Article
Oncology
Ajay Kumar, Anas Ahmad, Md Meraj Ansari, Vemana Gowd, Summya Rashid, Anis Ahmad Chaudhary, Hassan Ahmed Rudayni, Sulaiman A. Alsalamah, Rehan Khan
Summary: DNA nanostructures have shown remarkable potential in drug delivery and cancer therapy. Their high spatial addressability and self-assembly properties make them ideal for controlled drug release and targeted delivery, reducing cellular toxicity.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Chemistry, Medicinal
Anai A. Valencia-Lazcano, Dilawar Hassan, Mehrab Pourmadadi, Amin Shamsabadipour, Razieh Behzadmehr, Abbas Rahdar, Dora I. Medina, Ana M. Diez-Pascual
Summary: This study reviews the applications of 5-Fluorouracil (5-FU) as an anticancer drug for various types of cancers. Different approaches, such as nanoparticles loaded with 5-FU, co-delivery systems with other drugs, have been described to overcome the limitations of 5-FU therapy. This review provides the latest progress on 5-FU-loaded nanocarriers and their potential as an advanced tool for cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Gezhi Kong, Meng Zhang, Mengyi Xiong, Mei Chen, Chan Yang, Yan Zhao, Yue Yang, Zilong Zhao, Zhi-Ling Song, Liang Gong, Guoliang Ke, Xiao-Bing Zhang, Weihong Tan
Summary: The FNA-CEC system developed in this study, with spatial confinement on a DNA tetrahedron scaffold, improves the efficiency of intermediate metabolites transportation between enzyme cascades, enabling efficient synergistic cancer therapy in vitro and in vivo.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ramesh Singh, Pankaj Yadav, Hema Naveena, Dhiraj Bhatia
Summary: Self-assembled DNA nanocages have great potential in bioimaging and payload delivery. However, the cellular uptake of tetrahedral nanocages is hindered by electrostatic repulsion. In this study, we enhance the cellular uptake of DNA nanocages through the functionalization of a model cage with a cationic lipid. The results demonstrate the enhancement in cellular uptake and suggest multiple applications in gene transfection, drug delivery, and targeted bioimaging.
Review
Polymer Science
Azeez Yusuf, Awatif Rashed Z. Almotairy, Hanan Henidi, Ohoud Y. Alshehri, Mohammed S. Aldughaim
Summary: Nanotechnology has experienced rapid development in the past four decades and has revolutionized various aspects of everyday life. It has had significant impacts on fields like medicine and food industry, leading to improvements in shelf life of food, drug delivery, and development of specific therapeutics.
Review
Pharmacology & Pharmacy
Ghulam Mustafa, Dilawar Hassan, Gustavo Ruiz-Pulido, Mehrab Pourmadadi, Mohammad Mahdi Eshaghi, Razieh Behzadmehr, Fatemeh Soltani Tehrani, Abbas Rahdar, Dora Iliana Medina, Sadanand Pandey
Summary: Paclitaxel is an effective anticancer chemical with a broad spectrum of action. It is difficult to use due to its limited solubility, tendency to recrystallize, and cosolvent-induced toxicity. Nanotechnology and nanoparticles offer benefits in terms of improved drug half-life, decreased toxicity, and targeted drug delivery. Nano-drugs can accumulate in tissues, increasing permeability and anticancer activity while minimizing toxicity in healthy tissues.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Natalia A. D'Angelo, Mariana A. Noronha, Isabelle S. Kurnik, Mayra C. C. Camara, Jorge M. Vieira, Luis Abrunhosa, Joana T. Martins, Thais F. R. Alves, Louise L. Tundisi, Janaina A. Ataide, Juliana S. R. Costa, Angela F. Jozala, Laura O. Nascimento, Priscila G. Mazzola, Marco Chaud, Antonio A. Vicente, Andre M. Lopes
Summary: This study reviews the literature from the past 10 years on the encapsulation of curcumin (CUR) in nanostructured systems, highlighting its use and ability in cancer therapy. The findings show that these nanoformulations achieved higher solubility, improved tumor cytotoxicity, prolonged CUR release, and reduced side effects, among other interesting advantages.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Sandy Elmehrath, Ha L. Nguyen, Sherif M. Karam, Amr Amin, Yaser E. Greish
Summary: A variety of nanomaterials, including both synthetic and natural nanoparticles and nanofibers, have been developed for drug delivery in cancer treatment. Metal-organic framework (MOF) nanostructures have emerged as highly successful drug delivery systems (DDSs) due to their high surface area, interconnected porosity, and variable chemical functionality. This review provides an overview of the development and applications of chemically-functionalized MOF nanostructures in DDSs for cancer treatment.
