Article
Neurosciences
Bowei Chen, Jian Yi, Yaqian Xu, Huiqiao Wen, Fengming Tian, Yingfei Liu, Lan Xiao, Lisong Li, Baiyan Liu
Summary: This study investigated the role of ApoE in cognitive function in aging mice through the gut microbiota-brain axis. The results showed that ApoE deletion exacerbated cognitive dysfunction, hippocampal synaptic ultrastructural damage, and dysregulation of synaptic proteins. It also altered the gut microbial makeup and hippocampal metabolic profile.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Min Li, Yun Zhang, Jun Zhou, Hongmei Liu
Summary: SELENOF deficiency in young mice leads to glucose metabolism disorders, which improve with age. The knockout of SELENOF also causes oxidative stress and disrupts redox homeostasis in young mice.
Review
Biochemistry & Molecular Biology
Adam J. Nelson, Allan D. Sniderman, Marc Ditmarsch, Mary R. Dicklin, Stephen J. Nicholls, Michael H. Davidson, John J. P. Kastelein
Summary: Cholesteryl ester transfer protein (CETP) facilitates the exchange of cholesteryl esters and triglycerides between HDL particles and TG-rich, apoB-containing particles. Initially, CETP inhibitors were developed to raise plasma HDL-C levels to lower the risk of ASCVD. However, recent evidence suggests that CETP inhibitors can reduce LDL-C and apoB concentrations, thereby reducing the risk of major coronary events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Shu-Huei Wang, Feng-Chiao Tsai, Heng-Huei Lin, Tse-Ya Yu, Chun-Heng Kuo, Hung-Yuan Li, Mao-Shin Lin
Summary: Oxidative stress plays a crucial role in the development of atherosclerosis and non-alcoholic fatty liver disease. Monoamine oxidase is a major source of oxidative stress in the vascular system and liver. Inhibition of monoamine oxidase B shows potential as a novel treatment for atherosclerosis and NAFLD.
Article
Biochemistry & Molecular Biology
Tingting Liu, Xiaolei Zhu, Chaoli Huang, Jiang Chen, Shu Shu, Guiquan Chen, Yun Xu, Yimin Hu
Summary: The study shows that PP2A is critical for neuronal survival and inhibition of ERK may be an effective strategy to reduce cell death in brain diseases.
Article
Biochemistry & Molecular Biology
Yoshinori Ohmura, Naoki Ishimori, Akimichi Saito, Takashi Yokota, Shunpei Horii, Satoshi Tokuhara, Kazuya Iwabuchi, Hiroyuki Tsutsui
Summary: Our study demonstrated that iNKT cells are involved in exacerbating plaque instability by activating inflammatory cells and upregulating MMP-2 in vascular tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Safa Kinaneh, Walaa Hijaze, Lana Mansour-Wattad, Rawan Hammoud, Hisam Zaidani, Aviva Kabala, Shadi Hamoud
Summary: Heparanase inhibition significantly attenuates the development of liver steatosis by decreasing tissue lipid content and affecting the mRNA expression of key lipid metabolism regulators.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Samuel K. Lee, Rida A. Malik, Ji Zhou, Wei Wang, Peter L. Gross, Jeffrey I. Weitz, Rithwik Ramachandran, Bernardo L. Trigatti
Summary: This study investigated the effects of PAR4 inhibitory pepducin (RAG8) on coronary artery disease in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet. The results showed that RAG8 reduced coronary artery atherosclerosis and myocardial fibrosis, as well as platelet and leukocyte accumulation in atherosclerotic coronary arteries.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laeticia Scherler, Sofia N. Verouti, Daniel Ackermann, Bruno Vogt, Genevieve Escher
Summary: In this study, adenine was used to induce nephropathy in mice, showing the loss of protective effects of renal cholesterol and vitamin D-3 metabolism under this condition. It was found that adenine enhanced cholesterol efflux and eliminated lipids in feces, which had a protective effect against atherosclerosis but also affected bone growth.
Article
Multidisciplinary Sciences
Wenjiao Gu, Yujie Wei, Yu Tang, Shining Zhang, Shuangyi Li, Youming Shi, Fenxia Tang, Ali Mohamed Awad, Xiaowei Zhang, Futian Tang
Summary: This study investigated the effects of exogenous inorganic pyrophosphate sources ADTP and AL on atheromatous calcification in ApoE KO mice. The results showed that both ADTP and AL reduced calcification by increasing PPi levels and regulating inflammation.
Article
Biochemistry & Molecular Biology
Shi-Hui Law, Hua-Chen Chan, Guan-Ming Ke, Swetha Kamatam, Gopal Kedihithlu Marathe, Vinoth Kumar Ponnusamy, Liang-Yin Ke
Summary: Despite the availability of cholesterol-lowering drugs, atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality. Lipid moieties such as lysophosphatidylcholine (LPC) and ceramide (CER) contribute to atherogenic events. The HFD-fed apoE(-/-) mouse model shows elevated LPC and CER contents, making it suitable for developing LPC- and CER-lowering therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H. van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A. A. M. Kamps, Daniel H. van Raalte, Rutger W. van der Meer, Hildo J. Lamb, Jan-Luuk Hillebrands, Ton J. Rabelink, Marissa L. Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
Summary: PPAR y agonists can ameliorate proteinuria by inhibiting the expression of glomerular HPSE, providing a potential mechanism for the renoprotective effects of these drugs.
