Article
Cell Biology
Yanyan Wang, Mingzhi Zhu, Jingruo Li, Youyi Xiong, Jing Wang, Haihong Jing, Yuanting Gu
Summary: The study confirmed the involvement of PSMC2 in breast cancer development, with its overexpression correlated with malignancy and promoting breast cancer progression through interaction with PLAU. Knockdown of PSMC2 showed inhibitory effects on breast cancer development.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Hongyu Gao, Hanjun Li, Jingjie Wang, Cheng Xu, Yueyun Zhu, Dilihumaer Tuluhong, Xinfang Li, Shaohua Wang, Jieshou Li
Summary: In breast cancer, abnormal expression of AMD1 has been found to promote tumor growth and malignant progression. Increased AMD1 is associated with clinical indicators and predicts poor prognosis in breast cancer patients, indicating its potential as a therapeutic target and diagnostic biomarker.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Genetics & Heredity
Xiu-Xia Zhang, Jun-Hua Luo, Li-Qiang Wu
Summary: This study revealed that high expression of fibronectin 1 (FN1) is correlated with poor clinical outcomes and serves as an independent prognostic factor in breast cancer (BRCA). FN1 is also associated with tumor-infiltrating immune cells and immune checkpoint inhibitors, potentially aiding in the treatment of BRCA patients. The results highlight FN1 as a novel prognostic biomarker and therapeutic target for BRCA.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Ju Hee Kim, Eun-Shin Lee, Jihui Yun, Han Suk Ryu, Hong Kyu Kim, Young Wook Ju, Kwangsoo Kim, Jong-Il Kim, Hyeong-Gon Moon
Summary: CASQ2, a newly identified breast cancer-related gene, has been found to potentially regulate tumor-microenvironment interactions by promoting a more aggressive phenotype and altering epithelial-mesenchymal transition (EMT) markers in breast cancer cells. Overexpression of CASQ2 also induces cancer-associated fibroblast characteristics and increases hypoxia-inducible factor 1 alpha (HIF1 alpha) expression in stromal fibroblasts, leading to accelerated tumorigenesis, collagen structure remodeling, and distant metastasis in vivo. CASQ2 may confer more metaplastic features to triple-negative breast cancer cells, suggesting its key role in breast cancer tumorigenesis and metastasis through modulating various aspects of tumor-microenvironment interactions.
MOLECULAR ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
Summary: Inflammasomes play a crucial role as intracellular sensors in pathogen infection and cellular perturbation. Human NLRP1 has been identified as a direct sensor for dsRNA, triggering activation during RNA virus infection. The NLRP1 complex binds dsRNA through its leucine-rich repeat domain, leading to activation through adenosine triphosphatase activity in its NACHT domain.
Article
Oncology
Zhengwei Gui, Yao Tian, Shiyang Liu, Tianyao Yu, Chenguang Liu, Lin Zhang
Summary: This study investigated the expression of Centromere protein L (CENPL) in breast cancer and its relationship with patient prognosis. High CENPL expression was found to be associated with the cell cycle, nuclear division, organelle fission, and chromosome segregation in breast cancer. Furthermore, high CENPL expression was correlated with immune cell infiltration and ICP gene expression. Inhibition of CENPL reduced the proliferation and migration ability of breast cancer cells. Therefore, CENPL may function as an oncogene in breast cancer and serve as a predictor of immunotherapy efficacy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Aiqin Sun, Xianyan Tian, Wannian Yang, Qiong Lin
Summary: The study found that SCYL1 is overexpressed in breast cancer and is associated with poor clinical outcomes. Silencing SCYL1 can inhibit the proliferation and migration of breast cancer cells. Therefore, SCYL1 may be a biomarker for prognosis in breast cancer patients and a potential target for breast cancer therapy.
Article
Oncology
Brian G. Hunt, Angelle Jones, Carissa Lester, James C. Davis, Nancy M. Benight, Susan E. Waltz
Summary: The study reveals that co-overexpression of RON and HGFL in cancer cells, augmented by physiological sources of HGFL, promotes tumorigenesis through autocrine-mediated RON activation, MAPK-dependent secretion of chemotactic factors, and paracrine activation of macrophage RON to promote breast cancer stem cell self-renewal.
