comprehensive review

(2009) S.N. Naik et al.   RENEWABLE & SUSTAINABLE ENERGY REVIEWS

Selection and optimization of microbial hosts for biofuels production

(2008) Curt R. Fischer et al.   METABOLIC ENGINEERING

Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol

(2008) Eric J Steen et al.   Microbial Cell Factories

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

(2008) Shota Atsumi et al.   NATURE

Expanding metabolism for biosynthesis of nonnatural alcohols

(2008) K. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic engineering of Escherichia coli for 1-butanol production

(2007) Shota Atsumi et al.   METABOLIC ENGINEERING