Review
Pharmacology & Pharmacy
Lucia Ruxandra Tefas, Cristina Barbalata, Cristian Tefas, Ioan Tomuta
Summary: Cancer stem cells (CSCs) are resistant to conventional therapies, making salinomycin a promising new candidate that selectively targets CSCs. Nanotechnology allows for efficient delivery of salinomycin to tumors, reducing collateral damage and enhancing therapeutic outcomes.
Review
Nanoscience & Nanotechnology
Jing Yang, Jinlu Shang, Liuxuan Yang, Daiqing Wei, Xia Wang, Qinmin Deng, Zhirong Zhong, Yun Ye, Meiling Zhou
Summary: Honokiol (HNK) is a small-molecule polyphenol with diverse pharmacological properties. However, its clinical application is limited by challenges such as low solubility, poor bioavailability, and rapid metabolism. To overcome these limitations, researchers have developed various nano-formulations for HNK delivery, offering advantages such as enhanced solubility, improved bioavailability, extended circulation time, and targeted drug delivery. This paper comprehensively reviews different types of nanomaterials used for HNK delivery over the past 15 years and discusses their latest applications, development prospects, and future challenges.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Medicine, Research & Experimental
Rubiya Khursheed, Kamal Dua, Sukriti Vishwas, Monica Gulati, Niraj Kumar Jha, Ghalib Mohammed Aldhafeeri, Fayez Ghadeer Alanazi, Bey Hing Goh, Gaurav Gupta, Keshav Raj Paudel, Philip M. Hansbro, Dinesh Kumar Chellappan, Sachin Kumar Singh
Summary: The advancements in nanotechnology have led to extensive exploration of metallic nanoparticles for biomedical applications. These nanoparticles possess inert nature and nanoscale structures similar to biological molecules, and their characteristics can be altered by changing certain particle properties. They have found applications in targeted drug delivery, sensing, photothermal and photodynamic therapy, imaging, and modulation of multiple applications in biomedicine.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Huimin Shao, Pegah Varamini
Summary: This review discusses promising nanotechnologies for targeted delivery of therapeutics to improve the treatment of breast cancer bone metastasis. Understanding these new therapeutic approaches may improve the survival and quality of life of patients with bone metastasis from breast cancer.
Review
Pharmacology & Pharmacy
Marta Silva, Tangming Peng, Xia Zhao, Shuai Li, Mohd Farhan, Wenhua Zheng
Summary: Diabetic retinopathy is a common complication of diabetes, with challenges in treatment due to the low bioavailability of drugs at the target site in the eye, requiring long-term and frequent injections. Efforts have been made in recent years to develop new drug delivery platforms to enhance permeation, prolong retention time, and provide sustained release to reduce toxicity and improve efficacy.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Medicinal
Yusuf A. Haggag, Abeer A. Abd Elrahman, Roland Ulber, Ahmed Zayed
Summary: Fucoidan is a versatile group of polysaccharides derived from marine organisms, such as brown algae and marine invertebrates. It has attracted significant attention in the pharmaceutical industry due to its diverse physicochemical properties and potential bioactivities. Fucoidan possesses negatively charged surfaces, low/high molecular weight, and water solubility, and it has shown promising effects in various biomedical applications, including anti-tumor, immunomodulatory, and antiviral activities. The current research focuses on formulating fucoidan in different pharmaceutical dosage forms to effectively deliver its therapeutic benefits and enhance drug delivery systems. This study highlights the importance of further clinical research and market availability of fucoidan formulations.