Article
Pathology
Jia Chai, Tianqi Xu, Yanru Yang, Yuan Yuan, Junpeng Xu, Jin Liu, Kaijing Wang, Yao Lv, Jialin Chai, Yulin Kang, Ligang Chen, Junhui Qin, Qingge Jia, Mingyang Li
Summary: Esophageal squamous cell carcinoma (ESCC) is a common cancer with poor prognosis. This study found that overexpression of OTX1 is associated with the prognosis and tumorigenesis of ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Immunology
Renjie Yuan, Yulu Zhang, Yange Wang, Hongling Chen, Ruiming Zhang, Zhiyuan Hu, Chengsen Chai, Tingmei Chen
Summary: GNPNAT1 is upregulated in breast cancer tissues and is associated with patients' survival and immunotherapy response. Functional enrichment analysis reveals enriched pathways in high GNPNAT1 expression group including citrate cycle, N-glycan biosynthesis, DNA repair, and basal transcription factors. Silencing GNPNAT1 impairs the proliferation and invasion abilities of breast cancer cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Xiuyuan Zhang, Yiming Li, Pengbo Hu, Liang Xu, Hong Qiu
Summary: Kinesin superfamily member 2C (KIF2C) is an important regulator of the cell cycle and its aberrant expression is associated with tumor progression and poor prognosis. It is also involved in immune regulation and is associated with factors such as tumor mutation burden, microsatellite instability, mismatch repairs, and immune cell infiltration. Targeting KIF2C may improve the outcome of immunotherapy.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Qiang Song, Wenjin Zhang, Dan Shi, Zhiliang Zhang, Qiurong Zhao, Mengyuan Wang, Man Huang, Juanjuan Meng, Wei Cui, Xiaohe Luo
Summary: This study found that CB2 is lowly expressed in breast cancer, but highly expressed in benign tumors and ductal carcinoma in situ, and its expression is correlated with prognosis. Overexpression of CB2 and treatment with a CB2 agonist can inhibit proliferation and promote apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR signaling pathway. Moreover, overexpression of CB2 can increase the sensitivity of breast cancer cells to chemotherapy drugs. Therefore, CB2 could be a novel target for the diagnosis and treatment of breast cancer.
Article
Biochemistry & Molecular Biology
Shaojun Chen, Xiuwu Pan, Liang Zhang, Xingang Cui, Jianqing Ye
Summary: The expression of FOXK1 is increased in RCC, and its knockdown inhibits proliferation, migration, invasion, and promotes apoptosis in RCC cells. Additionally, FOXK1 knockdown suppresses epithelial-mesenchymal transition and Wnt signaling in RCC cells. There is a correlation between upregulated FOXK1 and tumor associated macrophages infiltration in RCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Multidisciplinary Sciences
Judit Doczi, Noemi Karnok, David Bui, Victoria Azarov, Gergely Pallag, Sara Nazarian, Bence Czumbel, Thomas N. N. Seyfried, Christos Chinopoulos
Summary: This study investigates the effects of severe hypoxia, site-specific inhibition of respiratory chain components, and uncouplers on 2D-cultured HepG2 and MCF-7 tumor cells. The results show that there is no correlation between oxidative phosphorylation activity and viability in these cell lines, indicating that the connection between oxidative phosphorylation and cancer cell survival is dependent on cell type and conditions.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jun Liu, Jinglin Mi, Shiqian Liu, Haiqiang Chen, Li Jiang
Summary: This study found that PSMB5 is highly expressed in hepatocellular carcinoma (HCC) and is associated with poor prognosis. Silencing PSMB5 can inhibit cell proliferation and migration in HCC while increasing apoptosis. PSMB5 appears to promote HCC cell proliferation by inactivating the phosphatidylinositol-3-kinase/Akt/mechanistic target of rapamycin signaling pathway. Therefore, PSMB5 may have potential as a biomarker for diagnosis and prognosis of HCC.