Article
Neurosciences
Kathia Ramirez-Armenta, Hector Alatriste-Leon, Anil K. Verma-Rodriguez, Argelia Llanos-Moreno, Josue O. Ramirez-Jarquin, Fatuel Tecuapetla
Summary: Excessive grooming in Sapap3-KO mice is used as a model for obsessive-compulsive disorder. Studies show that dysregulation of cortico-striatal circuits is crucial for compulsive behaviors, with alteration in striatal neural activity patterns thought to underlie excessive grooming in these mice. Inhibiting striatal neurons in Sapap3-KO mice increases grooming episodes, but specifically inhibiting indirect pathway neurons reduces compulsive grooming, suggesting potential treatment targets for OCD patients.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Jixin Liu, Qiuning Wang, Yujie Wei, Shining Zhang, Erqing Chai, Futian Tang
Summary: The study showed that CAI can inhibit the development of atherosclerotic lesions in ApoE KO mice by reducing oxidative stress and inflammation, as well as improving cholesterol intake and efflux pathways.
MICROVASCULAR RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Ji-Xian Song, Ji-Ren An, Qi Chen, Xin-Yue Yang, Cui-Ling Jia, Shan Xu, Ya-shuo Zhao, En-Sheng Ji
Summary: Liraglutide protects against liver pathological changes in a mouse model of type 2 diabetes by reducing iron accumulation, inhibiting oxidative damage, and preventing ferroptosis.
Correction
Multidisciplinary Sciences
Reem Ismael-Badarneh, Julia Guetta, Geula Klorin, Gidon Berger, Niroz Abu-saleh, Zaid Abassi, Zaher S. Azzam
Article
Medicine, Research & Experimental
Niroz Abu-Saleh, Michael Aviram, Tony Hayek
Article
Health Care Sciences & Services
A. Mandil, F. Curlet, H. Nour El-Din, N. Abu-Saleh, M. A. Ahmed
EASTERN MEDITERRANEAN HEALTH JOURNAL
(2016)
Article
Biochemistry & Molecular Biology
Oren Rom, Claudia Grajeda-Iglesias, Mahmoud Najjar, Niroz Abu-Saleh, Nina Volkova, Dalit Esther Dar, Tony Hayek, Michael Aviram
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Claudia Grajeda-Iglesias, Oren Rom, Shadi Hamoud, Nina Volkova, Tony Hayek, Niroz Abu-Saleh, Michael Aviram
Article
Hematology
Salmas Watad, Niroz Abu-Saleh, Awni Yousif, Abed Agbaria, Hanna Rosenbaum
BLOOD CELLS MOLECULES AND DISEASES
(2018)
Article
Cardiac & Cardiovascular Systems
Rabia Shekh Muhammad, Niroz Abu-Saleh, Safa Kinaneh, Mohammad Agbaria, Edmond Sabo, Claudia Grajeda-Iglesias, Nina Volkova, Shadi Hamoud
Article
Nanoscience & Nanotechnology
Morad K. Nakhleh, Haitham Amal, Hoda Awad, A'laa Gharra, Niroz Abu-Saleh, Raneen Jeries, Hossam Haick, Zaid Abassi
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2014)
Article
Multidisciplinary Sciences
Reem Ismael-Badarneh, Julia Guetta, Geula Klorin, Gidon Berger, Niroz Abu-saleh, Zaid Abassi, Zaher S. Azzam
Article
Cardiac & Cardiovascular Systems
Niroz Abu-Saleh, Doron Aronson, Mogher Khamaisi, Emad E. Khoury, Hoda Awad, Aviva Kabala, Rawi Ramadan, Tony Karram, Eli Kakiashvili, Bishara Bishara, Zaid Abassi
JOURNAL OF CARDIAC FAILURE
(2019)
Article
Cell Biology
Niroz Abu-Saleh, Hiba Yaseen, Safa Kinaneh, Mogher Khamaisi, Zaid Abassi
Summary: The study found that the combination of hyperglycemia and hyperlipidemia could lead to endothelial dysfunction, increase production of endothelin-1, decrease both total endothelial NO synthase and NRF2 activity, activate the endothelin system and attenuate the nitric oxide system.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Iyad N. Khamaysi, Preeti Singh, Neta Ilan, Israel Vlodavsky, Edward Hammond, Niroz Abu-Saleh, Hoda Awad, Yehuda Chowers, Zaid Abassi
Article
Physiology
Niroz Abu-Saleh, Hoda Awad, Mogher Khamaisi, Zaher Armaly, Tony Karram, Samuel N. Heyman, Aviva Kaballa, Takaharu Ichimura, James Holman, Zaid Abassi
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2014)
Article
Multidisciplinary Sciences
Safa Kinaneh, Mohammad Agbaria, Niroz Abu-Saleh, Shadi Hamoud