Review
Engineering, Biomedical
Wenyan Yu, Bingbing Liu, Lei Zhou, Enpeng Gong, Chengyuan Che, Jianchao Zhou, Zhenzhong Zhang, Junjie Liu, Jinjin Shi
Summary: Intracerebral hemorrhage (ICH) is a severe form of stroke, resulting in high morbidity and mortality. The limitations of traditional treatment methods have led to extensive research on ICH therapy. The rapid development of drug delivery systems offers a promising approach for treating ICH.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Ana C. Mengarda, Bruno Iles, Joao Paulo F. Longo, Josue de Moraes
Summary: This review focuses on the use of various types of nanomaterials to improve the therapy of praziquantel, the main drug for treating infections caused by parasitic flatworms. Recent advances in PZQ nanoformulations are also described, aiming to overcome the limitations of conventional drugs.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Chemistry, Physical
Fernanda Sodre Rodrigues, Hevelin Balbino de Almeida, Adailton Joao Bortoluzzi, Alexandre Cuin, Eduardo Tonon de Almeida, Elba Pereira de Gois, Jaqueline Rodrigues da Silva, Ricardo Bentes Azevedo, Maryene Alves Camargo
Summary: Schiffbases and benzimidazoles have a wide range of therapeutic applications, including as anticancer agents. The synthesis of BenzHCl mediated by chloride lanthanide and its cytotoxic activity against human breast cancer cells indicate potential anticancer properties.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
S. C. Andia-Huaracha, L. M. Zapana-Cayo, F. F. H. Aragon, J. C. Romero Aquino, J. A. H. Coaquira, C. D. Gonzales-Lorenzo, J. S. Ayala-Arenas, J. L. Solis, P. C. Morais, D. G. Pacheco-Salazar
Summary: The current study synthesized ZnO nanoparticles using the polymeric precursor technique and adjusted their physical properties through annealing. UV-Vis spectroscopy showed a decrease in the optical band gap of the nanoparticles with increasing annealing temperature. The photocatalytic activity of the nanoparticles against methylene blue dye increased with annealing temperature, reaching a maximum at 700°C.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Chemistry, Analytical
Patricia Bento da Silva, Jaqueline Rodrigues da Silva, Mosar Correa Rodrigues, Julia Augusto Vieira, Ikaro Alves de Andrade, Tatsuya Nagata, Alexandre Silva Santos, Sebastiao William da Silva, Marcia Cristina Oliveira da Rocha, Sonia Nair Bao, Pedro M. Moraes-Vieira, Jose Proenca-Modena, Monara K. C. Angelim, Gabriela Fabiano de Souza, Stefanie Primon Muraro, Andre Luis Branco de Barros, Glendara Aparecida de Souza Martins, Fatima Ribeiro-Dias, Giovanna Machado, Melissa Regina Fessel, Ana Marisa Chudzinski-Tavassi, Celia Machado Ronconi, Debora Goncalves, Rui Curi, Osvaldo N. Oliveira Jr, Ricardo Bentes Azevedo
Summary: A low-cost immunoassay using dynamic light scattering (DLS) was developed for the rapid detection of SARS-CoV-2 within 30 minutes. The immunosensor, composed of gold nanoparticles functionalized with antibodies, demonstrated specific binding to the virus and a limit of detection of 5.29 x 10(3) TCID50/mL. This technology can be extended to other detection principles, providing a potential solution for low-cost mass testing for COVID-19.
Article
Chemistry, Multidisciplinary
Danielle Galdino de Souza, Debora Silva Santos, Karina Smidt Simon, Jose Athayde Vasconcelos Morais, Luisa Coutinho Coelho, Thyago Jose Arruda Pacheco, Ricardo Bentes Azevedo, Anamelia Lorenzetti Bocca, Cesar Augusto Melo-Silva, Joao Paulo Figueiro Longo
Summary: Diets rich in omega-3 fatty acids, such as fish oil, can modulate inflammatory responses and cell membrane composition. This study found that the use of lipid nanoemulsion containing fish oil significantly reduced fibrotic progression and inflammation in an experimental model of pulmonary fibrosis.
Review
Pharmacology & Pharmacy
Mosar Correa Rodrigues, Jose Athayde Vasconcelos Morais, Rayane Ganassin, Giulia Rosa Tavares Oliveira, Fabiana Chagas Costa, Amanda Alencar Cabral Morais, Ariane Pandolfo Silveira, Victor Carlos Mello Silva, Joao Paulo Figueiro Longo, Luis Alexandre Muehlmann
Summary: Immunogenic cell death (ICD) is a regulated form of cell death that promotes an adaptive immune response to dying cell antigens. The release and exposure of damage-associated molecular patterns during ICD act as potent immune adjuvants. ICD induced by conventional cytotoxic agents shows promise as a potential approach for cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Victor Carlos Mello, Victor Hugo Sousa Araujo, Karen Letycia Rodrigues de Paiva, Marina Mesquita Simoes, Dafne Caroline Marques, Nelice Roberta da Silva Costa, Isadora Florencio de Souza, Patricia Bento da Silva, Igor Santos, Raquel Almeida, Kelly Grace Magalhaes, Sebastiao William da Silva, Alexandre Silva Santos, Fabiane Veiga-Souza, Paulo Eduardo Narcizo Souza, Marina Arantes Raddichi, Joao Paulo Figueiro Longo, Jennifer Thayanne Cavalcante de Araujo, Luis Alexandre Muehlmann, Marlus Chorilli, Sonia Nair Bao
Summary: Photodynamic therapy using solid lipid nanoparticles loaded with photosensitizers is an effective treatment against skin cancers. A new photosensitizing system, SLN-AlPc, based on Amazon butter, exhibited strong in vitro photodynamic activity on melanoma cells.
