Article
Critical Care Medicine
Kun He Lee, Vasileios-Arsenios Lioutas, Sarah Marchina, Magdy Selim
Summary: This study found that an early increase in ventricular size is independently associated with lower odds of good clinical outcome in the context of intracerebral hemorrhage, while measures of perihematomal edema (PHE) were not significantly associated with outcome.
NEUROCRITICAL CARE
(2022)
Article
Medicine, General & Internal
Jiahao Chen, Yiting Chen, Yisi Lin, Jingfang Long, Yufeng Chen, Jincai He, Guiqian Huang
Summary: This study explored the relation between bilirubin levels and spontaneous hemorrhagic transformation (sHT) and hemorrhagic transformation after mechanical thrombectomy (tHT) in acute ischemic stroke (AIS) patients. The results indicated that an increased total bilirubin level was associated with a higher risk of sHT and tHT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Yongfa Zhang, Xiaoyang Lu, Bai Tai, Weijia Li, Tao Li
Summary: Ferroptosis is a unique form of regulated cell death characterized by intracellular iron overload, and it has been shown to play important roles in various cancers as well as in the progression of cerebral stroke.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Anxin Wang, Xue Tian, Yingting Zuo, Shuohua Chen, Dapeng Mo, Licheng Zhang, Shouling Wu, Yanxia Luo, Yongjun Wang
Summary: The study found that stable high serum uric acid (SUA) levels were significantly associated with an increased risk of hemorrhagic stroke, but not with the risk of total and ischemic stroke.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Kathryn M. Rexrode, Tracy E. Madsen, Amy Y. X. Yu, Cheryl Carcel, Judith H. Lichtman, Eliza C. Miller
Summary: Women bear a disproportionate burden of stroke mortality and disability. Both biological sex and sociocultural gender contribute to differences in stroke risk factors, assessment, treatment, and outcomes. This review outlines the current knowledge of the impact of sex and gender on stroke, while also identifying research gaps and areas for future inquiry.
CIRCULATION RESEARCH
(2022)
Article
Clinical Neurology
Xue Tian, Shuohua Chen, Qin Xu, Penglian Wang, Yijun Zhang, Xiaoli Zhang, Yanxia Luo, Shouling Wu, Anxin Wang
Summary: This study found a longitudinal association between cumulative serum uric acid (SUA) and stroke risk in a cohort of 50,871 Chinese participants. Higher cumulative SUA and longer accumulation time were associated with an increased risk of stroke, highlighting the importance of early control of SUA to prevent stroke.
Article
Neurosciences
Biying Liu, Dan Huang, Yunlu Guo, Xiaoqiong Sun, Caiyang Chen, Xiaozhu Zhai, Xia Jin, Hui Zhu, Peiying Li, Weifeng Yu
Summary: Neurological disorders after surgery in elderly patients, such as postoperative delirium and cognitive dysfunction, pose significant challenges and can lead to worsened functional outcomes and quality of life. Preventive measures and prompt treatment are crucial in reducing long-term risks and improving recovery.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Mari Carmen Gomez-de Frutos, Fernando Laso-Garcia, Ivan Garcia-Suarez, Luke Diekhorst, Laura Otero-Ortega, Maria Alonso de Lecinana, Blanca Fuentes, Dolores Piniella, Gerardo Ruiz-Ares, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez
Summary: Ultrasound has shown potential in monitoring and treating acute ischemic stroke in experimental animal models, with studies demonstrating its safety and effectiveness in therapeutic applications. Further exploration is needed to determine the limitations and ensure accuracy in translational research.
Article
Geriatrics & Gerontology
Aline Mendes, Francois R. Herrmann, Laurence Genton, Christine Serratrice, Emmanuel Carrera, Maria Isabel Vargas, Gabriel Gold, Christophe E. Graf, Dina Zekry, Max Scheffler
Summary: The incidence of acute stroke in older COVID-19 patients was 4.15%, with common characteristics being altered consciousness/delirium and focal neurological deficits. Risk factors for stroke included smoking, previous stroke history, and low BMI. However, acute stroke did not affect in-hospital mortality or institutionalization rates at discharge.
Article
Neurosciences
Si-Ting Wu, Jin-Rui Han, Nan Yao, Yu-Lin Li, Fang Zhang, Yao Shi, Fu-Dong Shi, Zhi-Guo Li
Summary: The study found that P2X4 receptor is upregulated in ICH patients and in a mouse model, and inhibition of P2X4 receptor can attenuate acute brain injury triggered by ICH, protecting the brain from damage.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Environmental Sciences
Pei-Chun Chen, Fung-Chang Sung, Chih-Hsin Mou, Chao W. Chen, Shan P. Tsai, Dennis H. P. Hsieh, Chung Y. Hsu
Summary: Long-term exposure to PM2.5 is associated with an increased risk of developing ischemic stroke, particularly at high concentrations of PM2.5.
ENVIRONMENTAL HEALTH
(2022)
Article
Genetics & Heredity
Justyna Chojdak-Lukasiewicz, Edyta Dziadkowiak, Slawomir Budrewicz
Summary: Strokes are the leading cause of death and long-term disability worldwide, with monogenic disorders accounting for approximately 1% to 5% of cases. Early diagnosis of single-gene disorders associated with strokes is rare but crucial for providing appropriate therapy.
Article
Clinical Neurology
Shih-Kai Hung, Moon-Sing Lee, Hon-Yi Lin, Liang-Cheng Chen, Chi-Jou Chuang, Chia-Hui Chew, Ben-Hui Yu, Hsuan-Ju Yang, Feng-Chun Hsu, Wen-Yen Chiou
Summary: This study investigated the relationship between different subtypes of hypertensive disorders of pregnancy (HDP), stroke risk, and follow-up time. The results showed that women with HDP had a higher risk of stroke compared to those without HDP, and this risk was associated with the time after childbirth. Among the different HDP subtypes, chronic hypertension with superimposed preeclampsia had the highest stroke risk, while chronic preexisting hypertension had the lowest risk. Furthermore, HDP combined with preeclampsia further increased the risk of stroke.
Review
Biochemistry & Molecular Biology
Eun Chae Lee, Tae Won Ha, Dong-Hun Lee, Dong-Yong Hong, Sang-Won Park, Ji Young Lee, Man Ryul Lee, Jae Sang Oh
Summary: Stroke is a leading cause of death and neurological disorders globally, but diagnostic techniques and treatments are limited for certain types. Recent studies have focused on the clinical value of utilizing exosome mechanisms and reported changes in diagnostic biomarkers of exosomes after stroke, as well as their potential applications in therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xuan Wu, Siming Fu, Yun Liu, Hansheng Luo, Feng Li, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Clinical Neurology
Fushu Luo, Yuanyou Li, Yutong Zhao, Mingjiang Sun, Qiuguang He, Rong Wen, Zongyi Xie
Summary: The systemic immune-inflammation index (SII) is closely related to the prognosis of patients with aneurysmal subarachnoid hemorrhage (aSAH), with higher SII levels on admission associated with unfavorable outcomes at 6 months. Binary logistic regression analysis revealed an independent association between SII on admission and 6-month clinical outcomes.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Lingui Gu, Mingjiang Sun, Ruihao Li, Yihao Tao, Xu Luo, Jing Xu, Xuan Wu, Zongyi Xie
Summary: Activation of RKIP can mitigate neuronal pyroptosis and brain injury after ICH via the ASC/Caspase-1/GSDMD pathway.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ruihao Li, Xingyu Zhang, Lingui Gu, Ye Yuan, Xu Luo, Weiwei Shen, Zongyi Xie
Summary: Ferroptosis is involved in the development of secondary brain injury after intracerebral hemorrhage (ICH), and targeting this process may be a potential therapy for reducing further brain damage. This study found that over-expression of CDGSH iron sulfur domain 2 (CISD2) can inhibit ferroptosis and improve neurological outcomes in mice after ICH. CISD2 over-expression up-regulated markers of ferroptosis and decreased markers of neuronal cell death, suggesting that CISD2 may be a potential target for mitigating brain injury through its anti-ferroptotic effect.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Siming Fu, Xu Luo, Xuan Wu, Tongyu Zhang, Linggui Gu, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