Review
Pharmacology & Pharmacy
Camila Magalhaes Cardador, Luis Alexandre Muehlmann, Cintia Marques Coelho, Luciano Paulino Silva, Aisel Valle Garay, Alexandra Maria dos Santos Carvalho, Izabela Marques Dourado Bastos, Joao Paulo Figueiro Longo
Summary: The use of nucleotides in biomedical applications has been a longstanding desire in the scientific community. Nucleotides are unstable molecules and require additional protection to prolong their shelf life in a biological environment. Nano-sized liposomes have proven to be an effective tool for overcoming the instability of nucleotides. Due to their low immunogenicity and ease of preparation, liposomes have been selected as the main strategy for delivering mRNA in COVID-19 immunization. This review article presents examples of liposomes used to protect and deliver nucleotides for cancer therapy, immunostimulatory activities, enzymatic diagnostic applications, veterinarian use, and the treatment of neglected tropical diseases.
Article
Biochemistry & Molecular Biology
Karina Smidt Simon, Luisa Coutinho Coelho, Paulo Henrique de Holanda Veloso, Cesar Augusto Melo-Silva, Jose Athayde Vasconcelos Morais, Joao Paulo Figueiro Longo, Florencio Figueiredo, Leonora Viana, Ildinete Silva Pereira, Veronica Moreira Amado, Marcia Renata Mortari, Anamelia Lorenzetti Bocca
Summary: This study aimed to investigate the therapeutic potential of immunomodulatory peptides in a mouse model of chronic pulmonary fibrosis. The treatment with ToAP3 and ToAP4 peptides delayed the inflammatory process and regulated fibrotic-associated cytokine production, suggesting their potential as therapeutic alternatives for idiopathic pulmonary fibrosis (IPF).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Joao Paulo Figueiro Longo, Paulo Eduardo Narcizo de Souza, Paulo Cesar Morais
Article
Pharmacology & Pharmacy
Joao Paulo Figueiro Longo, Luis Alexandre Muehlmann
Article
Materials Science, Composites
Angelica Gomes Coelho, Jose Otavio Carvalho Sena de Almeida, Andressa Amorim dos Santos, Webysten Ronny Pereira dos Santos, Leonardo da Rocha Sousa, Nildomar Ribeiro Viana, Felipe Alves Batista, Maria de Sousa Brito Neta, Alexandre Silva Santos, Sebastiao William da Silva, Paulo Eduardo Narcizo de Souza, Alyne Rodrigues de Araujo-Nobre, Jose de Sousa Lima-Neto, Antonia Maria das Gracas Lopes Cito, Fernando Aecio de Amorim Carvalho, Michel Mualem de Moraes Alves, Massimo Lucarini, Alessandra Durazzo, Anderson Nogueira Mendes, Daniel Dias Rufino Arcanjo
Summary: This study aimed to develop and characterize solid lipid nanoparticles (SLNs) produced from Platonia insignis seed butter (BBI), and investigate their pharmacological, toxicological, and antioxidant properties. The results showed that the SLN/TW-1.5 formulation exhibited higher stability and antioxidant activity, indicating great potential for applications.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
F. F. H. Aragon, L. Villegas-Lelovsky, J. G. Parizaka, E. G. Zela, R. Bendezu, R. O. Gallegos, D. G. Pacheco-Salazar, S. W. da Silva, R. Cohen, L. C. C. M. Nagamine, J. A. H. Coaquira, P. C. Morais
Summary: Oxide-diluted magnetic semiconductors, specifically Fe-doped ZnO nanoparticles, were synthesized and investigated to understand the effect of Fe doping on their structural, vibrational, optical, hyperfine, and magnetic properties. The results showed that increasing Fe content led to a decrease in crystallite size. XRD analysis revealed different solid solution phases for low and high Fe content. Elliot's theory was used to determine band gap energy and exciton binding energy. FTIR analysis indicated changes in Zn-O bond length and intensity ratio of O-H and Zn-O modes with Fe content. Mossbauer spectra and magnetic measurements showed stabilization of iron ions and the presence of antiferromagnetic interactions.
MATERIALS ADVANCES
(2023)
